PDB: 8717 resultsInfo pagesStatus searchChemie searchBIRD

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2H6Q	Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex Descriptor: Histone H3 K4-Me3 9-residue peptide, WD-repeat protein 5 Authors: Ruthenburg, A.J, Wang, W.-K, Graybosch, D.M, Li, H, Allis, C.D, Patel, D.J, Verdine, G.L. Deposit date: 2006-06-01 Release date: 2006-07-04 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.87 Å) Cite: Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex. Nat.Struct.Mol.Biol., 13, 2006
8H05	Minor polymorph in alpha-synuclein fibril seeded by cerebrospinal fluid from a postmortal Parkinson's disease patient Descriptor: Alpha-synuclein Authors: Fan, Y, Sun, Y.P, Wang, J, Liu, C. Deposit date: 2022-09-28 Release date: 2022-11-30 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Conformational change of alpha-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson's disease. Structure, 31, 2023
2H6K	Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex Descriptor: Histone H3 K4-Me 9-residue peptide, WD-repeat protein 5 Authors: Ruthenburg, A.J, Wang, W.-K, Graybosch, D.M, Li, H, Allis, C.D, Patel, D.J, Verdine, G.L. Deposit date: 2006-05-31 Release date: 2006-07-04 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.89 Å) Cite: Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex. Nat.Struct.Mol.Biol., 13, 2006
2INT	CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-4 Descriptor: INTERLEUKIN-4 Authors: Walter, M.R, Cook, W.J, Zhao, B.G, Cameron Junior, R, Ealick, S.E, Walter Junior, R.L, Reichert, P, Nagabhushan, T.L, Trotta, P.P, Bugg, C.E. Deposit date: 1993-07-22 Release date: 1994-01-31 Last modified: 2019-08-14 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Crystal structure of recombinant human interleukin-4. J.Biol.Chem., 267, 1992
6EKL	Crystal structure of mammalian Rev7 in complex with human Chromosome alignment-maintaining phosphoprotein 1 Descriptor: Chromosome alignment-maintaining phosphoprotein 1, Mitotic spindle assembly checkpoint protein MAD2B Authors: Huber, F, Tropia, L, Emamzadah, S, Halazonetis, T. Deposit date: 2017-09-26 Release date: 2018-10-10 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Crystal structure of mammalian Rev7 in complex with Champ1 To Be Published
5M36	The molecular tweezer CLR01 stabilizes a disordered protein-protein interface Descriptor: (1R,5S,9S,16R,20R,24S,28S,35R)-3,22-Bis(dihydroxyphosphoryloxy)tridecacyclo[22.14.1.15,20.19,16.128,35.02,23.04,21.06,19.08,17.010,15.025,38.027,36.029,34]dotetraconta-2(23),3,6,8(17),10,12,14,18,21,25,27(36),29,31,33,37-pentadecaene, 14-3-3 protein zeta/delta, BENZOIC ACID, ... Authors: Bier, D, Ottmann, C. Deposit date: 2016-10-14 Release date: 2017-11-15 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.45 Å) Cite: The Molecular Tweezer CLR01 Stabilizes a Disordered Protein-Protein Interface. J. Am. Chem. Soc., 139, 2017
1MDI	HIGH RESOLUTION SOLUTION NMR STRUCTURE OF MIXED DISULFIDE INTERMEDIATE BETWEEN MUTANT HUMAN THIOREDOXIN AND A 13 RESIDUE PEPTIDE COMPRISING ITS TARGET SITE IN HUMAN NFKB Descriptor: TARGET SITE IN HUMAN NFKB, THIOREDOXIN Authors: Clore, G.M, Qin, J, Gronenborn, A.M. Deposit date: 1995-02-27 Release date: 1995-06-03 Last modified: 2022-02-23 Method: SOLUTION NMR Cite: Solution structure of human thioredoxin in a mixed disulfide intermediate complex with its target peptide from the transcription factor NF kappa B. Structure, 3, 1995
