9QWJ
 
 | | Crystal structure of S2c TCR in complex with CD1c | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Karuppiah, V. | | Deposit date: | 2025-04-14 | | Release date: | 2025-08-20 | | Method: | X-RAY DIFFRACTION (2.04 Å) | | Cite: | A CD1c lipid agnostic T cell receptor bispecific engager redirects T cells against CD1c + cells.
Front Immunol, 16, 2025
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9QBW
 | | Yeast 20S proteasome mutant: beta5_G128V (b5-propeptide in trans) in complex with Carfilzomib | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE, ... | | Authors: | Huber, E.M, Heinemeyer, W, Groll, M. | | Deposit date: | 2025-03-03 | | Release date: | 2025-10-08 | | Last modified: | 2025-10-15 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Proteasome-associated autoinflammatory syndromes: The impact of mutations in proteasome subunits on particle assembly, structure, and activity.
Structure, 2025
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9OFV
 | | Consensus reconstruction of the eukaryotic Ribosome-associated Quality Control complex | | Descriptor: | 25S rRNA, 5.8S rRNA, 5S rRNA, ... | | Authors: | Li, W, Cahoon, T, Shen, P.S. | | Deposit date: | 2025-04-30 | | Release date: | 2025-06-11 | | Last modified: | 2025-07-16 | | Method: | ELECTRON MICROSCOPY (3.16 Å) | | Cite: | Mechanism of nascent chain removal by the ribosome-associated quality control complex.
Nat Commun, 16, 2025
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9RZC
 | | State 3 MAP 1 SETD2 bound to distal H3 of upstream nucleosome | | Descriptor: | FACT complex subunit SPT16, Histone H2A type 1-B/E, Histone H2B type 1-K, ... | | Authors: | Walshe, J.L, Ochmann, M, Dienemann, C, Cramer, P. | | Deposit date: | 2025-07-15 | | Release date: | 2025-09-24 | | Method: | ELECTRON MICROSCOPY (3.66 Å) | | Cite: | Molecular mechanism of co-transcriptional H3K36 methylation by SETD2
To Be Published
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9OIM
 | | The von Hippel Lindau-ElonginB-ElonginC (VCB) complex with fragment 9 | | Descriptor: | 1-[5-[oxidanyl(oxidanylidene)-$l^{4}-azanyl]-2,3-dihydroindol-1-yl]ethanone, Elongin-B, Elongin-C, ... | | Authors: | Amporndanai, K, Katinas, J.M, Chopra, A, Fesik, S.W. | | Deposit date: | 2025-05-06 | | Release date: | 2025-07-09 | | Last modified: | 2025-09-03 | | Method: | X-RAY DIFFRACTION (2.61 Å) | | Cite: | NMR-Based Fragment Screen of the von Hippel-Lindau Elongin C&B Complex.
Acs Med.Chem.Lett., 16, 2025
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9OVJ
 | | Structure of human SHOC2 in complex with a small molecule inhibitor (R)-5 | | Descriptor: | (2R)-{2-[(4-chloro[1,1'-biphenyl]-3-yl)methoxy]phenyl}[(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)amino]acetic acid, Leucine-rich repeat protein SHOC-2, POTASSIUM ION | | Authors: | Dhembi, A, Hauseman, Z.J, King, D. | | Deposit date: | 2025-05-30 | | Release date: | 2025-06-25 | | Method: | X-RAY DIFFRACTION (2.68 Å) | | Cite: | Targeting the SHOC2-RAS interaction in RAS-mutant cancers.
Nature, 642, 2025
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8C1E
 | | Aurora A kinase in complex with TPX2-inhibitor 9 | | Descriptor: | 4-(4-chloranyl-3-cyano-phenyl)-7-methyl-1~{H}-indole-6-carboxylic acid, ADENOSINE-5'-TRIPHOSPHATE, Aurora kinase A, ... | | Authors: | Fischer, G, Rocaboy, M, Blaszczyk, B, Moschetti, T, Wang, X, Scott, D.E, Coyne, A.G, Dagostin, C, Rooney, T, Bayly, A, Feng, J, Asteian, A, Alcaide-Lopez, A, Stockwell, S, Skidmore, J, Venkitaraman, A.R, Abell, C, Blundell, T.L, Hyvonen, M. | | Deposit date: | 2022-12-20 | | Release date: | 2024-01-10 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.798 Å) | | Cite: | Selective Aurora A-TPX2 Interaction Inhibitors Have In Vivo Efficacy as Targeted Antimitotic Agents.
J.Med.Chem., 67, 2024
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9QB1
 | | Yeast 20S proteasome mutant: beta5_T3M in complex with Bortezomib | | Descriptor: | 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE, CHLORIDE ION, MAGNESIUM ION, ... | | Authors: | Huber, E.M, Heinemeyer, W, Groll, M. | | Deposit date: | 2025-02-28 | | Release date: | 2025-10-08 | | Last modified: | 2025-10-15 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Proteasome-associated autoinflammatory syndromes: The impact of mutations in proteasome subunits on particle assembly, structure, and activity.
Structure, 2025
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9OG3
 | | Crystal structure of WRN in complex with compound 4 | | Descriptor: | (3R,4S)-N-[(2R)-3-cyclohexyl-1-(dimethylamino)-1-oxopropan-2-yl]-1-[(2-fluoro-4-methylphenyl)acetyl]-4-[3-(2-oxo-2,3-dihydro-1H-1,3-benzimidazol-1-yl)propanamido]piperidine-3-carboxamide, Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, ZINC ION | | Authors: | Pemberton, O.A, Tong, Y, Nocek, B, Tang, H.Y.H. | | Deposit date: | 2025-04-30 | | Release date: | 2025-06-18 | | Last modified: | 2025-07-02 | | Method: | X-RAY DIFFRACTION (2.06 Å) | | Cite: | Validation, Key Pharmacophores, and X-ray Cocrystal Structures of Novel Biochemically and Cellularly Active WRN Inhibitors Derived from a DNA-Encoded Library Screen.
J.Med.Chem., 68, 2025
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9QDS
 | | Yeast 20S proteasome mutant: beta1_G128V (b1-propeptide deleted) in complex with Carfilzomib | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE, CHLORIDE ION, ... | | Authors: | Huber, E.M, Heinemeyer, W, Groll, M. | | Deposit date: | 2025-03-06 | | Release date: | 2025-10-08 | | Last modified: | 2025-10-15 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Proteasome-associated autoinflammatory syndromes: The impact of mutations in proteasome subunits on particle assembly, structure, and activity.
Structure, 2025
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9OLT
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9R4N
 | | Crystal structure of CtGH76 from Chaetomium thermophilum | | Descriptor: | FORMIC ACID, GLYCEROL, Uncharacterized protein, ... | | Authors: | Po-Hsun, W, Essen, L.-O. | | Deposit date: | 2025-05-07 | | Release date: | 2025-07-16 | | Last modified: | 2025-08-06 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Ct GH76, a Glycoside Hydrolase 76 from Chaetomium thermophilum , with Elongated Glycan-Binding Canyon.
Int J Mol Sci, 26, 2025
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9R4S
 | | Crystal structure of CtGH76 from Chaetomium thermophilum in complex with laminaribiose | | Descriptor: | FORMIC ACID, GLYCEROL, Uncharacterized protein, ... | | Authors: | Po-Hsun, W, Essen, L.-O. | | Deposit date: | 2025-05-07 | | Release date: | 2025-07-16 | | Last modified: | 2025-08-06 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Ct GH76, a Glycoside Hydrolase 76 from Chaetomium thermophilum , with Elongated Glycan-Binding Canyon.
Int J Mol Sci, 26, 2025
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9V21
 | | Cryo- EM structure of 75S ribosome with P- tRNA from Entamoeba histolytica | | Descriptor: | 17S rRNA, 25S rRNA, 40S ribosomal protein S10, ... | | Authors: | Sharma, S, Mishra, S, Gourinath, S, Kaushal, P.S. | | Deposit date: | 2025-05-19 | | Release date: | 2025-10-08 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Cryo-EM structure of ribosome from pathogenic protozoa Entamoeba histolytica reveals unique features of its architecture.
Nat Commun, 16, 2025
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9RPX
 | | Fragment screening of FosAKP, cryo structure in complex with fragment F2X-entry B06 | | Descriptor: | (1S)-1-(4-nitrophenyl)ethan-1-ol, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ... | | Authors: | Guenther, S, Galchenkova, M, Fischer, P, Reinke, P.Y.A, Falke, S, Thekku Veedu, S, Rodrigues, A.C, Senst, J, Meents, A. | | Deposit date: | 2025-06-25 | | Release date: | 2025-10-15 | | Last modified: | 2025-10-22 | | Method: | X-RAY DIFFRACTION (1.27 Å) | | Cite: | Room-temperature X-ray fragment screening with serial crystallography.
Nat Commun, 16, 2025
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9QDF
 | | Yeast 20S proteasome mutant: beta1_G128V (b1-propeptide deleted) in complex with Bortezomib | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE, CHLORIDE ION, ... | | Authors: | Huber, E.M, Heinemeyer, W, Groll, M. | | Deposit date: | 2025-03-06 | | Release date: | 2025-10-08 | | Last modified: | 2025-10-15 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Proteasome-associated autoinflammatory syndromes: The impact of mutations in proteasome subunits on particle assembly, structure, and activity.
Structure, 2025
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9R4P
 | | Crystal structure of inactive (D164N) variant CtGH76 from Chaetomium thermophilum in complex with alpha-1,6-mannobiose | | Descriptor: | CtGH76, alpha-D-mannopyranose, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose | | Authors: | Po-Hsun, W, Essen, L.-O. | | Deposit date: | 2025-05-07 | | Release date: | 2025-07-16 | | Last modified: | 2025-08-06 | | Method: | X-RAY DIFFRACTION (2.46 Å) | | Cite: | Ct GH76, a Glycoside Hydrolase 76 from Chaetomium thermophilum , with Elongated Glycan-Binding Canyon.
