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3CJ0	Crystal structure of hepatitis c virus rna-dependent rna polymerase ns5b in complex with small molecule fragments Descriptor: 4-[(5-bromopyridin-2-yl)amino]-4-oxobutanoic acid, RNA-directed RNA polymerase Authors: Kissinger, c. Deposit date: 2008-03-12 Release date: 2008-04-15 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors. Bioorg.Med.Chem.Lett., 18, 2008
2HFZ	Crystal structure of RNA dependent RNA polymerase domain from West Nile virus Descriptor: MAGNESIUM ION, RNA-directed RNA polymerase(NS5), ZINC ION Authors: Egloff, M.P, Malet, H, Marseilles Structural Genomics Program @ AFMB (MSGP) Deposit date: 2006-06-26 Release date: 2007-02-06 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (3 Å) Cite: Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5 J.Biol.Chem., 282, 2007
3CJ5	Crystal structure of hepatitis c virus rna-dependent rna polymerase ns5b in complex with optimized small molecule fragments Descriptor: N-(4-bromo-2-{[(3R,5S)-3,5-dimethylpiperidin-1-yl]carbonyl}phenyl)-4-morpholin-4-yl-4-oxobutanamide, RNA-directed RNA polymerase Authors: Hendle, j. Deposit date: 2008-03-12 Release date: 2008-04-15 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.92 Å) Cite: Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors. Bioorg.Med.Chem.Lett., 18, 2008
3CIZ	Crystal structure of hepatitis c virus rna-dependent rna polymerase ns5b in complex with small molecule fragments Descriptor: 2-amino-5-bromobenzoic acid, RNA-directed RNA polymerase, ZINC ION Authors: Hendle, j. Deposit date: 2008-03-12 Release date: 2008-04-15 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.87 Å) Cite: Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors. Bioorg.Med.Chem.Lett., 18, 2008
3CJ3	Crystal structure of hepatitis c virus rna-dependent rna polymerase ns5b in complex with optimized small molecule fragments Descriptor: 4-bromo-2-{[(2R)-2-(2-chlorobenzyl)pyrrolidin-1-yl]carbonyl}aniline, NICKEL (II) ION, RNA-directed RNA polymerase Authors: Kissinger, c. Deposit date: 2008-03-12 Release date: 2008-04-15 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.87 Å) Cite: Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors. Bioorg.Med.Chem.Lett., 18, 2008
2J7U	Dengue virus NS5 RNA dependent RNA polymerase domain Descriptor: CHLORIDE ION, MAGNESIUM ION, RNA DEPENDENT RNA POLYMERASE, ... Authors: Yap, T.L, Xu, T, Chen, Y.L, Malet, H, Egloff, M.P, Canard, B, Vasudevan, S.G, Lescar, J. Deposit date: 2006-10-17 Release date: 2007-03-13 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Crystal Structure of the Dengue Virus RNA- Dependent RNA Polymerase Catalytic Domain at 1.85 Angstrom Resolution. J.Virol., 81, 2007
1CSJ	CRYSTAL STRUCTURE OF THE RNA-DEPENDENT RNA POLYMERASE OF HEPATITIS C VIRUS Descriptor: HEPATITIS C VIRUS RNA POLYMERASE (NS5B) Authors: Bressanelli, S, Tomei, L, Roussel, A, Incitti, I, Vitale, R.L, Mathieu, M, De Francesco, R, Rey, F.A. Deposit date: 1999-08-18 Release date: 1999-11-08 Last modified: 2013-02-13 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus. Proc.Natl.Acad.Sci.USA, 96, 1999
3IHQ	Crystal Structure of Reduced C10S Spx in Complex with the Alpha C-terminal Domain of RNA Polymeras Descriptor: DNA-directed RNA polymerase subunit alpha, IMIDAZOLE, Regulatory protein spx Authors: Newberry, K.J, Brennan, R.G. Deposit date: 2009-07-30 Release date: 2010-02-02 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Promoter recognition by a complex of Spx and the C-terminal domain of the RNA polymerase alpha subunit. Plos One, 5, 2010
