3DC8
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7XE7
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![BU of 7xe7 by Molmil](/molmil-images/mine/7xe7) | T4 lysozyme mutant-S44C/C54T/N68C/A93C/C97A/T115C, pH10 | Descriptor: | Endolysin, GLYCEROL, HEXANE-1,6-DIOL | Authors: | Tamada, T, Hiromoto, T. | Deposit date: | 2022-03-30 | Release date: | 2023-03-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Creation of Cross-Linked Crystals With Intermolecular Disulfide Bonds Connecting Symmetry-Related Molecules Allows Retention of Tertiary Structure in Different Solvent Conditions. Front Mol Biosci, 9, 2022
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4N7Q
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![BU of 4n7q by Molmil](/molmil-images/mine/4n7q) | Crystal structure of eukaryotic THIC from A. thaliana | Descriptor: | COBALT (II) ION, HEXANE-1,6-DIOL, Phosphomethylpyrimidine synthase, ... | Authors: | Coquille, S.C, Roux, C, Mehta, A, Begley, T.P, Fitzpatrick, T.B, Thore, S. | Deposit date: | 2013-10-16 | Release date: | 2013-11-13 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | High-resolution crystal structure of the eukaryotic HMP-P synthase (THIC) from Arabidopsis thaliana. J.Struct.Biol., 184, 2013
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7XE9
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![BU of 7xe9 by Molmil](/molmil-images/mine/7xe9) | T4 lysozyme mutant-S44C/C54T/N68C/A93C/C97A/T115C, DMSO 20% | Descriptor: | CHLORIDE ION, DIMETHYL SULFOXIDE, Endolysin, ... | Authors: | Tamada, T, Hiromoto, T. | Deposit date: | 2022-03-30 | Release date: | 2023-03-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Creation of Cross-Linked Crystals With Intermolecular Disulfide Bonds Connecting Symmetry-Related Molecules Allows Retention of Tertiary Structure in Different Solvent Conditions. Front Mol Biosci, 9, 2022
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4RDV
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![BU of 4rdv by Molmil](/molmil-images/mine/4rdv) | The structure of N-formimino-L-Glutamate Iminohydrolase from Pseudomonas aeruginosa complexed with N-formimino-L-Aspartate | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, N-FORMIMINO-L-GLUTAMATE IMINOHYDROLASE, ... | Authors: | Fedorov, A.A, Fedorov, E.V, Marti-Arbona, R, Raushel, F.M, Almo, S.C. | Deposit date: | 2014-09-19 | Release date: | 2014-10-08 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | The structure of N-formimino-L-Glutamate Iminohydrolase from Pseudomonas aeruginosa complexed with N-formimino-L-Aspartate To be Published
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6I50
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7XE5
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![BU of 7xe5 by Molmil](/molmil-images/mine/7xe5) | T4 lysozyme mutant-S44C/C54T/N68C/A93C/C97A/T115C, pH4 | Descriptor: | Endolysin, GLYCEROL, HEXANE-1,6-DIOL, ... | Authors: | Tamada, T, Hiromoto, T. | Deposit date: | 2022-03-30 | Release date: | 2023-03-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Creation of Cross-Linked Crystals With Intermolecular Disulfide Bonds Connecting Symmetry-Related Molecules Allows Retention of Tertiary Structure in Different Solvent Conditions. Front Mol Biosci, 9, 2022
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3DAX
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![BU of 3dax by Molmil](/molmil-images/mine/3dax) | Crystal structure of human CYP7A1 | Descriptor: | Cytochrome P450 7A1, PROTOPORPHYRIN IX CONTAINING FE, UNKNOWN ATOM OR ION | Authors: | Strushkevich, N.V, Tempel, W, Dombrovski, L, Dong, A, Loppnau, P, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Wilkstrom, M, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2008-05-30 | Release date: | 2008-08-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Crystal structure of human CYP7A1 To be Published
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2X8H
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![BU of 2x8h by Molmil](/molmil-images/mine/2x8h) | Thioredoxin glutathione reductase from Schistosoma mansoni in complex with GSH | Descriptor: | BETA-MERCAPTOETHANOL, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Angelucci, F, Dimastrogiovanni, D, Boumis, G, Brunori, M, Miele, A.E, Saccoccia, F, Bellelli, A. | Deposit date: | 2010-03-09 | Release date: | 2010-07-21 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Mapping the Catalytic Cycle of Schistosoma Mansoni Thioredoxin Glutathione Reductase by X-Ray Crystallography J.Biol.Chem., 285, 2010
