4P1X
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4p1x by Molmil](/molmil-images/mine/4p1x) | Crystal structure of staphylococcal LUK prepore | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Gamma-hemolysin component B, Gamma-hemolysin component C | Authors: | Yamashita, D, Tanaka, Y, Tanaka, I, Yao, M. | Deposit date: | 2014-02-28 | Release date: | 2014-10-01 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Molecular basis of transmembrane beta-barrel formation of staphylococcal pore-forming toxins. Nat Commun, 5, 2014
|
|
4U6V
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4u6v by Molmil](/molmil-images/mine/4u6v) | Mechanisms of Neutralization of a Human Anti-Alpha Toxin Antibody | Descriptor: | Alpha-hemolysin, Fab, antigen binding fragment, ... | Authors: | Oganesyan, V.Y, Peng, L, Damschroder, M.M, Cheng, L, Sadowska, A, Tkaczyk, C, Sellman, B, Wu, H, Dall'Acqua, W.F. | Deposit date: | 2014-07-29 | Release date: | 2014-09-17 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.56 Å) | Cite: | Mechanisms of Neutralization of a Human Anti-alpha-toxin Antibody. J.Biol.Chem., 289, 2014
|
|
6U3F
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6u3f by Molmil](/molmil-images/mine/6u3f) | Structure-based discovery of a novel small-molecule inhibitor of methicillin-resistant S. aureus | Descriptor: | Panton-Valentine Leucocidin F, SULFATE ION, fos-choline-14 | Authors: | Liu, J, Kozhaya, L, Torres, V.J, Unutmaz, D, Lu, M. | Deposit date: | 2019-08-21 | Release date: | 2020-03-25 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Structure-based discovery of a small-molecule inhibitor of methicillin-resistantStaphylococcus aureusvirulence. J.Biol.Chem., 295, 2020
|
|
6U2S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6u2s by Molmil](/molmil-images/mine/6u2s) | Structure-based discovery of a novel small-molecule inhibitor of methicillin-resistant S. aureus | Descriptor: | Bi-component leukocidin LukED subunit D, fos-choline-14 | Authors: | Liu, J, Kozhaya, L, Torres, V.J, Unutmaz, D, Lu, M. | Deposit date: | 2019-08-20 | Release date: | 2020-03-25 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structure-based discovery of a small-molecule inhibitor of methicillin-resistantStaphylococcus aureusvirulence. J.Biol.Chem., 295, 2020
|
|
6U33
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6u33 by Molmil](/molmil-images/mine/6u33) | Structure-based discovery of a novel small-molecule inhibitor of methicillin-resistant S. aureus | Descriptor: | Bi-component leukocidin LukED subunit D, NICKEL (II) ION | Authors: | Liu, J, Kozhaya, L, Torres, V.J, Unutmaz, D, Lu, M. | Deposit date: | 2019-08-21 | Release date: | 2020-03-25 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structure-based discovery of a small-molecule inhibitor of methicillin-resistantStaphylococcus aureusvirulence. J.Biol.Chem., 295, 2020
|
|
6U3T
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6u3t by Molmil](/molmil-images/mine/6u3t) | Structure-based discovery of a novel small-molecule inhibitor of methicillin-resistant S. aureus | Descriptor: | Alpha-hemolysin, SULFATE ION, fos-choline-14 | Authors: | Liu, J, Kozhaya, L, Torres, V.J, Unutmaz, D, Lu, M. | Deposit date: | 2019-08-22 | Release date: | 2020-03-25 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.79 Å) | Cite: | Structure-based discovery of a small-molecule inhibitor of methicillin-resistantStaphylococcus aureusvirulence. J.Biol.Chem., 295, 2020
|
|
6U4P
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6u4p by Molmil](/molmil-images/mine/6u4p) | Structure-based discovery of a novel small-molecule inhibitor of methicillin-resistant S. aureus | Descriptor: | Alpha-hemolysin, SULFATE ION, fos-choline-14 | Authors: | Liu, J, Kozhaya, L, Torres, V.J, Unutmaz, D, Lu, M. | Deposit date: | 2019-08-26 | Release date: | 2020-03-25 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Structure-based discovery of a small-molecule inhibitor of methicillin-resistantStaphylococcus aureusvirulence. J.Biol.Chem., 295, 2020
|
|
7P8X
