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8Z1P
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BU of 8z1p by Molmil
Crystal structure of Saccharomyces cerevisiae isoleucyl-tRNA synthetase in complex with a mimic tRNA(Met) and isoleucine
Descriptor: (2S,3S)-2-amino-3-methylpentane-1,1-diol, isoleucine--tRNA ligase, tRNA(Met)
Authors:Chen, B, Yi, F, Zhou, H.
Deposit date:2024-04-11
Release date:2024-12-18
Last modified:2025-01-15
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:The mechanism of discriminative aminoacylation by isoleucyl-tRNA synthetase based on wobble nucleotide recognition.
Nat Commun, 15, 2024
1YSV
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BU of 1ysv by Molmil
Solution structure of the central region of the human GluR-B R/G pre-mRNA
Descriptor: 27-MER
Authors:Stefl, R, Allain, F.H.
Deposit date:2005-02-09
Release date:2005-07-19
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:A novel RNA pentaloop fold involved in targeting ADAR2.
Rna, 11, 2005
2YXN
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BU of 2yxn by Molmil
Structual basis of azido-tyrosine recognition by engineered bacterial Tyrosyl-tRNA synthetase
Descriptor: 3-AZIDO-L-TYROSINE, Tyrosyl-tRNA synthetase
Authors:Oki, K, Kobayashi, T, Sakamoto, K, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-04-26
Release date:2008-04-29
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Functional replacement of the endogenous tyrosyl-tRNA synthetase-tRNATyr pair by the archaeal tyrosine pair in Escherichia coli for genetic code expansion
Nucleic Acids Res., 38, 2010
4H3S
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BU of 4h3s by Molmil
The Structure of Glutaminyl-tRNA Synthetase from Saccharomyces Cerevisiae
Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ACETATE ION, BROMIDE ION, ...
Authors:Snell, E.H, Grant, T.D.
Deposit date:2012-09-14
Release date:2013-04-24
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The Structure of Yeast Glutaminyl-tRNA Synthetase and Modeling of Its Interaction with tRNA.
J.Mol.Biol., 425, 2013
2CT8
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BU of 2ct8 by Molmil
Crystal structure of Aquifex aeolicus methionyl-tRNA synthetase complexed with tRNA(Met) and methionyl-adenylate anologue
Descriptor: 5'-O-[(L-METHIONYL)-SULPHAMOYL]ADENOSINE, Methionyl-tRNA synthetase, RNA (74-MER)
Authors:Nakanishi, K, Ogiso, Y, Nakama, T, Fukai, S, Nureki, O, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-05-23
Release date:2005-09-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for anticodon recognition by methionyl-tRNA synthetase.
Nat.Struct.Mol.Biol., 12, 2005
2HRK
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BU of 2hrk by Molmil
Structural basis of yeast aminoacyl-tRNA synthetase complex formation revealed by crystal structures of two binary sub-complexes
Descriptor: CHLORIDE ION, GU4 nucleic-binding protein 1, Glutamyl-tRNA synthetase, ...
Authors:Simader, H, Suck, D.
Deposit date:2006-07-20
Release date:2006-09-05
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural basis of yeast aminoacyl-tRNA synthetase complex formation revealed by crystal structures of two binary sub-complexes.
Nucleic Acids Res., 34, 2006
2HSM
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BU of 2hsm by Molmil
Structural basis of yeast aminoacyl-tRNA synthetase complex formation revealed by crystal structures of two binary sub-complexes
Descriptor: GU4 nucleic-binding protein 1, Glutamyl-tRNA synthetase, cytoplasmic
Authors:Simader, H, Suck, D.
Deposit date:2006-07-22
Release date:2006-09-05
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis of yeast aminoacyl-tRNA synthetase complex formation revealed by crystal structures of two binary sub-complexes.
Nucleic Acids Res., 34, 2006
2HSN
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BU of 2hsn by Molmil
Structural basis of yeast aminoacyl-tRNA synthetase complex formation revealed by crystal structures of two binary sub-complexes
Descriptor: GU4 nucleic-binding protein 1, Methionyl-tRNA synthetase, cytoplasmic
Authors:Simader, H, Koehler, C, Basquin, J, Suck, D.
Deposit date:2006-07-22
Release date:2006-09-05
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis of yeast aminoacyl-tRNA synthetase complex formation revealed by crystal structures of two binary sub-complexes.
Nucleic Acids Res., 34, 2006
1QF6
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BU of 1qf6 by Molmil
STRUCTURE OF E. COLI THREONYL-TRNA SYNTHETASE COMPLEXED WITH ITS COGNATE TRNA
Descriptor: ADENOSINE MONOPHOSPHATE, THREONINE TRNA, THREONYL-TRNA SYNTHETASE, ...
