8TK6
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![BU of 8tk6 by Molmil](/molmil-images/mine/8tk6) | HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) in apo form | Descriptor: | Dual specificity protein phosphatase 3 | Authors: | Aleshin, A.E, Wu, J, Lambert, L.J, Cosford, N.D.P, Tautz, L. | Deposit date: | 2023-07-25 | Release date: | 2024-08-14 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Fragment Screening Platform and Discovery of Novel Fragment Binders of the VHR Phosphatase, a Drug Target for Sepsis and Septic Shock To Be Published
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8TK5
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![BU of 8tk5 by Molmil](/molmil-images/mine/8tk5) | HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) complexed with HEPES | Descriptor: | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, ... | Authors: | Aleshin, A.E, Wu, J, Lambert, L.J, Cosford, N.D.P, Tautz, L. | Deposit date: | 2023-07-25 | Release date: | 2024-08-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Fragment Screening Platform and Discovery of Novel Fragment Binders of the VHR Phosphatase, a Drug Target for Sepsis and Septic Shock To Be Published
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8TK4
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![BU of 8tk4 by Molmil](/molmil-images/mine/8tk4) | HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) complexed with phosphate | Descriptor: | Dual specificity protein phosphatase 3, PHOSPHATE ION | Authors: | Aleshin, A.E, Wu, J, Lambert, L.J, Cosford, N.D.P, Tautz, L. | Deposit date: | 2023-07-25 | Release date: | 2024-08-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) complexed with phosphate To Be Published
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8TK3
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![BU of 8tk3 by Molmil](/molmil-images/mine/8tk3) | HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) having oxidized catalytic cysteine and complexed with 6-(difluoromethyl)pyrimidin-4-ol at two allosteric sites | Descriptor: | 6-(difluoromethyl)pyrimidin-4-ol, DIMETHYL SULFOXIDE, Dual specificity protein phosphatase 3 | Authors: | Aleshin, A.E, Wu, J, Lambert, L.J, Cosford, N.D.P, Tautz, L. | Deposit date: | 2023-07-25 | Release date: | 2024-08-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) having oxidized catalytic cysteine and complexed with 6-(difluoromethyl)pyrimidin-4-ol at two allosteric sites To Be Published
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8TK2
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![BU of 8tk2 by Molmil](/molmil-images/mine/8tk2) | HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) complexed with 2-((2,4-difluorobenzyl)amino)-2-oxoacetic acid | Descriptor: | DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, Dual specificity protein phosphatase 3, ... | Authors: | Aleshin, A.E, Wu, J, Lambert, L.J, Cosford, N.D.P, Tautz, L. | Deposit date: | 2023-07-25 | Release date: | 2024-08-14 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) binding 2-((2,4-difluorobenzyl)amino)-2-oxoacetic acid To Be Published
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8TK1
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![BU of 8tk1 by Molmil](/molmil-images/mine/8tk1) | Structure of Gabija AB complex 1 | Descriptor: | Endonuclease GajA, Gabija protein GajB | Authors: | Shen, Z.F, Yang, X.Y, Fu, T.M. | Deposit date: | 2023-07-25 | Release date: | 2024-04-24 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Molecular basis of Gabija anti-phage supramolecular assemblies. Nat.Struct.Mol.Biol., 2024
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8TK0
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![BU of 8tk0 by Molmil](/molmil-images/mine/8tk0) | Structure of Gabija AB complex | Descriptor: | Endonuclease GajA | Authors: | Shen, Z.F, Yang, X.Y, Fu, T.M. | Deposit date: | 2023-07-24 | Release date: | 2024-04-24 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.23 Å) | Cite: | Molecular basis of Gabija anti-phage supramolecular assemblies. Nat.Struct.Mol.Biol., 2024
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8TJY
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![BU of 8tjy by Molmil](/molmil-images/mine/8tjy) | Structure of Gabija AB complex | Descriptor: | Endonuclease GajA, Gabija protein GajB | Authors: | Shen, Z.F, Yang, X.Y, Fu, T.M. | Deposit date: | 2023-07-24 | Release date: | 2024-04-24 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.79 Å) | Cite: | Molecular basis of Gabija anti-phage supramolecular assemblies. Nat.Struct.Mol.Biol., 2024
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8TJX
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![BU of 8tjx by Molmil](/molmil-images/mine/8tjx) | Tetrahymena Ribozyme cryo-EM scaffold | Descriptor: | MAGNESIUM ION, RNA (440-MER) | Authors: | Langeberg, C.J, Kieft, J.S. | Deposit date: | 2023-07-24 | Release date: | 2023-11-01 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (2.44 Å) | Cite: | A generalizable scaffold-based approach for structure determination of RNAs by cryo-EM. Nucleic Acids Res., 51, 2023
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8TJV
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![BU of 8tjv by Molmil](/molmil-images/mine/8tjv) | |
8TJU
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![BU of 8tju by Molmil](/molmil-images/mine/8tju) | Tetrahymena Ribozyme scaffolded TABV xrRNA | Descriptor: | DNA/RNA (416-MER), MAGNESIUM ION | Authors: | Langeberg, C.J, Kieft, J.S. | Deposit date: | 2023-07-24 | Release date: | 2023-11-01 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (3.46 Å) | Cite: | A generalizable scaffold-based approach for structure determination of RNAs by cryo-EM. Nucleic Acids Res., 51, 2023
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8TJT
