7ZJW
| Rabbit 80S ribosome as it decodes the Sec-UGA codon | Descriptor: | 18S rRNA, 28S rRNA, 40S Ribosomal protein eS19, ... | Authors: | Hilal, T, Simonovic, M, Spahn, C.M.T. | Deposit date: | 2022-04-12 | Release date: | 2022-10-19 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structure of the mammalian ribosome as it decodes the selenocysteine UGA codon. Science, 376, 2022
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1TUI
| INTACT ELONGATION FACTOR TU IN COMPLEX WITH GDP | Descriptor: | ELONGATION FACTOR TU, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | Authors: | Polekhina, G, Thirup, S, Kjeldgaard, M, Nissen, P, Lippmann, C, Nyborg, J. | Deposit date: | 1996-05-23 | Release date: | 1997-06-05 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Helix unwinding in the effector region of elongation factor EF-Tu-GDP. Structure, 4, 1996
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1TTT
| Phe-tRNA, elongation factoR EF-TU:GDPNP ternary complex | Descriptor: | MAGNESIUM ION, OF ELONGATION FACTOR TU (EF-TU), PHENYLALANINE, ... | Authors: | Nissen, P, Kjeldgaard, M, Thirup, S, Polekhina, G, Reshetnikova, L, Clark, B.F.C, Nyborg, J. | Deposit date: | 1995-11-16 | Release date: | 1996-12-23 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of the ternary complex of Phe-tRNAPhe, EF-Tu, and a GTP analog. Science, 270, 1995
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8BSI
| Giardia ribosome chimeric hybrid-like GDP+Pi bound state (B1) | Descriptor: | 40S ribosomal protein S21, 40S ribosomal protein S25, 40S ribosomal protein S26, ... | Authors: | Majumdar, S, Emmerich, A.G, Sanyal, S. | Deposit date: | 2022-11-25 | Release date: | 2023-03-15 | Last modified: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Insights into translocation mechanism and ribosome evolution from cryo-EM structures of translocation intermediates of Giardia intestinalis. Nucleic Acids Res., 51, 2023
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4FN5
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6D9J
| Mammalian 80S ribosome with a double translocated CrPV-IRES, P-sitetRNA and eRF1. | Descriptor: | 18S rRNA, 28S rRNA, 5.8S rRNA, ... | Authors: | Pisareva, V.P, Pisarev, A.V, Fernandez, I.S. | Deposit date: | 2018-04-30 | Release date: | 2018-06-06 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Dual tRNA mimicry in the Cricket Paralysis Virus IRES uncovers an unexpected similarity with the Hepatitis C Virus IRES. Elife, 7, 2018
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2H5E
| Crystal structure of E.coli polypeptide release factor RF3 | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Peptide chain release factor RF-3 | Authors: | Song, H.W, Zhou, Z.H. | Deposit date: | 2006-05-26 | Release date: | 2007-05-15 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | RF3 induces ribosomal conformational changes responsible for dissociation of class I release factors Cell(Cambridge,Mass.), 129, 2007
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2HDN
| Trypsin-modified Elongation Factor Tu in complex with tetracycline at 2.8 Angstrom resolution | Descriptor: | Elongation factor EF-Tu, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Mui, S, Heffron, S.E, Aorora, A, Abel, K, Bergmann, E, Jurnak, F. | Deposit date: | 2006-06-20 | Release date: | 2006-10-31 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Molecular complementarity between tetracycline and the GTPase active site of elongation factor Tu. Acta Crystallogr.,Sect.D, 62, 2006
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2HCJ
| Trypsin-modified Elongation Factor Tu in complex with tetracycline | Descriptor: | GLYOXYLIC ACID, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Mui, S, Heffron, S.E, Aorora, A, Abel, K, Bergmann, E, Jurnak, F. | Deposit date: | 2006-06-16 | Release date: | 2006-10-31 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | Molecular complementarity between tetracycline and the GTPase active site of elongation factor Tu. Acta Crystallogr.,Sect.D, 62, 2006
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1SKQ
