8HD4
| Full-length crystal structure of mycobacterium tuberculosis FadD23 in complex with AMPC16 | Descriptor: | Long-chain-fatty-acid--AMP ligase FadD23, palmitoyl adenylate | Authors: | Yan, M.R, Liu, X, Zhang, W, Rao, Z.H. | Deposit date: | 2022-11-03 | Release date: | 2023-02-15 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.68 Å) | Cite: | The Key Roles of Mycobacterium tuberculosis FadD23 C-terminal Domain in Catalytic Mechanisms. Front Microbiol, 14, 2023
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4CLP
| Crystal structure of human soluble Adenylyl Cyclase complex with adenosine-3',5'-cyclic-monophosphate | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ... | Authors: | Kleinboelting, S, Weyand, M, Steegborn, C. | Deposit date: | 2014-01-15 | Release date: | 2014-03-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of its Activation Through Bicarbonate. Proc.Natl.Acad.Sci.USA, 111, 2014
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4CLT
| Crystal structure of human soluble Adenylyl Cyclase with adenosine-3', 5'-cyclic-monophosphate and pyrophosphate | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ADENYLATE CYCLASE TYPE 10, ... | Authors: | Kleinboelting, S, Weyand, M, Steegborn, C. | Deposit date: | 2014-01-15 | Release date: | 2014-03-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of its Activation Through Bicarbonate. Proc.Natl.Acad.Sci.USA, 111, 2014
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6YNC
| Crystal structure of cAMP-dependent Protein Kinase (PKA) in complex with the methylated Fasudil-derived fragment N-methylisoquinoline-5-sulfonamide (soaked) | Descriptor: | cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, ~{N}-methylisoquinoline-5-sulfonamide | Authors: | Oebbeke, M, Wienen-Schmidt, B, Heine, A, Klebe, G. | Deposit date: | 2020-04-13 | Release date: | 2020-10-14 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Two Methods, One Goal: Structural Differences between Cocrystallization and Crystal Soaking to Discover Ligand Binding Poses. Chemmedchem, 16, 2021
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6YQI
| Crystal structure of cAMP-dependent Protein Kinase (PKA) in complex with long-chain Fasudil-derivative N-[2-(propylamino)ethyl]isoquinoline-5-sulfonamide (soaked) | Descriptor: | cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, ~{N}-[2-(propylamino)ethyl]isoquinoline-5-sulfonamide | Authors: | Oebbeke, M, Wienen-Schmidt, B, Heine, A, Klebe, G. | Deposit date: | 2020-04-17 | Release date: | 2020-10-14 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | Two Methods, One Goal: Structural Differences between Cocrystallization and Crystal Soaking to Discover Ligand Binding Poses. Chemmedchem, 16, 2021
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6YOT
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6YOU
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7AXT
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5NNT
| The dimeric structure of LL-37 crystallized in DPC | Descriptor: | Cathelicidin antimicrobial peptide, dodecyl 2-(trimethylammonio)ethyl phosphate | Authors: | Zeth, K, Sancho-Vaello, E. | Deposit date: | 2017-04-10 | Release date: | 2018-01-24 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.209 Å) | Cite: | Structural remodeling and oligomerization of human cathelicidin on membranes suggest fibril-like structures as active species. Sci Rep, 7, 2017
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5NNK
| The structure of LL-37 crystallized in the presence LDAO | Descriptor: | Cathelicidin antimicrobial peptide, LAURYL DIMETHYLAMINE-N-OXIDE | Authors: | Zeth, K, Sancho-Vaello, E. | Deposit date: | 2017-04-10 | Release date: | 2018-01-24 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.798 Å) | Cite: | Structural remodeling and oligomerization of human cathelicidin on membranes suggest fibril-like structures as active species. Sci Rep, 7, 2017
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5NNM
| The crystal structure of dimeric LL-37 | Descriptor: | CARBONATE ION, Cathelicidin antimicrobial peptide | Authors: | Zeth, K, Sancho-Vaello, E. | Deposit date: | 2017-04-10 | Release date: | 2018-01-24 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural remodeling and oligomerization of human cathelicidin on membranes suggest fibril-like structures as active species. Sci Rep, 7, 2017
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7PDC
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8VDT
| DNA Ligase 1 with nick DNA 3'rA:T | Descriptor: | DNA (5'-D(*GP*TP*CP*CP*GP*AP*CP*TP*AP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA ligase 1, DNA/RNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*T)-R(P*A)-D(P*GP*TP*CP*GP*GP*AP*C)-3'), ... | Authors: | KanalElamparithi, B, Gulkis, M, Caglayan, M. | Deposit date: | 2023-12-17 | Release date: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.78 Å) | Cite: | Structures of LIG1 provide a mechanistic basis for understanding a lack of sugar discrimination against a ribonucleotide at the 3'-end of nick DNA. J.Biol.Chem., 300, 2024
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8VDS
| DNA Ligase 1 with nick DNA 3'rG:C | Descriptor: | DNA (5'-D(*GP*TP*CP*CP*GP*AP*CP*CP*AP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA ligase 1, DNA/RNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*T)-R(P*G)-D(P*GP*TP*CP*GP*GP*AP*C)-3') | Authors: | KanalElamparithi, B, Gulkis, M, Caglayan, M. | Deposit date: | 2023-12-17 | Release date: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.79 Å) | Cite: | Structures of LIG1 provide a mechanistic basis for understanding a lack of sugar discrimination against a ribonucleotide at the 3'-end of nick DNA. J.Biol.Chem., 300, 2024