Authors:Sankaranarayanan, R, Dock-Bregeon, A.C, Rees, B, Moras, D.
Deposit date:1999-04-06
Release date:1999-05-06
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The structure of threonyl-tRNA synthetase-tRNA(Thr) complex enlightens its repressor activity and reveals an essential zinc ion in the active site
Cell(Cambridge,Mass.), 97, 1999
1BS2
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BU of 1bs2 by Molmil
YEAST ARGINYL-TRNA SYNTHETASE
Descriptor: ARGININE, PROTEIN (ARGINYL-TRNA SYNTHETASE)
Authors:Cavarelli, J, Delagouute, B, Eriani, G, Gangloff, J, Moras, D.
Deposit date:1998-08-31
Release date:1999-08-27
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:L-arginine recognition by yeast arginyl-tRNA synthetase.
EMBO J., 17, 1998
8VC5
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BU of 8vc5 by Molmil
Crystal structure of glutamyl-tRNA synthetase GluRS from Pseudomonas aeruginosa (Zinc bound)
Descriptor: CITRATE ANION, GLYCEROL, Glutamate--tRNA ligase, ...
Authors:Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2023-12-13
Release date:2023-12-27
Last modified:2025-05-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Architecture of Pseudomonas aeruginosa glutamyl-tRNA synthetase defines a subfamily of dimeric class Ib aminoacyl-tRNA synthetases.
Proc.Natl.Acad.Sci.USA, 122, 2025
8BRX
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Escherichia coli methionyl-tRNA synthetase mutant L13C,I297C complexed with beta-3-methionine
Descriptor: (3R)-3-amino-5-(methylsulfanyl)pentanoic acid, CITRIC ACID, Methionine--tRNA ligase, ...
Authors:Schmitt, E, Mechulam, Y, Nigro, G, Opuu, V, Lazennec-Schurdevin, C, Simonson, T.
Deposit date:2022-11-24
Release date:2023-08-16
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Redesigning methionyl-tRNA synthetase for beta-methionine activity with adaptive landscape flattening and experiments.
Protein Sci., 32, 2023
8BRV
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BU of 8brv by Molmil
Escherichia coli methionyl-tRNA synthetase mutant L13M,I297C complexed with beta3-methionine.
Descriptor: (3R)-3-amino-5-(methylsulfanyl)pentanoic acid, CITRIC ACID, Methionine--tRNA ligase, ...
Authors:Schmitt, E, Mechulam, Y, Nigro, G, Opuu, V, Lazennec-Schurdevin, C, Simonson, T.
Deposit date:2022-11-24
Release date:2023-08-16
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Redesigning methionyl-tRNA synthetase for beta-methionine activity with adaptive landscape flattening and experiments.
Protein Sci., 32, 2023
8BRU
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BU of 8bru by Molmil
Escherichia coli methionyl-tRNA synthetase mutant L13M,I297C
Descriptor: CITRIC ACID, Methionine--tRNA ligase, ZINC ION
Authors:Schmitt, E, Mechulam, Y, Nigro, G, Opuu, V, Lazennec-Schurdevin, C, Simonson, T.
Deposit date:2022-11-24
Release date:2023-08-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Redesigning methionyl-tRNA synthetase for beta-methionine activity with adaptive landscape flattening and experiments.
Protein Sci., 32, 2023
1NYQ
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BU of 1nyq by Molmil
Structure of Staphylococcus aureus threonyl-tRNA synthetase complexed with an analogue of threonyl adenylate
Descriptor: 5'-O-(N-(L-THREONYL)-SULFAMOYL)ADENOSINE, ZINC ION, threonyl-tRNA synthetase 1
Authors:Torres-Larios, A, Sankaranarayanan, R, Rees, B, Dock-Bregeon, A.C, Moras, D.
Deposit date:2003-02-13
Release date:2003-10-28
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Conformational movements and cooperativity upon amino acid, ATP and tRNA binding in threonyl-tRNA synthetase
J.Mol.Biol., 331, 2003
8WNG
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BU of 8wng by Molmil
Crystal structure of H. pylori isoleucyl-tRNA synthetase (HpIleRS) in complex with Ile
Descriptor: ACETATE ION, GLYCEROL, ISOLEUCINE, ...
Authors:Guo, Y, Li, S, Zhang, T.
Deposit date:2023-10-05
Release date:2024-02-14
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Structural basis for substrate and antibiotic recognition by Helicobacter pylori isoleucyl-tRNA synthetase.
Febs Lett., 598, 2024
8WO3
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BU of 8wo3 by Molmil
Crystal structure of H. pylori isoleucyl-tRNA synthetase (HpIleRS) in complex with Mupirocin
Descriptor: ACETATE ION, GLYCEROL, Isoleucine--tRNA ligase, ...
