4JPH
 
 | | Crystal structure of Protein Related to DAN and Cerberus (PRDC) | | Descriptor: | CITRIC ACID, GLUTATHIONE, GLYCEROL, ... | | Authors: | Deng, X, Nolan, K.T, Kattamuri, C, Thompson, T.B. | | Deposit date: | 2013-03-19 | | Release date: | 2013-07-24 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Structure of protein related to dan and cerberus: insights into the mechanism of bone morphogenetic protein antagonism.
Structure, 21, 2013
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6K1Z
 | | Crystal structure of farnesylated hGBP1 | | Descriptor: | FARNESYL, Guanylate-binding protein 1 | | Authors: | Du, S, Xiao, J.Y. | | Deposit date: | 2019-05-13 | | Release date: | 2019-06-12 | | Last modified: | 2019-12-25 | | Method: | X-RAY DIFFRACTION (2.307 Å) | | Cite: | Structural mechanism for guanylate-binding proteins (GBPs) targeting by the Shigella E3 ligase IpaH9.8.
Plos Pathog., 15, 2019
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6M7H
 | | Structure of calmodulin with KN93 | | Descriptor: | CALCIUM ION, Calmodulin-1, N-[2-[[[3-(4'-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4'-methoxybenzenesulfonamide | | Authors: | Damo, S.M, Pattanayek, R, Johnson, C.N. | | Deposit date: | 2018-08-20 | | Release date: | 2019-08-28 | | Last modified: | 2019-11-27 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | The CaMKII inhibitor KN93-calmodulin interaction and implications for calmodulin tuning of NaV1.5 and RyR2 function.
Cell Calcium, 82, 2019
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5EW0
 | | Crystal structure of the metallo-beta-lactamase Sfh-I in complex with the bisthiazolidine inhibitor L-CS319 | | Descriptor: | (3R,5R,7aS)-5-(sulfanylmethyl)tetrahydro[1,3]thiazolo[4,3-b][1,3]thiazole-3-carboxylic acid, Beta-lactamase, ZINC ION | | Authors: | Hinchliffe, P, Tooke, C.L, Spencer, J. | | Deposit date: | 2015-11-20 | | Release date: | 2016-06-01 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Cross-class metallo-beta-lactamase inhibition by bisthiazolidines reveals multiple binding modes.
Proc.Natl.Acad.Sci.USA, 113, 2016
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6LGV
 | | Crystal structure of a cysteine-pair mutant (P10C-S291C) of a bacterial bile acid transporter in an inward-facing state complexed with citrate | | Descriptor: | 2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CITRIC ACID, Transporter, ... | | Authors: | Wang, X, Lyu, Y, Ji, Y, Sun, Z, Zhou, X. | | Deposit date: | 2019-12-06 | | Release date: | 2020-12-09 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.847 Å) | | Cite: | Substrate binding in the bile acid transporter ASBT Yf from Yersinia frederiksenii.
Acta Crystallogr D Struct Biol, 77, 2021
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4ITR
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4GDK
 | | Crystal Structure of Human Atg12~Atg5 Conjugate in Complex with an N-terminal Fragment of Atg16L1 | | Descriptor: | Autophagy protein 5, Autophagy-related protein 16-1, SODIUM ION, ... | | Authors: | Otomo, C, Metlagel, Z, Takaesu, G, Otomo, T. | | Deposit date: | 2012-07-31 | | Release date: | 2012-12-05 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy.
Nat.Struct.Mol.Biol., 20, 2013
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4HR7
 | | Crystal Structure of Biotin Carboxyl Carrier Protein-Biotin Carboxylase Complex from E.coli | | Descriptor: | 1,2-ETHANEDIOL, Biotin carboxyl carrier protein of acetyl-CoA carboxylase, Biotin carboxylase, ... | | Authors: | Broussard, T.C, Kobe, M.J, Pakhomova, S, Neau, D.B, Price, A.E, Champion, T.S, Waldrop, G.L. | | Deposit date: | 2012-10-26 | | Release date: | 2013-03-13 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.495 Å) | | Cite: | The three-dimensional structure of the biotin carboxylase-biotin carboxyl carrier protein complex of E. coli acetyl-CoA carboxylase.
Structure, 21, 2013
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5BQX
 | | Crystal structure of human STING in complex with 3'2'-cGAMP | | Descriptor: | 3'2'-cGAMP, Stimulator of interferon genes protein | | Authors: | Wu, J, Zhang, X, Chen, Z.J, Chen, C. | | Deposit date: | 2015-05-29 | | Release date: | 2015-06-24 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Molecular basis for the specific recognition of the metazoan cyclic GMP-AMP by the innate immune adaptor protein STING.
