7D5E
Left-handed G-quadruplex containing two bulges
Summary for 7D5E
| Entry DOI | 10.2210/pdb7d5e/pdb |
| Descriptor | 2xBulge-LHG4motif, POTASSIUM ION, SPERMINE, ... (5 entities in total) |
| Functional Keywords | g-quadruplex, bulge, dna, left-handed |
| Biological source | synthetic construct |
| Total number of polymer chains | 2 |
| Total formula weight | 18851.33 |
| Authors | Das, P.,Maity, A.,Ngo, K.H.,Winnerdy, F.R.,Bakalar, B.,Mechulam, Y.,Schmitt, E.,Phan, A.T. (deposition date: 2020-09-25, release date: 2021-02-10, Last modification date: 2023-11-29) |
| Primary citation | Das, P.,Ngo, K.H.,Winnerdy, F.R.,Maity, A.,Bakalar, B.,Mechulam, Y.,Schmitt, E.,Phan, A.T. Bulges in left-handed G-quadruplexes. Nucleic Acids Res., 49:1724-1736, 2021 Cited by PubMed Abstract: G-quadruplex (G4) DNA structures with a left-handed backbone progression have unique and conserved structural features. Studies on sequence dependency of the structures revealed the prerequisites and some minimal motifs required for left-handed G4 formation. To extend the boundaries, we explore the adaptability of left-handed G4s towards the existence of bulges. Here we present two X-ray crystal structures and an NMR solution structure of left-handed G4s accommodating one, two and three bulges. Bulges in left-handed G4s show distinct characteristics as compared to those in right-handed G4s. The elucidation of intricate structural details will help in understanding the possible roles and limitations of these unique structures. PubMed: 33503265DOI: 10.1093/nar/gkaa1259 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.296 Å) |
Structure validation
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