9ENC
 
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9ENB
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9EN6
 | | Crystal structure of RNA G2C4 repeats - native model pH 6.5 | | Descriptor: | MAGNESIUM ION, RNA (5'-R(*GP*GP*CP*CP*CP*C)-3') | | Authors: | Mateja-Pluta, M, Kiliszek, A. | | Deposit date: | 2024-03-12 | | Release date: | 2024-05-01 | | Last modified: | 2024-07-03 | | Method: | X-RAY DIFFRACTION (0.918 Å) | | Cite: | Antisense RNA C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms a triplex-like structure and binds small synthetic ligand.
Nucleic Acids Res., 52, 2024
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9EN2
 | | Crystal structure of the metalloproteinase enhancer PCPE-1 complexed with nanobodies VHH-H4 and VHH-I5 | | Descriptor: | CALCIUM ION, GLYCEROL, Procollagen C-endopeptidase enhancer 1, ... | | Authors: | Lagoutte, P, Gueguen-Chaignon, V, Bourhis, J.-M, Vadon-Le Goff, S. | | Deposit date: | 2024-03-12 | | Release date: | 2024-07-03 | | Last modified: | 2024-07-17 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Mono- and Bi-specific Nanobodies Targeting the CUB Domains of PCPE-1 Reduce the Proteolytic Processing of Fibrillar Procollagens.
J.Mol.Biol., 436, 2024
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9EMV
 | | SARS-CoV-2 nsp10-16 methyltransferase in complex with Sangivamycin and m7GpppA (Cap0-analog)/m7GpppAm (Cap1-analog) | | Descriptor: | 1,2-ETHANEDIOL, 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | | Authors: | Kremling, V, Sprenger, J, Oberthuer, D, Scheer, T.E.S. | | Deposit date: | 2024-03-11 | | Release date: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.34 Å) | | Cite: | SARS-CoV-2 methyltransferase nsp10-16 in complex with natural and drug-like purine analogs for guiding structure-based drug development
To Be Published
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9EMU
 | | RosC-8-demethyl-8-amino-FMN - Phosphate complex | | Descriptor: | 1-deoxy-1-[8-(dimethylamino)-7-methyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl]-D-ribitol, GLYCEROL, PHOSPHATE ION, ... | | Authors: | Ermler, U, Mack, M, Demmer, U. | | Deposit date: | 2024-03-11 | | Release date: | 2024-09-04 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | The Phosphatase RosC from Streptomyces davaonensis is Used for Roseoflavin Biosynthesis and has Evolved to Largely Prevent Dephosphorylation of the Important Cofactor Riboflavin-5'-phosphate.
J.Mol.Biol., 436, 2024
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9EML
 | | SARS-CoV-2 methyltransferase nsp10-16 in complex with SAM and m7GpppA (Cap0-analog)/m7GpppAm (Cap1-analog) | | Descriptor: | 1,2-ETHANEDIOL, 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | | Authors: | Kremling, V, Sprenger, J, Oberthuer, D, Kiene, A. | | Deposit date: | 2024-03-08 | | Release date: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | SARS-CoV-2 methyltransferase nsp10-16 in complex with natural and drug-like purine analogs for guiding structure-based drug development
To Be Published
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9EMJ
 | | SARS-CoV-2 methyltransferase nsp10-16 in complex with Toyocamycin and m7GpppA (Cap0-analog) | | Descriptor: | 1,2-ETHANEDIOL, 2'-O-methyltransferase nsp16, 4-amino-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, ... | | Authors: | Kremling, V, Sprenger, J, Oberthuer, D, Kiene, A. | | Deposit date: | 2024-03-08 | | Release date: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.79 Å) | | Cite: | SARS-CoV-2 methyltransferase nsp10-16 in complex with natural and drug-like purine analogs for guiding structure-based drug development
To Be Published
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9EME
 | | AL amyloid fibril from the FOR103 light chain | | Descriptor: | lambda 3 immunoglobulin light chain fragment, residues 2-116 | | Authors: | Pfeiffer, P.B, Karimi-Farsijani, S, Kupfer, N, Schmidt, M, Faendrich, M. | | Deposit date: | 2024-03-08 | | Release date: | 2024-06-26 | | Method: | ELECTRON MICROSCOPY (2.92 Å) | | Cite: | Light chain mutations contribute to defining the fibril morphology in systemic AL amyloidosis.
Nat Commun, 15, 2024
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9EMC
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9EMB
 | | Structure of KefC Asp156Asn variant | | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE MONOPHOSPHATE, Glutathione-regulated potassium-efflux system protein KefC | | Authors: | Gulati, A, Kokane, S, Drew, D. | | Deposit date: | 2024-03-07 | | Release date: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (2.98 Å) | | Cite: | Structure of KefC Asp156Asn variant
To Be Published
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9EMA
 | | RUVBL1/2 in complex with ATP and CB-6644 inhibitor | | Descriptor: | 5-chloranyl-2-ethoxy-4-fluoranyl-~{N}-[4-[[3-(methoxymethyl)-1-oxidanylidene-6,7-dihydro-5~{H}-pyrazolo[1,2-a][1,2]benzodiazepin-2-yl]amino]-2,2-dimethyl-4-oxidanylidene-butyl]benzamide, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Lopez-Perrote, A, Llorca, O, Garcia-Martin, C. | | Deposit date: | 2024-03-07 | | Release date: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (2.4 Å) | | Cite: | Mechanism of allosteric inhibition of RUVBL1-RUVBL2 by the small-molecule CB-6644
Cell Rep Phys Sci, 2024
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9EM9
 | | Structure of SynDLP MGD with GMPPNP | | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Slr0869 protein | | Authors: | Junglas, B, Gewehr, L, Schoennenbeck, P, Schneider, D, Sachse, C. | | Deposit date: | 2024-03-07 | | Release date: | 2024-09-11 | | Method: | ELECTRON MICROSCOPY (3.76 Å) | | Cite: | Structural basis for GTPase activity and conformational changes of the bacterial dynamin-like protein SynDLP.