Proc.Natl.Acad.Sci.USA, 112, 2015
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1SV1
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6MX3
 | | Crystal structure of human STING (G230A, H232R, R293Q) in complex with Compound 1 | | Descriptor: | (3S,4S)-2-(4-tert-butylphenyl)-3-(4-methoxyphenyl)-1-oxo-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid, CALCIUM ION, Stimulator of interferon genes protein | | Authors: | Lesburg, C.A, Siu, T, Ho, T. | | Deposit date: | 2018-10-30 | | Release date: | 2018-12-19 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.362 Å) | | Cite: | Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING.
ACS Med Chem Lett, 10, 2019
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6MXE
 | | Crystal structure of human STING (G230A, H232R, R293Q) in complex with Compound 18 | | Descriptor: | CALCIUM ION, Stimulator of interferon genes protein, [(3S,4S)-2-(4-tert-butyl-3-chlorophenyl)-3-(2,3-dihydro-1,4-benzodioxin-6-yl)-7-fluoro-1-oxo-1,2,3,4-tetrahydroisoquinolin-4-yl]acetic acid | | Authors: | Lesburg, C.A, Siu, T, Ho, T. | | Deposit date: | 2018-10-30 | | Release date: | 2018-12-19 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.47 Å) | | Cite: | Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING.
ACS Med Chem Lett, 10, 2019
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6MX0
 | | Crystal structure of human STING apoprotein (G230A, H232R, R293Q) | | Descriptor: | CALCIUM ION, Stimulator of interferon genes protein | | Authors: | Lesburg, C.A, Siu, T, Ho, T. | | Deposit date: | 2018-10-30 | | Release date: | 2018-12-19 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.73 Å) | | Cite: | Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING.
ACS Med Chem Lett, 10, 2019
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2Z33
 | | Solution structure of the DNA complex of PhoB DNA-binding/transactivation Domain | | Descriptor: | 5'-D(*AP*CP*AP*GP*AP*TP*TP*TP*AP*TP*GP*AP*CP*AP*GP*T)-3', 5'-D(*AP*CP*TP*GP*TP*CP*AP*TP*AP*AP*AP*TP*CP*TP*GP*T)-3', Phosphate regulon transcriptional regulatory protein phoB | | Authors: | Yamane, T, Okamura, H, Ikeguchi, M, Nishimura, Y, Kidera, A. | | Deposit date: | 2007-05-31 | | Release date: | 2008-04-22 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Water-mediated interactions between DNA and PhoB DNA-binding/transactivation domain: NMR-restrained molecular dynamics in explicit water environment.
Proteins, 71, 2008
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6MGE
 | | Structure of human 4-1BBL | | Descriptor: | GLYCEROL, PHOSPHATE ION, Tumor necrosis factor ligand superfamily member 9 | | Authors: | Kimberlin, C.R, Chin, S.M, Roe-Zurz, Z, Xu, A, Yang, Y. | | Deposit date: | 2018-09-13 | | Release date: | 2018-11-21 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab.
Nat Commun, 9, 2018
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6SJA
 | | Structure of HPV16 E6 oncoprotein in complex with IRF3 LxxLL motif | | Descriptor: | Maltose/maltodextrin-binding periplasmic protein,Interferon regulatory factor 3, Protein E6, ZINC ION, ... | | Authors: | Suarez, I.P, Cousido-Siah, A, Bonhoure, A, Mitschler, A, Podjarny, A, Trave, G. | | Deposit date: | 2019-08-13 | | Release date: | 2019-09-04 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Deciphering de molecular and structural interaction between IRF3 and HPV16 E6
To be published
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6PQY
 | | Cryo-EM structure of HzTransib/TIR DNA transposon end complex (TEC) | | Descriptor: | DNA (5'-D(P*CP*AP*CP*GP*GP*TP*GP*GP*AP*TP*CP*GP*AP*AP*AP*A)-3'), DNA (5'-D(P*TP*TP*TP*TP*CP*GP*AP*TP*CP*CP*AP*CP*CP*GP*TP*G)-3'), Putative DNA-mediated transposase | | Authors: | Liu, C, Yang, Y, Schatz, D.G. | | Deposit date: | 2019-07-10 | | Release date: | 2019-10-09 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Structures of a RAG-like transposase during cut-and-paste transposition.
