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6K3X	G-quadruplex complex with linear dinucleotide d(AG) Descriptor: DNA (5'-D(*AP*G)-3'), DNA (5'-D(*TP*TP*GP*GP*TP*GP*GP*GP*TP*GP*GP*GP*TP*GP*GP*GP*T)-3') Authors: Winnerdy, F.R, Heddi, B, Phan, A.T. Deposit date: 2019-05-22 Release date: 2020-01-15 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Solution Structures of a G-Quadruplex Bound to Linear- and Cyclic-Dinucleotides. J.Am.Chem.Soc., 141, 2019
6JCD	G-quadruplex peripheral knot Descriptor: 24-mer DNA Authors: Winnerdy, F.R, Truong, T.H.A, Phan, A.T. Deposit date: 2019-01-28 Release date: 2019-08-28 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: An Unprecedented Knot-like G-Quadruplex Peripheral Motif. Angew.Chem.Int.Ed.Engl., 58, 2019
6LNZ	NMR solution structure of VEGF G-quadruplex bound a non-planar cyclometalated-carbene platinum(II) complex Descriptor: DNA (5'-D(*CP*GP*GP*GP*GP*CP*GP*GP*GP*CP*CP*TP*TP*GP*GP*GP*CP*GP*GP*GP*GP*T)-3'), cyclometalated-carbene platinum(II) complex Authors: Liu, W, Zhu, B.Z, Mao, Z.W. Deposit date: 2020-01-02 Release date: 2021-01-13 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Selectivity and Targeting of G-Quadruplex Binders Activated by Adaptive Binding and Controlled by Chemical Kinetics. Angew.Chem.Int.Ed.Engl., 60, 2021
7LL0	Crystal structure of a four-tetrad, parallel, and K+ stabilized Tetrahymena thermophila telomeric G-quadruplex Descriptor: 26-mer DNA, POTASSIUM ION Authors: Yatsunyk, L.A, Chen, E.V. Deposit date: 2021-02-03 Release date: 2021-07-07 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2 Å) Cite: The first crystal structures of hybrid and parallel four-tetrad intramolecular G-quadruplexes. Nucleic Acids Res., 50, 2022
7D5F	Left-handed G-quadruplex containing 3 bulges Descriptor: 3xBulge-LHG4motif Authors: Winnerdy, F.R, Das, P, Ngo, K.H, Maity, A, Bakalar, B, Mechulam, Y, Schmitt, E, Phan, A.T. Deposit date: 2020-09-25 Release date: 2021-02-10 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Bulges in left-handed G-quadruplexes. Nucleic Acids Res., 49, 2021
7D5D	Left-handed G-quadruplex containing one bulge Descriptor: 1xBulge-LHG4motif, POTASSIUM ION, SPERMINE Authors: Das, P, Ngo, K.H, Winnerdy, F.R, Maity, A, Bakalar, B, Mechulam, Y, Schmitt, E, Phan, A.T. Deposit date: 2020-09-25 Release date: 2021-02-10 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.18 Å) Cite: Bulges in left-handed G-quadruplexes. Nucleic Acids Res., 49, 2021
7D5E	Left-handed G-quadruplex containing two bulges Descriptor: 2xBulge-LHG4motif, POTASSIUM ION, SODIUM ION, ... Authors: Das, P, Maity, A, Ngo, K.H, Winnerdy, F.R, Bakalar, B, Mechulam, Y, Schmitt, E, Phan, A.T. Deposit date: 2020-09-25 Release date: 2021-02-10 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.296 Å) Cite: Bulges in left-handed G-quadruplexes. Nucleic Acids Res., 49, 2021
2LBY	G-quadruplex structure formed at the 5'-end of NHEIII_1 element in human c-MYC promoter Descriptor: DNA (5'-D(*TP*AP*GP*GP*GP*AP*GP*GP*GP*TP*AP*GP*GP*GP*AP*GP*GP*GP*T)-3') Authors: Mathad, R, Hatzakis, E, Yang, D. Deposit date: 2011-04-07 Release date: 2012-02-22 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: c-MYC promoter G-quadruplex formed at the 5'-end of NHE III1 element: insights into biological relevance and parallel-stranded G-quadruplex stability. Nucleic Acids Res., 39, 2011
2MWZ	Xanthine and 8-oxoguanine in G-quadruplexes: formation of a G G X O tetrad Descriptor: DNA (5'-D(*TP*TP*GP*GP*GP*TP*TP*AP*(8OG)P*GP*GP*TP*TP*AP*GP*GP*(3ZO)P*TP*TP*AP*GP*GP*GP*A)-3') Authors: Cheong, V.V, Heddi, B, Lech, C.J, Phan, A.T. Deposit date: 2014-12-04 Release date: 2015-10-14 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Xanthine and 8-oxoguanine in G-quadruplexes: formation of a GGXO tetrad. Nucleic Acids Res., 43, 2015