Int J Mol Sci, 26, 2025
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1E88
 | | Solution structure of 6F11F22F2, a compact three-module fragment of the gelatin-binding domain of human fibronectin | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FIBRONECTIN | | Authors: | Pickford, A.R, Smith, S.P, Staunton, D, Boyd, J, Campbell, I.D. | | Deposit date: | 2000-09-18 | | Release date: | 2000-10-09 | | Last modified: | 2024-10-16 | | Method: | SOLUTION NMR | | Cite: | The Hairpin Structure of the (6)F1(1)F2(2)F2 Fragment from Human Fibronectin Enhances Gelatin Binding
Embo J., 20, 2001
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9Q1O
 | | Crystal structure of human TEAD2-Yap binding domain covalently bound to an allosteric regulator | | Descriptor: | 1-{(3aS,4R,7aR)-4-[4-(trifluoromethyl)anilino]octahydro-2H-isoindol-2-yl}propan-1-one, FORMIC ACID, Transcriptional enhancer factor TEF-4 | | Authors: | Bum-Erdene, K, Gonzalez-Gutierrez, G, Meroueh, S.O. | | Deposit date: | 2025-08-14 | | Release date: | 2025-09-03 | | Last modified: | 2025-10-01 | | Method: | X-RAY DIFFRACTION (2.26 Å) | | Cite: | Small-Molecule Covalent Stabilization and Inhibition of the TEAD·YAP1 Transcription Factor in Cancer Cells.
Acs Chem.Biol., 20, 2025
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9R4U
 | | Crystal structure of CtGH76 from Chaetomium thermophilum in complex with isomaltose | | Descriptor: | FORMIC ACID, GLYCEROL, Uncharacterized protein, ... | | Authors: | Po-Hsun, W, Essen, L.-O. | | Deposit date: | 2025-05-07 | | Release date: | 2025-07-16 | | Last modified: | 2025-08-06 | | Method: | X-RAY DIFFRACTION (1.96 Å) | | Cite: | Ct GH76, a Glycoside Hydrolase 76 from Chaetomium thermophilum , with Elongated Glycan-Binding Canyon.
Int J Mol Sci, 26, 2025
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9PLY
 | | Crystal structure of the human DCAF1 WDR domain in complex with OICR-40156 | | Descriptor: | (4P)-N-[(1S)-3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl]-4-(4-chloro-2-fluorophenyl)-5-{(1E)-3-[(3-methoxypropyl)amino]-3-oxoprop-1-en-1-yl}-1H-pyrrole-3-carboxamide, 1,2-ETHANEDIOL, DDB1- and CUL4-associated factor 1, ... | | Authors: | Kimani, S, Dong, A, Li, Y, Seitova, A, Krausser, C, Wilson, B, Al-awar, R, Ackloo, S, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | | Deposit date: | 2025-07-16 | | Release date: | 2025-07-30 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Crystal structure of the human DCAF1 WDR domain in complex with OICR-40156
To be published
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9P7Q
 | | 273K human S-adenosylmethionine decarboxylase | | Descriptor: | 1,4-DIAMINOBUTANE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... | | Authors: | Patel, J.R, Bonzon, T.J, Bahkt, T, Fagbohun, O.O, Clinger, J.A. | | Deposit date: | 2025-06-21 | | Release date: | 2025-09-17 | | Last modified: | 2025-10-08 | | Method: | X-RAY DIFFRACTION (2.21 Å) | | Cite: | Multi-Temperature Crystallography of S-Adenosylmethionine Decarboxylase Observes Dynamic Loop Motions.
Biomolecules, 15, 2025
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9QBE
 | | Yeast 20S proteasome mutant: beta5_T3M in complex with ONX0914 | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE, CHLORIDE ION, ... | | Authors: | Huber, E.M, Heinemeyer, W, Groll, M. | | Deposit date: | 2025-03-02 | | Release date: | 2025-10-08 | | Last modified: | 2025-10-15 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Proteasome-associated autoinflammatory syndromes: The impact of mutations in proteasome subunits on particle assembly, structure, and activity.
Structure, 2025
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9VSP
 | | The DCY1020-bound structure of TMEM175 | | Descriptor: | (2S)-2-butyl-6,7-bis(chloranyl)-2-cyclopentyl-5-[3-(1H-1,2,3,4-tetrazol-5-yl)propoxy]-3H-inden-1-one, Endosomal/lysosomal proton channel TMEM175 | | Authors: | Zhu, X, Liu, H, Yin, W. | | Deposit date: | 2025-07-09 | | Release date: | 2025-09-17 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural insights into the activation of TMEM175 by small molecule.
Neuron, 2025
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9PLO
 | | Structure of alpha2a adrenergic receptor in complex with Go heterotrimer, scFv16, and N-(5-methylnaphthalen-1-yl)pyridin-4-amine (compound 4905) | | Descriptor: | Alpha-2A adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Srinivasan, K, Xu, X, Mailhot, O, Manglik, A, Shoichet, B. | | Deposit date: | 2025-07-15 | | Release date: | 2025-07-30 | | Method: | ELECTRON MICROSCOPY (2.74 Å) | | Cite: | Toward a Random Background for Ligand Optimization
To Be Published
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