3O0Q
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![BU of 3o0q by Molmil](/molmil-images/mine/3o0q) | Thermotoga maritima Ribonucleotide Reductase, NrdJ, in complex with dTTP, GDP and Adenosine | Descriptor: | ADENOSINE, CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Larsson, K.-M, Logan, D.T, Nordlund, P. | Deposit date: | 2010-07-19 | Release date: | 2010-07-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural Basis for Adenosylcobalamin Activation in AdoCbl-Dependent Ribonucleotide Reductases. Acs Chem.Biol., 5, 2010
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3O0O
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![BU of 3o0o by Molmil](/molmil-images/mine/3o0o) | Thermotoga maritima Ribonucleotide Reductase, NrdJ, in complex with dTTP, GDP and Adenosylcobalamin | Descriptor: | 5'-DEOXYADENOSINE, COBALAMIN, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Larsson, K.-M, Logan, D.T, Nordlund, P. | Deposit date: | 2010-07-19 | Release date: | 2010-07-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural Basis for Adenosylcobalamin Activation in AdoCbl-Dependent Ribonucleotide Reductases. Acs Chem.Biol., 5, 2010
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3PAW
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![BU of 3paw by Molmil](/molmil-images/mine/3paw) | |
3S87
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![BU of 3s87 by Molmil](/molmil-images/mine/3s87) | Structure of Yeast Ribonucleotide Reductase 1 with dGTP and ADP | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Ahmad, M.F, Kaushal, P.S, Wan, Q, Wijeratna, S.R, Huang, M, Dealwis, C.D. | Deposit date: | 2011-05-27 | Release date: | 2012-04-11 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structural and biochemical basis of lethal mutant R293A of yeast ribonucleotide reductase To be Published
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3S8C
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![BU of 3s8c by Molmil](/molmil-images/mine/3s8c) | Structure of Yeast Ribonucleotide Reductase 1 R293A with AMPPNP and CDP | Descriptor: | CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Ahmad, M.F, Kaushal, P.S, Wan, Q, Wijeratna, S.R, Huang, M, Dealwis, C.D. | Deposit date: | 2011-05-27 | Release date: | 2012-04-11 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.77 Å) | Cite: | Structural and biochemical basis of lethal mutant R293A of yeast ribonucleotide reductase To be Published
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3TBA
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![BU of 3tba by Molmil](/molmil-images/mine/3tba) | Structure of Yeast Ribonucleotide Reductase 1 Q288A with dGTP and ADP | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Ahmad, M.F, Kaushal, P.S, Wan, Q, Wijeratna, S.R, Huang, M, Dealwis, C. | Deposit date: | 2011-08-05 | Release date: | 2012-04-04 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Role of Arginine 293 and Glutamine 288 in Communication between Catalytic and Allosteric Sites in Yeast Ribonucleotide Reductase. J.Mol.Biol., 419, 2012
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3TB9
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![BU of 3tb9 by Molmil](/molmil-images/mine/3tb9) | Structure of Yeast Ribonucleotide Reductase 1 Q288A with AMPPNP and CDP | Descriptor: | CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Ahmad, M.F, Kaushal, P.S, Wan, Q, Wijeratna, S.R, Huang, M, Dealwis, C.D. | Deposit date: | 2011-08-05 | Release date: | 2012-04-04 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.53 Å) | Cite: | Role of Arginine 293 and Glutamine 288 in Communication between Catalytic and Allosteric Sites in Yeast Ribonucleotide Reductase. J.Mol.Biol., 419, 2012
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6L3R
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![BU of 6l3r by Molmil](/molmil-images/mine/6l3r) | Crystal structure of Ribonucleotide reductase R1 subunit, RRM1 in complex with 4-bromo-N-((1S,2R)-2-(naphthalen-1-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)benzenesulfonamide | Descriptor: | 4-bromo-N-((1S,2R)-2-(naphthalen-1-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)benzenesulfonamide, ACETATE ION, MAGNESIUM ION, ... | Authors: | Miyahara, S, Chong, K.T, Suzuki, T. | Deposit date: | 2019-10-15 | Release date: | 2020-10-28 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | TAS1553, a novel small molecule ribonucleotide reductase (RNR) subunit interaction inhibitor, displays remarkable anti-tumor activity To be published
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6L7L
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![BU of 6l7l by Molmil](/molmil-images/mine/6l7l) | Crystal structure of Ribonucleotide reductase R1 subunit, RRM1 in complex with 5-chloro-2-(N-((1S,2R)-2-(2,3-dihydro-1H-inden-4-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)sulfamoyl)benzamide | Descriptor: | 5-chloro-2-(N-((1S,2R)-2-(2,3-dihydro-1H-inden-4-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)sulfamoyl)benzamide, ACETATE ION, MAGNESIUM ION, ... | Authors: | Miyahara, S, Chong, K.T, Suzuki, T. | Deposit date: | 2019-11-01 | Release date: | 2020-11-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.171 Å) | Cite: | TAS1553, a novel small molecule ribonucleotide reductase (RNR) subunit interaction inhibitor, displays remarkable anti-tumor activity To be published
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3S8A
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![BU of 3s8a by Molmil](/molmil-images/mine/3s8a) | Structure of Yeast Ribonucleotide Reductase R293A with dGTP | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large chain 1 | Authors: | Ahmad, M.F, Kaushal, P.S, Wan, Q, Wijeratna, S.R, Huang, M, Dealwis, C.D. | Deposit date: | 2011-05-27 | Release date: | 2012-04-11 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural and biochemical basis of lethal mutant R293A of yeast ribonucleotide reductase To be Published
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1R1R
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![BU of 1r1r by Molmil](/molmil-images/mine/1r1r) | |
1RLR
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![BU of 1rlr by Molmil](/molmil-images/mine/1rlr) | |
3R1R
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![BU of 3r1r by Molmil](/molmil-images/mine/3r1r) | |
3RSR
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![BU of 3rsr by Molmil](/molmil-images/mine/3rsr) | Crystal Structure of 5-NITP Inhibition of Yeast Ribonucleotide Reductase | Descriptor: | 1-{2-DEOXY-5-O-[(R)-HYDROXY{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}PHOSPHORYL]-BETA-D-ERYTHRO-PENTOFURANOSYL}-5-NITRO-1H-INDOLE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large chain 1 | Authors: | Wan, Q, Mohammed, F, Jha, S, Motea, E, Berdis, A, Dealwis, C.G. | Deposit date: | 2011-05-02 | Release date: | 2012-11-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Evaluating the therapeutic potential of a non-natural nucleotide that inhibits human ribonucleotide reductase. Mol.Cancer Ther., 11, 2012
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6LKM
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![BU of 6lkm by Molmil](/molmil-images/mine/6lkm) | Crystal structure of Ribonucleotide reductase R1 subunit, RRM1 in complex with 5-chloro-N-((1S,2R)-2-(6-fluoro-2,3-dimethylphenyl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-sulfonamide | Descriptor: | 5-chloro-N-((1S,2R)-2-(6-fluoro-2,3-dimethylphenyl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-sulfonamide, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, ... | Authors: | Miyahara, S, Chong, K.T, Suzuki, T. | Deposit date: | 2019-12-19 | Release date: | 2020-12-23 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | TAS1553, a novel small molecule ribonucleotide reductase (RNR) subunit interaction inhibitor, displays remarkable anti-tumor activity To be published
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6MT9
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![BU of 6mt9 by Molmil](/molmil-images/mine/6mt9) | X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit with TTP, ATP, and ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Thomas, W.C, Brooks, F.P, Bacik, J.P, Ando, N. | Deposit date: | 2018-10-19 | Release date: | 2019-06-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Convergent allostery in ribonucleotide reductase. Nat Commun, 10, 2019
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6MV9
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![BU of 6mv9 by Molmil](/molmil-images/mine/6mv9) | X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit with TTP and ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase, ... | Authors: | Thomas, W.C, Brooks, F.P, Bacik, J.P, Ando, N. | Deposit date: | 2018-10-24 | Release date: | 2019-06-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Convergent allostery in ribonucleotide reductase. Nat Commun, 10, 2019
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6MVE
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![BU of 6mve by Molmil](/molmil-images/mine/6mve) | Reduced X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit with TTP, ATP, and ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Thomas, W.C, Brooks, F.P, Bacik, J.P, Ando, N. | Deposit date: | 2018-10-25 | Release date: | 2019-06-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Convergent allostery in ribonucleotide reductase. Nat Commun, 10, 2019
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1PEO
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![BU of 1peo by Molmil](/molmil-images/mine/1peo) | Ribonucleotide Reductase Protein R1E from Salmonella typhimurium | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase 2 alpha chain | Authors: | Uppsten, M, Farnegardh, M, Jordan, A, Eliasson, R, Eklund, H, Uhlin, U. | Deposit date: | 2003-05-22 | Release date: | 2004-05-25 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure of the large subunit of class Ib ribonucleotide reductase from Salmonella typhimurium and its complexes with allosteric effectors. J.Mol.Biol., 330, 2003
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1PEM
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![BU of 1pem by Molmil](/molmil-images/mine/1pem) | Ribonucleotide Reductase Protein R1E from Salmonella typhimurium | Descriptor: | Ribonucleoside-diphosphate reductase 2 alpha chain | Authors: | Uppsten, M, Farnegardh, M, Jordan, A, Eliasson, R, Eklund, H, Uhlin, U. | Deposit date: | 2003-05-22 | Release date: | 2004-05-25 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.99 Å) | Cite: | Structure of the large subunit of class Ib ribonucleotide reductase from Salmonella typhimurium and its complexes with allosteric effectors. J.Mol.Biol., 330, 2003
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1PEQ
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![BU of 1peq by Molmil](/molmil-images/mine/1peq) | Ribonucleotide Reductase Protein R1E from Salmonella typhimurium | Descriptor: | MAGNESIUM ION, Ribonucleoside-diphosphate reductase 2 alpha chain, THYMIDINE-5'-TRIPHOSPHATE | Authors: | Uppsten, M, Farnegardh, M, Jordan, A, Eliasson, R, Eklund, H, Uhlin, U. | Deposit date: | 2003-05-22 | Release date: | 2004-05-25 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of the large subunit of class Ib ribonucleotide reductase from Salmonella typhimurium and its complexes with allosteric effectors. J.Mol.Biol., 330, 2003
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1PEU
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![BU of 1peu by Molmil](/molmil-images/mine/1peu) | Ribonucleotide Reductase Protein R1E from Salmonella typhimurium | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase 2 alpha chain | Authors: | Uppsten, M, Farnegardh, M, Jordan, A, Eliasson, R, Eklund, H, Uhlin, U. | Deposit date: | 2003-05-22 | Release date: | 2004-05-25 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structure of the large subunit of class Ib ribonucleotide reductase from Salmonella typhimurium and its complexes with allosteric effectors. J.Mol.Biol., 330, 2003
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3S8B
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![BU of 3s8b by Molmil](/molmil-images/mine/3s8b) | Structure of Yeast Ribonucleotide Reductase 1 with AMPPNP and CDP | Descriptor: | CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Ahmad, M.F, Kaushal, P.S, Wan, Q, Wijeratna, S.R, Huang, M, Dealwis, C.D. | Deposit date: | 2011-05-27 | Release date: | 2012-04-11 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural and biochemical basis of lethal mutant R293A of yeast ribonucleotide reductase To be Published
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1XJE
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![BU of 1xje by Molmil](/molmil-images/mine/1xje) | Structural mechanism of allosteric substrate specificity in a ribonucleotide reductase: dTTP-GDP complex | Descriptor: | GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Larsson, K.-M, Jordan, A, Eliasson, R, Reichard, P, Logan, D.T, Nordlund, P. | Deposit date: | 2004-09-23 | Release date: | 2005-10-11 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural mechanism of allosteric substrate specificity regulation in a ribonucleotide reductase. Nat.Struct.Mol.Biol., 11, 2004
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1XJM
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![BU of 1xjm by Molmil](/molmil-images/mine/1xjm) | Structural mechanism of allosteric substrate specificity in a ribonucleotide reductase: dTTP complex | Descriptor: | MAGNESIUM ION, THYMIDINE-5'-TRIPHOSPHATE, ribonucleotide reductase, ... | Authors: | Larsson, K.-M, Jordan, A, Eliasson, R, Reichard, P, Logan, D.T, Nordlund, P. | Deposit date: | 2004-09-23 | Release date: | 2005-12-20 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural mechanism of allosteric substrate specificity regulation in a ribonucleotide reductase. Nat.Struct.Mol.Biol., 11, 2004
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