| The crystal structure of Sulfolobus solfataricus elongation factor 1-alpha in complex with magnesium and GDP | Descriptor: | Elongation factor 1-alpha, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | Authors: | Vitagliano, L, Ruggiero, A, Masullo, M, Cantiello, P, Arcari, P, Zagari, A. | Deposit date: | 2004-03-05 | Release date: | 2004-07-20 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The crystal structure of Sulfolobus solfataricus elongation factor 1alpha in complex with magnesium and GDP. Biochemistry, 43, 2004
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4C0S
| Mammalian translation elongation factor eEF1A2 | Descriptor: | ELONGATION FACTOR 1-ALPHA 2, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | Authors: | Crepin, T, Shalak, V.F, Yaremchuk, A.D, Vlasenko, D.O, McCarthy, A.A, Negrutskii, B.S, Tukalo, M.A, El'skaya, A.V. | Deposit date: | 2013-08-07 | Release date: | 2014-08-27 | Last modified: | 2017-01-25 | Method: | X-RAY DIFFRACTION (2.703 Å) | Cite: | Mammalian Translation Elongation Factor Eef1A2: X-Ray Structure and New Features of Gdp/GTP Exchange Mechanism in Higher Eukaryotes Nucleic Acids Res., 42, 2014
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4D61
| Cryo-EM structures of ribosomal 80S complexes with termination factors and cricket paralysis virus IRES reveal the IRES in the translocated state | Descriptor: | 18S RRNA, 40S RIBOSOMAL PROTEIN S10, 40S RIBOSOMAL PROTEIN S11, ... | Authors: | Muhs, M, Hilal, T, Mielke, T, Skabkin, M.A, Sanbonmatsu, K.Y, Pestova, T.V, Spahn, C.M.T. | Deposit date: | 2014-11-07 | Release date: | 2015-03-04 | Last modified: | 2017-08-30 | Method: | ELECTRON MICROSCOPY (9 Å) | Cite: | Cryo-Em of Ribosomal 80S Complexes with Termination Factors Reveals the Translocated Cricket Paralysis Virus Ires. Mol.Cell, 57, 2015
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4CXG
| Regulation of the mammalian elongation cycle by 40S subunit rolling: a eukaryotic-specific ribosome rearrangement | Descriptor: | 18S RRNA - H44, 18S RRNA - H5-H14, 18S RRNA - H8, ... | Authors: | Budkevich, T.V, Giesebrecht, J, Behrmann, E, Loerke, J, Ramrath, D.J.F, Mielke, T, Ismer, J, Hildebrand, P, Tung, C.-S, Nierhaus, K.H, Sanbonmatsu, K.Y, Spahn, C.M.T. | Deposit date: | 2014-04-07 | Release date: | 2014-07-16 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (8.7 Å) | Cite: | Regulation of the Mammalian Elongation Cycle by Subunit Rolling: A Eukaryotic-Specific Ribosome Rearrangement. Cell(Cambridge,Mass.), 158, 2014
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1N0U
| Crystal structure of yeast elongation factor 2 in complex with sordarin | Descriptor: | Elongation factor 2, [1R-(1.ALPHA.,3A.BETA.,4.BETA.,4A.BETA.,7.BETA.,7A.ALPHA.,8A.BETA.)]8A-[(6-DEOXY-4-O-METHYL-BETA-D-ALTROPYRANOSYLOXY)METHYL]-4-FORMYL-4,4A,5,6,7,7A,8,8A-OCTAHYDRO-7-METHYL-3-(1-METHYLETHYL)-1,4-METHANO-S-INDACENE-3A(1H)-CARBOXYLIC ACID | Authors: | Joergensen, R, Ortiz, P.A, Carr-Schmid, A, Nissen, P, Kinzy, T.G, Andersen, G.R. | Deposit date: | 2002-10-15 | Release date: | 2003-02-11 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | Two crystal structures demonstrate large conformational changes in the eukaryotic ribosomal translocase. Nat. Struct. Biol., 10, 2003
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1OB2
| E. coli elongation factor EF-Tu complexed with the antibiotic kirromycin, a GTP analog, and Phe-tRNA | Descriptor: | ELONGATION FACTOR TU, KIRROMYCIN, MAGNESIUM ION, ... | Authors: | Kristensen, O, Nissen, P, Nyborg, J. | Deposit date: | 2003-01-24 | Release date: | 2004-05-27 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.35 Å) | Cite: | Kirromycin Defines a Specific Domain Arrangement of Elongation Factor EF-TU To be Published
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1OB5
| T. aquaticus elongation factor EF-Tu complexed with the antibiotic enacyloxin IIa, a GTP analog, and Phe-tRNA | Descriptor: | ELONGATION FACTOR TU, ENACYLOXIN IIA, MAGNESIUM ION, ... | Authors: | Dahlberg, C, Nielsen, R.C, Parmeggiani, A, Nyborg, J, Nissen, P. | Deposit date: | 2003-01-24 | Release date: | 2005-10-13 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Enacyloxin Iia Pinpoints a Binding Pocket of Elongation Factor TU for Development of Novel Antibiotics. J.Biol.Chem., 281, 2006
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1QZD
