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7UA3
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BU of 7ua3 by Molmil
Structure of PKA phosphorylated human RyR2-R2474S in the closed state in the presence of Calmodulin
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Calmodulin-1, Peptidyl-prolyl cis-trans isomerase FKBP1B, ...
Authors:Miotto, M.C, Marks, A.R.
Deposit date:2022-03-11
Release date:2022-08-03
Method:ELECTRON MICROSCOPY (2.97 Å)
Cite:Structural analyses of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment.
Sci Adv, 8, 2022
7UA4
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BU of 7ua4 by Molmil
Structure of PKA phosphorylated human RyR2-R2474S in the open state in the presence of Calmodulin
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Calmodulin-1, ...
Authors:Miotto, M.C, Marks, A.R.
Deposit date:2022-03-11
Release date:2022-08-03
Method:ELECTRON MICROSCOPY (2.93 Å)
Cite:Structural analyses of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment.
Sci Adv, 8, 2022
1S6I
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BU of 1s6i by Molmil
Ca2+-regulatory region (CLD) from soybean calcium-dependent protein kinase-alpha (CDPK) in the presence of Ca2+ and the junction domain (JD)
Descriptor: CALCIUM ION, Calcium-dependent protein kinase SK5
Authors:Weljie, A.M, Vogel, H.J.
Deposit date:2004-01-23
Release date:2004-06-15
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Unexpected structure of the Ca2+-regulatory region from soybean calcium-dependent protein kinase-alpha
J.Biol.Chem., 279, 2004
7MIR
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BU of 7mir by Molmil
Cryo-EM structure of SidJ-SdeA-CaM reaction intermediate complex
Descriptor: ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, ...
Authors:Osinski, A, Black, M.H, Pawlowski, K, Chen, Z, Li, Y, Tagliabracci, V.S.
Deposit date:2021-04-17
Release date:2021-08-18
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Structural and mechanistic basis for protein glutamylation by the kinase fold.
Mol.Cell, 81, 2021
3EKH
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BU of 3ekh by Molmil
Calcium-saturated GCaMP2 T116V/K378W mutant monomer
Descriptor: CALCIUM ION, GLYCEROL, Myosin light chain kinase, ...
Authors:Akerboom, J, Velez Rivera, J.D, Looger, L.L, Schreiter, E.R.
Deposit date:2008-09-19
Release date:2008-12-16
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures of the GCaMP Calcium Sensor Reveal the Mechanism of Fluorescence Signal Change and Aid Rational Design
J.Biol.Chem., 284, 2009
3EK8
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BU of 3ek8 by Molmil
Calcium-saturated GCaMP2 T116V/G87R mutant monomer
Descriptor: CALCIUM ION, Myosin light chain kinase, Green fluorescent protein, ...
Authors:Akerboom, J, Velez Rivera, J.D, Looger, L.L, Schreiter, E.R.
Deposit date:2008-09-19
Release date:2008-12-16
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structures of the GCaMP Calcium Sensor Reveal the Mechanism of Fluorescence Signal Change and Aid Rational Design
J.Biol.Chem., 284, 2009
3EKJ
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BU of 3ekj by Molmil
Calcium-free GCaMP2 (calcium binding deficient mutant)
Descriptor: Myosin light chain kinase, Green fluorescent protein, Calmodulin chimera
Authors:Akerboom, J, Velez Rivera, J.D, Looger, L.L, Schreiter, E.R.
Deposit date:2008-09-19
Release date:2008-12-16
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structures of the GCaMP Calcium Sensor Reveal the Mechanism of Fluorescence Signal Change and Aid Rational Design
J.Biol.Chem., 284, 2009
3EVV
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BU of 3evv by Molmil
Crystal Structure of Calcium bound dimeric GCAMP2 (#2)
Descriptor: CALCIUM ION, Myosin light chain kinase, Green fluorescent protein, ...
Authors:Wang, Q, Shui, B, Kotlikoff, M.I, Sondermann, H.
Deposit date:2008-10-13
Release date:2008-12-09
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Basis for Calcium Sensing by GCaMP2.
Structure, 16, 2008
3KL8
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BU of 3kl8 by Molmil
CaMKIINtide Inhibitor Complex
Descriptor: Calcium/calmodulin dependent protein kinase II, Calcium/calmodulin-dependent protein kinase II inhibitor 1
Authors:Kuriyan, J, Chao, L.H, Pellicena, P, Deindl, S, Barclay, L.A, Schulman, H.
