6GZ5
 
 | | tRNA translocation by the eukaryotic 80S ribosome and the impact of GTP hydrolysis, Translocation-intermediate-POST-3 (TI-POST-3) | | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 5.8S ribosomal RNA, ... | | Authors: | Flis, J, Holm, M, Rundlet, E.J, Loerke, J, Hilal, T, Dabrowski, M, Buerger, J, Mielke, T, Blanchard, S.C, Spahn, C.M.T, Budkevich, T.V. | | Deposit date: | 2018-07-03 | | Release date: | 2018-12-05 | | Last modified: | 2022-03-30 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | tRNA Translocation by the Eukaryotic 80S Ribosome and the Impact of GTP Hydrolysis.
Cell Rep, 25, 2018
|
|
7P7R
 | | PoxtA-EQ2 antibiotic resistance ABCF bound to E. faecalis 70S ribosome, state I | | Descriptor: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | | Authors: | Crowe-McAuliffe, C, Wilson, D.N. | | Deposit date: | 2021-07-20 | | Release date: | 2022-03-23 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics.
Nat Commun, 13, 2022
|
|
8BB2
 | | Structure of human WDR5 and pVHL:ElonginC:ElonginB bound to PROTAC with PEG linker (conformation #2) | | Descriptor: | 1,2-ETHANEDIOL, Elongin-B, Elongin-C, ... | | Authors: | Kraemer, A, Doelle, A, Knapp, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2022-10-12 | | Release date: | 2022-11-09 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Structure of human WDR5 and pVHL:ElonginC:ElonginB bound to PROTAC with PEG linker (conformation #2)
To Be Published
|
|
8BB3
 | | Structure of human WDR5 and pVHL:ElonginC:ElonginB bound to PROTAC with PEG linker (conformation #1) | | Descriptor: | 1,2-ETHANEDIOL, Elongin-B, Elongin-C, ... | | Authors: | Kraemer, A, Doelle, A, Knapp, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2022-10-12 | | Release date: | 2022-11-09 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structure of human WDR5 and pVHL:ElonginC:ElonginB bound to PROTAC with PEG linker (conformation #1)
To Be Published
|
|
8BB5
 | | Structure of human WDR5 and pVHL:ElonginC:ElonginB bound to PROTAC with Aryl linker | | Descriptor: | 1,2-ETHANEDIOL, Elongin-B, Elongin-C, ... | | Authors: | Kraemer, A, Doelle, A, Knapp, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2022-10-12 | | Release date: | 2022-11-09 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization.
Cell Chem Biol, 30, 2023
|
|
8BB4
 | | Structure of human WDR5 and pVHL:ElonginC:ElonginB bound to PROTAC with C3 linker | | Descriptor: | Elongin-B, Elongin-C, WD repeat-containing protein 5, ... | | Authors: | Kraemer, A, Doelle, A, Knapp, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2022-10-12 | | Release date: | 2022-11-09 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization.
Cell Chem Biol, 30, 2023
|
|
5IJ7
 | | Structure of Hs/AcPRC2 in complex with a pyridone inhibitor | | Descriptor: | 5,8-dichloro-2-[(4-ethyl-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-7-({1-[(2R)-2-hydroxypropanoyl]piperidin-4-yl}oxy)-3,4-dihydroisoquinolin-1(2H)-one, Enhancer of Zeste Homolog 2 (EZH2),Histone-lysine N-methyltransferase EZH2, Polycomb protein EED, ... | | Authors: | Gajiwala, K.S, Brooun, A, Deng, Y.-L, Liu, W. | | Deposit date: | 2016-03-01 | | Release date: | 2016-05-04 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.62 Å) | | Cite: | Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance.
Nat Commun, 7, 2016
|
|
7PAK
 | | 70S ribosome with EF-Tu-tRNA and P-site tRNA in Mycoplasma pneumoniae cells | | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Xue, L, Lenz, S, Rappsilber, J, Mahamid, J. | | Deposit date: | 2021-07-30 | | Release date: | 2022-05-25 | | Last modified: | 2022-10-19 | | Method: | ELECTRON MICROSCOPY (5.3 Å) | | Cite: | Visualizing translation dynamics at atomic detail inside a bacterial cell.