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6CP4
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![BU of 6cp4 by Molmil](/molmil-images/mine/6cp4) | P450CAM D251N MUTANT | Descriptor: | CAMPHOR, CYTOCHROME P450CAM, GLYCEROL, ... | Authors: | Li, H, Poulos, T.L. | Deposit date: | 1998-05-28 | Release date: | 1998-09-16 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Understanding the role of the essential Asp251 in cytochrome p450cam using site-directed mutagenesis, crystallography, and kinetic solvent isotope effect. Biochemistry, 37, 1998
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3DFY
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![BU of 3dfy by Molmil](/molmil-images/mine/3dfy) | Crystal structure of apo dipeptide epimerase from Thermotoga maritima | Descriptor: | MAGNESIUM ION, Muconate cycloisomerase | Authors: | Fedorov, A.A, Fedorov, E.V, Imker, H.J, Gerlt, J.A, Almo, S.C. | Deposit date: | 2008-06-12 | Release date: | 2008-11-25 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Discovery of a dipeptide epimerase enzymatic function guided by homology modeling and virtual screening. Structure, 16, 2008
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5WMU
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![BU of 5wmu by Molmil](/molmil-images/mine/5wmu) | Structural Insights into Substrate and Inhibitor Binding Sites in Human Indoleamine 2,3-Dioxygenase I | Descriptor: | CYANIDE ION, Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Lewis-Ballester, A, Yeh, S.R, Pham, K.N, Batabyal, D, Karkashon, S, Bonanno, J.B, Poulos, T.L. | Deposit date: | 2017-07-31 | Release date: | 2017-12-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 1. Nat Commun, 8, 2017
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3DHP
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![BU of 3dhp by Molmil](/molmil-images/mine/3dhp) | Probing the role of aromatic residues at the secondary saccharide binding sites of human salivary alpha-amylase in substrate hydrolysis and bacterial binding | Descriptor: | 4-amino-4,6-dideoxy-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, 5-HYDROXYMETHYL-CHONDURITOL, Alpha-amylase 1, ... | Authors: | Ragunath, C, Manuel, S.G.A, Sait, H.M, Kasinathan, C. | Deposit date: | 2008-06-18 | Release date: | 2008-07-01 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Probing the role of aromatic residues To be Published
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3HHY
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![BU of 3hhy by Molmil](/molmil-images/mine/3hhy) | Crystal structure determination of Catechol 1,2-Dioxygenase from Rhodococcus opacus 1CP in complex with catechol | Descriptor: | (4S,7R)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, CATECHOL, CHLORIDE ION, ... | Authors: | Matera, I, Ferraroni, M, Kolomytseva, M, Briganti, F, Scozzafava, A. | Deposit date: | 2009-05-18 | Release date: | 2010-01-12 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Catechol 1,2-dioxygenase from the Gram-positive Rhodococcus opacus 1CP: Quantitative structure/activity relationship and the crystal structures of native enzyme and catechols adducts. J.Struct.Biol., 170, 2010
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5WN8
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![BU of 5wn8 by Molmil](/molmil-images/mine/5wn8) | Structural Insights into Substrate and Inhibitor Binding Sites in Human Indoleamine 2,3-Dioxygenase 1 | Descriptor: | Indoleamine 2,3-dioxygenase 1, N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-{[2-(sulfamoylamino)ethyl]amino}-1,2,5-oxadiazole-3-carboximidamide, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Lewis-Ballester, A, Pham, K.N, Batabyal, D, Karkashon, S, Bonanno, J.B, Poulos, T.L, Yeh, S.R. | Deposit date: | 2017-07-31 | Release date: | 2017-12-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 1. Nat Commun, 8, 2017
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7XDG
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![BU of 7xdg by Molmil](/molmil-images/mine/7xdg) | Cryo-EM structures of human mitochondrial NAD(P)+-dependent malic enzyme in a ternary complex with NAD+ and allosteric inhibitor MDSA | Descriptor: | 5-[(3-carboxy-4-oxidanyl-phenyl)methyl]-2-oxidanyl-benzoic acid, NAD-dependent malic enzyme, mitochondrial, ... | Authors: | Wang, C.H, Hsieh, J.T, Ho, M.C, Hung, H.C. | Deposit date: | 2022-03-27 | Release date: | 2023-03-29 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (2.84 Å) | Cite: | Suppression of the human malic enzyme 2 modifies energy metabolism and inhibits cellular respiration Commun Biol, 6, 2023