4BOC	Structure of mitochondrial RNA polymerase elongation complex Descriptor: 5'-D(*CP*AP*TP*GP*GP*GP*GP*TP*AP*AP*TP*TP*AP*TP *TP*TP*CP*GP*AP*CP*GP*CP*CP*AP*GP*AP*CP*G)-3', 5'-D(*CP*GP*TP*CP*TP*GP*GP*CP*GP*TP*GP*CP*GP*CP *GP*CP*CP*GP*CP*TP*AP*CP*CP*CP*CP*AP*TP*G)-3', 5'-R(*AP*GP*UP*CP*UP*GP*CP*GP*GP*CP*GP*CP*GP*CP)-3', ... Authors: Schwinghammer, K, Cheung, A, Morozov, Y, Agaronyan, K, Temiakov, D, Cramer, P. Deposit date: 2013-05-18 Release date: 2013-09-25 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Structure of Human Mitochondrial RNA Polymerase Elongation Complex Nat.Struct.Mol.Biol., 20, 2013
1OS5	Crystal structure of HCV NS5B RNA polymerase complexed with a novel non-competitive inhibitor. Descriptor: 3-(4-AMINO-2-TERT-BUTYL-5-METHYL-PHENYLSULFANYL)-6-CYCLOPENTYL-4-HYDROXY-6-[2-(4-HYDROXY-PHENYL)-ETHYL]-5,6-DIHYDRO-PYRAN-2-ONE, Hepatitis C virus NS5B RNA polymerase Authors: Love, R.A, Parge, H.E, Yu, X, Hickey, M.J, Diehl, W, Gao, J, Wriggers, H, Ekker, A, Wang, L, Thomson, J.A, Dragovich, P.S, Fuhrman, S.A. Deposit date: 2003-03-18 Release date: 2004-03-18 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystallographic identification of a noncompetitive inhibitor binding site on the hepatitis C virus NS5B RNA polymerase enzyme. J.Virol., 77, 2003
2HAI	Crystal structure of HCV NS5B RNA polymerase in complex with novel class of dihydropyrone-containing inhibitor. Descriptor: (6S)-6-CYCLOPENTYL-6-[2-(3-FLUORO-4-ISOPROPOXYPHENYL)ETHYL]-4-HYDROXY-5,6-DIHYDRO-2H-PYRAN-2-ONE, HEPATITIS C VIRUS NS5B RNA POLYMERASE Authors: Li, H, Love, R.L. Deposit date: 2006-06-12 Release date: 2006-09-05 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.58 Å) Cite: Identification and structure-based optimization of novel dihydropyrones as potent HCV RNA polymerase inhibitors. Bioorg.Med.Chem.Lett., 16, 2006
2PO4	X-ray crystal structure of polymerase domain of the bacteriophage N4 virion RNA polymerase Descriptor: Virion RNA polymerase Authors: Murakami, K.S, Davydova, E.K, Rothman-Denes, L.B. Deposit date: 2007-04-25 Release date: 2008-04-01 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2 Å) Cite: X-ray crystal structure of polymerase domain of the bacteriophage N4 virion RNA polymerase Proc.Natl.Acad.Sci.USA, 15, 2008
1EF4	SOLUTION STRUCTURE OF THE ESSENTIAL RNA POLYMERASE SUBUNIT RPB10 FROM METHANOBACTERIUM THERMOAUTOTROPHICUM Descriptor: DNA-DIRECTED RNA POLYMERASE, ZINC ION Authors: Mackereth, C.D, Arrowsmith, C.H, Edwards, A.M, Mcintosh, L.P, Northeast Structural Genomics Consortium (NESG) Deposit date: 2000-02-07 Release date: 2000-06-14 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Zinc-bundle structure of the essential RNA polymerase subunit RPB10 from Methanobacterium thermoautotrophicum. Proc.Natl.Acad.Sci.USA, 97, 2000
2RF4	Crystal structure of the RNA Polymerase I subcomplex A14/43 Descriptor: DNA-directed RNA polymerase I subunit RPA4 Authors: Geiger, S.R, Kuhn, C.D, Cramer, P. Deposit date: 2007-09-28 Release date: 2008-01-15 Last modified: 2017-10-25 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Functional architecture of RNA polymerase I. Cell(Cambridge,Mass.), 131, 2007
2GHQ	CTD-specific phosphatase Scp1 in complex with peptide C-terminal domain of RNA polymerase II Descriptor: Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1, DNA-directed RNA polymerase II largest subunit, MAGNESIUM ION Authors: Zhang, Y, Noel, J.P. Deposit date: 2006-03-27 Release date: 2006-12-05 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1. Mol.Cell, 24, 2006
2GHT	CTD-specific phosphatase Scp1 in complex with peptide from C-terminal domain of RNA polymerase II Descriptor: Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1, DNA-directed RNA polymerase II largest subunit, MAGNESIUM ION Authors: Zhang, Y, Noel, J.P. Deposit date: 2006-03-27 Release date: 2006-12-05 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1. Mol.Cell, 24, 2006
1QUV	CRYSTAL STRUCTURE OF THE RNA DIRECTED RNA POLYMERASE OF HEPATITIS C VIRUS Descriptor: PROTEIN (RNA-DIRECTED RNA POLYMERASE) Authors: Ago, H, Miyano, M, Adachi, T, Habuka, N. Deposit date: 1999-07-04 Release date: 1999-11-05 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus. Structure Fold.Des., 7, 1999
