1MLX
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![BU of 1mlx by Molmil](/molmil-images/mine/1mlx) | Crystal Structure Analysis of a 2'-O-[2-(Methylthio)-ethyl]-Modified Oligodeoxynucleotide Duplex | Descriptor: | 5'-D(*GP*CP*GP*TP*AP*SMTP*AP*CP*GP*C)-3' | Authors: | Prakash, T.P, Manoharan, M, Kawasaki, A.M, Fraser, A.S, Lesnik, E.A, Sioufi, N, Leeds, J.M, Teplova, M, Egli, M. | Deposit date: | 2002-08-31 | Release date: | 2002-12-04 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | 2'-O-[2-(Methylthio)ethyl]-Modified Oligonucleotide: An Analogue of 2'-O-[2-(Methoxy)-ethyl]-Modified
Oligonucleotide with Improved Protein Binding Properties and High Binding Affinity to Target RNA Biochemistry, 41, 2002
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2BH2
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![BU of 2bh2 by Molmil](/molmil-images/mine/2bh2) | Crystal Structure of E. coli 5-methyluridine methyltransferase RumA in complex with ribosomal RNA substrate and S-adenosylhomocysteine. | Descriptor: | 23S RIBOSOMAL RNA 1932-1968, 23S RRNA (URACIL-5-)-METHYLTRANSFERASE RUMA, IRON/SULFUR CLUSTER, ... | Authors: | Lee, T.T, Agarwalla, S, Stroud, R.M. | Deposit date: | 2005-01-06 | Release date: | 2005-03-30 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | A Unique RNA Fold in the Ruma-RNA-Cofactor Ternary Complex Contributes to Substrate Selectivity and Enzymatic Function Cell(Cambridge,Mass.), 120, 2005
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1QPY
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![BU of 1qpy by Molmil](/molmil-images/mine/1qpy) | CRYSTAL STRUCTURE OF BACKBONE MODIFIED PNA HEXAMER | Descriptor: | PEPTIDE NUCLEIC ACID 5'-(*CP1*GPN*TP1*APN*CP1*GPN*LYS)-3' | Authors: | Haima, G, Rasmussen, H, Schmidt, G, Jensen, D.K, Kastrup, J.S, Stafshede, P.W, Norden, B, Buchardt, O, Nielsen, P.E. | Deposit date: | 1999-05-14 | Release date: | 2001-02-21 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Peptide Nucleic Acids (PNA) derived from N-(N-methylaminoethyl)glycine. Synthesis, hybridization and structural properties New J.Chem., 23, 1999
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1BD3
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![BU of 1bd3 by Molmil](/molmil-images/mine/1bd3) | STRUCTURE OF THE APO URACIL PHOSPHORIBOSYLTRANSFERASE, 2 MUTANT C128V | Descriptor: | PHOSPHATE ION, URACIL PHOSPHORIBOSYLTRANSFERASE | Authors: | Schumacher, M.A, Carter, D, Scott, D, Roos, D, Ullman, B, Brennan, R.G. | Deposit date: | 1998-05-12 | Release date: | 1999-05-18 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding. EMBO J., 17, 1998
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1BD4
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![BU of 1bd4 by Molmil](/molmil-images/mine/1bd4) | UPRT-URACIL COMPLEX | Descriptor: | PHOSPHATE ION, URACIL, URACIL PHOSPHORIBOSYLTRANSFERASE | Authors: | Schumacher, M.A, Carter, D, Scott, D, Roos, D, Ullman, B, Brennan, R.G. | Deposit date: | 1998-05-12 | Release date: | 1999-05-18 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding. EMBO J., 17, 1998
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1PWF
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![BU of 1pwf by Molmil](/molmil-images/mine/1pwf) | One Sugar Pucker Fits All: Pairing Versatility Despite Conformational Uniformity in TNA | Descriptor: | 5'-D(*GP*CP*GP*TP*AP*(2MU)P*(FA2)P*CP*GP*C)-3', SPERMINE | Authors: | Pallan, P.S, Wilds, C.J, Wawrzak, Z, Krishnamurthy, R, Eschenmoser, A, Egli, M. | Deposit date: | 2003-07-01 | Release date: | 2004-07-13 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.16 Å) | Cite: | Why does TNA cross-pair more strongly with RNA than with DNA? an answer from X-ray analysis. ANGEW.CHEM.INT.ED.ENGL., 42, 2003
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1RTD