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2IZY
| Molecular Basis of AKAP Specificity for PKA Regulatory Subunits | Descriptor: | CAMP-DEPENDENT PROTEIN KINASE REGULATORY SUBUNIT II | Authors: | Gold, M.G, Lygren, B, Dokurno, P, Hoshi, N, McConnachie, G, Tasken, K, Carlson, C.R, Scott, J.D, Barford, D. | Deposit date: | 2006-07-27 | Release date: | 2006-11-13 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Molecular Basis of Akap Specificity for Pka Regululatory Subunits Mol.Cell, 24, 2006
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8WO3
| Crystal structure of H. pylori isoleucyl-tRNA synthetase (HpIleRS) in complex with Mupirocin | Descriptor: | ACETATE ION, GLYCEROL, Isoleucine--tRNA ligase, ... | Authors: | Guo, Y, Li, S, Zhang, T. | Deposit date: | 2023-10-06 | Release date: | 2024-02-14 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis for substrate and antibiotic recognition by Helicobacter pylori isoleucyl-tRNA synthetase. Febs Lett., 598, 2024
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8WNF
| Crystal structure of H. pylori isoleucyl-tRNA synthetase (HpIleRS) in apo form | Descriptor: | ACETATE ION, GLYCEROL, Isoleucine--tRNA ligase, ... | Authors: | Guo, Y, Li, S, Zhang, T. | Deposit date: | 2023-10-05 | Release date: | 2024-02-14 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for substrate and antibiotic recognition by Helicobacter pylori isoleucyl-tRNA synthetase. Febs Lett., 598, 2024
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8WNI
| Crystal structure of H. pylori isoleucyl-tRNA synthetase (HpIleRS) in complex with Val | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, GLYCEROL, ... | Authors: | Guo, Y, Li, S, Zhang, T. | Deposit date: | 2023-10-06 | Release date: | 2024-02-14 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural basis for substrate and antibiotic recognition by Helicobacter pylori isoleucyl-tRNA synthetase. Febs Lett., 598, 2024
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2P9V
| Structure of AmpC beta-lactamase with cross-linked active site after exposure to small molecule inhibitor | Descriptor: | Beta-lactamase, PHOSPHATE ION | Authors: | Babaoglu, K, Wyrembak, P.N, Pelto, R.B, Shoichet, B.K, Pratt, R.F. | Deposit date: | 2007-03-26 | Release date: | 2007-08-14 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | O-Aryloxycarbonyl Hydroxamates: New beta-Lactamase Inhibitors That Cross-Link the Active Site. J.Am.Chem.Soc., 129, 2007
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3JBV
| Mechanisms of Ribosome Stalling by SecM at Multiple Elongation Steps | Descriptor: | 30S ribosomal protein S10, 30S ribosomal protein S11, 30S ribosomal protein S12, ... | Authors: | Zhang, J, Pan, X.J, Yan, K.G, Sun, S, Gao, N, Sui, S.F. | Deposit date: | 2015-10-16 | Release date: | 2016-01-27 | Last modified: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (3.32 Å) | Cite: | Mechanisms of ribosome stalling by SecM at multiple elongation steps Elife, 4, 2015
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2P98
| E. coli methionine aminopeptidase monometalated with inhibitor YE7 | Descriptor: | IMIDAZO[2,1-A]ISOQUINOLINE-2-CARBOHYDRAZIDE, MANGANESE (II) ION, Methionine aminopeptidase, ... | Authors: | Ye, Q. | Deposit date: | 2007-03-24 | Release date: | 2007-11-20 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Inhibition of Monometalated Methionine Aminopeptidase: Inhibitor Discovery and Crystallographic Analysis. J.Med.Chem., 50, 2007
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2P9A
| E. coli methionine aminopeptidase dimetalated with inhibitor YE6 | Descriptor: | 5-(2-chlorophenyl)furan-2-carbohydrazide, MANGANESE (II) ION, Methionine aminopeptidase, ... | Authors: | Ye, Q. | Deposit date: | 2007-03-24 | Release date: | 2007-11-20 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Inhibition of Monometalated Methionine Aminopeptidase: Inhibitor Discovery and Crystallographic Analysis. J.Med.Chem., 50, 2007
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2P99
| E. coli methionine aminopeptidase monometalated with inhibitor YE6 | Descriptor: | 5-(2-chlorophenyl)furan-2-carbohydrazide, MANGANESE (II) ION, Methionine aminopeptidase, ... | Authors: | Ye, Q. | Deposit date: | 2007-03-24 | Release date: | 2007-11-20 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Inhibition of Monometalated Methionine Aminopeptidase: Inhibitor Discovery and Crystallographic Analysis. J.Med.Chem., 50, 2007
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1M5Z
| The PDZ7 of Glutamate Receptor Interacting Protein Binds to its Target via a Novel Hydrophobic Surface Area | Descriptor: | AMPA receptor interacting protein | Authors: | Feng, W, Fan, J, Jiang, M, Shi, Y, Zhang, M. | Deposit date: | 2002-07-11 | Release date: | 2002-11-06 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | The PDZ7 of Glutamate Receptor Interacting Protein Binds to its Target via a Novel Hydrophobic Surface Area J.Biol.Chem., 277, 2002
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1KFR
| Structural plasticity in the eight-helix fold of a trematode hemoglobin | Descriptor: | Hemoglobin, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION | Authors: | Milani, M, Pesce, A, Dewilde, S, Ascenzi, P, Moens, L, Bolognesi, M. | Deposit date: | 2001-11-22 | Release date: | 2002-04-24 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structural plasticity in the eight-helix fold of a trematode haemoglobin. Acta Crystallogr.,Sect.D, 58, 2002
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