8FOJ
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![BU of 8foj by Molmil](/molmil-images/mine/8foj) | Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in the post RNA handoff state | Descriptor: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | Authors: | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | Deposit date: | 2022-12-30 | Release date: | 2023-05-31 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.8 Å) | Cite: | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase. Nat Commun, 14, 2023
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8FOH
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![BU of 8foh by Molmil](/molmil-images/mine/8foh) | Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in the RNA synthesis state | Descriptor: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | Authors: | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | Deposit date: | 2022-12-30 | Release date: | 2023-05-31 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase. Nat Commun, 14, 2023
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3HHN
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![BU of 3hhn by Molmil](/molmil-images/mine/3hhn) | Crystal structure of class I ligase ribozyme self-ligation product, in complex with U1A RBD | Descriptor: | Class I ligase ribozyme, self-ligation product, MAGNESIUM ION, ... | Authors: | Shechner, D.M, Grant, R.A, Bagby, S.C, Bartel, D.P. | Deposit date: | 2009-05-15 | Release date: | 2009-11-24 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.987 Å) | Cite: | Crystal structure of the catalytic core of an RNA-polymerase ribozyme. Science, 326, 2009
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6H02
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![BU of 6h02 by Molmil](/molmil-images/mine/6h02) | |
6T9L
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![BU of 6t9l by Molmil](/molmil-images/mine/6t9l) | |
8D71
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![BU of 8d71 by Molmil](/molmil-images/mine/8d71) | Human Ago2 bound to miR122(21nt) | Descriptor: | MAGNESIUM ION, Protein argonaute-2, miR-122-21nt | Authors: | Xiao, Y, MacRae, I. | Deposit date: | 2022-06-07 | Release date: | 2023-05-03 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | A tiny loop in the Argonaute PIWI domain tunes small RNA seed strength. Embo Rep., 24, 2023
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6UEB
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![BU of 6ueb by Molmil](/molmil-images/mine/6ueb) | |
5EHG
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![BU of 5ehg by Molmil](/molmil-images/mine/5ehg) | |
8FOC
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![BU of 8foc by Molmil](/molmil-images/mine/8foc) | Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase in Apo state conformation I | Descriptor: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | Authors: | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | Deposit date: | 2022-12-30 | Release date: | 2023-05-31 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase. Nat Commun, 14, 2023
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8VRD
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![BU of 8vrd by Molmil](/molmil-images/mine/8vrd) | |
2W9B
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![BU of 2w9b by Molmil](/molmil-images/mine/2w9b) | Binary complex of Dpo4 bound to N2,N2-dimethyl-deoxyguanosine modified DNA | Descriptor: | 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP *TP*TP*CP*DOCP)-3', 5'-D(*TP*CP*AP*TP*M2GP*GP*AP*AP*TP*CP*CP *TP*TP*CP*CP*CP*CP*C)-3', DNA POLYMERASE IV, ... | Authors: | Eoff, R.L, Zhang, H, Kosekov, I.D, Rizzo, C.J, Egli, M, Guengerich, F.P. | Deposit date: | 2009-01-22 | Release date: | 2009-05-12 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Structure-Function Relationships in Miscoding by Sulfolobus Solfataricus DNA Polymerase Dpo4: Guanine N2,N2-Dimethyl Substitution Produces Inactive and Miscoding Polymerase Complexes. J.Biol.Chem., 284, 2009
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6U1X
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![BU of 6u1x by Molmil](/molmil-images/mine/6u1x) | Structure of the Vesicular Stomatitis Virus L Protein in Complex with Its Phosphoprotein Cofactor (3.0 A resolution) | Descriptor: | Phosphoprotein, RNA-directed RNA polymerase L, ZINC ION | Authors: | Jenni, S, Bloyet, L.M, Dias-Avalos, R, Liang, B, Wheelman, S.P.J, Grigorieff, N, Harrison, S.C. | Deposit date: | 2019-08-17 | Release date: | 2020-01-22 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structure of the Vesicular Stomatitis Virus L Protein in Complex with Its Phosphoprotein Cofactor. Cell Rep, 30, 2020
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7R08
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![BU of 7r08 by Molmil](/molmil-images/mine/7r08) | Abortive infection DNA polymerase Abi-P2 | Descriptor: | Reverse transcriptase | Authors: | Gapinska, M.A, Figiel, M, Czarnocki Cieciura, M, Nowotny, M, Zajko, W. | Deposit date: | 2022-02-01 | Release date: | 2022-09-07 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Mechanism of protein-primed template-independent DNA synthesis by Abi polymerases. Nucleic Acids Res., 50, 2022
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8ASG
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![BU of 8asg by Molmil](/molmil-images/mine/8asg) | Structure of the SFTSV L protein bound in a resting state [RESTING] | Descriptor: | MAGNESIUM ION, RNA (5'-R(*AP*CP*AP*CP*AP*GP*AP*GP*AP*CP*GP*CP*CP*CP*AP*GP*AP*UP*GP*A*)-3'), RNA (5'-R(*GP*AP*UP*CP*UP*GP*GP*GP*CP*GP*GP*UP*CP*UP*UP*UP*GP*UP*GP*U*)-3'), ... | Authors: | Williams, H.M, Thorkelsson, S.R, Vogel, D, Milewski, M, Busch, C, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M. | Deposit date: | 2022-08-19 | Release date: | 2023-01-18 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein. Nucleic Acids Res., 51, 2023
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8ASB
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![BU of 8asb by Molmil](/molmil-images/mine/8asb) | Structure of the SFTSV L protein stalled at early elongation with the endonuclease domain in a raised conformation [EARLY-ELONGATION-ENDO] | Descriptor: | 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, MAGNESIUM ION, RNA (5'-R(*AP*CP*AP*CP*AP*GP*AP*GP*AP*CP*GP*CP*CP*CP*AP*GP*A)-3'), ... | Authors: | Williams, H.M, Thorkelsson, S.R, Vogel, D, Milewski, M, Busch, C, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M. | Deposit date: | 2022-08-18 | Release date: | 2023-01-18 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein. Nucleic Acids Res., 51, 2023
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8AS7
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![BU of 8as7 by Molmil](/molmil-images/mine/8as7) | Structure of the SFTSV L protein stalled at early elongation [EARLY-ELONGATION] | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, MAGNESIUM ION, ... | Authors: | Williams, H.M, Thorkelsson, S.R, Vogel, D, Milewski, M, Busch, C, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M. | Deposit date: | 2022-08-18 | Release date: | 2023-01-18 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein. Nucleic Acids Res., 51, 2023
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8D5V
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![BU of 8d5v by Molmil](/molmil-images/mine/8d5v) | WhiB6 bound to the SigmaAr4-RNAP Beta flap tip chimera | Descriptor: | IRON/SULFUR CLUSTER, Probable transcriptional regulator WhiB6, RNA polymerase sigma factor SigA,DNA-directed RNA polymerase subunit beta | Authors: | Wan, T, Zhang, L.M. | Deposit date: | 2022-06-06 | Release date: | 2023-06-14 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of WhiB6 and SigA4-betaTip complex To Be Published
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4KRE
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![BU of 4kre by Molmil](/molmil-images/mine/4kre) | |
4KXT
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7CYQ
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![BU of 7cyq by Molmil](/molmil-images/mine/7cyq) | Cryo-EM structure of an extended SARS-CoV-2 replication and transcription complex reveals an intermediate state in cap synthesis | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Helicase, MAGNESIUM ION, ... | Authors: | Yan, L, Ge, J, Zheng, L, Zhang, Y, Gao, Y, Wang, T, Wang, H, Huang, Y, Li, M, Wang, Q, Rao, Z, Lou, Z. | Deposit date: | 2020-09-04 | Release date: | 2020-12-09 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.83 Å) | Cite: | Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis. Cell, 184, 2021
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6G0R
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![BU of 6g0r by Molmil](/molmil-images/mine/6g0r) | Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated POLR2A peptide (K775ac/K778ac) | Descriptor: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, DNA-directed RNA polymerase II subunit RPB1 | Authors: | Filippakopoulos, P, Picaud, S, Pike, A.C.W, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C. | Deposit date: | 2018-03-19 | Release date: | 2018-11-28 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains. Mol. Cell, 73, 2019
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6XYA
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![BU of 6xya by Molmil](/molmil-images/mine/6xya) | Cap-binding domain of SFTSV L protein | Descriptor: | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, RNA-dependent RNA polymerase, SODIUM ION | Authors: | Gogrefe, N, Guenther, S, Rosenthal, M. | Deposit date: | 2020-01-30 | Release date: | 2020-04-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Structural and functional characterization of the severe fever with thrombocytopenia syndrome virus L protein. Nucleic Acids Res., 48, 2020
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4ES5
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![BU of 4es5 by Molmil](/molmil-images/mine/4es5) | |
8BY6
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![BU of 8by6 by Molmil](/molmil-images/mine/8by6) | Structure of the human nuclear cap-binding complex bound to NCBP3(560-620) and cap-analogue m7GpppG | Descriptor: | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, Nuclear cap-binding protein subunit 1, Nuclear cap-binding protein subunit 2, ... | Authors: | Dubiez, E, Pellegrini, E, Foucher, A.E, Cusack, S, Kadlec, J. | Deposit date: | 2022-12-12 | Release date: | 2024-01-24 | Last modified: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (3.19 Å) | Cite: | Structural basis for competitive binding of productive and degradative co-transcriptional effectors to the nuclear cap-binding complex. Cell Rep, 43, 2024
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5A53
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![BU of 5a53 by Molmil](/molmil-images/mine/5a53) | Crystal Structure of the Rpf2-Rrs1 complex | Descriptor: | REGULATOR OF RIBOSOME BIOSYNTHESIS, RIBOSOME BIOGENESIS PROTEIN RPF2, SULFATE ION | Authors: | Madru, C, Lebaron, S, Blaud, M, Delbos, L, Rety, S, Leulliot, N. | Deposit date: | 2015-06-16 | Release date: | 2015-10-21 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.401 Å) | Cite: | Chaperoning 5S RNA Assembly. Genes Dev., 29, 2015
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