4Q10
 
 | | The catalytic core of Rad2 in complex with DNA substrate (complex IV) | | Descriptor: | CALCIUM ION, DNA (5'-D(*TP*TP*TP*TP*CP*TP*GP*AP*GP*AP*CP*AP*AP*GP*GP*GP*AP*GP*CP*TP*TP*TP*T)-3'), DNA (5'-D(*TP*TP*TP*TP*GP*CP*TP*CP*CP*CP*TP*TP*GP*TP*CP*TP*CP*AP*GP*TP*TP*TP*T)-3'), ... | | Authors: | Mietus, M, Nowak, E, Jaciuk, M, Kustosz, P, Nowotny, M. | | Deposit date: | 2014-04-02 | | Release date: | 2014-08-27 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding.
Nucleic Acids Res., 42, 2014
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4Q0R
 | | The catalytic core of Rad2 (complex I) | | Descriptor: | DNA (5'-D(*CP*TP*GP*AP*GP*TP*CP*AP*GP*AP*GP*CP*AP*AP*A)-3'), DNA repair protein RAD2 | | Authors: | Mietus, M, Nowak, E, Jaciuk, M, Kustosz, P, Nowotny, M. | | Deposit date: | 2014-04-02 | | Release date: | 2014-08-27 | | Last modified: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding.
Nucleic Acids Res., 42, 2014
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4Q0Z
 | | The catalytic core of Rad2 in complex with DNA substrate (complex III) | | Descriptor: | CALCIUM ION, DNA (5'-D(*TP*CP*TP*GP*AP*GP*AP*CP*AP*AP*GP*GP*GP*AP*GP*CP*T)-3'), DNA (5'-D(*TP*GP*CP*TP*CP*CP*CP*TP*TP*GP*TP*CP*TP*CP*AP*GP*T)-3'), ... | | Authors: | Mietus, M, Nowak, E, Jaciuk, M, Kustosz, P, Nowotny, M. | | Deposit date: | 2014-04-02 | | Release date: | 2014-08-27 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.398 Å) | | Cite: | Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding.
Nucleic Acids Res., 42, 2014
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6TNZ
 | | Human polymerase delta-FEN1-PCNA toolbelt | | Descriptor: | DNA polymerase delta catalytic subunit, DNA polymerase delta subunit 2, DNA polymerase delta subunit 3, ... | | Authors: | Lancey, C, Hamdan, S.M, De Biasio, A. | | Deposit date: | 2019-12-10 | | Release date: | 2019-12-18 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (4.05 Å) | | Cite: | Structure of the processive human Pol delta holoenzyme.
Nat Commun, 11, 2020
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6TUR
 | | human XPG, Apo1 form | | Descriptor: | DNA repair protein complementing XP-G cells,DNA repair protein complementing XP-G cells | | Authors: | Ruiz, F.M, Fernandez-Tornero, C. | | Deposit date: | 2020-01-08 | | Release date: | 2020-09-16 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | The crystal structure of human XPG, the xeroderma pigmentosum group G endonuclease, provides insight into nucleotide excision DNA repair.
Nucleic Acids Res., 48, 2020
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6TUX
 | | human XPG-DNA, Complex 2 | | Descriptor: | DNA (5'-D(P*AP*AP*CP*TP*CP*TP*GP*C)-3'), DNA (5'-D(P*GP*CP*AP*GP*AP*GP*TP*T)-3'), DNA repair protein complementing XP-G cells,DNA repair protein complementing XP-G cells | | Authors: | Ruiz, F.M, Fernandez-Tornero, C. | | Deposit date: | 2020-01-08 | | Release date: | 2020-09-16 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | The crystal structure of human XPG, the xeroderma pigmentosum group G endonuclease, provides insight into nucleotide excision DNA repair.
Nucleic Acids Res., 48, 2020
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6TUW
 | | human XPG-DNA, Complex 1 | | Descriptor: | DNA (5'-D(P*GP*AP*AP*CP*TP*CP*TP*G)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*AP*GP*TP*TP*C)-3'), DNA repair protein complementing XP-G cells,DNA repair protein complementing XP-G cells | | Authors: | Ruiz, F.M, Fernandez-Tornero, C. | | Deposit date: | 2020-01-08 | | Release date: | 2020-09-16 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | The crystal structure of human XPG, the xeroderma pigmentosum group G endonuclease, provides insight into nucleotide excision DNA repair.
Nucleic Acids Res., 48, 2020
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6TUS
 | | human XPG, Apo2 form | | Descriptor: | DNA repair protein complementing XP-G cells,DNA repair protein complementing XP-G cells, GLYCEROL, SULFATE ION | | Authors: | Ruiz, F.M, Fernandez-Tornero, C. | | Deposit date: | 2020-01-08 | | Release date: | 2020-09-16 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | The crystal structure of human XPG, the xeroderma pigmentosum group G endonuclease, provides insight into nucleotide excision DNA repair.
Nucleic Acids Res., 48, 2020
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3Q8K
 | | Crystal Structure of Human Flap Endonuclease FEN1 (WT) in complex with product 5'-flap DNA, SM3+, and K+ | | Descriptor: | DNA (5'-D(*AP*CP*CP*GP*TP*CP*C)-3'), DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3'), DNA (5'-D(P*TP*GP*AP*GP*GP*CP*AP*GP*AP*GP*T)-3'), ... | | Authors: | Tsutakawa, S.E, Classen, S, Chapados, B.R, Arvai, A, Finger, D.L, Guenther, G, Tomlinson, C.G, Thompson, P, Sarker, A.H, Shen, B, Cooper, P.K, Grasby, J.A, Tainer, J.A. | | Deposit date: | 2011-01-06 | | Release date: | 2011-04-27 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.2001 Å) | | Cite: | Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily.
Cell(Cambridge,Mass.), 145, 2011
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3Q8L
 | | Crystal Structure of Human Flap Endonuclease FEN1 (WT) in complex with substrate 5'-flap DNA, SM3+, and K+ | | Descriptor: | DNA (5'-D(*AP*CP*CP*GP*TP*CP*C)-3'), DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3'), DNA (5'-D(*TP*TP*GP*AP*GP*GP*CP*AP*GP*AP*GP*T)-3'), ... | | Authors: | Tsutakawa, S.E, Classen, S, Chapados, B.R, Arvai, A, Finger, D.L, Guenther, G, Tomlinson, C.G, Thompson, P, Sarker, A.H, Shen, B, Cooper, P.K, Grasby, J.A, Tainer, J.A. | | Deposit date: | 2011-01-06 | | Release date: | 2011-04-27 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.319 Å) | | Cite: | Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily.
Cell(Cambridge,Mass.), 145, 2011
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3QEB
 | | Crystal structure of human exonuclease 1 Exo1 (WT) in complex with DNA and Mn2+ (complex III) | | Descriptor: | DNA (5'-D(*CP*GP*CP*TP*AP*GP*TP*CP*GP*AP*CP*AP*T)-3'), DNA (5'-D(P*TP*CP*GP*AP*CP*TP*AP*GP*CP*G)-3'), Exonuclease 1, ... | | Authors: | Orans, J, McSweeney, E.A, Iyer, R.R, Hast, M.A, Hellinga, H.W, Modrich, P, Beese, L.S. | | Deposit date: | 2011-01-20 | | Release date: | 2011-04-20 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family.
Cell(Cambridge,Mass.), 145, 2011
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3QEA
 | | Crystal structure of human exonuclease 1 Exo1 (WT) in complex with DNA (complex II) | | Descriptor: | BARIUM ION, DNA (5'-D(P*CP*GP*CP*TP*AP*GP*TP*CP*GP*AP*CP*AP*T)-3'), DNA (5'-D(P*TP*CP*GP*AP*CP*TP*AP*GP*CP*G)-3'), ... | | Authors: | Orans, J, McSweeney, E.A, Iyer, R.R, Hast, M.A, Hellinga, H.W, Modrich, P, Beese, L.S. | | Deposit date: | 2011-01-20 | | Release date: | 2011-04-20 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family.
