7Z2A
 
 | | P. berghei kinesin-8B motor domain in no nucleotide state bound to tubulin dimer | | Descriptor: | Detyrosinated tubulin alpha-1B chain, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-8, ... | | Authors: | Liu, T, Shilliday, F, Cook, A.D, Moores, C.A. | | Deposit date: | 2022-02-26 | | Release date: | 2022-10-19 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission.
Nat Commun, 13, 2022
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7NB8
 | | Plasmodium falciparum kinesin-5 motor domain without nucleotide, complexed with 14 protofilament microtubule. | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, Kinesin-5, MAGNESIUM ION, ... | | Authors: | Cook, A.D, Roberts, A, Atherton, J, Tewari, R, Topf, M, Moores, C.A. | | Deposit date: | 2021-01-25 | | Release date: | 2021-10-13 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Cryo-EM structure of a microtubule-bound parasite kinesin motor and implications for its mechanism and inhibition.
J.Biol.Chem., 297, 2021
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6EVW
 | | Cryo-EM structure of GMPCPP-microtubule co-polymerised with doublecortin | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... | | Authors: | Manka, S.W. | | Deposit date: | 2017-11-02 | | Release date: | 2018-07-04 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | The role of tubulin-tubulin lattice contacts in the mechanism of microtubule dynamic instability.
Nat. Struct. Mol. Biol., 25, 2018
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6EVY
 | | Cryo-EM structure of GTPgammaS-microtubule co-polymerised with doublecortin | | Descriptor: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Manka, S.W. | | Deposit date: | 2017-11-03 | | Release date: | 2018-07-04 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | The role of tubulin-tubulin lattice contacts in the mechanism of microtubule dynamic instability.
Nat. Struct. Mol. Biol., 25, 2018
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6VPP
 | | Cryo-EM structure of microtubule-bound KLP61F motor with tail domain in the nucleotide-free state | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein Klp61F, ... | | Authors: | Bodrug, T, Wilson-Kubalek, E.M, Nithianantham, S, Debs, G, Sindelar, C.V, Milligan, R, Al-Bassam, J. | | Deposit date: | 2020-02-04 | | Release date: | 2020-02-19 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding.
Elife, 9, 2020
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6VPO
 | | Cryo-EM structure of microtubule-bound KLP61F motor domain in the AMPPNP state | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein Klp61F, ... | | Authors: | Bodrug, T, Wilson-Kubalek, E.M, Nithianantham, S, Debs, G, Sindelar, C.V, Milligan, R, Al-Bassam, J. | | Deposit date: | 2020-02-04 | | Release date: | 2020-02-19 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding.
Elife, 9, 2020
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6MZF
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6ZPI
 | | Microtubule complexed with Kif15 motor domain. Symmetrised asymmetric unit | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF15, ... | | Authors: | Atherton, J, Hummel, J.J.A, Olieric, N, Locke, J, Pena, A, Rosenfeld, S.S, Steinmetz, M.O, Hoogenraad, C.C, Moores, C.A. | | Deposit date: | 2020-07-08 | | Release date: | 2020-12-30 | | Method: | ELECTRON MICROSCOPY (4.5 Å) | | Cite: | The mechanism of kinesin inhibition by kinesin-binding protein.
Elife, 9, 2020
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5MM4
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6RZA
 | | Cryo-EM structure of the human inner arm dynein DNAH7 microtubule binding domain bound to microtubules | | Descriptor: | Cytoplasmic dynein 1 heavy chain 1,Dynein heavy chain 7, axonemal,Cytoplasmic dynein 1 heavy chain 1, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Lacey, S.E, He, S, Scheres, S.H.W, Carter, A.P. | | Deposit date: | 2019-06-13 | | Release date: | 2019-07-10 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (4.5 Å) | | Cite: | Cryo-EM of dynein microtubule-binding domains shows how an axonemal dynein distorts the microtubule.
Elife, 8, 2019
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3J6E
 | | Energy minimized average structure of Microtubules stabilized by GmpCpp | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... | | Authors: | Alushin, G.M, Lander, G.C, Kellogg, E.H, Zhang, R, Baker, D, Nogales, E. | | Deposit date: | 2014-02-18 | | Release date: | 2014-06-04 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (4.7 Å) | | Cite: | High-Resolution Microtubule Structures Reveal the Structural Transitions in alpha beta-Tubulin upon GTP Hydrolysis.
Cell(Cambridge,Mass.), 157, 2014
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5OGC
 | | Molecular basis of human kinesin-8 function and inhibition | | Descriptor: | 4-chloranyl-2-nitro-1-(phenylsulfonyl)benzene, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Locke, J, Joseph, A.P, Topf, M, Moores, C.A. | | Deposit date: | 2017-07-12 | | Release date: | 2017-10-25 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (4.8 Å) | | Cite: | Structural basis of human kinesin-8 function and inhibition.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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3J6F
 | | Minimized average structure of GDP-bound dynamic microtubules | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Alushin, G.M, Lander, G.C, Kellogg, E.H, Zhang, R, Baker, D, Nogales, E. | | Deposit date: | 2014-02-19 | | Release date: | 2014-06-04 | | Last modified: | 2018-07-18 | | Method: | ELECTRON MICROSCOPY (4.9 Å) | | Cite: | High-Resolution Microtubule Structures Reveal the Structural Transitions in alpha beta-Tubulin upon GTP Hydrolysis.
Cell(Cambridge,Mass.), 157, 2014
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5MM7
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5OCU
 | | Molecular basis of human kinesin-8 function and inhibition | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF18A, ... | | Authors: | Locke, J, Joseph, A.P, Topf, M, Moores, C.A. | | Deposit date: | 2017-07-03 | | Release date: | 2017-10-25 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (5.2 Å) | | Cite: | Structural basis of human kinesin-8 function and inhibition.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5XXT
 | | GDP-microtubule complexed with nucleotide-free KIF5C | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Morikawa, M, Shigematsu, H, Nitta, R, Hirokawa, N. | | Deposit date: | 2017-07-05 | | Release date: | 2018-10-10 | | Last modified: | 2019-11-06 | | Method: | ELECTRON MICROSCOPY (5.35 Å) | | Cite: | Kinesin-binding-triggered conformation switching of microtubules contributes to polarized transport
J. Cell Biol., 217, 2018
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3J6G
 | | Minimized average structure of microtubules stabilized by taxol | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Alushin, G.M, Lander, G.C, Kellogg, E.H, Zhang, R, Baker, D, Nogales, E. | | Deposit date: | 2014-02-19 | | Release date: | 2014-06-04 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (5.5 Å) | | Cite: | High-Resolution Microtubule Structures Reveal the Structural Transitions in alpha beta-Tubulin upon GTP Hydrolysis.
Cell(Cambridge,Mass.), 157, 2014
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5OAM
 | | Molecular basis of human kinesin-8 function and inhibition | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF18A, ... | | Authors: | Locke, J, Joseph, A.P, Topf, M, Moores, C.A. | | Deposit date: | 2017-06-23 | | Release date: | 2017-10-25 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (5.5 Å) | | Cite: | Structural basis of human kinesin-8 function and inhibition.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5XXW
 | | GDP-microtubule complexed with KIF5C in ATP state | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Morikawa, M, Shigematsu, H, Nitta, R, Hirokawa, N. | | Deposit date: | 2017-07-05 | | Release date: | 2018-10-10 | | Last modified: | 2019-11-06 | | Method: | ELECTRON MICROSCOPY (6 Å) | | Cite: | Kinesin-binding-triggered conformation switching of microtubules contributes to polarized transport
J. Cell Biol., 217, 2018
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6TA4
 | | Human kinesin-5 motor domain in the AMPPNP state bound to microtubules | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF11, MAGNESIUM ION, ... | | Authors: | Pena, A.P, Sweeney, A, Cook, A.D, Moores, C.A, Topf, M. | | Deposit date: | 2019-10-29 | | Release date: | 2020-03-04 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (6.1 Å) | | Cite: | Structure of Microtubule-Trapped Human Kinesin-5 and Its Mechanism of Inhibition Revealed Using Cryoelectron Microscopy.
Structure, 28, 2020
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5XXX
 | | GMPCPP-microtubule complexed with nucleotide-free KIF5C | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... | | Authors: | Morikawa, M, Shigematsu, H, Nitta, R, Hirokawa, N. | | Deposit date: | 2017-07-05 | | Release date: | 2018-10-10 | | Last modified: | 2019-11-06 | | Method: | ELECTRON MICROSCOPY (6.43 Å) | | Cite: | Kinesin-binding-triggered conformation switching of microtubules contributes to polarized transport
J. Cell Biol., 217, 2018
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5XXV
 | | GDP-microtubule complexed with KIF5C in AMPPNP state | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Morikawa, M, Shigematsu, H, Nitta, R, Hirokawa, N. | | Deposit date: | 2017-07-05 | | Release date: | 2018-10-10 | | Last modified: | 2019-11-06 | | Method: | ELECTRON MICROSCOPY (6.46 Å) | | Cite: | Kinesin-binding-triggered conformation switching of microtubules contributes to polarized transport
J. Cell Biol., 217, 2018
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3J6H
 | | Nucleotide-free Kinesin motor domain complexed with GMPCPP-microtubule | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, Kinesin heavy chain isoform 5C, MAGNESIUM ION, ... | | Authors: | Morikawa, M, Yajima, H, Nitta, R, Inoue, S, Ogura, T, Sato, C, Hirokawa, N. | | Deposit date: | 2014-02-21 | | Release date: | 2015-04-01 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (8.1 Å) | | Cite: | X-ray and Cryo-EM structures reveal mutual conformational changes of Kinesin and GTP-state microtubules upon binding
Embo J., 2015
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3J6P
 | | Pseudo-atomic model of dynein microtubule binding domain-tubulin complex based on a cryoEM map | | Descriptor: | Dynein heavy chain, cytoplasmic, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Uchimura, S, Fujii, T, Takazaki, H, Ayukawa, R, Nishikawa, Y, Minoura, I, Hachikubo, Y, Kurisu, G, Sutoh, K, Kon, T, Namba, K, Muto, E. | | Deposit date: | 2014-03-20 | | Release date: | 2014-12-31 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (8.2 Å) | | Cite: | A flipped ion pair at the dynein-microtubule interface is critical for dynein motility and ATPase activation
J.Cell Biol., 208, 2015
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4ABO
 | | Mal3 CH domain homology model and mammalian tubulin (2XRP) docked into the 8.6-Angstrom cryo-EM map of Mal3-GTPgammaS-microtubules | | Descriptor: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MICROTUBULE INTEGRITY PROTEIN MAL3, ... | | Authors: | Maurer, S.P, Fourniol, F.J, Bohner, G, Moores, C.A, Surrey, T. | | Deposit date: | 2011-12-09 | | Release date: | 2012-06-06 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (8.6 Å) | | Cite: | Ebs Recognize a Nucleotide-Dependent Structural CAP at Growing Microtubule Ends.
Cell(Cambridge,Mass.), 149, 2012
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