8SRG
 
 | | Cryo-EM structure of TRPM2 chanzyme in the presence of Magnesium, Adenosine monophosphate, and Ribose-5-phosphate | | Descriptor: | 5-O-phosphono-beta-D-ribofuranose, ADENOSINE MONOPHOSPHATE, CHOLESTEROL, ... | | Authors: | Huang, Y, Kumar, S, Lu, W, Du, J. | | Deposit date: | 2023-05-05 | | Release date: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.03 Å) | | Cite: | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution
To Be Published
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8SRF
 | | Cryo-EM structure of TRPM2 chanzyme in the presence of Magnesium, ADP-ribose, Adenosine monophosphate, and Ribose-5-phosphate, closed state | | Descriptor: | 5-O-phosphono-beta-D-ribofuranose, ADENOSINE MONOPHOSPHATE, ADENOSINE-5-DIPHOSPHORIBOSE, ... | | Authors: | Huang, Y, Kumar, S, Lu, W, Du, J. | | Deposit date: | 2023-05-05 | | Release date: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (2.52 Å) | | Cite: | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution
To Be Published
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8SRD
 | | Cryo-EM structure of TRPM2 chanzyme in the presence of Magnesium and ADP-ribose, open state | | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, CHOLESTEROL, MAGNESIUM ION, ... | | Authors: | Huang, Y, Kumar, S, Lu, W, Du, J. | | Deposit date: | 2023-05-05 | | Release date: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (2.91 Å) | | Cite: | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution
To Be Published
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1C72
 | | TYR115, GLN165 AND TRP209 CONTRIBUTE TO THE 1,2-EPOXY-3-(P-NITROPHENOXY)PROPANE CONJUGATING ACTIVITIES OF GLUTATHIONE S-TRANSFERASE CGSTM1-1 | | Descriptor: | 1-HYDROXY-2-S-GLUTATHIONYL-3-PARA-NITROPHENOXY-PROPANE, PROTEIN (GLUTATHIONE S-TRANSFERASE) | | Authors: | Chern, M.K, Wu, T.C, Hsieh, C.H, Chou, C.C, Liu, L.F, Kuan, I.C, Yeh, Y.H, Hsiao, C.D, Tam, M.F. | | Deposit date: | 2000-02-02 | | Release date: | 2000-08-30 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Tyr115, gln165 and trp209 contribute to the 1, 2-epoxy-3-(p-nitrophenoxy)propane-conjugating activity of glutathione S-transferase cGSTM1-1.
J.Mol.Biol., 300, 2000
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1XCP
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2LDJ
 | | 1H Chemical Shift Assignments and structure of Trp-Cage mini-protein with D-amino acid | | Descriptor: | Trp-Cage mini-protein | | Authors: | Granillo, A.R, Annavarapu, S, Zhang, L, Koder, R, Nanda, V. | | Deposit date: | 2011-05-27 | | Release date: | 2011-11-23 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Computational Design of Thermostabilizing d-Amino Acid Substitutions.
J.Am.Chem.Soc., 133, 2011
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7ZJE
 | | C16-2 | | Descriptor: | Transient receptor potential cation channel subfamily V member 2,Enhanced green fluorescent protein | | Authors: | Zhang, L, Gourdon, P, Zygmunt, P.M. | | Deposit date: | 2022-04-10 | | Release date: | 2023-01-18 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.12 Å) | | Cite: | Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function.
Nat Commun, 13, 2022
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7ZJG
 | | Probenecid | | Descriptor: | Transient receptor potential cation channel subfamily V member 2 | | Authors: | Zhang, L, Gourdon, P, Zygmunt, P.M. | | Deposit date: | 2022-04-11 | | Release date: | 2023-01-18 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.49 Å) | | Cite: | Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function.
Nat Commun, 13, 2022
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7ZJI
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7ZJD
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5DW0
 | | TrpB from Pyrococcus furiosus with L-serine bound as the external aldimine | | Descriptor: | SODIUM ION, Tryptophan synthase beta chain 1, [3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-SERINE | | Authors: | Buller, A.R, Arnold, F.H. | | Deposit date: | 2015-09-22 | | Release date: | 2015-11-11 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | Directed evolution of the tryptophan synthase beta-subunit for stand-alone function recapitulates allosteric activation.
Proc.Natl.Acad.Sci.USA, 112, 2015
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5L34
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6OFA
 | | Wasabi Receptor Toxin | | Descriptor: | Wasabi Receptor Toxin | | Authors: | Lin King, J.V, Kelly, M.J.S, Julius, D. | | Deposit date: | 2019-03-28 | | Release date: | 2019-08-28 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain.
Cell, 178, 2019
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3ZTE
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4V4F
 | | The structure of the trp RNA-binding attenuation protein (TRAP) bound to a RNA molecule containing UAGAU repeats | | Descriptor: | 5'-R(*UP*AP*GP*AP*UP)-3', TRANSCRIPTION ATTENUATION PROTEIN MTRB, TRYPTOPHAN | | Authors: | Hopcroft, N.H, Manfredo, A, Wendt, A.L, Brzozowski, A.M, Gollnick, P, Antson, A.A. | | Deposit date: | 2003-12-08 | | Release date: | 2014-07-09 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | The Interaction of RNA with Trap: The Role of Triplet Repeats and Separating Spacer Nucleotides
J.Mol.Biol., 338, 2004
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4V5P
 | | The crystal structure of EF-Tu and A9C-tRNA-Trp bound to a near- cognate codon on the 70S ribosome | | Descriptor: | 16S RRNA, 23S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, ... | | Authors: | Schmeing, T.M, Voorhees, R.M, Ramakrishnan, V. | | Deposit date: | 2010-12-07 | | Release date: | 2014-07-09 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | How Mutations in tRNA Distant from the Anticodon Affect the Fidelity of Decoding.
