7D0A
| Acinetobacter MlaFEDB complex in ADP-vanadate trapped Vclose conformation | Descriptor: | ABC transporter ATP-binding protein, ADENOSINE-5'-DIPHOSPHATE, Anti-sigma factor antagonist, ... | Authors: | Zhang, Y.Y, Fan, Q.X, Chi, X.M, Zhou, Q, Li, Y.Y. | Deposit date: | 2020-09-09 | Release date: | 2020-12-16 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Cryo-EM structures of Acinetobacter baumannii glycerophospholipid transporter. Cell Discov, 6, 2020
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7D08
| Acinetobacter MlaFEDB complex in ATP-bound Vtrans1 conformation | Descriptor: | ABC transporter ATP-binding protein, ADENOSINE-5'-TRIPHOSPHATE, Anti-sigma factor antagonist, ... | Authors: | Zhang, Y.Y, Fan, Q.X, Chi, X.M, Zhou, Q, Li, Y.Y. | Deposit date: | 2020-09-09 | Release date: | 2020-12-16 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Cryo-EM structures of Acinetobacter baumannii glycerophospholipid transporter. Cell Discov, 6, 2020
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7D09
| Acinetobacter MlaFEDB complex in ATP-bound Vtrans2 conformation | Descriptor: | ABC transporter ATP-binding protein, ADENOSINE-5'-TRIPHOSPHATE, Anti-sigma factor antagonist, ... | Authors: | Zhang, Y.Y, Fan, Q.X, Chi, X.M, Zhou, Q, Li, Y.Y. | Deposit date: | 2020-09-09 | Release date: | 2020-12-16 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cryo-EM structures of Acinetobacter baumannii glycerophospholipid transporter. Cell Discov, 6, 2020
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7D06
| Cryo EM structure of the nucleotide free Acinetobacter MlaFEDB complex | Descriptor: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, ABC transporter ATP-binding protein, Anti-sigma factor antagonist, ... | Authors: | Zhang, Y.Y, Fan, Q.X, Chi, X.M, Zhou, Q, Li, Y.Y. | Deposit date: | 2020-09-09 | Release date: | 2020-12-16 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Cryo-EM structures of Acinetobacter baumannii glycerophospholipid transporter. Cell Discov, 6, 2020
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7DQV
| Crystal structure of a CmABCB1 mutant | Descriptor: | DECYL-BETA-D-MALTOPYRANOSIDE, MAGNESIUM ION, NITRATE ION, ... | Authors: | Matsuoka, K, Nakatsu, T, Kato, H. | Deposit date: | 2020-12-24 | Release date: | 2021-03-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | The crystal structure of the CmABCB1 G132V mutant, which favors the outward-facing state, reveals the mechanism of the pivotal joint between TM1 and TM3. Protein Sci., 30, 2021
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8EIG
| The complex of phosphorylated human delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) with elexacaftor (VX-445) and ATP/Mg | Descriptor: | (6P)-N-(1,3-dimethyl-1H-pyrazole-4-sulfonyl)-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, ... | Authors: | Fiedorczuk, K, Chen, J. | Deposit date: | 2022-09-15 | Release date: | 2022-10-19 | Last modified: | 2022-11-23 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Molecular structures reveal synergistic rescue of Delta 508 CFTR by Trikafta modulators. Science, 378, 2022
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8EJ1
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8EIQ
| The complex of phosphorylated human delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) with Trikafta [elexacaftor (VX-445), tezacaftor (VX-661), ivacaftor (VX-770)] and ATP/Mg | Descriptor: | (6P)-N-(1,3-dimethyl-1H-pyrazole-4-sulfonyl)-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, ... | Authors: | Fiedorczuk, K, Chen, J. | Deposit date: | 2022-09-15 | Release date: | 2022-10-19 | Last modified: | 2022-11-23 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Molecular structures reveal synergistic rescue of Delta 508 CFTR by Trikafta modulators. Science, 378, 2022
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8EIO