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7p8x by Molmil](/molmil-images/mine/7p8x) | Crystal Structure of leukotoxin LukE from Staphylococcus aureus in complex with a doubly sulfated CCR2 N-terminal peptide | Descriptor: | C-C chemokine receptor type 2, IMIDAZOLE, Leucotoxin LukEv, ... | Authors: | Lambey, P, Hoh, F, Peysson, F, Granier, S, Leyrat, C. | Deposit date: | 2021-07-23 | Release date: | 2022-04-06 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structural insights into recognition of chemokine receptors by Staphylococcus aureus leukotoxins. Elife, 11, 2022
|
|
7P8U
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7p8u by Molmil](/molmil-images/mine/7p8u) | Crystal Structure of leukotoxin LukE from Staphylococcus aureus in complex with p-cresyl sulfate | Descriptor: | (4-methylphenyl) hydrogen sulfate, DI(HYDROXYETHYL)ETHER, IMIDAZOLE, ... | Authors: | Lambey, P, Hoh, F, Peysson, F, Granier, S, Leyrat, C. | Deposit date: | 2021-07-23 | Release date: | 2022-04-06 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural insights into recognition of chemokine receptors by Staphylococcus aureus leukotoxins. Elife, 11, 2022
|
|
7P93
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7p93 by Molmil](/molmil-images/mine/7p93) | Crystal Structure of leukotoxin LukE from Staphylococcus aureus in complex with a sulfated ACKR1 N-terminal peptide | Descriptor: | Atypical chemokine receptor 1, Leucotoxin LukEv | Authors: | Lambey, P, Hoh, F, Peysson, F, Granier, S, Leyrat, C. | Deposit date: | 2021-07-23 | Release date: | 2022-04-06 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structural insights into recognition of chemokine receptors by Staphylococcus aureus leukotoxins. Elife, 11, 2022
|
|
7P8S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7p8s by Molmil](/molmil-images/mine/7p8s) | Crystal Structure of leukotoxin LukE from Staphylococcus aureus at 1.9 Angstrom resolution | Descriptor: | (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, HEXAETHYLENE GLYCOL, Leucotoxin LukEv, ... | Authors: | Lambey, P, Hoh, F, Granier, S, Leyrat, C. | Deposit date: | 2021-07-23 | Release date: | 2022-04-06 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural insights into recognition of chemokine receptors by Staphylococcus aureus leukotoxins. Elife, 11, 2022
|
|
7P8T
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7p8t by Molmil](/molmil-images/mine/7p8t) | Crystal Structure of leukotoxin LukE from Staphylococcus aureus at 1.5 Angstrom resolution | Descriptor: | CHLORIDE ION, Leucotoxin LukEv | Authors: | Lambey, P, Hoh, F, Granier, S, Leyrat, C. | Deposit date: | 2021-07-23 | Release date: | 2022-04-06 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.459 Å) | Cite: | Structural insights into recognition of chemokine receptors by Staphylococcus aureus leukotoxins. Elife, 11, 2022
|
|
7Q9Y
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7q9y by Molmil](/molmil-images/mine/7q9y) | |
4IYC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4iyc by Molmil](/molmil-images/mine/4iyc) | Structure of the T244A mutant of the PANTON-VALENTINE LEUCOCIDIN component from STAPHYLOCOCCUS AUREUS | Descriptor: | LukS-PV | Authors: | Maveyraud, L, Guerin, F, Lavnetie, B.J, Prevost, G, Mourey, L. | Deposit date: | 2013-01-28 | Release date: | 2014-01-29 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Residues essential for panton-valentine leukocidin s component binding to its cell receptor suggest both plasticity and adaptability in its interaction surface Plos One, 9, 2014
|
|
4IYA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4iya by Molmil](/molmil-images/mine/4iya) | Structure of the Y250A mutant of the PANTON-VALENTINE LEUCOCIDIN S component from STAPHYLOCOCCUS AUREUS | Descriptor: | 1,2-ETHANEDIOL, CITRATE ANION, LukS-PV | Authors: | Maveyraud, L, Guerin, F, Laventie, B.J, Prevost, G, Mourey, L. | Deposit date: | 2013-01-28 | Release date: | 2014-01-29 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Residues essential for panton-valentine leukocidin s component binding to its cell receptor suggest both plasticity and adaptability in its interaction surface Plos One, 9, 2014
