1HX4

MOLECULAR TOPOLOGY OF POLYCYCLIC AROMATIC CARCINOGENS DETERMINES DNA ADDUCT CONFORMATION: A LINK TO TUMORIGENIC ACTIVITY

Summary for 1HX4

Related1HWV
Descriptor5'-D(*CP*CP*AP*TP*CP*GP*CP*TP*AP*CP*C)-3', 5'-D(*GP*GP*TP*AP*GP*CP*GP*AP*TP*GP*G)-3', (1R)-1,2,3,4-TETRAHYDRO-BENZO[C]PHENANTHRENE-2,3,4-TRIOL (3 entities in total)
Functional Keywords1r-trans-anti-bph-n2-g adduct, carcinogen-dna adduct, benzo[c]phenanthrene dna adduct, dna
Total number of polymer chains2
Total molecular weight6988.71
Authors
Patel, D.J.,Lin, C.H.,Geacintov, N.E.,Broyde, S.,Huang, X.,Kolbanovskii, A.,Hingerty, B.E.,Amin, S. (deposition date: 2001-01-11, release date: 2001-03-21, Last modification date: 2011-07-13)
Primary citation
Lin, C.H.,Huang, X.,Kolbanovskii, A.,Hingerty, B.E.,Amin, S.,Broyde, S.,Geacintov, N.E.,Patel, D.J.
Molecular topology of polycyclic aromatic carcinogens determines DNA adduct conformation: a link to tumorigenic activity.
J.Mol.Biol., 306:1059-1080, 2001
PubMed: 11237618 (PDB entries with the same primary citation)
DOI: 10.1006/jmbi.2001.4425
MImport into Mendeley
Experimental method
SOLUTION NMR
?

Structure validation

Clashscore11MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures

More Asymmetric unit images

Molmil generated image of 1hx4
no rotation
Molmil generated image of 1hx4
rotated about x axis by 90°
Molmil generated image of 1hx4
rotated about y axis by 90°