| The complex of phosphorylated human delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) with elexacaftor (VX-445), lumacaftor (VX-809) and ATP/Mg | Descriptor: | (6P)-N-(1,3-dimethyl-1H-pyrazole-4-sulfonyl)-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, ... | Authors: | Fiedorczuk, K, Chen, J. | Deposit date: | 2022-09-15 | Release date: | 2022-10-19 | Last modified: | 2022-11-23 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Molecular structures reveal synergistic rescue of Delta 508 CFTR by Trikafta modulators. Science, 378, 2022
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8EEB
| Cryo-EM structure of human ABCA7 in Digitonin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Phospholipid-transporting ATPase ABCA7, ... | Authors: | Alam, A, Le, L.T.M, Thompson, J.R. | Deposit date: | 2022-09-06 | Release date: | 2022-12-21 | Last modified: | 2023-02-15 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Cryo-EM structures of human ABCA7 provide insights into its phospholipid translocation mechanisms. Embo J., 42, 2023
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8EE6
| Cryo-EM Structure of human ABCA7 in PE/Ch nanodiscs | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Phospholipid-transporting ATPase ABCA7, ... | Authors: | Alam, A, Le, L.T.M, Thompson, J.R. | Deposit date: | 2022-09-06 | Release date: | 2022-12-21 | Last modified: | 2023-02-15 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Cryo-EM structures of human ABCA7 provide insights into its phospholipid translocation mechanisms. Embo J., 42, 2023
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8EDW
| Cryo-EM Structure of human ABCA7 in BPL/Ch Nanodiscs | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | Authors: | Alam, A, Le, L.T.M, Thompson, J.R. | Deposit date: | 2022-09-06 | Release date: | 2022-12-21 | Last modified: | 2023-02-15 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cryo-EM structures of human ABCA7 provide insights into its phospholipid translocation mechanisms. Embo J., 42, 2023
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7DNZ
| Cryo-EM structure of the human ABCB6 (Hemin and GSH-bound) | Descriptor: | ATP-binding cassette sub-family B member 6, mitochondrial, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Kim, S, Lee, S.S, Park, J.G, Kim, J.W, Kim, S, Kim, N.J, Hong, S, Kang, J.Y, Jin, M.S. | Deposit date: | 2020-12-11 | Release date: | 2022-06-22 | Last modified: | 2022-08-31 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural Insights into Porphyrin Recognition by the Human ATP-Binding Cassette Transporter ABCB6. Mol.Cells, 45, 2022
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7DNY
| Cryo-EM structure of the human ABCB6 (coproporphyrin III-bound) | Descriptor: | ATP-binding cassette sub-family B member 6, mitochondrial, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Kim, S, Lee, S.S, Park, J.G, Kim, J.W, Kim, S, Kim, N.J, Hong, S, Kang, J.Y, Jin, M.S. | Deposit date: | 2020-12-11 | Release date: | 2022-06-22 | Last modified: | 2022-08-31 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural Insights into Porphyrin Recognition by the Human ATP-Binding Cassette Transporter ABCB6. Mol.Cells, 45, 2022
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7EHL
| Cryo-EM structure of human ABCB8 transporter in nucleotide binding state | Descriptor: | CHOLESTEROL, MAGNESIUM ION, Mitochondrial potassium channel ATP-binding subunit, ... | Authors: | Li, S.J, Yang, X, Shen, Y.Q. | Deposit date: | 2021-03-29 | Release date: | 2021-05-05 | Method: | ELECTRON MICROSCOPY | Cite: | Cryo-EM structure of human ABCB8 transporter in nucleotide binding state. Biochem.Biophys.Res.Commun., 557, 2021
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7E7I
| Cryo-EM structure of human ABCA4 in the apo state | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, Retinal-specific phospholipid-transporting ATPase ABCA4, ... | Authors: | Xie, T, Zhang, Z.K, Gong, X. | Deposit date: | 2021-02-26 | Release date: | 2021-06-30 | Last modified: | 2021-07-07 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis of substrate recognition and translocation by human ABCA4. Nat Commun, 12, 2021
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7E7Q