|
|
4IZL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4izl by Molmil](/molmil-images/mine/4izl) | |
4I0N
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4i0n by Molmil](/molmil-images/mine/4i0n) | Pore forming protein | Descriptor: | 1,2-ETHANEDIOL, MAGNESIUM ION, Necrotic enteritis toxin B | Authors: | Yan, X, Porter, C.J, Hardy, S.P, Steer, D, Smith, A.I, Quinset, N, Hughes, V, Cheung, J.K, Keyburn, A.L, Kaldhusdal, M, Moore, R.J, Bannam, T.L, Whisstock, J.C, Rood, J.I. | Deposit date: | 2012-11-16 | Release date: | 2013-03-20 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural and functional analysis of the pore-forming toxin NetB from Clostridium perfringens MBio, 4, 2013
|
|
4H56
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4h56 by Molmil](/molmil-images/mine/4h56) | Crystal structure of the Clostridium perfringens NetB toxin in the membrane inserted form | Descriptor: | Necrotic enteritis toxin B | Authors: | Savva, C.G, Fernandes da Costa, S.P, Bokori-Brown, M, Naylor, C, Cole, A.R, Moss, D.S, Titball, R.W, Basak, A.K. | Deposit date: | 2012-09-18 | Release date: | 2012-12-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.9 Å) | Cite: | Molecular Architecture and Functional Analysis of NetB, a Pore-forming Toxin from Clostridium perfringens. J.Biol.Chem., 288, 2013
|
|
4IDJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4idj by Molmil](/molmil-images/mine/4idj) | S.Aureus a-hemolysin monomer in complex with Fab | Descriptor: | Alpha-hemolysin, Fab Heavy chain, Fab Light chain, ... | Authors: | Strop, P. | Deposit date: | 2012-12-12 | Release date: | 2013-06-26 | Last modified: | 2021-05-26 | Method: | X-RAY DIFFRACTION (3.36 Å) | Cite: | Mechanism of Action and In Vivo Efficacy of a Human-Derived Antibody against Staphylococcus aureus alpha-Hemolysin. J.Mol.Biol., 425, 2013
|
|
4J0O
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4j0o by Molmil](/molmil-images/mine/4j0o) | |
4IYT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4iyt by Molmil](/molmil-images/mine/4iyt) | Structure Of The Y184A Mutant Of The PANTON-VALENTINE LEUCOCIDIN S Component From STAPHYLOCOCCUS AUREUS | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, LukS-PV | Authors: | Guerin, F, Laventie, B.J, Prevost, G, Mourey, L, Maveyraud, L. | Deposit date: | 2013-01-29 | Release date: | 2014-01-29 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Residues essential for panton-valentine leukocidin s component binding to its cell receptor suggest both plasticity and adaptability in its interaction surface Plos One, 9, 2014
|
|
1XEZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1xez by Molmil](/molmil-images/mine/1xez) | |
7YL9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7yl9 by Molmil](/molmil-images/mine/7yl9) | Cryo-EM structure of complete transmembrane channel E289A mutant Vibrio cholerae Cytolysin | Descriptor: | Hemolysin | Authors: | Mondal, A.K, Sengupta, N, Singh, M, Biswas, R, Lata, K, Lahiri, I, Dutta, S, Chattopadhyay, K. | Deposit date: | 2022-07-25 | Release date: | 2022-08-31 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Cryo-EM structure of complete transmembrane channel E289A mutant Vibrio cholerae Cytolysin J.Biol.Chem.
|
|
3O44
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3o44 by Molmil](/molmil-images/mine/3o44) | |
7O1Q
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7o1q by Molmil](/molmil-images/mine/7o1q) | Amyloid beta oligomer displayed on the alpha hemolysin scaffold | Descriptor: | Alpha-hemolysin hybridized Abeta | Authors: | Wu, J, Blum, T.B, Farrell, D.P, DiMaio, F, Abrahams, J.P, Luo, J. | Deposit date: | 2021-03-30 | Release date: | 2021-04-14 | Last modified: | 2021-08-18 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-electron Microscopy Imaging of Alzheimer's Amyloid-beta 42 Oligomer Displayed on a Functionally and Structurally Relevant Scaffold. Angew.Chem.Int.Ed.Engl., 60, 2021
|
|