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![BU of 8tjt by Molmil](/molmil-images/mine/8tjt) | The Fab fragment of an anti-glucagon receptor (GCGR) antibody | Descriptor: | anti-GCGR Fab heavy chain, anti-GCGR Fab light chain | Authors: | Dai, J, Carter, P.J, Sudhamsu, J, Kung, J. | Deposit date: | 2023-07-24 | Release date: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Variable domain mutational analysis to probe the molecular mechanisms of high viscosity of an IgG 1 antibody. Mabs, 16, 2024
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8TJS
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![BU of 8tjs by Molmil](/molmil-images/mine/8tjs) | |
8TJR
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![BU of 8tjr by Molmil](/molmil-images/mine/8tjr) | CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO HERH-c.01 FAB | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody HERH-a.01 Heavy Chain, ... | Authors: | Morano, N.C, Hoyt, F, Hansen, B, Fischer, E, Shapiro, L. | Deposit date: | 2023-07-24 | Release date: | 2024-07-31 | Method: | ELECTRON MICROSCOPY (3.29 Å) | Cite: | CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO HERH-c.01 FAB To Be Published
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8TJQ
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8TJP
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![BU of 8tjp by Molmil](/molmil-images/mine/8tjp) | KS-AT core of 6-deoxyerythronolide B synthase (DEBS) Module 3 crosslinked with its elongation ACP partner | Descriptor: | EryAII | Authors: | Cogan, D.P, Soohoo, A.M, Chen, M, Brodsky, K.L, Liu, Y, Khosla, C. | Deposit date: | 2023-07-23 | Release date: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.71 Å) | Cite: | Structural Basis for Intermodular Communication in Assembly-Line Polyketide Biosynthesis To Be Published
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8TJO
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![BU of 8tjo by Molmil](/molmil-images/mine/8tjo) | Crosslinked 6-deoxyerythronolide B synthase (DEBS) Module 1 in complex with antibody fragment 1B2: Crosslinked Intra-State 1 | Descriptor: | Antibody Fragment 1B2, Heavy Chain, Light Chain, ... | Authors: | Cogan, D.P, Soohoo, A.M, Chen, M, Brodsky, K.L, Liu, Y, Khosla, C. | Deposit date: | 2023-07-23 | Release date: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.61 Å) | Cite: | Structural Basis for Intermodular Communication in Assembly-Line Polyketide Biosynthesis To Be Published
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8TJN
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![BU of 8tjn by Molmil](/molmil-images/mine/8tjn) | Crosslinked 6-deoxyerythronolide B synthase (DEBS) Module 1 in complex with antibody fragment 1B2: Crosslinked State 1 | Descriptor: | Antibody Fragment 1B2, Heavy Chain, Light Chain, ... | Authors: | Cogan, D.P, Soohoo, A.M, Chen, M, Brodsky, K.L, Liu, Y, Khosla, C. | Deposit date: | 2023-07-23 | Release date: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.73 Å) | Cite: | Structural Basis for Intermodular Communication in Assembly-Line Polyketide Biosynthesis To Be Published
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8TJM
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![BU of 8tjm by Molmil](/molmil-images/mine/8tjm) | Crystal structure of KPC-44 carbapenemase | Descriptor: | 1,2-ETHANEDIOL, SULFATE ION, beta-lactamase | Authors: | Sun, Z, Palzkill, T, Hu, L, Lin, H, Sankaran, B, Wang, J, Prasad, B. | Deposit date: | 2023-07-23 | Release date: | 2023-12-06 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.28 Å) | Cite: | Klebsiella pneumoniae carbapenemase variant 44 acquires ceftazidime-avibactam resistance by altering the conformation of active-site loops. J.Biol.Chem., 300, 2023
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8TJL
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![BU of 8tjl by Molmil](/molmil-images/mine/8tjl) | EGFR kinase in complex with pyrazolopyrimidine covalent inhibitor | Descriptor: | 1-{3-[(4-amino-1-tert-butyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)oxy]azetidin-1-yl}propan-1-one, Epidermal growth factor receptor | Authors: | Beyett, T.S, Eck, M.J. | Deposit date: | 2023-07-22 | Release date: | 2024-02-14 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | ZNL0325, a Pyrazolopyrimidine-Based Covalent Probe, Demonstrates an Alternative Binding Mode for Kinases. J.Med.Chem., 67, 2024
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8TJK
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![BU of 8tjk by Molmil](/molmil-images/mine/8tjk) | SAM-dependent methyltransferase RedM bound to SAH | Descriptor: | CHLORIDE ION, RedM, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Daniel-Ivad, P, Ryan, K.S. | Deposit date: | 2023-07-22 | Release date: | 2023-12-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structure of methyltransferase RedM that forms the dimethylpyrrolinium of the bisindole reductasporine. J.Biol.Chem., 300, 2023
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8TJJ
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![BU of 8tjj by Molmil](/molmil-images/mine/8tjj) | SAM-dependent methyltransferase RedM bound to SAM | Descriptor: | 1,2-ETHANEDIOL, POTASSIUM ION, RedM, ... | Authors: | Daniel-Ivad, P, Ryan, K.S. | Deposit date: | 2023-07-22 | Release date: | 2023-12-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Structure of methyltransferase RedM that forms the dimethylpyrrolinium of the bisindole reductasporine. J.Biol.Chem., 300, 2023
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8TJI
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![BU of 8tji by Molmil](/molmil-images/mine/8tji) | SAM-dependent methyltransferase RedM, apo | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, RedM, ... | Authors: | Daniel-Ivad, P, Ryan, K.S. | Deposit date: | 2023-07-22 | Release date: | 2023-12-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Structure of methyltransferase RedM that forms the dimethylpyrrolinium of the bisindole reductasporine. J.Biol.Chem., 300, 2023
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8TJH
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8TJG
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![BU of 8tjg by Molmil](/molmil-images/mine/8tjg) | |