9PLO

Structure of alpha2a adrenergic receptor in complex with Go heterotrimer, scFv16, and N-(5-methylnaphthalen-1-yl)pyridin-4-amine (compound 4905)

This is a non-PDB format compatible entry.

Summary for 9PLO

• Entry DOI: 10.2210/pdb9plo/pdb
• Related: 9PLN
• EMDB information: 71719
• Descriptor: Guanine nucleotide-binding protein G(o) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: receptor, drug, complex, gpcr, g-protein, scfv16, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 169042.78

Authors

Srinivasan, K.,Xu, X.,Mailhot, O.,Manglik, A.,Shoichet, B. (deposition date: 2025-07-15, release date: 2025-07-30)

• Primary citation: Xu, X.,Mailhot, O.,Correy, G.,Huang, X.P.,Braz, J.,Shi, D.,Srinivasan, K.,Holota, Y.,Kuziv, Y.,Tsoutsouvas, C.,Levinzon, N.,Doruk, Y.U.,Rachman, M.,Diolaiti, M.,Stevens, M.,Liu, F.,Hubner, H.,Wang, J.,Wu, Y.,Ashworth, A.,Makriyannis, A.,Zhang, Y.,Moroz, Y.,Gmeiner, P.,Abel, R.,Manglik, A.,Basbaum, A.,Roth, B.,Fraser, J.,Shoichet, B.; Toward a Random Background for Ligand Optimization; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.74 Å)