6M61
| Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) with inhibitor heptelidic acid | Descriptor: | (5aS,6R,9S,9aS)-9-methyl-9-oxidanyl-1-oxidanylidene-6-propan-2-yl-3,5a,6,7,8,9a-hexahydro-2-benzoxepine-4-carboxylic acid, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ... | Authors: | Yan, Y, Zang, X, Cooper, S.J, Lin, H, Zhou, J, Tang, Y. | Deposit date: | 2020-03-12 | Release date: | 2020-12-30 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.82449543 Å) | Cite: | Biosynthesis of the fungal glyceraldehyde-3-phosphate dehydrogenase inhibitor heptelidic acid and mechanism of self-resistance Chem Sci, 11, 2020
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8UMU
| Atomic model of the human CTF18-RFC-PCNA binary complex in the four-subunit binding state (state 3) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Chromosome transmission fidelity protein 18 homolog, MAGNESIUM ION, ... | Authors: | Wang, F, He, Q, Li, H. | Deposit date: | 2023-10-18 | Release date: | 2024-05-08 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.16 Å) | Cite: | Cryo-EM reveals a nearly complete PCNA loading process and unique features of the human alternative clamp loader CTF18-RFC. Proc.Natl.Acad.Sci.USA, 121, 2024
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8UII
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8H9Z
| Annexin A5 protein mutant | Descriptor: | Annexin A5, CALCIUM ION | Authors: | Hua, Z.C, Tang, W. | Deposit date: | 2022-10-26 | Release date: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | structure dissection of the membrane aggregation mechanism induced by Annexin A5 mutation To Be Published
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8UI8
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8UMW
| Atomic model of the human CTF18-RFC-PCNA-DNA ternary complex in the five-subunit binding state (state 4) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Chromosome transmission fidelity protein 18 homolog, DNA (20-MER), ... | Authors: | Wang, F, He, Q, Li, H. | Deposit date: | 2023-10-18 | Release date: | 2024-05-08 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (2.93 Å) | Cite: | Cryo-EM reveals a nearly complete PCNA loading process and unique features of the human alternative clamp loader CTF18-RFC. Proc.Natl.Acad.Sci.USA, 121, 2024
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8HE7
| ADP-ribosyltransferase 1 (PARP1) catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor | Descriptor: | 1-[[4-fluoranyl-3-(3-oxidanylidene-4-pentan-3-yl-piperazin-1-yl)carbonyl-phenyl]methyl]quinazoline-2,4-dione, Poly [ADP-ribose] polymerase 1, processed C-terminus, ... | Authors: | Wang, X.Y, Zhou, J, Xu, B.L. | Deposit date: | 2022-11-07 | Release date: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Discovery of Quinazoline-2,4(1 H ,3 H )-dione Derivatives Containing a Piperizinone Moiety as Potent PARP-1/2 Inhibitors─Design, Synthesis, In Vivo Antitumor Activity, and X-ray Crystal Structure Analysis. J.Med.Chem., 66, 2023
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2LBD
| LIGAND-BINDING DOMAIN OF THE HUMAN RETINOIC ACID RECEPTOR GAMMA BOUND TO ALL-TRANS RETINOIC ACID | Descriptor: | RETINOIC ACID, RETINOIC ACID RECEPTOR GAMMA | Authors: | Renaud, J.-P, Rochel, N, Ruff, M, Moras, D, Structural Proteomics in Europe (SPINE) | Deposit date: | 1997-08-19 | Release date: | 1997-11-12 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid. Nature, 378, 1995
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6MTD
| Rabbit 80S ribosome with eEF2 and SERBP1 (unrotated state with 40S head swivel) | Descriptor: | 18S rRNA, 28S rRNA, 5.8S rRNA, ... | Authors: | Brown, A, Baird, M.R, Yip, M.C.J, Murray, J, Shao, S. | Deposit date: | 2018-10-19 | Release date: | 2018-11-21 | Last modified: | 2019-05-15 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structures of translationally inactive mammalian ribosomes. Elife, 7, 2018