Nature, 610, 2022
|
|
7PAR
 | | 70S ribosome with EF-G, ap/P- and pe/E-site tRNAs in Mycoplasma pneumoniae cells | | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Xue, L, Lenz, S, Rappsilber, J, Mahamid, J. | | Deposit date: | 2021-07-30 | | Release date: | 2022-05-25 | | Last modified: | 2022-10-19 | | Method: | ELECTRON MICROSCOPY (8.2 Å) | | Cite: | Visualizing translation dynamics at atomic detail inside a bacterial cell.
Nature, 610, 2022
|
|
7PAQ
 | | 70S ribosome with EF-G, A/P- and P/E-site tRNAs in Mycoplasma pneumoniae cells | | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Xue, L, Lenz, S, Rappsilber, J, Mahamid, J. | | Deposit date: | 2021-07-30 | | Release date: | 2022-05-25 | | Last modified: | 2022-10-19 | | Method: | ELECTRON MICROSCOPY (8.9 Å) | | Cite: | Visualizing translation dynamics at atomic detail inside a bacterial cell.
Nature, 610, 2022
|
|
7PAJ
 | | 70S ribosome with EF-Tu-tRNA, P- and E-site tRNAs in Mycoplasma pneumoniae cells | | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Xue, L, Lenz, S, Rappsilber, J, Mahamid, J. | | Deposit date: | 2021-07-30 | | Release date: | 2022-05-25 | | Last modified: | 2022-10-19 | | Method: | ELECTRON MICROSCOPY (7.3 Å) | | Cite: | Visualizing translation dynamics at atomic detail inside a bacterial cell.
Nature, 610, 2022
|
|
7PAS
 | | 70S ribosome with P/E-site tRNA in Mycoplasma pneumoniae cells | | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Xue, L, Lenz, S, Rappsilber, J, Mahamid, J. | | Deposit date: | 2021-07-30 | | Release date: | 2022-05-25 | | Last modified: | 2022-10-19 | | Method: | ELECTRON MICROSCOPY (16 Å) | | Cite: | Visualizing translation dynamics at atomic detail inside a bacterial cell.
Nature, 610, 2022
|
|
7P6Z
 | | Mycoplasma pneumoniae 70S ribosome in untreated cells | | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Xue, L, Lenz, S, Rappsilber, J, Mahamid, J. | | Deposit date: | 2021-07-18 | | Release date: | 2022-05-25 | | Last modified: | 2022-10-19 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Visualizing translation dynamics at atomic detail inside a bacterial cell.
Nature, 610, 2022
|
|
7PAM
 | | 70S ribosome with A*- and P/E-site tRNAs in Mycoplasma pneumoniae cells | | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Xue, L, Lenz, S, Rappsilber, J, Mahamid, J. | | Deposit date: | 2021-07-30 | | Release date: | 2022-05-25 | | Last modified: | 2022-10-19 | | Method: | ELECTRON MICROSCOPY (6.8 Å) | | Cite: | Visualizing translation dynamics at atomic detail inside a bacterial cell.
Nature, 610, 2022
|
|
7PAL
 | | 70S ribosome with A- and P-site tRNAs in Mycoplasma pneumoniae cells | | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Xue, L, Lenz, S, Rappsilber, J, Mahamid, J. | | Deposit date: | 2021-07-30 | | Release date: | 2022-05-25 | | Last modified: | 2023-07-26 | | Method: | ELECTRON MICROSCOPY (4.7 Å) | | Cite: | Visualizing translation dynamics at atomic detail inside a bacterial cell.
Nature, 610, 2022
|
|
7PAI
 | | 70S ribosome with P-site tRNA in Mycoplasma pneumoniae cells | | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Xue, L, Lenz, S, Rappsilber, J, Mahamid, J. | | Deposit date: | 2021-07-30 | | Release date: | 2022-05-25 | | Last modified: | 2022-10-19 | | Method: | ELECTRON MICROSCOPY (6.7 Å) | | Cite: | Visualizing translation dynamics at atomic detail inside a bacterial cell.
