7K3O
Crystal structure of the unliganded second bromodomain (BD2) of human TAF1
Summary for 7K3O
| Entry DOI | 10.2210/pdb7k3o/pdb |
| Descriptor | Transcription initiation factor TFIID subunit 1, SULFATE ION, 1,2-ETHANEDIOL, ... (4 entities in total) |
| Functional Keywords | taf1, non-bet, bet, kinase inhibitor, atr, dual brd-kinase, transferase-transferase inhibitor complex, gene regulation |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 32826.70 |
| Authors | Karim, M.R.,Schonbrunn, E. (deposition date: 2020-09-12, release date: 2021-09-22, Last modification date: 2023-10-18) |
| Primary citation | Karim, R.M.,Yang, L.,Chen, L.,Bikowitz, M.J.,Lu, J.,Grassie, D.,Shultz, Z.P.,Lopchuk, J.M.,Chen, J.,Schonbrunn, E. Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain. J.Med.Chem., 65:4182-4200, 2022 Cited by PubMed: 35191694DOI: 10.1021/acs.jmedchem.1c01999 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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