Cell Rep, 43, 2024
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9EM8
 | | Oligomeric structure of SynDLP in presence of GDP | | Descriptor: | Slr0869 protein | | Authors: | Junglas, B, Gewehr, L, Schoennenbeck, P, Schneider, D, Sachse, C. | | Deposit date: | 2024-03-07 | | Release date: | 2024-09-11 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Structural basis for GTPase activity and conformational changes of the bacterial dynamin-like protein SynDLP.
Cell Rep, 43, 2024
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9EM7
 | | Oligomeric structure of SynDLP in presence of GTP | | Descriptor: | Slr0869 protein | | Authors: | Junglas, B, Gewehr, L, Schoennenbeck, P, Schneider, D, Sachse, C. | | Deposit date: | 2024-03-07 | | Release date: | 2024-09-11 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structural basis for GTPase activity and conformational changes of the bacterial dynamin-like protein SynDLP.
Cell Rep, 43, 2024
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9EM6
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9EM5
 | | OPR3 variant Y364P in its monomeric form | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 12-oxophytodienoate reductase 3, CHLORIDE ION, ... | | Authors: | Bijelic, A, Macheroux, P, Kerschbaumer, B. | | Deposit date: | 2024-03-07 | | Release date: | 2024-08-14 | | Last modified: | 2024-08-21 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Analysis of homodimer formation in 12-oxophytodienoate reductase 3 in solutio and crystallo challenges the physiological role of the dimer.
Sci Rep, 14, 2024
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9EM4
 | | OPR3 variant Y364P in its dimeric form obtained with ammonium sulfate | | Descriptor: | 12-oxophytodienoate reductase 3, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, FLAVIN MONONUCLEOTIDE, ... | | Authors: | Bijelic, A, Macheroux, P, Kerschbaumer, B. | | Deposit date: | 2024-03-07 | | Release date: | 2024-08-14 | | Last modified: | 2024-08-21 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | Analysis of homodimer formation in 12-oxophytodienoate reductase 3 in solutio and crystallo challenges the physiological role of the dimer.
Sci Rep, 14, 2024
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9EM3
 | | OPR3 wild type in its monomeric form | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 12-oxophytodienoate reductase 3, FLAVIN MONONUCLEOTIDE | | Authors: | Bijelic, A, Macheroux, P, Kerschbaumer, B. | | Deposit date: | 2024-03-07 | | Release date: | 2024-08-14 | | Last modified: | 2024-08-21 | | Method: | X-RAY DIFFRACTION (2.27 Å) | | Cite: | Analysis of homodimer formation in 12-oxophytodienoate reductase 3 in solutio and crystallo challenges the physiological role of the dimer.
Sci Rep, 14, 2024
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9EM2
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9EM1
 | | Human pyridoxal phosphatase in complex with 7,8-dihydroxyflavone and phosphate | | Descriptor: | 7,8-bis(oxidanyl)-2-phenyl-chromen-4-one, Chronophin, GLYCEROL, ... | | Authors: | Brenner, M, Gohla, A, Schindelin, H. | | Deposit date: | 2024-03-07 | | Release date: | 2024-06-12 | | Last modified: | 2024-06-26 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | 7,8-Dihydroxyflavone is a direct inhibitor of human and murine pyridoxal phosphatase.
Elife, 13, 2024
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9EM0
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9DNA
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9DE2
 | | ETO2 MYND bound to MPPL peptide from GATAD2A | | Descriptor: | GATAD2A-MPPL motif and ETO2 NHR4 domain fusion protein, ZINC ION | | Authors: | Williams, D.C. | | Deposit date: | 2024-08-28 | | Release date: | 2024-09-18 | | Method: | SOLUTION NMR | | Cite: | The role of multivalency in the association of the eight twenty-one protein 2 (ETO2) with the nucleosome remodeling and deacetylase (NuRD) complex
To Be Published
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9DDY
 | | The Crystal Structure of Geranyltranstransferase from Streptococcus pneumoniae TIGR4 | | Descriptor: | GLYCEROL, Geranyltranstransferase | | Authors: | Kim, Y, Tan, A, Endres, M, Tan, K, Joachimik, A, Center for Structural Biology of Infectious Diseases (CSBID) | | Deposit date: | 2024-08-28 | | Release date: | 2024-09-18 | | Method: | X-RAY DIFFRACTION (2.32 Å) | | Cite: | The Crystal Structure of Geranyltranstransferase from Streptococcus pneumoniae TIGR4
To Be Published
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