2MAX	NMR structure of the RNA polymerase alpha subunit C-terminal domain from Helicobacter pylori Descriptor: DNA-directed RNA polymerase subunit alpha Authors: Borin, B.N, Krezel, A.M. Deposit date: 2013-07-21 Release date: 2014-03-12 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Helicobacter pylori RNA polymerase alpha-subunit C-terminal domain shows features unique to -proteobacteria and binds NikR/DNA complexes. Protein Sci., 23, 2014
1GO3	Structure of an archeal homolog of the eukaryotic RNA polymerase II RPB4/RPB7 complex Descriptor: DNA-DIRECTED RNA POLYMERASE SUBUNIT E, DNA-DIRECTED RNA POLYMERASE SUBUNIT F Authors: Todone, F, Brick, P, Werner, F, Weinzierl, R.O.J, Onesti, S. Deposit date: 2001-10-17 Release date: 2001-12-07 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structure of an Archaeal Homolog of the Eukaryotic RNA Polymerase II Rpb4/Rpb7 Complex Mol.Cell, 8, 2001
2LO6	Structure of Nrd1 CID bound to phosphorylated RNAP II CTD Descriptor: DNA-directed RNA polymerase II subunit RPB1, Protein NRD1 Authors: Kubicek, K, Cerna, H, Pasulka, J, Holub, P, Hrossova, D, Loehr, F, Hofr, C, Vanacova, S, Stefl, R. Deposit date: 2012-01-17 Release date: 2012-12-26 Method: SOLUTION NMR Cite: Serine phosphorylation and proline isomerization in RNAP II CTD control recruitment of Nrd1. Genes Dev., 26, 2012
2M4K	Solution structure of the delta subunit of RNA polymerase from Bacillus subtilis Descriptor: DNA-directed RNA polymerase subunit delta Authors: Papouskova, V, Novacek, J, Kaderavek, P, Zidek, L, Rabatinova, A, Sanderova, H, Krasny, L, Sklenar, V. Deposit date: 2013-02-07 Release date: 2013-10-09 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Structural Study of the Partially Disordered Full-Length delta Subunit of RNA Polymerase from Bacillus subtilis. Chembiochem, 14, 2013
2LT1	Solution NMR structure of the 72-residue N-terminal domain of Myxococcus xanthus CarD Descriptor: CarD protein Authors: Jimenez, M.A, Padmanabhan, S. Deposit date: 2012-05-10 Release date: 2013-11-13 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Structure-Function Dissection of Myxococcus xanthus CarD N-Terminal Domain, a Defining Member of the CarD_CdnL_TRCF Family of RNA Polymerase Interacting Proteins. Plos One, 10
4MTP	RdRp from Japanesese Encephalitis Virus Descriptor: RNA dependent RNA polymerase, ZINC ION Authors: Surana, P, Nair, D.T. Deposit date: 2013-09-20 Release date: 2013-12-25 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.65 Å) Cite: RNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation state. Nucleic Acids Res., 42, 2014
2E9R	Foot-and-mouth disease virus RNA-dependent RNA polymerase in complex with a template-primer RNA and with ribavirin Descriptor: 5'-R(*CP*AP*UP*GP*GP*GP*CP*CP*C)-3', 5'-R(*CP*CP*C*GP*GP*GP*CP*CP*C)-3', MAGNESIUM ION, ... Authors: Ferrer-Orta, C, Arias, A, Perez-Luque, R, Escarmis, C, Domingo, E, Verdaguer, N. Deposit date: 2007-01-26 Release date: 2007-06-26 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.81 Å) Cite: Sequential structures provide insights into the fidelity of RNA replication Proc.Natl.Acad.Sci.Usa, 104, 2007
8IIC	Crystal structure of Israeli acute paralysis virus RNA-dependent RNA polymerase delta40 mutant (residues 41-546) Descriptor: Polymerase polyprotein Authors: Fang, X, Lu, G, Hou, C, Gong, P. Deposit date: 2023-02-24 Release date: 2023-06-07 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (3.25 Å) Cite: Unusual substructure conformations observed in crystal structures of a dicistrovirus RNA-dependent RNA polymerase suggest contribution of the N-terminal extension in proper folding. Virol Sin, 38, 2023

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