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![BU of 1rtd by Molmil](/molmil-images/mine/1rtd) | STRUCTURE OF A CATALYTIC COMPLEX OF HIV-1 REVERSE TRANSCRIPTASE: IMPLICATIONS FOR NUCLEOSIDE ANALOG DRUG RESISTANCE | Descriptor: | DNA PRIMER FOR REVERSE TRANSCRIPTASE, DNA TEMPLATE FOR REVERSE TRANSCRIPTASE, MAGNESIUM ION, ... | Authors: | Chopra, R, Huang, H, Verdine, G.L, Harrison, S.C. | Deposit date: | 1998-08-26 | Release date: | 1998-12-09 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance. Science, 282, 1998
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1CX5
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![BU of 1cx5 by Molmil](/molmil-images/mine/1cx5) | ANTISENSE DNA/RNA HYBRID CONTAINING MODIFIED BACKBONE | Descriptor: | 5'-D(*CP*GP*CP*GP*TP*T*(MMT)P*TP*GP*CP*GP*C), 5'-R(*GP*CP*GP*CP*AP*AP*AP*AP*CP*GP*CP*G) | Authors: | Yang, X, Han, X, Cross, C, Sanghvi, Y, Gao, X. | Deposit date: | 1999-08-28 | Release date: | 1999-09-14 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | NMR structure of an antisense DNA.RNA hybrid duplex containing a 3'-CH(2)N(CH(3))-O-5' or an MMI backbone linker. Biochemistry, 38, 1999
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1GTH
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![BU of 1gth by Molmil](/molmil-images/mine/1gth) | DIHYDROPYRIMIDINE DEHYDROGENASE (DPD) FROM PIG, TERNARY COMPLEX WITH NADPH AND 5-IODOURACIL | Descriptor: | (5S)-5-IODODIHYDRO-2,4(1H,3H)-PYRIMIDINEDIONE, 5-IODOURACIL, DIHYDROPYRIMIDINE DEHYDROGENASE, ... | Authors: | Dobritzsch, D, Ricagno, S, Schneider, G, Schnackerz, K.D, Lindqvist, Y. | Deposit date: | 2002-01-15 | Release date: | 2002-04-11 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Crystal structure of the productive ternary complex of dihydropyrimidine dehydrogenase with NADPH and 5-iodouracil. Implications for mechanism of inhibition and electron transfer. J. Biol. Chem., 277, 2002
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1QP0
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![BU of 1qp0 by Molmil](/molmil-images/mine/1qp0) | PURINE REPRESSOR-HYPOXANTHINE-PALINDROMIC OPERATOR COMPLEX | Descriptor: | DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*CP*CP*GP*GP*TP*TP*GP*CP*GP*T)-3'), HYPOXANTHINE, PROTEIN (PURINE NUCLEOTIDE SYNTHESIS REPRESSOR) | Authors: | Glasfeld, A, Koehler, A.N, Schumacher, M.A, Brennan, R.G. | Deposit date: | 1999-06-01 | Release date: | 1999-06-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The role of lysine 55 in determining the specificity of the purine repressor for its operators through minor groove interactions. J.Mol.Biol., 291, 1999
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1QP7
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![BU of 1qp7 by Molmil](/molmil-images/mine/1qp7) | PURINE REPRESSOR MUTANT-HYPOXANTHINE-PALINDROMIC OPERATOR COMPLEX | Descriptor: | DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*CP*CP*GP*GP*TP*TP*GP*CP*GP*T)-3'), HYPOXANTHINE, PROTEIN (PURINE NUCLEOTIDE SYNTHESIS REPRESSOR) | Authors: | Glasfeld, A, Koehler, A.N, Schumacher, M.A, Brennan, R.G. | Deposit date: | 1999-06-01 | Release date: | 1999-06-04 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The role of lysine 55 in determining the specificity of the purine repressor for its operators through minor groove interactions. J.Mol.Biol., 291, 1999
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1QPZ
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![BU of 1qpz by Molmil](/molmil-images/mine/1qpz) | PURINE REPRESSOR-HYPOXANTHINE-PALINDROMIC OPERATOR COMPLEX | Descriptor: | DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*AP*CP*GP*TP*TP*TP*GP*CP*GP*T)-3'), HYPOXANTHINE, PROTEIN (PURINE NUCLEOTIDE SYNTHESIS REPRESSOR) | Authors: | Glasfeld, A, Koehler, A.N, Schumacher, M.A, Brennan, R.G. | Deposit date: | 1999-06-01 | Release date: | 1999-06-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The role of lysine 55 in determining the specificity of the purine repressor for its operators through minor groove interactions. J.Mol.Biol., 291, 1999
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1QQA
