7K3O
Crystal structure of the unliganded second bromodomain (BD2) of human TAF1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004402 | molecular_function | histone acetyltransferase activity |
| A | 0005669 | cellular_component | transcription factor TFIID complex |
| A | 0006366 | biological_process | transcription by RNA polymerase II |
| A | 0016251 | molecular_function | RNA polymerase II general transcription initiation factor activity |
| A | 0017025 | molecular_function | TBP-class protein binding |
| B | 0004402 | molecular_function | histone acetyltransferase activity |
| B | 0005669 | cellular_component | transcription factor TFIID complex |
| B | 0006366 | biological_process | transcription by RNA polymerase II |
| B | 0016251 | molecular_function | RNA polymerase II general transcription initiation factor activity |
| B | 0017025 | molecular_function | TBP-class protein binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 1701 |
| Chain | Residue |
| A | ARG1554 |
| A | SER1587 |
| A | GLN1588 |
| A | TYR1589 |
| A | HOH1844 |
| A | HOH1881 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 1702 |
| Chain | Residue |
| A | HOH1808 |
| A | HOH1810 |
| A | HOH1812 |
| A | HOH1869 |
| A | PHE1509 |
| A | PHE1528 |
| A | ASN1583 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 1703 |
| Chain | Residue |
| A | ALA1577 |
| A | ASN1578 |
| A | LYS1581 |
| A | HOH1815 |
| A | HOH1841 |
| B | PRO1585 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | binding site for residue EDO A 1704 |
| Chain | Residue |
| A | PHE1509 |
| A | TRP1526 |
| A | PRO1527 |
| A | HIS1530 |
| A | PRO1531 |
| A | VAL1532 |
| A | ASN1533 |
| A | HOH1806 |
| A | HOH1812 |
| A | HOH1863 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 1705 |
| Chain | Residue |
| A | PRO1585 |
| A | GLU1586 |
| A | HOH1889 |
| B | ASN1546 |
| B | HOH1831 |
| B | HOH1832 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 1706 |
| Chain | Residue |
| A | THR1620 |
| A | HOH1802 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 1707 |
| Chain | Residue |
| A | SER1508 |
| A | HIS1560 |
| A | GLN1588 |
| A | TYR1589 |
| A | HOH1801 |
| A | HOH1847 |
| A | HOH1858 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 1708 |
| Chain | Residue |
| A | ASP1502 |
| A | ASP1503 |
| A | TRP1526 |
| A | LEU1614 |
| A | HOH1803 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 1709 |
| Chain | Residue |
| A | ASN1533 |
| A | LYS1535 |
| A | HIS1610 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 1701 |
| Chain | Residue |
| B | ARG1554 |
| B | SER1587 |
| B | GLN1588 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 1702 |
| Chain | Residue |
| A | ASN1573 |
| A | ALA1577 |
| B | PRO1585 |
| B | THR1590 |
| B | HOH1808 |
| B | HOH1854 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 1703 |
| Chain | Residue |
| B | PHE1509 |
| B | PHE1528 |
| B | ASN1583 |
| B | HOH1806 |
| B | HOH1811 |
| B | HOH1826 |
| B | HOH1851 |
| site_id | AD4 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 1704 |
| Chain | Residue |
| B | PHE1509 |
| B | TRP1526 |
| B | PRO1531 |
| B | VAL1532 |
| B | ASN1533 |
| B | HOH1803 |
| B | HOH1826 |
| B | HOH1848 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 1705 |
| Chain | Residue |
| B | ARG1565 |
| B | TYR1601 |
| B | THR1605 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 1706 |
| Chain | Residue |
| B | LYS1591 |
| B | GLU1595 |
| B | HOH1814 |
| B | HOH1839 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 1707 |
| Chain | Residue |
| B | LYS1561 |
| B | TYR1562 |
| B | GLN1563 |
| B | SER1564 |
| B | SER1567 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 58 |
| Details | BROMODOMAIN_1 Bromodomain signature. SwpFhhpvNkkfvp..DYYkvIvnpMdletIrkniskhk..Yqsresflddvnl.IlaNSvkY |
| Chain | Residue | Details |
| A | SER1525-TYR1582 |
