6MXE
Crystal structure of human STING (G230A, H232R, R293Q) in complex with Compound 18
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002218 | biological_process | activation of innate immune response |
| A | 0032481 | biological_process | positive regulation of type I interferon production |
| B | 0002218 | biological_process | activation of innate immune response |
| B | 0032481 | biological_process | positive regulation of type I interferon production |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue K5S B 401 |
| Chain | Residue |
| A | LEU159 |
| B | TYR167 |
| B | LEU170 |
| B | K5S402 |
| A | SER162 |
| A | THR263 |
| A | PRO264 |
| A | GLN266 |
| A | THR267 |
| B | SER162 |
| B | TYR163 |
| B | GLY166 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue K5S B 402 |
| Chain | Residue |
| A | SER162 |
| A | TYR163 |
| A | GLY166 |
| A | TYR167 |
| B | LEU159 |
| B | SER162 |
| B | THR263 |
| B | PRO264 |
| B | GLN266 |
| B | THR267 |
| B | K5S401 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 403 |
| Chain | Residue |
| B | ASP205 |
| B | GLU316 |
| B | ALA318 |
| B | ASP320 |
| B | HOH504 |
| B | HOH512 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue CA B 404 |
| Chain | Residue |
| B | ALA215 |
| B | ASP320 |
| B | HOH517 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22728660","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4F5Y","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22579474","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22705373","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728658","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728659","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728660","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4EF4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EMT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F5D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F5Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F9G","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22579474","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22705373","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728658","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728660","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4EF4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EMT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F5Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F9G","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"37832545","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