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![BU of 1qqa by Molmil](/molmil-images/mine/1qqa) | PURINE REPRESSOR MUTANT-HYPOXANTHINE-PALINDROMIC OPERATOR COMPLEX | Descriptor: | DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*GP*CP*GP*CP*TP*TP*GP*CP*GP*T)-3'), HYPOXANTHINE, PROTEIN (PURINE NUCLEOTIDE SYNTHESIS REPRESSOR) | Authors: | Glasfeld, A, Koehler, A.N, Schumacher, M.A, Brennan, R.G. | Deposit date: | 1999-06-01 | Release date: | 1999-06-09 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The role of lysine 55 in determining the specificity of the purine repressor for its operators through minor groove interactions. J.Mol.Biol., 291, 1999
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1QP4
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![BU of 1qp4 by Molmil](/molmil-images/mine/1qp4) | PURINE REPRESSOR-HYPOXANTHINE-PALINDROMIC OPERATOR COMPLEX | Descriptor: | DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*TP*CP*GP*AP*TP*TP*GP*CP*GP*T)-3'), HYPOXANTHINE, PROTEIN (PURINE NUCLEOTIDE SYNTHESIS REPRESSOR) | Authors: | Glasfeld, A, Koehler, A.N, Schumacher, M.A, Brennan, R.G. | Deposit date: | 1999-06-01 | Release date: | 1999-06-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The role of lysine 55 in determining the specificity of the purine repressor for its operators through minor groove interactions. J.Mol.Biol., 291, 1999
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1QQB
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![BU of 1qqb by Molmil](/molmil-images/mine/1qqb) | PURINE REPRESSOR MUTANT-HYPOXANTHINE-PALINDROMIC OPERATOR COMPLEX | Descriptor: | 5'-D(*TP*AP*CP*GP*CP*AP*AP*TP*CP*GP*AP*TP*TP*GP*CP*GP*T)-3', HYPOXANTHINE, PURINE NUCLEOTIDE SYNTHESIS REPRESSOR | Authors: | Glasfeld, A, Koehler, A.N, Schumacher, M.A, Brennan, R.G. | Deposit date: | 1999-06-01 | Release date: | 1999-06-09 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The role of lysine 55 in determining the specificity of the purine repressor for its operators through minor groove interactions. J.Mol.Biol., 291, 1999
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1HX4
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![BU of 1hx4 by Molmil](/molmil-images/mine/1hx4) | MOLECULAR TOPOLOGY OF POLYCYCLIC AROMATIC CARCINOGENS DETERMINES DNA ADDUCT CONFORMATION: A LINK TO TUMORIGENIC ACTIVITY | Descriptor: | (1R)-1,2,3,4-TETRAHYDRO-BENZO[C]PHENANTHRENE-2,3,4-TRIOL, 5'-D(*CP*CP*AP*TP*CP*GP*CP*TP*AP*CP*C)-3', 5'-D(*GP*GP*TP*AP*GP*CP*GP*AP*TP*GP*G)-3' | Authors: | Patel, D.J, Lin, C.H, Geacintov, N.E, Broyde, S, Huang, X, Kolbanovskii, A, Hingerty, B.E, Amin, S. | Deposit date: | 2001-01-11 | Release date: | 2001-03-21 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Molecular topology of polycyclic aromatic carcinogens determines DNA adduct conformation: a link to tumorigenic activity. J.Mol.Biol., 306, 2001
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1GV6
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![BU of 1gv6 by Molmil](/molmil-images/mine/1gv6) | Solution structure of alfa-L-LNA:DNA duplex | Descriptor: | 5- D(*CP*(ATL)P*GP*CP*(ATL)P*(ATL)P*CP*(ATL)P* GP*C) -3, 5- D(*GP*CP*AP*GP*AP*AP*GP*CP*AP*G) -3 | Authors: | Nielsen, K.M.E, Petersen, M, Haakansson, A.E, Wengel, J, Jacobsen, J.P. | Deposit date: | 2002-02-06 | Release date: | 2002-07-05 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Alfa-L-Lna (Alfa-L-Ribo Configured Locked Nucleic Acid) Recognition of DNA: An NMR Spectroscopic Study Chemistry, 8, 2002
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8SX6
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![BU of 8sx6 by Molmil](/molmil-images/mine/8sx6) | RNA duplex bound with GMP and AMP monomers | Descriptor: | ADENOSINE MONOPHOSPHATE, GUANOSINE-5'-MONOPHOSPHATE, MAGNESIUM ION, ... | Authors: | Zhang, W, Dantsu, Y. | Deposit date: | 2023-05-19 | Release date: | 2023-05-31 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Insight into the structures of unusual base pairs in RNA complexes containing a primer/template/adenosine ligand. Rsc Chem Biol, 4, 2023
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8SX5