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8HQ4
| B27 in complex with CRM1-Ran-RanBP1 | Descriptor: | 3-[(4-fluorophenyl)carbonylamino]-4-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]benzoic acid, CHLORIDE ION, CRM1 isoform 1, ... | Authors: | Lei, Y, Sun, Q. | Deposit date: | 2022-12-13 | Release date: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | B27 in complex with CRM1-Ran-RanBP1 To Be Published
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2LEH
| Solution structure of the core SMN-Gemin2 complex | Descriptor: | Survival motor neuron protein, Survival of motor neuron protein-interacting protein 1 | Authors: | Sarachan, K.L, Valentine, K, Gupta, K, Moorman, V, Gledhill, J, Bernens, M, Tommos, C, Wand, A.J, Van Duyne, G. | Deposit date: | 2011-06-15 | Release date: | 2012-06-27 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution structure of the core SMN-Gemin2 complex. Biochem.J., 445, 2012
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8HQ5
| G6 in complex with CRM1-Ran-RanBP1 | Descriptor: | 3-[(4-bromophenyl)carbonylamino]-4-[4-(5-chloranyl-2-methyl-phenyl)piperazin-1-yl]benzoic acid, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, ... | Authors: | Sun, Q, Lei, Y. | Deposit date: | 2022-12-13 | Release date: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | F1 in complex with CRM1-Ran-RanBP1 To Be Published
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2L5F
| Solution structure of the tandem WW domains from HYPA/FBP11 | Descriptor: | Pre-mRNA-processing factor 40 homolog A | Authors: | Jiang, Y, Hu, H. | Deposit date: | 2010-11-01 | Release date: | 2011-05-11 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Interaction with polyglutamine expanded huntingtin alters cellular distribution and RNA processing of huntingtin yeast two-hybrid protein A (HYPA) To be Published
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2MZU
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2N0T
| Structural ensemble of the enzyme cyclophilin reveals an orchestrated mode of action at atomic resolution | Descriptor: | Peptidyl-prolyl cis-trans isomerase A | Authors: | Chi, C.N, Voegeli, B, Bibow, S, Strotz, D, Orts, J, Guntert, P, Riek, R. | Deposit date: | 2015-03-13 | Release date: | 2015-08-26 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | A Structural Ensemble for the Enzyme Cyclophilin Reveals an Orchestrated Mode of Action at Atomic Resolution. Angew.Chem.Int.Ed.Engl., 54, 2015
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2MS4
| Cyclophilin a complexed with a fragment of crk-ii | Descriptor: | Peptide, Peptidyl-prolyl cis-trans isomerase A | Authors: | Jankowski, W, Saleh, T, Rossi, P, Kalodimos, C. | Deposit date: | 2014-07-22 | Release date: | 2015-09-09 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Cyclophilin A promotes cell migration via the Abl-Crk signaling pathway. Nat.Chem.Biol., 12, 2016
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8XAM
| Co-crystal structure of compound 7 in complex with MAT2A | Descriptor: | 2-[3-[7-chloranyl-4-(dimethylamino)-2-oxidanylidene-quinazolin-1-yl]phenoxy]-~{N}-[3-[7-chloranyl-4-(dimethylamino)-2-oxidanylidene-quinazolin-1-yl]phenyl]ethanamide, S-ADENOSYLMETHIONINE, S-adenosylmethionine synthase isoform type-2 | Authors: | Gao, F, Ding, X. | Deposit date: | 2023-12-04 | Release date: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Discovery of novel MAT2A inhibitors by an allosteric site-compatible fragment growing approach. Bioorg.Med.Chem., 100, 2024
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2MQ6
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8TAR