Deposit date:2009-11-06
Release date:2010-02-09
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.372 Å)
Cite:Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation.
Nat.Struct.Mol.Biol., 17, 2010
5V03
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BU of 5v03 by Molmil
A positive allosteric modulator binding pocket in SK2 ion channels is shared by Riluzole and CyPPA
Descriptor: CALCIUM ION, Calmodulin, N-(4-chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)pyrimidin-4-amine, ...
Authors:Liu, S.
Deposit date:2017-02-28
Release date:2018-03-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:An Intracellular Allosteric Modulator Binding Pocket in SK2 Ion Channels Is Shared by Multiple Chemotypes.
Structure, 26, 2018
2W4J
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BU of 2w4j by Molmil
X-ray structure of a DAP-Kinase 2-277
Descriptor: ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, DEATH-ASSOCIATED PROTEIN KINASE 1, ...
Authors:De Diego, I, Kuper, J, Lehmann, F, Wilmanns, M.
Deposit date:2008-11-27
Release date:2009-12-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:X-Ray Structure of a Dap-Kinase Calmodulin Complex
To be Published
2YGG
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BU of 2ygg by Molmil
Complex of CaMBR and CaM
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, ...
Authors:Koester, S, Yildiz, O.
Deposit date:2011-04-15
Release date:2011-09-28
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.227 Å)
Cite:Structure of Human Na+/H+ Exchanger Nhe1 Regulatory Region in Complex with Cam and Ca2+
J.Biol.Chem., 286, 2011
5WBX
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BU of 5wbx by Molmil
Structural insights into the potency of SK/IK channel positive modulators
Descriptor: (3Z)-6-bromo-3-(hydroxyimino)-5-methyl-1,3-dihydro-2H-indol-2-one, CALCIUM ION, Calmodulin-1, ...
Authors:Nam, Y.W, Zhang, M.
Deposit date:2017-06-29
Release date:2017-12-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural insights into the potency of SK channel positive modulators.
Sci Rep, 7, 2017
5WC5
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BU of 5wc5 by Molmil
Structural insights into the potency of SK/IK channel positive modulators
Descriptor: 7-fluoro-3-(hydroxyamino)-2H-indol-2-one, CALCIUM ION, Calmodulin-1, ...
Authors:Nam, Y.W, Zhang, M.
Deposit date:2017-06-29
Release date:2017-12-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural insights into the potency of SK channel positive modulators.
Sci Rep, 7, 2017
6Y4K
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BU of 6y4k by Molmil
Crystal structure of human 14-3-3 gamma in complex with CaMKK2 14-3-3 binding motif Ser100 and Fusicoccin A
Descriptor: 14-3-3 protein gamma, Calcium/calmodulin-dependent protein kinase kinase 2, FUSICOCCIN
Authors:Lentini Santo, D, Obsilova, V, Obsil, T.
Deposit date:2020-02-21
Release date:2021-01-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:Stabilization of Protein-Protein Interactions between CaMKK2 and 14-3-3 by Fusicoccins.
Acs Chem.Biol., 15, 2020
6Y6B
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BU of 6y6b by Molmil
Crystal structure of human 14-3-3 gamma in complex with CaMKK2 14-3-3 binding motif Ser100 and 16-OMe-Fusicoccin H
Descriptor: (2~{R},3~{S},4~{S},5~{R},6~{S})-2-(hydroxymethyl)-6-[[(1~{S},3~{R},6~{S},7~{S},8~{R},9~{R},10~{R},11~{R},14~{S})-14-(me thoxymethyl)-3,10-dimethyl-9-oxidanyl-6-propan-2-yl-8-tricyclo[9.3.0.0^{3,7}]tetradecanyl]oxy]oxane-3,4,5-triol, 14-3-3 protein gamma, Calcium/calmodulin-dependent protein kinase kinase 2
Authors:Lentini Santo, D, Obsilova, V, Obsil, T.
Deposit date:2020-02-26
Release date:2021-02-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.08 Å)
Cite:Stabilization of Protein-Protein Interactions between CaMKK2 and 14-3-3 by Fusicoccins.
Acs Chem.Biol., 15, 2020
5H7D
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BU of 5h7d by Molmil
Crystal structure of the YgjG-protein A-Zpa963-calmodulin complex
Descriptor: CALCIUM ION, Putrescine aminotransferase,Immunoglobulin G-binding protein A, Zpa963,Calmodulin
Authors:Youn, S.J, Kwon, N.Y, Lee, J.H, Kim, J.H, Lee, H, Lee, J.O.