1MDK	HIGH RESOLUTION SOLUTION NMR STRUCTURE OF MIXED DISULFIDE INTERMEDIATE BETWEEN HUMAN THIOREDOXIN (C35A, C62A, C69A, C73A) MUTANT AND A 13 RESIDUE PEPTIDE COMPRISING ITS TARGET SITE IN HUMAN NFKB (RESIDUES 56-68 OF THE P50 SUBUNIT OF NFKB) Descriptor: TARGET SITE IN HUMAN NFKB, THIOREDOXIN Authors: Clore, G.M, Qin, J, Gronenborn, A.M. Deposit date: 1995-02-27 Release date: 1995-06-03 Last modified: 2022-02-23 Method: SOLUTION NMR Cite: Solution structure of human thioredoxin in a mixed disulfide intermediate complex with its target peptide from the transcription factor NF kappa B. Structure, 3, 1995
1MDJ	HIGH RESOLUTION SOLUTION NMR STRUCTURE OF MIXED DISULFIDE INTERMEDIATE BETWEEN HUMAN THIOREDOXIN (C35A, C62A, C69A, C73A) MUTANT AND A 13 RESIDUE PEPTIDE COMPRISING ITS TARGET SITE IN HUMAN NFKB (RESIDUES 56-68 OF THE P50 SUBUNIT OF NFKB) Descriptor: TARGET SITE IN HUMAN NFKB, THIOREDOXIN Authors: Clore, G.M, Qin, J, Gronenborn, A.M. Deposit date: 1995-02-27 Release date: 1995-06-03 Last modified: 2022-02-23 Method: SOLUTION NMR Cite: Solution structure of human thioredoxin in a mixed disulfide intermediate complex with its target peptide from the transcription factor NF kappa B. Structure, 3, 1995
7K79	CBF3 Descriptor: Centromere DNA-binding protein complex CBF3 subunit B, Centromere DNA-binding protein complex CBF3 subunit C, Suppressor of kinetochore protein 1 Authors: Ruifang, G, Yawen, B. Deposit date: 2020-09-22 Release date: 2021-03-31 Method: ELECTRON MICROSCOPY (4 Å) Cite: Structural and dynamic mechanisms of CBF3-guided centromeric nucleosome formation. Nat Commun, 12, 2021
3MFK	Ets1 complex with stromelysin-1 promoter DNA Descriptor: Protein C-ets-1, stromelysin-1 promoter DNA Authors: Babayeva, N.D, Mino, K, Tahirov, T.H. Deposit date: 2010-04-02 Release date: 2010-08-18 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (3 Å) Cite: Structural basis of Ets1 cooperative binding to palindromic sequences on stromelysin-1 promoter DNA. Cell Cycle, 9, 2010
6K9K	Monomeric human ATM (Ataxia telangiectasia mutated) kinase Descriptor: Serine-protein kinase ATM Authors: Xiao, J, Liu, M, Qi, Y, Yuriy, C, Zhang, P, Xu, Y. Deposit date: 2019-06-16 Release date: 2019-12-25 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (7.82 Å) Cite: Structural insights into the activation of ATM kinase. Cell Res., 29, 2019
5M37	The molecular tweezer CLR01 stabilizes a disordered protein-protein interface Descriptor: (1R,5S,9S,16R,20R,24S,28S,35R)-3,22-Bis(dihydroxyphosphoryloxy)tridecacyclo[22.14.1.15,20.19,16.128,35.02,23.04,21.06,19.08,17.010,15.025,38.027,36.029,34]dotetraconta-2(23),3,6,8(17),10,12,14,18,21,25,27(36),29,31,33,37-pentadecaene, 14-3-3 protein zeta/delta, BENZOIC ACID, ... Authors: Bier, D, Ottmann, C. Deposit date: 2016-10-14 Release date: 2017-11-15 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.35 Å) Cite: The Molecular Tweezer CLR01 Stabilizes a Disordered Protein-Protein Interface. J. Am. Chem. Soc., 139, 2017
2H6N	Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex Descriptor: Histone H3 K4-Me2 9-residue peptide, WD-repeat protein 5 Authors: Ruthenburg, A.J, Wang, W.-K, Graybosch, D.M, Li, H, Allis, C.D, Patel, D.J, Verdine, G.L. Deposit date: 2006-05-31 Release date: 2006-07-04 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex. Nat.Struct.Mol.Biol., 13, 2006
3N0E	Crystal structure of WDR5 mutant (W330Y) Descriptor: WD repeat-containing protein 5 Authors: Wu, Y.-D, Wu, X.-H, Gao, Y, Chen, R.-C. Deposit date: 2010-05-13 Release date: 2010-10-20 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.5 Å) Cite: The Effect of Asp-His-Ser/Thr-Trp Tetrad on the Thermostability of WD40-Repeat Proteins Biochemistry, 49, 2010
1PE0	Crystal structure of the K130R mutant of human DJ-1 Descriptor: DJ-1 Authors: Tao, X, Tong, L. Deposit date: 2003-05-20 Release date: 2003-06-24 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal Structure of Human DJ-1, a Protein Associated with Early Onset Parkinson's Disease. J.Biol.Chem., 278, 2003