2N3M	G-quadruplex structure of an anti-proliferative DNA sequence Descriptor: DNA_(28-MER) Authors: Do, N.Q, Chung, W.J, Truong, T.H.A, Heddi, B, Phan, A.T. Deposit date: 2015-06-05 Release date: 2016-07-06 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: G-quadruplex structure of an anti-proliferative DNA sequence To be Published
3MIJ	Crystal structure of a telomeric RNA G-quadruplex complexed with an acridine-based ligand. Descriptor: N,N'-[acridine-3,6-diylbis(1H-1,2,3-triazole-1,4-diylbenzene-3,1-diyl)]bis[3-(diethylamino)propanamide], POTASSIUM ION, RNA (5'-R(*UP*AP*GP*GP*GP*UP*UP*AP*GP*GP*GP*U)-3') Authors: Collie, G.W, Neidle, S, Parkinson, G.N. Deposit date: 2010-04-10 Release date: 2011-02-16 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural basis of telomeric RNA quadruplex-acridine ligand recognition. J.Am.Chem.Soc., 133, 2011
3IBK	Crystal structure of a telomeric RNA quadruplex Descriptor: POTASSIUM ION, RNA (5'-R(*(5BU)P*AP*GP*GP*GP*UP*UP*AP*GP*GP*GP*U)-3') Authors: Collie, G.W, Neidle, S, Parkinson, G.N. Deposit date: 2009-07-16 Release date: 2010-05-12 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.2 Å) Cite: A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex Nucleic Acids Res., 38, 2010
7NWD	Three-quartet c-kit2 G-quadruplex stabilized by a pyrene conjugate Descriptor: POTASSIUM ION, c-kit2_py1 Authors: Peterkova, K, Durnik, I, Marek, R, Plavec, J, Podbevsek, P. Deposit date: 2021-03-16 Release date: 2021-08-04 Last modified: 2024-06-19 Method: SOLUTION NMR Cite: c-kit2 G-quadruplex stabilized via a covalent probe: exploring G-quartet asymmetry. Nucleic Acids Res., 49, 2021
6PNK	Crystal structure of the G-quadruplex formed by (GGGTT)3GGG in complex with N-methylmesoporphryin IX Descriptor: DNA (5'-D(P*GP*GP*GP*TP*TP*GP*GP*GP*TP*TP*GP*GP*GP*TP*TP*GP*GP*G)-3'), FORMIC ACID, N-METHYLMESOPORPHYRIN, ... Authors: Yatsunyk, L.A, Lin, L.Y. Deposit date: 2019-07-02 Release date: 2020-07-08 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.39 Å) Cite: Biophysical and X-ray structural studies of the (GGGTT)3GGG G-quadruplex in complex with N-methyl mesoporphyrin IX. Plos One, 15, 2020
2HY9	Human telomere DNA quadruplex structure in K+ solution hybrid-1 form Descriptor: DNA (26-MER) Authors: Dai, J, Punchihewa, C, Jones, R.A, Hurley, L, Yang, D. Deposit date: 2006-08-04 Release date: 2007-04-10 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Structure of the intramolecular human telomeric G-quadruplex in potassium solution: a novel adenine triple formation. Nucleic Acids Res., 35, 2007
7ALU	NMR structure of a DNA G-quadruplex containing two SP1 binding sites from HIV-1 promoter Descriptor: DNA (5'-D(*AP*GP*GP*GP*AP*GP*GP*TP*GP*TP*GP*GP*CP*CP*TP*GP*GP*GP*CP*GP*GP*G)-3'), POTASSIUM ION Authors: De Rache, A, Marquevielle, J, Amrane, S. Deposit date: 2020-10-07 Release date: 2022-06-01 Last modified: 2023-12-13 Method: SOLUTION NMR Cite: Structure of a DNA G-quadruplex that modulates SP1 binding sites architecture in HIV-1 promoter. J.Mol.Biol., 2023
6CCW	Hybrid-2 form Human Telomeric G Quadruplex in Complex with Epiberberine Descriptor: DNA (26-MER), Epiberberine Authors: Lin, C, Yang, D.Z. Deposit date: 2018-02-07 Release date: 2018-06-20 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Molecular Recognition of the Hybrid-2 Human Telomeric G-Quadruplex by Epiberberine: Insights into Conversion of Telomeric G-Quadruplex Structures. Angew. Chem. Int. Ed. Engl., 57, 2018