| Cryo-EM structure of human ABCA4 in ATP-bound state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Xie, T, Zhang, Z.K, Gong, X. | Deposit date: | 2021-02-26 | Release date: | 2021-06-30 | Last modified: | 2021-07-07 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis of substrate recognition and translocation by human ABCA4. Nat Commun, 12, 2021
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7E7O
| Cryo-EM structure of human ABCA4 in NRPE-bound state | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, Retinal-specific phospholipid-transporting ATPase ABCA4, ... | Authors: | Xie, T, Zhang, Z.K, Gong, X. | Deposit date: | 2021-02-26 | Release date: | 2021-06-30 | Last modified: | 2021-07-07 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis of substrate recognition and translocation by human ABCA4. Nat Commun, 12, 2021
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7EKL
| Mitochondrial outer membrane protein | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family B member 6, MAGNESIUM ION | Authors: | Zhang, S.S. | Deposit date: | 2021-04-05 | Release date: | 2021-08-25 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Molecular insights into the human ABCB6 transporter. Cell Discov, 7, 2021
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7EKM
| Mitochondrial outer membrane protein | Descriptor: | ATP-binding cassette sub-family B member 6, mitochondrial | Authors: | Zhang, S.S. | Deposit date: | 2021-04-05 | Release date: | 2021-08-25 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Molecular insights into the human ABCB6 transporter. Cell Discov, 7, 2021
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7DV5
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8EOP
| Cryo-EM Structure of Nanodisc reconstituted human ABCA7 EQ mutant in ATP bound closed state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Alam, A, Le, L.T.M, Thompson, J.R. | Deposit date: | 2022-10-04 | Release date: | 2022-12-21 | Last modified: | 2023-02-15 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Cryo-EM structures of human ABCA7 provide insights into its phospholipid translocation mechanisms. Embo J., 42, 2023
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7E1A
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7EFO
| LptB2FG-LPS from Klebsiella pneumoniae in nanodiscs | Descriptor: | (2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-[(2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-5-[(2~{S},3~{S},4~{R},5~{R},6~{R})-6-[(1~{S})-1,2-bis(oxidanyl)ethyl]-4-[(2~{R},3~{S},4~{R},5~{S},6~{R})-6-[(1~{S})-2-[(2~{S},3~{S},4~{S},5~{S},6~{R})-6-[(1~{S})-1,2-bis(oxidanyl)ethyl]-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-1-oxidanyl-ethyl]-3,4-bis(oxidanyl)-5-phosphonooxy-oxan-2-yl]oxy-3-oxidanyl-5-phosphonooxy-oxan-2-yl]oxy-2-carboxy-2-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-5-[[(3~{R})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-3-oxidanyl-5-[[(3~{R})-3-oxidanyltetradecanoyl]amino]-4-[(3~{R})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{R})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]oxan-4-yl]oxy-4,5-bis(oxidanyl)oxane-2-carboxylic acid, LPS export ABC transporter permease LptG, Lipopolysaccharide export system ATP-binding protein LptB, ... | Authors: | Luo, Q, Shi, H. | Deposit date: | 2021-03-22 | Release date: | 2022-03-02 | Method: | ELECTRON MICROSCOPY (3.85 Å) | Cite: | Cryo-EM structures of LptB 2 FG and LptB 2 FGC from Klebsiella pneumoniae in complex with lipopolysaccharide. Biochem.Biophys.Res.Commun., 571, 2021
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8FEE
| Structure of Mce1 transporter from Mycobacterium smegmatis in the absence of LucB (Map2) | Descriptor: | ABC transporter, ATP-binding protein,Green fluorescent protein chimera, ABC-transporter integral membrane protein, ... | Authors: | Chen, J, Bhabha, G, Ekiert, D.C. | Deposit date: | 2022-12-06 | Release date: | 2023-02-22 | Last modified: | 2023-08-23 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structure of an endogenous mycobacterial MCE lipid transporter. Nature, 620, 2023
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