3N0D	Crystal structure of WDR5 mutant (W330F) Descriptor: WD repeat-containing protein 5 Authors: Wu, Y.-D, Wu, X.-H, Gao, Y, Chen, R.-C. Deposit date: 2010-05-13 Release date: 2010-10-20 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.3 Å) Cite: The Effect of Asp-His-Ser/Thr-Trp Tetrad on the Thermostability of WD40-Repeat Proteins Biochemistry, 49, 2010
3MXX	Crystal structure of WDR5 mutant (S62A) Descriptor: WD repeat-containing protein 5 Authors: Wu, Y.-D, Wu, X.-H, Gao, Y, Chen, R.-C. Deposit date: 2010-05-08 Release date: 2010-10-20 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.05 Å) Cite: The Effect of Asp-His-Ser/Thr-Trp Tetrad on the Thermostability of WD40-Repeat Proteins Biochemistry, 49, 2010
7K1P	Crystal structure of the second bromodomain (BD2) of human TAF1 bound to bromosporine Descriptor: 1,2-ETHANEDIOL, Bromosporine, Transcription initiation factor TFIID subunit 1 Authors: Karim, M.R, Schonbrunn, E. Deposit date: 2020-09-08 Release date: 2021-09-22 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain. J.Med.Chem., 65, 2022
7K27	Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 bound to ATR inhibitor AZ20 Descriptor: 1,2-ETHANEDIOL, 4-{4-[(3R)-3-methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole, DIMETHYL SULFOXIDE, ... Authors: Karim, M.R, Schonbrunn, E. Deposit date: 2020-09-08 Release date: 2021-09-22 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain. J.Med.Chem., 65, 2022
7K3O	Crystal structure of the unliganded second bromodomain (BD2) of human TAF1 Descriptor: 1,2-ETHANEDIOL, SULFATE ION, Transcription initiation factor TFIID subunit 1 Authors: Karim, M.R, Schonbrunn, E. Deposit date: 2020-09-12 Release date: 2021-09-22 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain. J.Med.Chem., 65, 2022
7K6F	Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 in complex with MES (2-(N-morpholino)ethanesulfonic acid) Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ACETATE ION, ... Authors: Karim, M.R, Bikowitz, M.J, Schonbrunn, E. Deposit date: 2020-09-20 Release date: 2021-09-22 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain. J.Med.Chem., 65, 2022
7K0D	Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 bound to mTORC1/2 inhibitor AZD3147 Descriptor: N-(4-{4-[1-(cyclopropylsulfonyl)cyclopropyl]-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl}phenyl)-N'-(2-hydroxyethyl)thiourea, Transcription initiation factor TFIID subunit 1 Authors: Karim, M.R, Schonbrunn, E. Deposit date: 2020-09-04 Release date: 2021-09-22 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain. J.Med.Chem., 65, 2022
7K0U	Crystal structure of the second bromodomain (BD2) of human TAF1 bound to PLK1 kinase inhibitor BI2536 Descriptor: 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, Transcription initiation factor TFIID subunit 1 Authors: Karim, M.R, Schonbrunn, E. Deposit date: 2020-09-06 Release date: 2021-09-22 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.52 Å) Cite: Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain. J.Med.Chem., 65, 2022
7K03	Crystal structure of the tandem bromodomain (BD1 and BD2) of human TAF1 bound to ATR kinase inhibitor AZD6738 Descriptor: 1,2-ETHANEDIOL, 4-(4-{1-[(R)-amino(hydroxy)methyl-lambda~4~-sulfanyl]cyclopropyl}-6-[(3R)-3-methylmorpholin-4-yl]pyrimidin-2-yl)-1H-pyrrolo[2,3-b]pyridine, Transcription initiation factor TFIID subunit 1 Authors: Karim, M.R, Schonbrunn, E. Deposit date: 2020-09-03 Release date: 2021-09-22 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain. J.Med.Chem., 65, 2022

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