6MXE

Crystal structure of human STING (G230A, H232R, R293Q) in complex with Compound 18

Summary for 6MXE

Entry DOI	10.2210/pdb6mxe/pdb
Descriptor	Stimulator of interferon genes protein, [(3S,4S)-2-(4-tert-butyl-3-chlorophenyl)-3-(2,3-dihydro-1,4-benzodioxin-6-yl)-7-fluoro-1-oxo-1,2,3,4-tetrahydroisoquinolin-4-yl]acetic acid, CALCIUM ION, ... (4 entities in total)
Functional Keywords	innate immunity, signaling, open conformation, immune system, immune system-inhibitor complex, immune system/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	44184.45
Authors	Lesburg, C.A.,Siu, T.,Ho, T. (deposition date: 2018-10-30, release date: 2018-12-19, Last modification date: 2024-03-13)
Primary citation	Siu, T.,Altman, M.D.,Baltus, G.A.,Childers, M.,Ellis, J.M.,Gunaydin, H.,Hatch, H.,Ho, T.,Jewell, J.,Lacey, B.M.,Lesburg, C.A.,Pan, B.S.,Sauvagnat, B.,Schroeder, G.K.,Xu, S. Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING. ACS Med Chem Lett, 10:92-97, 2019 Cited by PubMed: 30655953 DOI: 10.1021/acsmedchemlett.8b00466 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.47 Å)

Structure validation