6YOU
Crystal structure of the cAMP-dependent protein kinase A in complex with Pyrido[3,2-d]pyrimidin-4-amine (soaked)
Summary for 6YOU
Entry DOI | 10.2210/pdb6you/pdb |
Descriptor | cAMP-dependent protein kinase catalytic subunit alpha, pyrido[3,2-d]pyrimidin-4-amine (3 entities in total) |
Functional Keywords | phosphotransferase, signalling pathways, glycogen metabolism, serine/threonine kinase, transferase |
Biological source | Cricetulus griseus (Chinese hamster) |
Total number of polymer chains | 1 |
Total formula weight | 41339.89 |
Authors | Oebbeke, M.,Heine, A.,Klebe, G. (deposition date: 2020-04-15, release date: 2021-04-28, Last modification date: 2024-01-24) |
Primary citation | Oebbeke, M.,Wienen-Schmidt, B.,Gerber, H.-D.,Heine, A.,Klebe, G. Fragment based drug design - Small chemical changes of fragments effecting big changes in binding To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.73 Å) |
Structure validation
Download full validation report