Nature, 575, 2019
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6PR5
 | | Cryo-EM structure of HzTransib strand transfer complex (STC) | | Descriptor: | DNA (30-MER), DNA (39-MER), DNA (5'-D(*GP*AP*TP*CP*TP*GP*GP*CP*CP*TP*AP*GP*AP*TP*CP*TP*CP*A)-3'), ... | | Authors: | Liu, C, Yang, Y, Schatz, D.G. | | Deposit date: | 2019-07-10 | | Release date: | 2019-10-09 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structures of a RAG-like transposase during cut-and-paste transposition.
Nature, 575, 2019
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8F5V
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1WPL
 | | Crystal structure of the inhibitory form of rat GTP cyclohydrolase I/GFRP complex | | Descriptor: | 7,8-DIHYDROBIOPTERIN, GTP cyclohydrolase I, GTP cyclohydrolase I feedback regulatory protein, ... | | Authors: | Maita, N, Hatakeyama, K, Okada, K, Hakoshima, T. | | Deposit date: | 2004-09-08 | | Release date: | 2004-09-28 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural basis of biopterin-induced inhibition of GTP cyclohydrolase I by GFRP, its feedback regulatory protein
J.Biol.Chem., 279, 2004
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6PQU
 | | Cryo-EM structure of HzTransib/nicked TIR substrate DNA pre-reaction complex (PRC) | | Descriptor: | DNA (5'-D(P*AP*TP*CP*TP*GP*GP*CP*CP*TP*AP*GP*AP*TP*CP*T)-3'), DNA (5'-D(P*CP*AP*CP*GP*GP*TP*GP*GP*AP*TP*CP*GP*AP*AP*AP*A)-3'), DNA-mediated transposase, ... | | Authors: | Liu, C, Yang, Y, Schatz, D.G. | | Deposit date: | 2019-07-10 | | Release date: | 2019-10-09 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structures of a RAG-like transposase during cut-and-paste transposition.
Nature, 575, 2019
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8EFN
 | | Structure of Sp-STING3 from Stylophora pistillata coral in complex with 3',3'-cGAMP | | Descriptor: | 1,2-ETHANEDIOL, 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, Stimulator of interferon genes protein | | Authors: | Li, Y, Slavik, K.M, Morehouse, B.R, Mears, K, Kranzusch, P.J. | | Deposit date: | 2022-09-08 | | Release date: | 2023-07-05 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.73 Å) | | Cite: | cGLRs are a diverse family of pattern recognition receptors in innate immunity.
Cell, 186, 2023
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8EFM
 | | Structure of coral STING receptor from Stylophora pistillata in complex with 2',3'-cGAMP | | Descriptor: | SULFATE ION, Stimulator of interferon genes protein, cGAMP | | Authors: | Li, Y, Slavik, K.M, Morehouse, B.R, Mears, K, Kranzusch, P.J. | | Deposit date: | 2022-09-08 | | Release date: | 2023-07-05 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.13 Å) | | Cite: | cGLRs are a diverse family of pattern recognition receptors in innate immunity.
Cell, 186, 2023
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6PQX
 | | Cryo-EM structure of HzTransib/nicked TIR substrate DNA hairpin forming complex (HFC) | | Descriptor: | CALCIUM ION, DNA (5'-D(P*CP*AP*CP*GP*GP*TP*GP*GP*AP*TP*CP*GP*AP*AP*AP*A)-3'), DNA (5'-D(P*TP*CP*TP*GP*GP*CP*CP*TP*AP*GP*AP*TP*CP*T)-3'), ... | | Authors: | Liu, C, Yang, Y, Schatz, D.G. | | Deposit date: | 2019-07-10 | | Release date: | 2019-10-09 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (4.6 Å) | | Cite: | Structures of a RAG-like transposase during cut-and-paste transposition.
Nature, 575, 2019
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6PQR
 | | Cryo-EM structure of HzTransib/intact TIR substrate DNA pre-reaction complex (PRC) | | Descriptor: | DNA (5'-D(*CP*TP*AP*GP*AP*TP*CP*TP*CP*AP*CP*GP*GP*TP*GP*GP*AP*TP*CP*GP*AP*AP*AP*A)-3'), DNA (5'-D(P*TP*TP*TP*TP*CP*GP*AP*TP*CP*CP*AP*CP*CP*GP*TP*GP*AP*GP*AP*TP*CP*TP*AP*G)-3'), DNA-mediated transposase, ... | | Authors: | Liu, C, Yang, Y, Schatz, D.G. | | Deposit date: | 2019-07-09 | | Release date: | 2019-10-09 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structures of a RAG-like transposase during cut-and-paste transposition.
Nature, 575, 2019
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