Nature, 610, 2022
|
|
7PAH
 | | 70S ribosome with P- and E-site tRNAs in Mycoplasma pneumoniae cells | | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Xue, L, Lenz, S, Rappsilber, J, Mahamid, J. | | Deposit date: | 2021-07-30 | | Release date: | 2022-05-25 | | Last modified: | 2022-10-19 | | Method: | ELECTRON MICROSCOPY (9.5 Å) | | Cite: | Visualizing translation dynamics at atomic detail inside a bacterial cell.
Nature, 610, 2022
|
|
7PAN
 | | 70S ribosome with A/P- and P/E-site tRNAs in Mycoplasma pneumoniae cells | | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Xue, L, Lenz, S, Rappsilber, J, Mahamid, J. | | Deposit date: | 2021-07-30 | | Release date: | 2022-05-25 | | Last modified: | 2022-10-19 | | Method: | ELECTRON MICROSCOPY (9.7 Å) | | Cite: | Visualizing translation dynamics at atomic detail inside a bacterial cell.
Nature, 610, 2022
|
|
5I72
 | | Crystal structure of the oligomeric form of the Lassa virus matrix protein Z | | Descriptor: | RING finger protein Z, ZINC ION | | Authors: | Hastie, K, Zandonatti, M, Liu, T, Li, S, Woods Jr, V, Saphire, E.O. | | Deposit date: | 2016-02-16 | | Release date: | 2016-03-09 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Crystal Structure of the Oligomeric Form of Lassa Virus Matrix Protein Z.
J.Virol., 90, 2016
|
|
7PAO
 | | 70S ribosome with EF-G, A*- and P/E-site tRNAs in Mycoplasma pneumoniae cells | | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Xue, L, Lenz, S, Rappsilber, J, Mahamid, J. | | Deposit date: | 2021-07-30 | | Release date: | 2022-05-25 | | Last modified: | 2022-10-19 | | Method: | ELECTRON MICROSCOPY (7 Å) | | Cite: | Visualizing translation dynamics at atomic detail inside a bacterial cell.
Nature, 610, 2022
|
|
8BC3
 | | Cryo-EM Structure of a BmSF-TAL - Sulfofructose Schiff Base Complex | | Descriptor: | (2~{R},3~{S},4~{S})-2,3,4,6-tetrakis(oxidanyl)hexane-1-sulfonic acid, BmSF-TAL | | Authors: | Snow, A.J.D, Sharma, M, Blaza, J, Davies, G.J. | | Deposit date: | 2022-10-14 | | Release date: | 2023-01-18 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (2.1 Å) | | Cite: | Structure and mechanism of sulfofructose transaldolase, a key enzyme in sulfoquinovose metabolism.
Structure, 31, 2023
|
|
8BC2
 | | Ligand-Free Structure of the decameric sulfofructose transaldolase BmSF-TAL | | Descriptor: | Transaldolase | | Authors: | Snow, A.J.D, Sharma, M, Blaza, J, Davies, G.J. | | Deposit date: | 2022-10-14 | | Release date: | 2023-01-18 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Structure and mechanism of sulfofructose transaldolase, a key enzyme in sulfoquinovose metabolism.
Structure, 31, 2023
|
|
8BC4
 | | Cryo-EM Structure of a BmSF-TAL - Sulfofructose Schiff Base Complex in symmetry group C1 | | Descriptor: | (2~{R},3~{S},4~{S})-2,3,4,6-tetrakis(oxidanyl)hexane-1-sulfonic acid, Transaldolase | | Authors: | Snow, A.J.D, Sharma, M, Blaza, J, Davies, G.J. | | Deposit date: | 2022-10-14 | | Release date: | 2023-01-18 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structure and mechanism of sulfofructose transaldolase, a key enzyme in sulfoquinovose metabolism.
Structure, 31, 2023
|
|
5IGQ
 | |
7OYA
 | | Cryo-EM structure of the 1 hpf zebrafish embryo 80S ribosome | | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... | | Authors: | Leesch, F, Lorenzo-Orts, L, Grishkovskaya, I, Kandolf, S, Belacic, K, Meinhart, A, Haselbach, D, Pauli, A. | | Deposit date: | 2021-06-24 | | Release date: | 2022-07-13 | | Last modified: | 2023-02-08 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | A molecular network of conserved factors keeps ribosomes dormant in the egg.
Nature, 613, 2023
|
|