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6E58
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![BU of 6e58 by Molmil](/molmil-images/mine/6e58) | Crystal structure of Streptococcus pyogenes endo-beta-N-acetylglucosaminidase (EndoS2) | Descriptor: | CALCIUM ION, Secreted Endo-beta-N-acetylglucosaminidase (EndoS) | Authors: | Klontz, E.H, Trastoy, B, Gunther, S, Guerin, M.E, Sundberg, E.J. | Deposit date: | 2018-07-19 | Release date: | 2019-02-06 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Molecular Basis of Broad SpectrumN-Glycan Specificity and Processing of Therapeutic IgG Monoclonal Antibodies by Endoglycosidase S2. ACS Cent Sci, 5, 2019
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6EQ2
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![BU of 6eq2 by Molmil](/molmil-images/mine/6eq2) | MTH1 in complex with fragment 6 | Descriptor: | 1~{H}-imidazo[4,5-b]pyridin-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase | Authors: | Wiedmer, L, Sledz, P, Caflisch, A. | Deposit date: | 2017-10-12 | Release date: | 2018-10-31 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.802 Å) | Cite: | Ligand retargeting by binding site analogy. Eur.J.Med.Chem., 175, 2019
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4QWT
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6EQ7
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![BU of 6eq7 by Molmil](/molmil-images/mine/6eq7) | MTH1 in complex with fragment 11 | Descriptor: | 7,8-dihydro-8-oxoguanine triphosphatase, 7-(3-fluoranylpyridin-4-yl)-1~{H}-imidazo[4,5-b]pyridin-2-amine, SULFATE ION | Authors: | Wiedmer, L, Sledz, P, Caflisch, A. | Deposit date: | 2017-10-12 | Release date: | 2018-10-31 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Ligand retargeting by binding site analogy. Eur.J.Med.Chem., 175, 2019
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5W7C
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![BU of 5w7c by Molmil](/molmil-images/mine/5w7c) | Human acyloxyacyl hydrolase (AOAH), proteolytically processed, S263A mutant, with LPS | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-HYDROXY-TETRADECANOIC ACID, ... | Authors: | Gorelik, A, Illes, K, Nagar, B. | Deposit date: | 2017-06-19 | Release date: | 2018-01-03 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | Crystal structure of the mammalian lipopolysaccharide detoxifier. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6IAO
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![BU of 6iao by Molmil](/molmil-images/mine/6iao) | Structure of Cytochrome P450 BM3 M11 mutant in complex with DTT at resolution 2.16A | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Bifunctional cytochrome P450/NADPH--P450 reductase, CHLORIDE ION, ... | Authors: | Mirza, O, Rafiq, M, Frydenvang, K. | Deposit date: | 2018-11-27 | Release date: | 2019-06-05 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | Structural analysis of Cytochrome P450 BM3 mutant M11 in complex with dithiothreitol. Plos One, 14, 2019
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2WU5
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![BU of 2wu5 by Molmil](/molmil-images/mine/2wu5) | Crystal structure of the E. coli succinate:quinone oxidoreductase (SQR) SdhD His71Met mutant | Descriptor: | 2-METHYL-N-PHENYL-5,6-DIHYDRO-1,4-OXATHIINE-3-CARBOXAMIDE, FE2/S2 (INORGANIC) CLUSTER, FE3-S4 CLUSTER, ... | Authors: | Ruprecht, J, Yankovskaya, V, Maklashina, E, Iwata, S, Cecchini, G. | Deposit date: | 2009-09-29 | Release date: | 2010-08-25 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.803 Å) | Cite: | Crystal Structure of the E. Coli Succinate:Quinone Oxidoreductase (Sqr) Sdhd His71met Mutant To be Published
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3HF8
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![BU of 3hf8 by Molmil](/molmil-images/mine/3hf8) | Crystal structure of human tryoptophan hydroxylase type 1 with bound LP-533401 and Fe | Descriptor: | 4-{2-amino-6-[(1R)-2,2,2-trifluoro-1-(3'-fluorobiphenyl-4-yl)ethoxy]pyrimidin-4-yl}-L-phenylalanine, FE (III) ION, Tryptophan 5-hydroxylase 1 | Authors: | Tari, L.W, Swanson, R.V, Hunter, M.J. | Deposit date: | 2009-05-11 | Release date: | 2010-04-21 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Mechanism of Inhibition of Novel Tryptophan Hydroxylase Inhibitors Revealed by Co-crystal Structures and Kinetic Analysis. Curr Chem Genomics, 4, 2010
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3DKQ
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