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PDB: 394 results

6QEX
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BU of 6qex by Molmil
Nanodisc reconstituted human ABCB1 in complex with UIC2 fab and taxol
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ...
Authors:Alam, A, Locher, K.P.
Deposit date:2019-01-08
Release date:2019-02-27
Last modified:2021-06-02
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural insight into substrate and inhibitor discrimination by human P-glycoprotein.
Science, 363, 2019
6QV1
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BU of 6qv1 by Molmil
Structure of ATPgS-bound outward-facing TM287/288 in complex with nanobody Nb_TM1
Descriptor: ABC transporter, ATP-binding protein, MAGNESIUM ION, ...
Authors:Hutter, C.A.J, Huerlimann, L.M, Zimmermann, I, Egloff, P, Seeger, M.A.
Deposit date:2019-03-01
Release date:2019-05-29
Last modified:2019-06-05
Method:X-RAY DIFFRACTION (3.48 Å)
Cite:The extracellular gate shapes the energy profile of an ABC exporter.
Nat Commun, 10, 2019
6QV2
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BU of 6qv2 by Molmil
Structure of ATPgS-bound outward-facing TM287/288 in complex with nanobody Nb_TM#2
Descriptor: ABC transporter, ATP-binding protein, MAGNESIUM ION, ...
Authors:Hutter, C.A.J, Huerlimann, L.M, Zimmermann, I, Egloff, P, Seeger, M.A.
Deposit date:2019-03-01
Release date:2019-05-29
Last modified:2019-06-05
Method:X-RAY DIFFRACTION (4.23 Å)
Cite:The extracellular gate shapes the energy profile of an ABC exporter.
Nat Commun, 10, 2019
6QUZ
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BU of 6quz by Molmil
Structure of ATPgS-bound outward-facing TM287/288 in complex with sybody Sb_TM35
Descriptor: ABC transporter, ATP-binding protein, MAGNESIUM ION, ...
Authors:Hutter, C.A.J, Huerlimann, L.M, Zimmermann, I, Egloff, P, Seeger, M.A.
Deposit date:2019-03-01
Release date:2019-05-29
Last modified:2019-06-05
Method:X-RAY DIFFRACTION (3.21 Å)
Cite:The extracellular gate shapes the energy profile of an ABC exporter.
Nat Commun, 10, 2019
6QV0
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BU of 6qv0 by Molmil
Structure of ATP-bound outward-facing TM287/288 in complex with sybody Sb_TM35
Descriptor: ABC transporter, ATP-binding protein, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Hutter, C.A.J, Huerlimann, L.M, Zimmermann, I, Egloff, P, Seeger, M.A.
Deposit date:2019-03-01
Release date:2019-05-29
Last modified:2019-06-05
Method:X-RAY DIFFRACTION (3.12 Å)
Cite:The extracellular gate shapes the energy profile of an ABC exporter.
Nat Commun, 10, 2019
6RAH
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BU of 6rah by Molmil
Heterodimeric ABC exporter TmrAB in ATP-bound outward-facing open conformation
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Multidrug resistance ABC transporter ATP-binding and permease protein, ...
Authors:Thomas, C, Januliene, D, Mehdipour, A.R, Hofmann, S, Hummer, G, Moeller, A, Tampe, R.
Deposit date:2019-04-06
Release date:2019-07-31
Last modified:2024-10-09
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Conformation space of a heterodimeric ABC exporter under turnover conditions.
Nature, 571, 2019
6RAM
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BU of 6ram by Molmil
Heterodimeric ABC exporter TmrAB under turnover conditions in asymmetric unlocked return conformation with wider opened intracellular gate
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Thomas, C, Januliene, D, Mehdipour, A.R, Hofmann, S, Hummer, G, Moeller, A, Tampe, R.
Deposit date:2019-04-06
Release date:2019-07-31
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Conformation space of a heterodimeric ABC exporter under turnover conditions.
Nature, 571, 2019
6R72
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BU of 6r72 by Molmil
Crystal structure of BmrA-E504A in an outward-facing conformation
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Multidrug exporter ATP-binding cassette
Authors:Chaptal, V, Zampieri, V, Kilburg, A, Magnard, S, Falson, P.
Deposit date:2019-03-28
Release date:2020-05-06
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.95 Å)
Cite:Substrate-bound and substrate-free outward-facing structures of a multidrug ABC exporter.
