6M7H

Structure of calmodulin with KN93

Summary for 6M7H

Entry DOI	10.2210/pdb6m7h/pdb
Descriptor	Calmodulin-1, N-[2-[[[3-(4'-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4'-methoxybenzenesulfonamide, CALCIUM ION, ... (4 entities in total)
Functional Keywords	ca2+ binding ef-hand inhibitor complex, signaling protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	18630.76
Authors	Damo, S.M.,Pattanayek, R.,Johnson, C.N. (deposition date: 2018-08-20, release date: 2019-08-28, Last modification date: 2019-11-27)
Primary citation	Johnson, C.N.,Pattanayek, R.,Potet, F.,Rebbeck, R.T.,Blackwell, D.J.,Nikolaienko, R.,Sequeira, V.,Le Meur, R.,Radwanski, P.B.,Davis, J.P.,Zima, A.V.,Cornea, R.L.,Damo, S.M.,Gyorke, S.,George Jr., A.L.,Knollmann, B.C. The CaMKII inhibitor KN93-calmodulin interaction and implications for calmodulin tuning of NaV1.5 and RyR2 function. Cell Calcium, 82:102063-102063, 2019 Cited by PubMed: 31401388 DOI: 10.1016/j.ceca.2019.102063 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation