4KTS

Bovine trypsin in complex with microviridin J at pH 8.5

Summary for 4KTS

Related3MYW 4KTU
Related PRD IDPRD_001086
DescriptorCationic trypsin, Microviridin, CALCIUM ION, ... (5 entities in total)
Functional Keywordsserine protease, hydrolase, natural product inhibitor, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceMicrocystis aeruginosa MRC
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Cellular locationSecreted, extracellular space P00760
Total number of polymer chains2
Total molecular weight25195.35
Authors
Quitterer, F.,Groll, M.,Hertweck, C.,Dittmann, E. (deposition date: 2013-05-21, release date: 2014-04-02, Last modification date: 2014-04-16)
Primary citation
Weiz, A.R.,Ishida, K.,Quitterer, F.,Meyer, S.,Kehr, J.C.,Muller, K.M.,Groll, M.,Hertweck, C.,Dittmann, E.
Harnessing the evolvability of tricyclic microviridins to dissect protease-inhibitor interactions.
Angew.Chem.Int.Ed.Engl., 53:3735-3738, 2014
PubMed: 24591244 (PDB entries with the same primary citation)
DOI: 10.1002/anie.201309721
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.130100.5%1.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4kts
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Molmil generated image of 4kts
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Molmil generated image of 4kts
rotated about y axis by 90°