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1DDS
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BU of 1dds by Molmil
MOLECULE: DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH METHOTREXATE
Descriptor: CALCIUM ION, CHLORIDE ION, DIHYDROFOLATE REDUCTASE, ...
Authors:Yennawar, H.P, Farber, G.K.
Deposit date:1995-06-29
Release date:1995-10-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The effect of denaturants on protein structure.
Protein Sci., 6, 1997
1DRF
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BU of 1drf by Molmil
CRYSTAL STRUCTURE OF HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE
Descriptor: DIHYDROFOLATE REDUCTASE, FOLIC ACID, SULFATE ION
Authors:Oefner, C, D'Arcy, A, Winkler, F.K.
Deposit date:1990-08-09
Release date:1992-01-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of human dihydrofolate reductase complexed with folate.
Eur.J.Biochem., 174, 1988
1DYI
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BU of 1dyi by Molmil
ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5-DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS
Descriptor: CALCIUM ION, CHLORIDE ION, DIHYDROFOLATE REDUCTASE, ...
Authors:Reyes, V.M, Kraut, J.
Deposit date:1994-10-26
Release date:1995-06-03
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications.
Biochemistry, 34, 1995
1DAJ
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BU of 1daj by Molmil
COMPARISON OF TERNARY COMPLEXES OF PNEUMOCYSTIS CARINII AND WILD TYPE HUMAN DIHYDROFOLATE REDUCTASE WITH COENZYME NADPH AND A NOVEL CLASSICAL ANTITUMOR FURO[2,3D]PYRIMIDINE ANTIFOLATE
Descriptor: DIHYDROFOLATE REDUCTASE, N-[4-[(2,4-DIAMINOFURO[2,3D]PYRIMIDIN-5-YL)METHYL]METHYLAMINO]-BENZOYL]-L-GLUTAMATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Cody, V, Galitsky, N, Luft, J.R, Pangborn, W, Gangjee, A, Devraj, R, Queener, S.F, Blakley, R.L.
Deposit date:1997-07-29
Release date:1997-12-24
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Comparison of ternary complexes of Pneumocystis carinii and wild-type human dihydrofolate reductase with coenzyme NADPH and a novel classical antitumor furo[2,3-d]pyrimidine antifolate.
Acta Crystallogr.,Sect.D, 53, 1997
1DYJ
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BU of 1dyj by Molmil
ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5-DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS
Descriptor: 5,10-DIDEAZATETRAHYDROFOLIC ACID, CALCIUM ION, CHLORIDE ION, ...
Authors:Reyes, V.M, Kraut, J.
Deposit date:1994-10-26
Release date:1995-06-03
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications.
Biochemistry, 34, 1995
1DRH
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BU of 1drh by Molmil
ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5-DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS
Descriptor: DIHYDROFOLATE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Sawaya, M.R, Kraut, J.
Deposit date:1994-11-30
Release date:1995-02-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications.
Biochemistry, 34, 1995
1DLS
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BU of 1dls by Molmil
METHOTREXATE-RESISTANT VARIANTS OF HUMAN DIHYDROFOLATE REDUCTASE WITH SUBSTITUTION OF LEUCINE 22: KINETICS, CRYSTALLOGRAPHY AND POTENTIAL AS SELECTABLE MARKERS
Descriptor: DIHYDROFOLATE REDUCTASE, METHOTREXATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Cody, V, Galitsky, N, Luft, J.R, Pangborn, W.
Deposit date:1995-01-25
Release date:1995-04-20
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Methotrexate-resistant variants of human dihydrofolate reductase with substitutions of leucine 22. Kinetics, crystallography, and potential as selectable markers.
J.Biol.Chem., 270, 1995
1DYH
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BU of 1dyh by Molmil
ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5-DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS
Descriptor: 5-DEAZAFOLIC ACID, CALCIUM ION, CHLORIDE ION, ...
Authors:Reyes, V.M, Kraut, J.
Deposit date:1994-10-26
Release date:1995-06-03
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications.
Biochemistry, 34, 1995
1DG8
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BU of 1dg8 by Molmil
DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH
Descriptor: DIHYDROFOLATE REDUCTASE, GLYCEROL, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Li, R, Sirawaraporn, R, Chitnumsub, P, Sirawaraporn, W, Wooden, J, Athappilly, F, Turley, S, Hol, W.G.
Deposit date:1999-11-23
Release date:2000-03-09
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs.
J.Mol.Biol., 295, 2000
1DF7
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BU of 1df7 by Molmil
DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND METHOTREXATE
Descriptor: DIHYDROFOLATE REDUCTASE, GLYCEROL, METHOTREXATE, ...
Authors:Li, R, Sirawaraporn, R, Chitnumsub, P, Sirawaraporn, W, Wooden, J, Athappilly, F, Turley, S, Hol, W.G.
Deposit date:1999-11-17
Release date:2000-03-09
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs.
J.Mol.Biol., 295, 2000
1DG7
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BU of 1dg7 by Molmil
DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND 4-BROMO WR99210
Descriptor: 1-[3-(4-BROMO-PHENOXY)-PROPOXY]-6,6-DIMETHYL-1.6-DIHYDRO-[1,3,5]TRIAZINE-2,4-DIAMINE, DIHYDROFOLATE REDUCTASE, GLYCEROL, ...
Authors:Li, R, Sirawaraporn, R, Chitnumsub, P, Sirawaraporn, W, Wooden, J, Athappilly, F, Turley, S, Hol, W.G.
Deposit date:1999-11-23
Release date:2000-03-09
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs.