Deposit date:2016-11-17
Release date:2017-06-28
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Construction of novel repeat proteins with rigid and predictable structures using a shared helix method.
Sci Rep, 7, 2017
7TCI
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BU of 7tci by Molmil
Structure of Xenopus KCNQ1-CaM in complex with ML277
Descriptor: (2R)-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylbenzene-1-sulfonyl)piperidine-2-carboxamide, CALCIUM ION, Calmodulin-1, ...
Authors:Willegems, K, Kyriakis, E, Van Petegem, F, Eldstrom, J, Fedida, D.
Deposit date:2021-12-23
Release date:2022-07-06
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural and electrophysiological basis for the modulation of KCNQ1 channel currents by ML277.
Nat Commun, 13, 2022
7TCP
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BU of 7tcp by Molmil
Structure of Xenopus KCNQ1-CaM
Descriptor: CALCIUM ION, Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 1
Authors:Willegems, K, Kyriakis, E, Van Petegem, F, Eldstrom, J, Fedida, D.
Deposit date:2021-12-27
Release date:2022-07-06
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (3.84 Å)
Cite:Structural and electrophysiological basis for the modulation of KCNQ1 channel currents by ML277.
Nat Commun, 13, 2022
6ALE
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BU of 6ale by Molmil
A V-to-F substitution in SK2 channels causes Ca2+ hypersensitivity and improves locomotion in a C. elegans ALS model
Descriptor: (3E)-6,7-dichloro-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-one, CALCIUM ION, Calmodulin-2, ...
Authors:Nam, Y.W, Zhang, M.
Deposit date:2017-08-07
Release date:2018-08-08
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A V-to-F substitution in SK2 channels causes Ca2+hypersensitivity and improves locomotion in a C. elegans ALS model.
Sci Rep, 8, 2018
4ZLK
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BU of 4zlk by Molmil
Crystal structure of mouse myosin-5a in complex with calcium-bound calmodulin
Descriptor: CALCIUM ION, Calmodulin, Unconventional myosin-Va
Authors:Shen, M, Zhang, N, Zheng, S, Zhang, W.-B, Zhang, H.-M, Lu, Z, Su, Q.P, Sun, Y, Ye, K, Li, X.-D.
Deposit date:2015-05-01
Release date:2016-05-04
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.502 Å)
Cite:Structural basis for calcium regulation of myosin 5 motor function
To Be Published
5COC
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BU of 5coc by Molmil
Fusion protein of human calmodulin and B4 domain of protein A from staphylococcal aureus
Descriptor: CALCIUM ION, Immunoglobulin G-binding protein A,Calmodulin
Authors:Jeong, W.H, Lee, H, Song, D.H, Lee, J.O.
Deposit date:2015-07-20
Release date:2016-03-30
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.6691 Å)
Cite:Connecting two proteins using a fusion alpha helix stabilized by a chemical cross linker.
Nat Commun, 7, 2016
3HR4
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BU of 3hr4 by Molmil
Human iNOS Reductase and Calmodulin Complex
Descriptor: CALCIUM ION, Calmodulin, FLAVIN MONONUCLEOTIDE, ...
Authors:Xia, C, Misra, I, Iyanaki, T, Kim, J.J.K.
Deposit date:2009-06-08
Release date:2009-09-08
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Regulation of Interdomain Interactions by CaM in Inducible Nitric Oxide Synthase
J.Biol.Chem., 2009
7MIS
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BU of 7mis by Molmil
Cryo-EM structure of SidJ-SdeC-CaM reaction intermediate complex
Descriptor: ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, ...
Authors:Osinski, A, Black, M.H, Pawlowski, K, Chen, Z, Li, Y, Tagliabracci, V.S.
Deposit date:2021-04-17
Release date:2021-08-18
Last modified:2021-11-17
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural and mechanistic basis for protein glutamylation by the kinase fold.
Mol.Cell, 81, 2021
5WSV
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BU of 5wsv by Molmil
Crystal structure of Myosin VIIa IQ5 in complex with Ca2+-CaM
Descriptor: CALCIUM ION, Calmodulin, SULFATE ION, ...
Authors:Li, J, Chen, Y, Deng, Y, Lu, Q, Zhang, M.
Deposit date:2016-12-08
Release date:2017-06-07
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Ca(2+)-Induced Rigidity Change of the Myosin VIIa IQ Motif-Single alpha Helix Lever Arm Extension
Structure, 25, 2017

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