5DE5	Crystal structure of the complex between human FMRP RGG motif and G-quadruplex RNA. Descriptor: Fragile X mental retardation protein 1, POTASSIUM ION, sc1 Authors: Vasilyev, N, Polonskaia, A, Darnell, J.C, Darnell, R.B, Patel, D.J, Serganov, A. Deposit date: 2015-08-25 Release date: 2015-09-23 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (3.0011 Å) Cite: Crystal structure reveals specific recognition of a G-quadruplex RNA by a beta-turn in the RGG motif of FMRP. Proc.Natl.Acad.Sci.USA, 112, 2015
5DEA	Crystal structure of the complex between human FMRP RGG motif and G-quadruplex RNA, cesium bound form. Descriptor: CESIUM ION, Fragile X mental retardation protein 1, POTASSIUM ION, ... Authors: Vasilyev, N, Polonskaia, A, Darnell, J.C, Darnell, R.B, Patel, D.J, Serganov, A. Deposit date: 2015-08-25 Release date: 2015-09-23 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.7973 Å) Cite: Crystal structure reveals specific recognition of a G-quadruplex RNA by a beta-turn in the RGG motif of FMRP. Proc.Natl.Acad.Sci.USA, 112, 2015
5UA3	Crystal Structure of a DNA G-Quadruplex with a Cytosine Bulge Descriptor: DNA (5'-D(*GP*GP*GP*TP*TP*GP*CP*GP*GP*AP*GP*GP*GP*TP*GP*GP*GP*CP*CP*T)-3'), POTASSIUM ION Authors: Meier, M, McDougall, M.D, Krahn, N.J, Moya-Torres, A, McRae, E.K.S, Booy, E.P, Patel, T.R, McKenna, S.A, Stetefeld, J. Deposit date: 2016-12-18 Release date: 2017-11-22 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.8802 Å) Cite: Structure and hydrodynamics of a DNA G-quadruplex with a cytosine bulge. Nucleic Acids Res., 46, 2018
139D	SOLUTION STRUCTURE OF A PARALLEL-STRANDED G-QUADRUPLEX DNA Descriptor: DNA (5'-D(*TP*TP*GP*GP*GP*GP*T)-3') Authors: Patel, D.J, Wang, Y. Deposit date: 1993-09-28 Release date: 1994-01-31 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Solution structure of a parallel-stranded G-quadruplex DNA. J.Mol.Biol., 234, 1993
6CRM	Crystal Structure of RecQ catalytic core from C. sakazakii bound to an unfolded G-quadruplex Descriptor: DNA (5'-D(P*GP*GP*GP*TP*CP*GP*GP*TP*GP*CP*CP*TP*TP*A)-3'), RecQ, ZINC ION Authors: Voter, A.F, Keck, J.L. Deposit date: 2018-03-19 Release date: 2018-10-17 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.19286251 Å) Cite: A guanine-flipping and sequestration mechanism for G-quadruplex unwinding by RecQ helicases. Nat Commun, 9, 2018
8UTG	An RNA G-Quadruplex from the NS5 gene in the West Nile Virus Genome Descriptor: AMMONIUM ION, POTASSIUM ION, RNA (5'-R(*UP*AP*UP*GP*GP*AP*AP*GP*AP*GP*GP*CP*GP*GP*UP*UP*GP*GP*UP*AP*U)-3') Authors: Terrell, J.R, Le, T.T, Wilson, W.D, Siemer, J.L. Deposit date: 2023-10-31 Release date: 2024-06-19 Last modified: 2024-07-17 Method: X-RAY DIFFRACTION (1.97 Å) Cite: Structure of an RNA G-quadruplex from the West Nile virus genome. Nat Commun, 15, 2024
3EUM	A bimolecular anti-parallel-stranded Oxytricha nova telomeric quadruplex in complex with a 3,6-disubstituted acridine BSU-6066 Descriptor: 3,6-Bis[3-(azepan-1-yl)propionamido]acridine, 5'-D(*DGP*DGP*DGP*DGP*DTP*DTP*DTP*DTP*DGP*DGP*DGP*DG)-3', POTASSIUM ION Authors: Campbell, N.H, Parkinson, G, Neidle, S. Deposit date: 2008-10-10 Release date: 2008-10-21 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.78 Å) Cite: Selectivity in Ligand Recognition of G-Quadruplex Loops. Biochemistry, 48, 2009
3EUI	A bimolecular anti-parallel-stranded Oxytricha nova telomeric quadruplex in complex with a 3,6-disubstituted acridine BSU-6042 in a large unit cell Descriptor: 3,6-Bis{3-[(2R)-(2-ethylpiperidino)]propionamido}acridine, 3-[(2R)-2-ethylpiperidin-1-yl]-N-[6-({3-[(2S)-2-ethylpiperidin-1-yl]propanoyl}amino)acridin-3-yl]propanamide, 5'-D(*DGP*DGP*DGP*DGP*DTP*DTP*DTP*DTP*DGP*DGP*DGP*DG)-3', ... Authors: Campbell, N.H, Parkinson, G, Neidle, S. Deposit date: 2008-10-10 Release date: 2008-12-02 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Selectivity in Ligand Recognition of G-Quadruplex Loops. Biochemistry, 48, 2009

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