4ABH
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![BU of 4abh by Molmil](/molmil-images/mine/4abh) | Fragments bound to bovine trypsin for the SAMPL challenge | Descriptor: | 1,2-ETHANEDIOL, 1-(3-PYRROLIDIN-1-YLPHENYL)METHANAMINE, CALCIUM ION, ... | Authors: | Newman, J, Peat, T.S. | Deposit date: | 2011-12-08 | Release date: | 2012-02-08 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | The Dingo Dataset: A Comprehensive Set of Data for the Sampl Challenge. J.Comput.Aided Mol.Des., 26, 2012
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2AGG
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![BU of 2agg by Molmil](/molmil-images/mine/2agg) | succinyl-AAPK-trypsin acyl-enzyme at 1.28 A resolution | Descriptor: | CALCIUM ION, Cationic trypsin, SULFATE ION, ... | Authors: | Radisky, E.S, Lee, J.M, Lu, C.J, Koshland Jr, D.E. | Deposit date: | 2005-07-26 | Release date: | 2006-05-16 | Last modified: | 2024-04-24 | Method: | X-RAY DIFFRACTION (1.28 Å) | Cite: | Insights into the serine protease mechanism from atomic resolution structures of trypsin reaction intermediates Proc.Natl.Acad.Sci.USA, 103, 2006
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7BS3
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![BU of 7bs3 by Molmil](/molmil-images/mine/7bs3) | Bovine Pancreatic Trypsin with 4-Bromo-benzamidine (Cryo) | Descriptor: | 4-bromanylbenzenecarboximidamide, CALCIUM ION, Cationic trypsin, ... | Authors: | Maeki, M, Ito, S, Takeda, R, Funakubo, T, Ueno, G, Ishida, A, Tani, H, Yamamoto, M, Tokeshi, M. | Deposit date: | 2020-03-30 | Release date: | 2020-08-26 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.28 Å) | Cite: | Room-temperature crystallography using a microfluidic protein crystal array device and its application to protein-ligand complex structure analysis. Chem Sci, 11, 2020
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6MRQ
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![BU of 6mrq by Molmil](/molmil-images/mine/6mrq) | Structure of ToPI1 inhibitor from Tityus obscurus scorpion venom in complex with trypsin | Descriptor: | CALCIUM ION, Cationic trypsin, SULFATE ION, ... | Authors: | Fernandes, J.C, Mourao, C.B.F, Schwartz, E.F, Barbosa, J.A.R.G. | Deposit date: | 2018-10-15 | Release date: | 2020-07-01 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.288 Å) | Cite: | Head-to-Tail Cyclization after Interaction with Trypsin: A Scorpion Venom Peptide that Resembles Plant Cyclotides. J.Med.Chem., 63, 2020
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6EAW
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![BU of 6eaw by Molmil](/molmil-images/mine/6eaw) | Crystallographic structure of the cyclic heptapeptide derived from the BTCI inhibitor bound to beta-trypsin in space group P 21 21 21 | Descriptor: | CALCIUM ION, CYS-THR-LYS-SER-ILE, Cationic trypsin, ... | Authors: | Fernandes, J.C, Valadares, N.F, Freitas, S.M, Barbosa, J.A.R.G. | Deposit date: | 2018-08-03 | Release date: | 2019-08-07 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.289 Å) | Cite: | Crystallographic structure of the cyclic heptapeptide derived from the BTCI inhibitor bound to beta-trypsin in space group P 21 21 21 To Be Published
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6ZQ2
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![BU of 6zq2 by Molmil](/molmil-images/mine/6zq2) | |
4HGC
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![BU of 4hgc by Molmil](/molmil-images/mine/4hgc) | Crystal structure of bovine trypsin complexed with sfti-1 analog containing a peptoid residue at position p1 | Descriptor: | CALCIUM ION, Cationic trypsin, GLYCEROL, ... | Authors: | Krzywda, S, Jaskolski, M, Rolka, K, Stawikowski, M. | Deposit date: | 2012-10-08 | Release date: | 2013-10-09 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.29 Å) | Cite: | Structure of a proteolytically resistant analogue of (NLys)(5)SFTI-1 in complex with trypsin: evidence for the direct participation of the Ser214 carbonyl group in serine protease-mediated proteolysis. Acta Crystallogr.,Sect.D, 70, 2014
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6BFP
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![BU of 6bfp by Molmil](/molmil-images/mine/6bfp) | Bovine trypsin bound to potent inhibitor | Descriptor: | 3-{2-[(4-carbamimidoylphenyl)carbamoyl]-4-ethenyl-5-methoxyphenyl}-6-[(cyclopropylmethyl)carbamoyl]pyridine-2-carboxylic acid, CALCIUM ION, Cationic trypsin | Authors: | Partridge, J.R, Choy, R.M. | Deposit date: | 2017-10-26 | Release date: | 2018-10-31 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.292 Å) | Cite: | Structures of full-length plasma kallikrein bound to highly specific inhibitors describe a new mode of targeted inhibition. J.Struct.Biol., 206, 2019
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6YZA
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![BU of 6yza by Molmil](/molmil-images/mine/6yza) | |
4ABE
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![BU of 4abe by Molmil](/molmil-images/mine/4abe) | |
4Y11
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![BU of 4y11 by Molmil](/molmil-images/mine/4y11) | Trypsin in complex with with BPTI mutant (2S)-2-amino-4,4,4-trifluorobutanoic acid | Descriptor: | CALCIUM ION, Cationic trypsin, GLYCEROL, ... | Authors: | Loll, B, Ye, S, Berger, A.A, Muelow, U, Alings, C, Wahl, M.C, Koksch, B. | Deposit date: | 2015-02-06 | Release date: | 2015-06-24 | Last modified: | 2018-04-18 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Fluorine teams up with water to restore inhibitor activity to mutant BPTI. Chem Sci, 6, 2015
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4ABF
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![BU of 4abf by Molmil](/molmil-images/mine/4abf) | Fragments bound to bovine trypsin for the SAMPL challenge | Descriptor: | 1,2-ETHANEDIOL, 1-(5-BROMO-1-BENZOTHIOPHEN-3-YL)METHANAMINE, CALCIUM ION, ... | Authors: | Newman, J, Peat, T.S. | Deposit date: | 2011-12-08 | Release date: | 2012-02-08 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | The Dingo Dataset: A Comprehensive Set of Data for the Sampl Challenge. J.Comput.Aided Mol.Des., 26, 2012
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4TPY
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![BU of 4tpy by Molmil](/molmil-images/mine/4tpy) | High throughput screening using acoustic droplet ejection to combine protein crystals and chemical libraries on crystallization plates at high density | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, ... | Authors: | Teplitsky, E, Joshi, K, Mullen, J.D, Soares, A.S. | Deposit date: | 2014-06-10 | Release date: | 2014-10-22 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | High throughput screening using acoustic droplet ejection to combine protein crystals and chemical libraries on crystallization plates at high density. J.Struct.Biol., 191, 2015
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7BRZ
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![BU of 7brz by Molmil](/molmil-images/mine/7brz) | Bovine Pancreatic Trypsin with 2-Methyltryptamine (Room Temperature) | Descriptor: | 2-(2-methyl-1H-indol-3-yl)ethanamine, CALCIUM ION, Cationic trypsin, ... | Authors: | Maeki, M, Ito, S, Takeda, R, Funakubo, T, Ueno, G, Ishida, A, Tani, H, Yamamoto, M, Tokeshi, M. | Deposit date: | 2020-03-30 | Release date: | 2020-08-26 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Room-temperature crystallography using a microfluidic protein crystal array device and its application to protein-ligand complex structure analysis. Chem Sci, 11, 2020
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2BY6
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![BU of 2by6 by Molmil](/molmil-images/mine/2by6) | Is radiation damage dependent on the dose-rate used during macromolecular crystallography data collection | Descriptor: | BENZAMIDINE, CALCIUM ION, CATIONIC TRYPSIN, ... | Authors: | Leiros, H.-K.S, Timmins, J, Ravelli, R.B.G, McSweeney, S.M. | Deposit date: | 2005-07-29 | Release date: | 2006-02-06 | Last modified: | 2021-08-04 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Is Radiation Damage Dependent on the Dose-Rate Used During Macromolecular Crystallography Data Collection? Acta Crystallogr.,Sect.D, 62, 2006
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2BY7
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![BU of 2by7 by Molmil](/molmil-images/mine/2by7) | Is radiation damage dependent on the dose-rate used during macromolecular crystallography data collection | Descriptor: | BENZAMIDINE, CALCIUM ION, CATIONIC TRYPSIN, ... | Authors: | Leiros, H.-K.S, Timmins, J, Ravelli, R.B.G, McSweeney, S.M. | Deposit date: | 2005-07-29 | Release date: | 2006-02-06 | Last modified: | 2021-08-04 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Is Radiation Damage Dependent on the Dose-Rate Used During Macromolecular Crystallography Data Collection? Acta Crystallogr.,Sect.D, 62, 2006
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2BY9
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![BU of 2by9 by Molmil](/molmil-images/mine/2by9) | Is radiation damage dependent on the dose-rate used during macromolecular crystallography data collection | Descriptor: | BENZAMIDINE, CALCIUM ION, CATIONIC TRYPSIN, ... | Authors: | Leiros, H.-K.S, Timmins, J, Ravelli, R.B.G, McSweeney, S.M. | Deposit date: | 2005-07-29 | Release date: | 2006-02-06 | Last modified: | 2021-08-04 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Is Radiation Damage Dependent on the Dose-Rate Used During Macromolecular Crystallography Data Collection? Acta Crystallogr.,Sect.D, 62, 2006
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2BYA
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![BU of 2bya by Molmil](/molmil-images/mine/2bya) | Is radiation damage dependent on the dose-rate used during macromolecular crystallography data collection | Descriptor: | BENZAMIDINE, CALCIUM ION, CATIONIC TRYPSIN, ... | Authors: | Leiros, H.-K.S, Timmins, J, Ravelli, R.B.G, McSweeney, S.M. | Deposit date: | 2005-07-29 | Release date: | 2006-02-06 | Last modified: | 2021-08-04 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Is Radiation Damage Dependent on the Dose-Rate Used During Macromolecular Crystallography Data Collection? Acta Crystallogr.,Sect.D, 62, 2006
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2BY5
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![BU of 2by5 by Molmil](/molmil-images/mine/2by5) | Is radiation damage dependent on the dose-rate used during macromolecular crystallography data collection | Descriptor: | BENZAMIDINE, CALCIUM ION, CATIONIC TRYPSIN, ... | Authors: | Leiros, H.-K.S, Timmins, J, Ravelli, R.B.G, McSweeney, S.M. | Deposit date: | 2005-07-29 | Release date: | 2006-02-06 | Last modified: | 2021-08-04 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Is Radiation Damage Dependent on the Dose-Rate Used During Macromolecular Crystallography Data Collection? Acta Crystallogr.,Sect.D, 62, 2006
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2BY8
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![BU of 2by8 by Molmil](/molmil-images/mine/2by8) | Is radiation damage dependent on the dose-rate used during macromolecular crystallography data collection | Descriptor: | BENZAMIDINE, CALCIUM ION, CATIONIC TRYPSIN, ... | Authors: | Leiros, H.-K.S, Timmins, J, Ravelli, R.B.G, McSweeney, S.M. | Deposit date: | 2005-07-29 | Release date: | 2006-02-06 | Last modified: | 2021-08-04 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Is Radiation Damage Dependent on the Dose-Rate Used During Macromolecular Crystallography Data Collection? Acta Crystallogr.,Sect.D, 62, 2006
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4KTS
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![BU of 4kts by Molmil](/molmil-images/mine/4kts) | Bovine trypsin in complex with microviridin J at pH 8.5 | Descriptor: | CALCIUM ION, Cationic trypsin, DI(HYDROXYETHYL)ETHER, ... | Authors: | Quitterer, F, Groll, M, Hertweck, C, Dittmann, E. | Deposit date: | 2013-05-21 | Release date: | 2014-04-02 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Harnessing the evolvability of tricyclic microviridins to dissect protease-inhibitor interactions. Angew.Chem.Int.Ed.Engl., 53, 2014
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1UTP
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![BU of 1utp by Molmil](/molmil-images/mine/1utp) | Trypsin specificity as elucidated by LIE calculations, X-ray structures and association constant measurements | Descriptor: | 4-PHENYLBUTYLAMINE, CALCIUM ION, GLYCEROL, ... | Authors: | Leiros, H.-K.S, Brandsdal, B.O, Andersen, O.A, Os, V, Leiros, I, Helland, R, Otlewski, J, Willassen, N.P, Smalas, A.O. | Deposit date: | 2003-12-09 | Release date: | 2004-01-15 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Trypsin Specificity as Elucidated by Lie Calculations, X-Ray Structures, and Association Constant Measurements Protein Sci., 13, 2004
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4NIX
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![BU of 4nix by Molmil](/molmil-images/mine/4nix) | Crystal structure of trypsiligase (K60E/N143H/Y151H/D189K trypsin) orthorhombic form, zinc-bound | Descriptor: | CALCIUM ION, Cationic trypsin, GLYCEROL, ... | Authors: | Schoepfel, M, Parthier, C, Stubbs, M.T. | Deposit date: | 2013-11-08 | Release date: | 2014-02-19 | Last modified: | 2014-03-19 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | N-terminal protein modification by substrate-activated reverse proteolysis. Angew.Chem.Int.Ed.Engl., 53, 2014
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4NIW
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![BU of 4niw by Molmil](/molmil-images/mine/4niw) | |
6YIX
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![BU of 6yix by Molmil](/molmil-images/mine/6yix) | |