| APC/C-CDH1-UBE2C-Ubiquitin-CyclinB-NTD | Descriptor: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | Authors: | Bodrug, T, Welsh, K.A, Bolhuis, D.L, Paulakonis, E, Martinez-Chacin, R.C, Liu, B, Pinkin, N, Bonacci, T, Cui, L, Xu, P, Roscow, O, Amann, S.J, Grishkovskaya, I, Emanuele, M.J, Harrison, J.S, Steimel, J.P, Hahn, K.M, Zhang, W, Zhong, E, Haselbach, D, Brown, N.G. | Deposit date: | 2023-06-27 | Release date: | 2023-09-27 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C). Nat.Struct.Mol.Biol., 30, 2023
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2N3O
| Structure of PTB RRM1(41-163) bound to an RNA stemloop containing a structured loop derived from viral internal ribosomal entry site RNA | Descriptor: | Polypyrimidine tract-binding protein 1, RNA (5'-R(*GP*GP*GP*AP*CP*CP*UP*GP*GP*UP*CP*UP*UP*UP*CP*CP*AP*GP*GP*UP*CP*CP*C)-3') | Authors: | Maris, C, Jayne, S.F, Damberger, F.F, Ravindranathan, S, Allain, F.H.-T. | Deposit date: | 2015-06-08 | Release date: | 2016-08-10 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | C-terminal helix folding upon pyrimidine-rich hairpin binding to PTB RRM1. Implications for PTB function in Encephalomyocarditis virus IRES activity. To be Published
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8TAU
| APC/C-CDH1-UBE2C-UBE2S-Ubiquitin-CyclinB | Descriptor: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | Authors: | Bodrug, T, Welsh, K.A, Bolhuis, D.L, Paulakonis, E, Martinez-Chacin, R.C, Liu, B, Pinkin, N, Bonacci, T, Cui, L, Xu, P, Roscow, O, Amann, S.J, Grishkovskaya, I, Emanuele, M.J, Harrison, J.S, Steimel, J.P, Hahn, K.M, Zhang, W, Zhong, E, Haselbach, D, Brown, N.G. | Deposit date: | 2023-06-27 | Release date: | 2023-09-27 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C). Nat.Struct.Mol.Biol., 30, 2023
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8TAH
| Cryo-EM structure of Cortactin-bound to Arp2/3 complex | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin-related protein 2, Actin-related protein 2/3 complex subunit 1A, ... | Authors: | Fregoso, F.E, van Eeuwen, T, Dominguez, R. | Deposit date: | 2023-06-27 | Release date: | 2023-09-27 | Last modified: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (2.89 Å) | Cite: | Mechanism of synergistic activation of Arp2/3 complex by cortactin and WASP-family proteins. Nat Commun, 14, 2023
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8TKL
| Murine NF-kappaB p50 Rel Homology Region homodimer in complex with a Test 16-mer kappaB-like DNA | Descriptor: | Nuclear factor NF-kappa-B p50 subunit, Test 17-mer kappaB-like DNA | Authors: | Mitchel, S, Mealka, M, Rogers, W.E, Milani, C, Acuna, L.M, Huxford, T. | Deposit date: | 2023-07-25 | Release date: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | X-ray Crystallographic Study of Preferred Spacing by the NF-kappa B p50 Homodimer on kappa B DNA. Biomolecules, 13, 2023
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8TKN
| Murine NF-kappaB p50 Rel Homology Region homodimer in complex with 10-mer kappaB DNA from human Neutrophil Gelatinase-associated Lipocalin (NGAL) promoter | Descriptor: | DNA A, DNA B, Nuclear factor NF-kappa-B p50 subunit | Authors: | Zhu, N, Mealka, M, Mitchel, S, Rogers, W.E, Huxford, T. | Deposit date: | 2023-07-25 | Release date: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | X-ray Crystallographic Study of Preferred Spacing by the NF-kappa B p50 Homodimer on kappa B DNA. Biomolecules, 13, 2023
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6MV8
| LDHA structure in complex with inhibitor 14 | Descriptor: | (6S)-3-[(2-chlorophenyl)sulfanyl]-4-hydroxy-6-(2-hydroxyphenyl)-6-phenyl-5,6-dihydro-2H-pyran-2-one, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | Authors: | Eigenbrot, C.E, Ultsch, M, Wei, B. | Deposit date: | 2018-10-24 | Release date: | 2019-10-30 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structure-based Optimization of Potent, Cell-Active
Hydroxylactam Inhibitors of Lactate Dehydrogenase To Be Published
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