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![BU of 8sx5 by Molmil](/molmil-images/mine/8sx5) | GpppA dinucleotide binding to RNA CU template | Descriptor: | GUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, RNA (5'-R(*(TLN)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*G*(GA3))-3') | Authors: | Zhang, W, Dantsu, Y. | Deposit date: | 2023-05-19 | Release date: | 2023-05-31 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Insight into the structures of unusual base pairs in RNA complexes containing a primer/template/adenosine ligand. Rsc Chem Biol, 4, 2023
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8SXL
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![BU of 8sxl by Molmil](/molmil-images/mine/8sxl) | RNA UU template binding to AMP monomer | Descriptor: | ADENOSINE MONOPHOSPHATE, RNA (5'-R(*(TLN)P*(TLN)P*(LCA)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*U)-3') | Authors: | Zhang, W, Dantsu, Y. | Deposit date: | 2023-05-22 | Release date: | 2023-05-31 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Insight into the structures of unusual base pairs in RNA complexes containing a primer/template/adenosine ligand. Rsc Chem Biol, 4, 2023
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8SWO
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![BU of 8swo by Molmil](/molmil-images/mine/8swo) | GpppA dinucleotide ligand binding to RNA UC template | Descriptor: | GUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, MAGNESIUM ION, RNA (5'-R(*(TLN)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*G*(GA3))-3') | Authors: | Zhang, W, Dantsu, Y. | Deposit date: | 2023-05-19 | Release date: | 2023-05-31 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Insight into the structures of unusual base pairs in RNA complexes containing a primer/template/adenosine ligand. Rsc Chem Biol, 4, 2023
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8SY1
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![BU of 8sy1 by Molmil](/molmil-images/mine/8sy1) | RNA duplex bound with imidazolium bridged GA dinucleotide | Descriptor: | RNA (5'-R(*(TLN)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*G*(GMA))-3'), [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-[2-azanyl-3-[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]imidazol-1-yl]phosphinic acid | Authors: | Zhang, W, Dantsu, Y. | Deposit date: | 2023-05-24 | Release date: | 2023-05-31 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Insight into the structures of unusual base pairs in RNA complexes containing a primer/template/adenosine ligand. Rsc Chem Biol, 4, 2023
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5HBW
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![BU of 5hbw by Molmil](/molmil-images/mine/5hbw) | RNA primer-template complex with 2-methylimidazole-activated monomer analogue | Descriptor: | RNA (5'-R(*(LCC)P*(TLN)P*(LCG)P*UP*AP*CP*A)-3'), [(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-(3-methyl-1~{H}-pyrazol-4-yl)phosphinic acid | Authors: | Zhang, W, Tam, C.P, Szostak, J.W. | Deposit date: | 2016-01-03 | Release date: | 2016-12-07 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Unusual Base-Pairing Interactions in Monomer-Template Complexes. ACS Cent Sci, 2, 2016
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6U89
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![BU of 6u89 by Molmil](/molmil-images/mine/6u89) | RNA duplex, bound with TNA monomer | Descriptor: | 2-azanyl-9-[(2~{R},3~{R},4~{S})-3-oxidanyl-4-[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxy-oxolan-2-yl]-1~{H}-purin-6-one, RNA (5'-R(*(LCC)P*(TLN)P*(LCG)P*UP*AP*CP*A)-3') | Authors: | Szostak, J.W, Zhang, W. | Deposit date: | 2019-09-04 | Release date: | 2020-12-09 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.36 Å) | Cite: | Structural interpretation of the effects of threo-nucleotides on nonenzymatic template-directed polymerization. Nucleic Acids Res., 49, 2021
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481D
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![BU of 481d by Molmil](/molmil-images/mine/481d) | |