Sci Adv, 8, 2022
8RQ4
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BU of 8rq4 by Molmil
Cryo-em structure of the rat Multidrug resistance-associated protein 2 (rMrp2) in complex with probenecid
Descriptor: 4-(dipropylsulfamoyl)benzoic acid, ATP-binding cassette sub-family C member 2, CHOLESTEROL HEMISUCCINATE
Authors:Mazza, T, Beis, K.
Deposit date:2024-01-17
Release date:2024-02-14
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.45 Å)
Cite:Structural basis for the modulation of MRP2 activity by phosphorylation and drugs.
Nat Commun, 15, 2024
8RQ3
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BU of 8rq3 by Molmil
Cryo-em structure of the rat Multidrug resistance-associated protein 2 (rMrp2) in an autoinhibited state (nucleotide-free)
Descriptor: ATP-binding cassette sub-family C member 2
Authors:Mazza, T, Beis, K.
Deposit date:2024-01-17
Release date:2024-02-14
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.21 Å)
Cite:Structural basis for the modulation of MRP2 activity by phosphorylation and drugs.
Nat Commun, 15, 2024
8SG4
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BU of 8sg4 by Molmil
E1435Q Ycf1 mutant in dephosphorylated state
Descriptor: Metal resistance protein YCF1
Authors:Khandelwal, N.K, Tomasiak, T.M.
Deposit date:2023-04-11
Release date:2024-03-06
Last modified:2024-09-18
Method:ELECTRON MICROSCOPY (3.11 Å)
Cite:Structural basis for autoinhibition by the dephosphorylated regulatory domain of Ycf1.
Nat Commun, 15, 2024
8T46
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BU of 8t46 by Molmil
Transporter associated with antigen processing (TAP) in the apo state
Descriptor: Antigen peptide transporter 1, Antigen peptide transporter 2
Authors:Lee, J, Oldham, M.L, Chen, J.
Deposit date:2023-06-08
Release date:2024-06-12
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Principles of peptide selection by the transporter associated with antigen processing.
Proc.Natl.Acad.Sci.USA, 121, 2024
8T1P
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BU of 8t1p by Molmil
Heterodimeric ABC transporter BmrCD in the occluded conformation bound to ADPVi: BmrCD_OC-ADPVi
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ADENOSINE-5'-TRIPHOSPHATE, ADP ORTHOVANADATE, ...
Authors:Tang, Q, Mchaourab, H.S.
Deposit date:2023-06-02
Release date:2023-11-15
Last modified:2023-11-22
Method:ELECTRON MICROSCOPY (2.96 Å)
Cite:Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter.
Nat Commun, 14, 2023
8SZC
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BU of 8szc by Molmil
Heterodimeric ABC transporter BmrCD in the inward-facing conformation bound to substrate and ATP: BmrCD_IF-1HT/ATP
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2'-(4-ETHOXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Tang, Q, Mchaourab, H.
Deposit date:2023-05-29
Release date:2023-11-15
Last modified:2023-11-22
Method:ELECTRON MICROSCOPY (3.06 Å)
Cite:Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter.
Nat Commun, 14, 2023
8T3K
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BU of 8t3k by Molmil
Heterodimeric ABC transporter BmrCD in the inward-facing conformation bound to ATP: BmrCD_IF-ATP2
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ADENOSINE-5'-TRIPHOSPHATE, Probable multidrug resistance ABC transporter ATP-binding/permease protein YheH, ...
Authors:Tang, Q, Mchaourab, H.
Deposit date:2023-06-07
Release date:2023-11-29
Method:ELECTRON MICROSCOPY (3.33 Å)
Cite:Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter.
Nat Commun, 14, 2023
8SX9
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BU of 8sx9 by Molmil
Inward-facing narrow conformation of bovine multidrug resistance protein 4 (MRP4) in MSP lipid nanodisc
Descriptor: Multidrug resistance-associated protein 4
Authors:Pourmal, S, Stroud, R.M.
Deposit date:2023-05-20
Release date:2024-01-17
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis of prostaglandin efflux by MRP4.
Nat.Struct.Mol.Biol., 31, 2024
8SX8
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BU of 8sx8 by Molmil
Bovine multidrug resistance protein 4 (MRP4) bound to prostaglandin E1 in MSP lipid nanodisc
Descriptor: 7-[(1R,3R)-3-hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopentyl]heptanoic acid, Multidrug resistance-associated protein 4
Authors:Pourmal, S, Stroud, R.M.
Deposit date:2023-05-20
Release date:2024-01-17
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural basis of prostaglandin efflux by MRP4.
Nat.Struct.Mol.Biol., 31, 2024
8SXB
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BU of 8sxb by Molmil
Bovine multidrug resistance protein 4 (MRP4) bound to prostaglandin E2 in MSP lipid nanodisc
Descriptor: (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid, Multidrug resistance-associated protein 4 isoform X1
Authors:Pourmal, S, Stroud, R.M.
Deposit date:2023-05-20
Release date:2024-01-17
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis of prostaglandin efflux by MRP4.
Nat.Struct.Mol.Biol., 31, 2024
8SX7
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BU of 8sx7 by Molmil
Bovine multidrug resistance protein 4 (MRP4) bound to DHEA-S in MSP lipid nanodisc
Descriptor: 17-oxoandrost-5-en-3beta-yl hydrogen sulfate, Multidrug resistance-associated protein 4
Authors:Pourmal, S, Stroud, R.M.
Deposit date:2023-05-20
Release date:2024-01-17
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structural basis of prostaglandin efflux by MRP4.
Nat.Struct.Mol.Biol., 31, 2024
8SWN
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BU of 8swn by Molmil
Bovine multidrug resistance protein 4 (MRP4) E1202Q mutant bound to ATP in MSP lipid nanodisc
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, ATP binding cassette subfamily C member 4, MAGNESIUM ION, ...
Authors:Pourmal, S, Stroud, R.M.
Deposit date:2023-05-19
Release date:2024-01-17
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis of prostaglandin efflux by MRP4.
Nat.Struct.Mol.Biol., 31, 2024
8SXA
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BU of 8sxa by Molmil
Inward-facing wide conformation of bovine multidrug resistance protein 4 (MRP4) in MSP lipid nanodisc
Descriptor: Multidrug resistance-associated protein 4
Authors:Pourmal, S, Stroud, R.M.
Deposit date:2023-05-20
Release date:2024-01-17
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis of prostaglandin efflux by MRP4.
Nat.Struct.Mol.Biol., 31, 2024
8SQ0
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BU of 8sq0 by Molmil
Cleaved Ycf1p Dimer in the IFwide-beta conformation
Descriptor: (1R)-2-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(pentadecanoyloxy)methyl]ethyl (12E)-hexadeca-9,12-dienoate, 2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL HEXADECANOATE, Metal resistance protein YCF1, ...
Authors:Bickers, S.C, Benlekbir, S, Rubinstein, J.L, Kanelis, V.
Deposit date:2023-05-04
Release date:2024-05-08
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure of a dimeric ABC transporter
To Be Published
8SQL
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BU of 8sql by Molmil
Cleaved Ycf1p Monomer in the Beta Conformation
Descriptor: Metal resistance protein YCF1, PHOSPHATIDYLETHANOLAMINE, Unknown peptide from Ycf1p R region
Authors:Bickers, S.C, Benlekbir, S, Rubinstein, J.L, Kanelis, V.
Deposit date:2023-05-04
Release date:2024-05-08
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Cleaved Ycf1p Monomer in the Beta Conformation
To Be Published
8SQM
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BU of 8sqm by Molmil
Cleaved Ycf1p Monomer in the IFwide-alpha conformation
Descriptor: (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate, Metal resistance protein YCF1, Unknown peptide from Ycf1p R region
Authors:Bickers, S.C, Benlekbir, S, Rubinstein, J.L, Kanelis, V.
Deposit date:2023-05-04
Release date:2024-05-08
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure of a dimeric ABC transporter
To Be Published
8QOE
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BU of 8qoe by Molmil
Inward-facing conformation of the ABC transporter BmrA
Descriptor: Multidrug resistance ABC transporter ATP-binding/permease protein BmrA
Authors:Di Cesare, M, Kaplan, E, Valimehr, S, Hanssen, E, Orelle, C, Jault, J.M.
Deposit date:2023-09-28
Release date:2023-12-20
Last modified:2024-01-24
Method:ELECTRON MICROSCOPY (3.16 Å)
Cite:The transport activity of the multidrug ABC transporter BmrA does not require a wide separation of the nucleotide-binding domains.
J.Biol.Chem., 300, 2023

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PDB entries from 2024-10-09

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