Cell(Cambridge,Mass.), 145, 2011
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3Q8M
 | | Crystal Structure of Human Flap Endonuclease FEN1 (D181A) in complex with substrate 5'-flap DNA and K+ | | Descriptor: | DNA (5'-D(*AP*CP*CP*GP*TP*CP*C)-3'), DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3'), DNA (5'-D(*TP*TP*GP*AP*GP*GP*CP*AP*GP*AP*GP*T)-3'), ... | | Authors: | Tsutakawa, S.E, Classen, S, Chapados, B.R, Arvai, A, Finger, D.L, Guenther, G, Tomlinson, C.G, Thompson, P, Sarker, A.H, Shen, B, Cooper, P.K, Grasby, J.A, Tainer, J.A. | | Deposit date: | 2011-01-06 | | Release date: | 2011-04-27 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily.
Cell(Cambridge,Mass.), 145, 2011
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3QE9
 | | Crystal structure of human exonuclease 1 Exo1 (D173A) in complex with DNA (complex I) | | Descriptor: | CALCIUM ION, DNA (5'-D(*CP*GP*CP*TP*AP*GP*TP*CP*GP*AP*CP*AP*T)-3'), DNA (5'-D(P*TP*CP*GP*AP*CP*TP*AP*GP*CP*G)-3'), ... | | Authors: | Orans, J, McSweeney, E.A, Iyer, R.R, Hast, M.A, Hellinga, H.W, Modrich, P, Beese, L.S. | | Deposit date: | 2011-01-20 | | Release date: | 2011-04-20 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.51 Å) | | Cite: | Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family.
Cell(Cambridge,Mass.), 145, 2011
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3ORY
 | | Crystal structure of Flap endonuclease 1 from hyperthermophilic archaeon Desulfurococcus amylolyticus | | Descriptor: | PHOSPHATE ION, flap endonuclease 1 | | Authors: | Mase, T, Kubota, K, Miyazono, K, Kawarabayashii, Y, Tanokura, M. | | Deposit date: | 2010-09-08 | | Release date: | 2011-02-09 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure of flap endonuclease 1 from the hyperthermophilic archaeon Desulfurococcus amylolyticus
Acta Crystallogr.,Sect.F, 67, 2011
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7MXR
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7MXS
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7MXU
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7MXV
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7MXT
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7MXQ
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7MXW
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7MXX
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8YJL
 | | Structure of the human endogenous PCNA-FEN1 complex - State B | | Descriptor: | 5 prime DNA, Flap endonuclease 1, Proliferating cell nuclear antigen, ... | | Authors: | Tian, Y, Gao, N. | | Deposit date: | 2024-03-02 | | Release date: | 2024-12-04 | | Last modified: | 2025-01-29 | | Method: | ELECTRON MICROSCOPY (3.51 Å) | | Cite: | Structural insight into Okazaki fragment maturation mediated by PCNA-bound FEN1 and RNaseH2.
Embo J., 44, 2025
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8YJS
 | | Structure of the human endogenous PCNA-FEN1 complex - State E | | Descriptor: | 5 prime flap DNA, Flap endonuclease 1, Proliferating cell nuclear antigen, ... | | Authors: | Tian, Y, Gao, N. | | Deposit date: | 2024-03-02 | | Release date: | 2024-12-04 | | Last modified: | 2025-01-29 | | Method: | ELECTRON MICROSCOPY (3.55 Å) | | Cite: | Structural insight into Okazaki fragment maturation mediated by PCNA-bound FEN1 and RNaseH2.
Embo J., 44, 2025
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