Authors:Guo, Y, Li, S, Zhang, T.
Deposit date:2023-10-06
Release date:2024-02-14
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for substrate and antibiotic recognition by Helicobacter pylori isoleucyl-tRNA synthetase.
Febs Lett., 598, 2024
8WNF
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BU of 8wnf by Molmil
Crystal structure of H. pylori isoleucyl-tRNA synthetase (HpIleRS) in apo form
Descriptor: ACETATE ION, GLYCEROL, Isoleucine--tRNA ligase, ...
Authors:Guo, Y, Li, S, Zhang, T.
Deposit date:2023-10-05
Release date:2024-02-14
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for substrate and antibiotic recognition by Helicobacter pylori isoleucyl-tRNA synthetase.
Febs Lett., 598, 2024
8WNI
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BU of 8wni by Molmil
Crystal structure of H. pylori isoleucyl-tRNA synthetase (HpIleRS) in complex with Val
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, GLYCEROL, ...
Authors:Guo, Y, Li, S, Zhang, T.
Deposit date:2023-10-06
Release date:2024-02-14
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural basis for substrate and antibiotic recognition by Helicobacter pylori isoleucyl-tRNA synthetase.
Febs Lett., 598, 2024
8WO2
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BU of 8wo2 by Molmil
Crystal structure of H. pylori isoleucyl-tRNA synthetase (HpIleRS) in complex with Val-AMP
Descriptor: ACETATE ION, GLYCEROL, Isoleucine--tRNA ligase, ...
Authors:Guo, Y, Li, S, Zhang, T.
Deposit date:2023-10-06
Release date:2024-02-14
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Structural basis for substrate and antibiotic recognition by Helicobacter pylori isoleucyl-tRNA synthetase.
Febs Lett., 598, 2024
8WNJ
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BU of 8wnj by Molmil
Crystal structure of H. pylori isoleucyl-tRNA synthetase (HpIleRS) in complex with Ile-AMP
Descriptor: ACETATE ION, GLYCEROL, Isoleucine--tRNA ligase, ...
Authors:Guo, Y, Li, S, Zhang, T.
Deposit date:2023-10-06
Release date:2024-02-14
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structural basis for substrate and antibiotic recognition by Helicobacter pylori isoleucyl-tRNA synthetase.
Febs Lett., 598, 2024
1NYR
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BU of 1nyr by Molmil
Structure of Staphylococcus aureus threonyl-tRNA synthetase complexed with ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, THREONINE, ZINC ION, ...
Authors:Torres-Larios, A, Sankaranarayanan, R, Rees, B, Dock-Bregeon, A.C, Moras, D.
Deposit date:2003-02-13
Release date:2003-10-28
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Conformational movements and cooperativity upon amino acid, ATP and tRNA binding in threonyl-tRNA synthetase
J.Mol.Biol., 331, 2003
4MSX
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BU of 4msx by Molmil
Crystal structure of an essential yeast splicing factor
Descriptor: ACETATE ION, Pre-mRNA-splicing factor SAD1, ZINC ION
Authors:Hadjivassiliou, H, Guthrie, C, Rosenberg, O.S.
Deposit date:2013-09-18
Release date:2014-04-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:The crystal structure of S. cerevisiae Sad1, a catalytically inactive deubiquitinase that is broadly required for pre-mRNA splicing.
Rna, 20, 2014
4FNO
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BU of 4fno by Molmil
Crystal structure of peptidyl t-RNA hydrolase from Pseudomonas aeruginosa at 2.2 Angstrom resolution
Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, Peptidyl-tRNA hydrolase
Authors:Singh, A, Kumar, A, Arora, A, Singh, N, Sinha, M, Kaur, P, Sharma, S, Singh, T.P.
Deposit date:2012-06-20
Release date:2012-07-04
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural and binding studies of peptidyl-tRNA hydrolase from Pseudomonas aeruginosa provide a platform for the structure-based inhibitor design against peptidyl-tRNA hydrolase
Biochem.J., 463, 2014
5DK4
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BU of 5dk4 by Molmil
Crystal structure analysis of Tryptophanyl-trna synthetase from Bacillus stearothermophilus in complex with indolmycin and Mg*ATP
Descriptor: (5S)-5-[(1R)-1-(1H-indol-3-yl)ethyl]-2-(methylamino)-1,3-oxazol-4(5H)-one, ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, ...
Authors:Williams, T, Yin, W.Y, Carter Jr, C.W.
Deposit date:2015-09-02
Release date:2015-11-18
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Selective Inhibition of Bacterial Tryptophanyl-tRNA Synthetases by Indolmycin Is Mechanism-based.
J.Biol.Chem., 291, 2016

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