Nat.Struct.Mol.Biol., 18, 2011
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4V5R
 | | The crystal structure of EF-Tu and Trp-tRNA-Trp bound to a cognate codon on the 70S ribosome. | | Descriptor: | 16S RRNA, 23S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, ... | | Authors: | Schmeing, T.M, Voorhees, R.M, Ramakrishnan, V. | | Deposit date: | 2010-12-07 | | Release date: | 2014-07-09 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | How Mutations in tRNA Distant from the Anticodon Affect the Fidelity of Decoding.
Nat.Struct.Mol.Biol., 18, 2011
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4V5S
 | | The crystal structure of EF-Tu and G24A-tRNA-Trp bound to a cognate codon on the 70S ribosome. | | Descriptor: | 16S RRNA, 23S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, ... | | Authors: | Schmeing, T.M, Voorhees, R.M, Ramakrishnan, V. | | Deposit date: | 2010-12-07 | | Release date: | 2014-07-09 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | How Mutations in tRNA Distant from the Anticodon Affect the Fidelity of Decoding.
Nat.Struct.Mol.Biol., 18, 2011
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1JKB
 | | HUMAN LYSOZYME MUTANT WITH GLU 35 REPLACED BY ALA | | Descriptor: | LYSOZYME, NITRATE ION | | Authors: | Muraki, M, Harata, K, Goda, S, Nagahora, H. | | Deposit date: | 1996-11-13 | | Release date: | 1997-05-15 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (1.66 Å) | | Cite: | Importance of van der Waals contact between Glu 35 and Trp 109 to the catalytic action of human lysozyme.
Protein Sci., 6, 1997
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1JKA
 | | HUMAN LYSOZYME MUTANT WITH GLU 35 REPLACED BY ASP | | Descriptor: | LYSOZYME, NITRATE ION | | Authors: | Muraki, M, Harata, K, Goda, S, Nagahora, H. | | Deposit date: | 1996-11-13 | | Release date: | 1997-05-15 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (1.66 Å) | | Cite: | Importance of van der Waals contact between Glu 35 and Trp 109 to the catalytic action of human lysozyme.
Protein Sci., 6, 1997
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4V5Q
 | | The crystal structure of EF-Tu and G24A-tRNA-Trp bound to a near- cognate codon on the 70S ribosome | | Descriptor: | 16S RRNA, 23S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, ... | | Authors: | Schmeing, T.M, Voorhees, R.M, Ramakrishnan, V. | | Deposit date: | 2010-12-07 | | Release date: | 2014-07-09 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | How Mutations in tRNA Distant from the Anticodon Affect the Fidelity of Decoding.
Nat.Struct.Mol.Biol., 18, 2011
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2WA9
 | | Structural basis of N-end rule substrate recognition in Escherichia coli by the ClpAP adaptor protein ClpS - Trp peptide structure | | Descriptor: | ATP-DEPENDENT CLP PROTEASE ADAPTER PROTEIN CLPS, TRP PEPTIDE | | Authors: | Schuenemann, V.J, Kralik, S.M, Albrecht, R, Spall, S.K, Truscott, K.N, Dougan, D.A, Zeth, K. | | Deposit date: | 2009-02-03 | | Release date: | 2009-04-28 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural Basis of N-End Rule Substrate Recognition in Escherichia Coli by the Clpap Adaptor Protein Clps.
Embo Rep., 10, 2009
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6IQZ
 | | High resolution structure of bilirubin oxidase from Myrothecium verrucaria - wild type | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Bilirubin oxidase, COPPER (II) ION, ... | | Authors: | Shibata, N, Akter, M, Higuchi, Y. | | Deposit date: | 2018-11-09 | | Release date: | 2018-11-21 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.46 Å) | | Cite: | Redox Potential-Dependent Formation of an Unusual His-Trp Bond in Bilirubin Oxidase.
Chemistry, 24, 2018
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6IQY
 | | High resolution structure of bilirubin oxidase from Myrothecium verrucaria - M467Q mutant, anaerobically prepared | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, Bilirubin oxidase, ... | | Authors: | Shibata, N, Akter, M, Higuchi, Y. | | Deposit date: | 2018-11-09 | | Release date: | 2018-11-21 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Redox Potential-Dependent Formation of an Unusual His-Trp Bond in Bilirubin Oxidase.
Chemistry, 24, 2018
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3FI0
 | | Crystal Structure Analysis of B. stearothermophilus Tryptophanyl-tRNA Synthetase Complexed with Tryptophan, AMP, and Inorganic Phosphate | | Descriptor: | ADENOSINE MONOPHOSPHATE, PHOSPHATE ION, TRYPTOPHAN, ... | | Authors: | Laowanapiban, P, Kapustina, M, Vonrhein, C, Delarue, M, Koehl, P, Carter Jr, C.W. | | Deposit date: | 2008-12-10 | | Release date: | 2009-02-03 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Independent saturation of three TrpRS subsites generates a partially assembled state similar to those observed in molecular simulations.
Proc.Natl.Acad.Sci.Usa, 106, 2009
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