J.Mol.Biol., 295, 2000
1DLR
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BU of 1dlr by Molmil
METHOTREXATE-RESISTANT VARIANTS OF HUMAN DIHYDROFOLATE REDUCTASE WITH SUBSTITUTION OF LEUCINE 22: KINETICS, CRYSTALLOGRAPHY AND POTENTIAL AS SELECTABLE MARKERS
Descriptor: 6-(2,5-DIMETHOXY-BENZYL)-5-METHYL-PYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE, DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Cody, V, Galitsky, N, Luft, J.R, Pangborn, W.
Deposit date:1995-01-25
Release date:1995-04-20
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Methotrexate-resistant variants of human dihydrofolate reductase with substitutions of leucine 22. Kinetics, crystallography, and potential as selectable markers.
J.Biol.Chem., 270, 1995
1BZF
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BU of 1bzf by Molmil
NMR SOLUTION STRUCTURE AND DYNAMICS OF THE COMPLEX OF LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE WITH THE NEW LIPOPHILIC ANTIFOLATE DRUG TRIMETREXATE, 22 STRUCTURES
Descriptor: DIHYDROFOLATE REDUCTASE, TRIMETREXATE
Authors:Polshakov, V.I, Birdsall, B, Frenkiel, T.A, Gargaro, A.R, Feeney, J.
Deposit date:1998-10-28
Release date:1999-05-18
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Structure and dynamics in solution of the complex of Lactobacillus casei dihydrofolate reductase with the new lipophilic antifolate drug trimetrexate.
Protein Sci., 8, 1999
7FPQ
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BU of 7fpq by Molmil
DHFR:NADP+:FOL complex at 280 K (multi-crystal)
Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ...
Authors:Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R.
Deposit date:2022-09-09
Release date:2023-09-20
Method:X-RAY DIFFRACTION (1.03 Å)
Cite:DHFR:NADP+:FOL complex at 280 K
To Be Published
7FPN
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BU of 7fpn by Molmil
DHFR:NADP+:FOL complex at 280 K (crystal 3)
Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ...
Authors:Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R.
Deposit date:2022-09-09
Release date:2023-09-20
Method:X-RAY DIFFRACTION (1.04 Å)
Cite:DHFR:NADP+:FOL complex at 280 K
To Be Published
7FPS
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BU of 7fps by Molmil
DHFR:NADP+:FOL complex at 290 K (crystal 2)
Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ...
Authors:Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R.
Deposit date:2022-09-10
Release date:2023-09-20
Method:X-RAY DIFFRACTION (1.26 Å)
Cite:DHFR:NADP+:FOL complex at 290 K
To Be Published
7FPL
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BU of 7fpl by Molmil
DHFR:NADP+:FOL complex at 280 K (crystal 1)
Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ...
Authors:Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R.
Deposit date:2022-09-09
Release date:2023-09-20
Method:X-RAY DIFFRACTION (1.17 Å)
Cite:DHFR:NADP+:FOL complex at 280 K
To Be Published
7FPT
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BU of 7fpt by Molmil
DHFR:NADP+:FOL complex at 290 K (crystal 3)
Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ...
Authors:Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R.
Deposit date:2022-09-10
Release date:2023-09-20
Method:X-RAY DIFFRACTION (1.07 Å)
Cite:DHFR:NADP+:FOL complex at 290 K
To Be Published
7FPR
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BU of 7fpr by Molmil
DHFR:NADP+:FOL complex at 290 K (crystal 1)
Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ...
Authors:Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R.
Deposit date:2022-09-10
Release date:2023-09-20
Method:X-RAY DIFFRACTION (1.07 Å)
Cite:DHFR:NADP+:FOL complex at 290 K
To Be Published
7FPP
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BU of 7fpp by Molmil
DHFR:NADP+:FOL complex at 280 K (crystal 5)
Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ...
Authors:Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R.
Deposit date:2022-09-09
Release date:2023-09-20
Method:X-RAY DIFFRACTION (1.03 Å)
Cite:DHFR:NADP+:FOL complex at 280 K
To Be Published
7FPM
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BU of 7fpm by Molmil
DHFR:NADP+:FOL complex at 280 K (crystal 2)
Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ...
Authors:Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R.
Deposit date:2022-09-09
Release date:2023-09-20
Method:X-RAY DIFFRACTION (1.04 Å)
Cite:DHFR:NADP+:FOL complex at 280 K
To Be Published
7FPV
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BU of 7fpv by Molmil
DHFR:NADP+:FOL complex at 290 K (crystal 5)
Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ...
Authors:Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R.
Deposit date:2022-09-10
Release date:2023-09-20
Method:X-RAY DIFFRACTION (1.04 Å)
Cite:DHFR:NADP+:FOL complex at 290 K
To Be Published
7FPU
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BU of 7fpu by Molmil
DHFR:NADP+:FOL complex at 290 K (crystal 4)
Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ...
Authors:Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R.
Deposit date:2022-09-10
Release date:2023-09-20
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:DHFR:NADP+:FOL complex at 290 K
To Be Published
7FPO
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BU of 7fpo by Molmil
DHFR:NADP+:FOL complex at 280 K (crystal 4)
Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ...
Authors:Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R.
Deposit date:2022-09-09
Release date:2023-09-20
Method:X-RAY DIFFRACTION (1.06 Å)
Cite:DHFR:NADP+:FOL complex at 280 K
To Be Published
7FPY
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BU of 7fpy by Molmil
DHFR:NADP+:FOL complex at 300 K (crystal 2)
Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ...
Authors:Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R.
Deposit date:2022-09-10
Release date:2023-09-20
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:DHFR:NADP+:FOL complex at 300 K
To Be Published

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