8TJL

EGFR kinase in complex with pyrazolopyrimidine covalent inhibitor

Summary for 8TJL

Entry DOI	10.2210/pdb8tjl/pdb
Descriptor	Epidermal growth factor receptor, 1-{3-[(4-amino-1-tert-butyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)oxy]azetidin-1-yl}propan-1-one (3 entities in total)
Functional Keywords	egfr, kinase, covalent inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	37954.82
Authors	Beyett, T.S.,Eck, M.J. (deposition date: 2023-07-22, release date: 2024-02-14, Last modification date: 2024-03-06)
Primary citation	Li, Z.,Lu, W.,Beyett, T.S.,Ficarro, S.B.,Jiang, J.,Tse, J.,Kim, A.Y.,Marto, J.A.,Che, J.,Janne, P.A.,Eck, M.J.,Zhang, T.,Gray, N.S. ZNL0325, a Pyrazolopyrimidine-Based Covalent Probe, Demonstrates an Alternative Binding Mode for Kinases. J.Med.Chem., 67:2837-2848, 2024 Cited by PubMed: 38300264 DOI: 10.1021/acs.jmedchem.3c01891 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation