5DGE
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![BU of 5dge by Molmil](/molmil-images/mine/5dge) | Coping with proline stalling: structural basis of hypusine-induced protein synthesis by the eukaryotic ribosome | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | Authors: | Melnikov, S, Mailliot, J, Shin, B.-S, Rigger, L, Yusupova, G, Micura, R, Dever, T.E, Yusupov, M. | Deposit date: | 2015-08-27 | Release date: | 2017-01-25 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.45 Å) | Cite: | Coping with proline stalling: structural basis of hypusine-induced protein synthesis by the eukaryotic ribosome To Be Published
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4U56
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![BU of 4u56 by Molmil](/molmil-images/mine/4u56) | Crystal structure of Blasticidin S bound to the yeast 80S ribosome | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | Authors: | Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M. | Deposit date: | 2014-07-24 | Release date: | 2014-10-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.45 Å) | Cite: | Structural basis for the inhibition of the eukaryotic ribosome. Nature, 513, 2014
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7ZPQ
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![BU of 7zpq by Molmil](/molmil-images/mine/7zpq) | Structure of the RQT-bound 80S ribosome from S. cerevisiae (C1) | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | Authors: | Best, K.M, Ikeuchi, K, Kater, L, Best, D.M, Musial, J, Matsuo, Y, Berninghausen, O, Becker, T, Inada, T, Beckmann, R. | Deposit date: | 2022-04-28 | Release date: | 2023-02-22 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.47 Å) | Cite: | Structural basis for clearing of ribosome collisions by the RQT complex. Nat Commun, 14, 2023
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6N8O
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![BU of 6n8o by Molmil](/molmil-images/mine/6n8o) | Cryo-EM structure of Rpl10-inserted (RI) pre-60S ribosomal subunit | Descriptor: | 5.8S rRNA, 5S rRNA, 60S ribosomal export protein NMD3, ... | Authors: | Zhou, Y, Musalgaonkar, S, Johnson, A.W, Taylor, D.W. | Deposit date: | 2018-11-29 | Release date: | 2019-03-13 | Last modified: | 2020-01-08 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Tightly-orchestrated rearrangements govern catalytic center assembly of the ribosome. Nat Commun, 10, 2019
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6N8J
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![BU of 6n8j by Molmil](/molmil-images/mine/6n8j) | Cryo-EM structure of late nuclear (LN) pre-60S ribosomal subunit | Descriptor: | 5.8S rRNA, 5S rRNA, 60S ribosomal protein L11-A, ... | Authors: | Zhou, Y, Musalgaonkar, S, Johnson, A.W, Taylor, D.W. | Deposit date: | 2018-11-29 | Release date: | 2019-03-13 | Last modified: | 2020-01-08 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Tightly-orchestrated rearrangements govern catalytic center assembly of the ribosome. Nat Commun, 10, 2019
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5JUP
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![BU of 5jup by Molmil](/molmil-images/mine/5jup) | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure II (mid-rotated 40S subunit) | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 5.8S ribosomal RNA, ... | Authors: | Abeyrathne, P, Koh, C.S, Grant, T, Grigorieff, N, Korostelev, A.A. | Deposit date: | 2016-05-10 | Release date: | 2016-10-05 | Last modified: | 2019-11-27 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome. Elife, 5, 2016
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6QTZ
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![BU of 6qtz by Molmil](/molmil-images/mine/6qtz) | |
6N8M
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![BU of 6n8m by Molmil](/molmil-images/mine/6n8m) | Cryo-EM structure of pre-Lsg1 (PL) pre-60S ribosomal subunit | Descriptor: | 5.8S RNA, 5S rRNA, 60S ribosomal export protein NMD3, ... | Authors: | Zhou, Y, Musalgaonkar, S, Johnson, A.W, Taylor, D.W. | Deposit date: | 2018-11-29 | Release date: | 2019-03-13 | Last modified: | 2020-01-08 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Tightly-orchestrated rearrangements govern catalytic center assembly of the ribosome. Nat Commun, 10, 2019
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5MEI
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![BU of 5mei by Molmil](/molmil-images/mine/5mei) | Crystal structure of Agelastatin A bound to the 80S ribosome | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | Authors: | McClary, B, Zinshteyn, B, Meyer, M, Jouanneau, M, Pellegrino, S, Yusupova, G, Schuller, A, Reyes, J.C.P, Lu, J, Luo, C, Dang, Y, Romo, D, Yusupov, M, Green, R, Liu, J.O. | Deposit date: | 2016-11-15 | Release date: | 2017-06-28 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Inhibition of Eukaryotic Translation by the Antitumor Natural Product Agelastatin A. Cell Chem Biol, 24, 2017
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5TGM
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![BU of 5tgm by Molmil](/molmil-images/mine/5tgm) | Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 3'-amino-3'-deoxyadenosine 5'-(dihydrogen phosphate), ... | Authors: | Melnikov, S, Mailliot, J, Yusupov, M. | Deposit date: | 2016-09-28 | Release date: | 2017-01-18 | Last modified: | 2022-12-07 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Molecular insights into protein synthesis with proline residues. EMBO Rep., 17, 2016
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8Y0U
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![BU of 8y0u by Molmil](/molmil-images/mine/8y0u) | dormant ribosome with STM1 | Descriptor: | 18S rRNA, 25S rRNA, 40S ribosomal protein S1-A, ... | Authors: | Du, M, Zeng, F. | Deposit date: | 2024-01-23 | Release date: | 2024-02-07 | Last modified: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (3.59 Å) | Cite: | Implication of Stm1 in the protection of eIF5A, eEF2 and tRNA through dormant ribosomes. Front Mol Biosci, 11, 2024
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6N8K
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![BU of 6n8k by Molmil](/molmil-images/mine/6n8k) | Cryo-EM structure of early cytoplasmic-immediate (ECI) pre-60S ribosomal subunit | Descriptor: | 5.8S rRNA, 5S rRNA, 60S ribosomal export protein NMD3, ... | Authors: | Zhou, Y, Musalgaonkar, S, Johnson, A.W, Taylor, D.W. | Deposit date: | 2018-11-29 | Release date: | 2019-03-13 | Last modified: | 2020-01-08 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Tightly-orchestrated rearrangements govern catalytic center assembly of the ribosome. Nat Commun, 10, 2019
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4U4O
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![BU of 4u4o by Molmil](/molmil-images/mine/4u4o) | Crystal structure of Geneticin bound to the yeast 80S ribosome | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | Authors: | Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M. | Deposit date: | 2014-07-24 | Release date: | 2014-10-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Structural basis for the inhibition of the eukaryotic ribosome. Nature, 513, 2014
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6N8L
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![BU of 6n8l by Molmil](/molmil-images/mine/6n8l) | Cryo-EM structure of early cytoplasmic-late (ECL) pre-60S ribosomal subunit | Descriptor: | 5.8S rRNA, 5S rRNA, 60S ribosomal export protein NMD3, ... | Authors: | Zhou, Y, Musalgaonkar, S, Johnson, A.W, Taylor, D.W. | Deposit date: | 2018-11-29 | Release date: | 2019-03-13 | Last modified: | 2020-01-08 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Tightly-orchestrated rearrangements govern catalytic center assembly of the ribosome. Nat Commun, 10, 2019
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6R84
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![BU of 6r84 by Molmil](/molmil-images/mine/6r84) | Yeast Vms1 (Q295L)-60S ribosomal subunit complex (pre-state with Arb1) | Descriptor: | 25S rRNA, 5.8S rRNA, 5S rRNA, ... | Authors: | Su, T, Izawa, T, Cheng, J, Yamashita, Y, Berninghausen, O, Inada, T, Neupert, W, Beckmann, R. | Deposit date: | 2019-03-31 | Release date: | 2019-06-26 | Last modified: | 2019-07-10 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structure and function of Vms1 and Arb1 in RQC and mitochondrial proteome homeostasis. Nature, 570, 2019
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5NDG
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![BU of 5ndg by Molmil](/molmil-images/mine/5ndg) | Crystal structure of geneticin (G418) bound to the yeast 80S ribosome | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | Authors: | Prokhorova, I, Djumagulov, M, Urzhumtsev, A, Yusupov, M, Yusupova, G. | Deposit date: | 2017-03-08 | Release date: | 2017-12-13 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Aminoglycoside interactions and impacts on the eukaryotic ribosome. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5NDW
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![BU of 5ndw by Molmil](/molmil-images/mine/5ndw) | Crystal structure of aminoglycoside TC007 bound to the yeast 80S ribosome | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | Authors: | Prokhorova, I, Djumagulov, M, Urzhumtsev, A, Yusupov, M, Yusupova, G. | Deposit date: | 2017-03-09 | Release date: | 2017-12-13 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Aminoglycoside interactions and impacts on the eukaryotic ribosome. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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8CMJ
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![BU of 8cmj by Molmil](/molmil-images/mine/8cmj) | Translocation intermediate 4 (TI-4*) of 80S S. cerevisiae ribosome with eEF2 in the absence of sordarin | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | Authors: | Milicevic, N, Jenner, L, Myasnikov, A, Yusupov, M, Yusupova, G. | Deposit date: | 2023-02-20 | Release date: | 2023-09-20 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.79 Å) | Cite: | mRNA reading frame maintenance during eukaryotic ribosome translocation. Nature, 625, 2024
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7Z34
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![BU of 7z34 by Molmil](/molmil-images/mine/7z34) | Structure of pre-60S particle bound to DRG1(AFG2). | Descriptor: | 35S pre-ribosomal RNA, 5.8S rRNA, 5S rRNA, ... | Authors: | Prattes, M, Grishkovskaya, I, Bergler, H, Haselbach, D. | Deposit date: | 2022-03-01 | Release date: | 2022-09-21 | Last modified: | 2023-07-19 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Visualizing maturation factor extraction from the nascent ribosome by the AAA-ATPase Drg1. Nat.Struct.Mol.Biol., 29, 2022
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5MC6
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![BU of 5mc6 by Molmil](/molmil-images/mine/5mc6) | Cryo-EM structure of a native ribosome-Ski2-Ski3-Ski8 complex from S. cerevisiae | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | Authors: | Schmidt, C, Kowalinski, E, Shanmuganathan, V, Defenouillere, Q, Braunger, K, Heuer, A, Pech, M, Namane, A, Berninghausen, O, Fromont-Racine, M, Jacquier, A, Conti, E, Becker, T, Beckmann, R. | Deposit date: | 2016-11-09 | Release date: | 2017-01-18 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | The cryo-EM structure of a ribosome-Ski2-Ski3-Ski8 helicase complex. Science, 354, 2016
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8BJQ
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![BU of 8bjq by Molmil](/molmil-images/mine/8bjq) | Structure of a yeast 80S ribosome-bound N-Acetyltransferase B complex | Descriptor: | 25S rRNA, 5.8S rRNA, 5S rRNA, ... | Authors: | Knorr, A.G, Mackens-Kiani, T, Musial, J, Berninghausen, O, Becker, T, Beatrix, B, Beckmann, R. | Deposit date: | 2022-11-05 | Release date: | 2023-02-08 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | The dynamic architecture of Map1- and NatB-ribosome complexes coordinates the sequential modifications of nascent polypeptide chains. Plos Biol., 21, 2023
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6N8N
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![BU of 6n8n by Molmil](/molmil-images/mine/6n8n) | Cryo-EM structure of Lsg1-engaged (LE) pre-60S ribosomal subunit | Descriptor: | 5.8S rRNA, 5S rRNA, 60S ribosomal export protein NMD3, ... | Authors: | Zhou, Y, Musalgaonkar, S, Johnson, A.W, Taylor, D.W. | Deposit date: | 2018-11-29 | Release date: | 2019-03-13 | Last modified: | 2020-01-08 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Tightly-orchestrated rearrangements govern catalytic center assembly of the ribosome. Nat Commun, 10, 2019
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6OIG
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![BU of 6oig by Molmil](/molmil-images/mine/6oig) | Subunit joining exposes nascent pre-40S rRNA for processing and quality control | Descriptor: | 25S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | Authors: | Rai, J, Parker, M.D, Ghalei, H, Johnson, M.C, Karbstein, K, Stroupe, M.E. | Deposit date: | 2019-04-09 | Release date: | 2020-09-30 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | An open interface in the pre-80S ribosome coordinated by ribosome assembly factors Tsr1 and Dim1 enables temporal regulation of Fap7. Rna, 27, 2021
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8BQX
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![BU of 8bqx by Molmil](/molmil-images/mine/8bqx) | Yeast 80S ribosome in complex with Map1 (conformation 2) | Descriptor: | 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ... | Authors: | Knorr, A.G, Mackens-Kiani, T, Musial, J, Berninghausen, O, Becker, T, Beatrix, B, Beckmann, R. | Deposit date: | 2022-11-21 | Release date: | 2023-03-22 | Last modified: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | The dynamic architecture of Map1- and NatB-ribosome complexes coordinates the sequential modifications of nascent polypeptide chains. Plos Biol., 21, 2023
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5GAK
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![BU of 5gak by Molmil](/molmil-images/mine/5gak) | Yeast 60S ribosomal subunit with A-site tRNA, P-site tRNA and eIF-5A | Descriptor: | 25S rRNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, 5.8S rRNA, ... | Authors: | Schmidt, C, Becker, T. | Deposit date: | 2015-12-09 | Release date: | 2016-02-24 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (3.88 Å) | Cite: | Structure of the hypusinylated eukaryotic translation factor eIF-5A bound to the ribosome. Nucleic Acids Res., 44, 2016
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