| EF-Tu.kirromycin coordinates fitted into the cryo-EM map of EF-Tu ternary complex (GDP.Kirromycin) bound 70S ribosome | Descriptor: | Elongation factor Tu | Authors: | Valle, M, Zavialov, A, Li, W, Stagg, S.M, Sengupta, J, Nielsen, R.C, Nissen, P, Harvey, S.C, Ehrenberg, M, Frank, J. | Deposit date: | 2003-09-16 | Release date: | 2003-11-04 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (10 Å) | Cite: | Incorporation of Aminoacyl-tRNA into the Ribosome as seen by Cryo-electron Microscopy Nat.Struct.Biol., 10, 2003
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4CXH
| Regulation of the mammalian elongation cycle by 40S subunit rolling: a eukaryotic-specific ribosome rearrangement | Descriptor: | 18S RRNA - H44, 18S RRNA - H5-H14, 18S RRNA - H8, ... | Authors: | Budkevich, T.V, Giesebrecht, J, Behrmann, E, Loerke, J, Ramrath, D.J.F, Mielke, T, Ismer, J, Hildebrand, P, Tung, C.-S, Nierhaus, K.H, Sanbonmatsu, K.Y, Spahn, C.M.T. | Deposit date: | 2014-04-07 | Release date: | 2014-07-16 | Last modified: | 2019-06-26 | Method: | ELECTRON MICROSCOPY (8.9 Å) | Cite: | Regulation of the Mammalian Elongation Cycle by Subunit Rolling: A Eukaryotic-Specific Ribosome Rearrangement. Cell(Cambridge,Mass.), 158, 2014
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4CRN
| Cryo-EM of a pretermination complex with eRF1 and eRF3 | Descriptor: | ERF1 IN RIBOSOME-BOUND ERF1-ERF3-GDPNP COMPLEX, ERF3 IN RIBOSOME BOUND ERF1-ERF3-GDPNP COMPLEX, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | Authors: | Preis, A, Heuer, A, Barrio-Garcia, C, Hauser, A, Eyler, D, Berninghausen, O, Green, R, Becker, T, Beckmann, R. | Deposit date: | 2014-02-28 | Release date: | 2014-07-23 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (9.1 Å) | Cite: | Cryoelectron Microscopic Structures of Eukaryotic Translation Termination Complexes Containing Erf1-Erf3 or Erf1-Abce1. Cell Rep., 8, 2014
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1PN6
| Domain-wise fitting of the crystal structure of T.thermophilus EF-G into the low resolution map of the release complex.Puromycin.EFG.GDPNP of E.coli 70S ribosome. | Descriptor: | Elongation factor G | Authors: | Valle, M, Zavialov, A, Sengupta, J, Rawat, U, Ehrenberg, M, Frank, J. | Deposit date: | 2003-06-12 | Release date: | 2003-07-15 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (10.8 Å) | Cite: | Locking and Unlocking of Ribosomal Motions Cell(Cambridge,Mass.), 114, 2003
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8HL2
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6XK9
| Cereblon in complex with DDB1, CC-90009, and GSPT1 | Descriptor: | 2-(4-chlorophenyl)-N-({2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}methyl)-2,2-difluoroacetamide, DNA damage-binding protein 1, Eukaryotic peptide chain release factor GTP-binding subunit ERF3A, ... | Authors: | Clayton, T.L, Tran, E.T, Zhu, J, Pagarigan, B.E, Matyskiela, M.E, Chamberlain, P.P. | Deposit date: | 2020-06-25 | Release date: | 2020-12-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.64 Å) | Cite: | CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells. Blood, 137, 2021
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1FNM
| STRUCTURE OF THERMUS THERMOPHILUS EF-G H573A | Descriptor: | ELONGATION FACTOR G, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | Authors: | Laurberg, M, Kristensen, O, Martemyanov, K, Gudkov, A.T, Nagaev, I, Hughes, D, Liljas, A. | Deposit date: | 2000-08-22 | Release date: | 2000-11-22 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of a mutant EF-G reveals domain III and possibly the fusidic acid binding site. J.Mol.Biol., 303, 2000
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8HL4
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8H6E
| Cryo-EM structure of human exon-defined spliceosome in the late pre-B state. | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Zhang, W, Zhan, X, Zhang, X, Bai, R, Lei, J, Yan, C, Shi, Y. | Deposit date: | 2022-10-17 | Release date: | 2024-05-01 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural insights into human exon-defined spliceosome prior to activation. Cell Res., 34, 2024
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