6J1L
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![BU of 6j1l by Molmil](/molmil-images/mine/6j1l) | Crystal Structure Analysis of the ROR gamma(C455E) | Descriptor: | 2-[4-(ethylsulfonyl)phenyl]-N-[2'-fluoro-4'-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)[1,1'-biphenyl]-4-yl]acetamide, Nuclear receptor ROR-gamma | Authors: | zhang, Y, Li, C.C, wu, X.S. | Deposit date: | 2018-12-28 | Release date: | 2019-05-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable ROR gamma Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer. J.Med.Chem., 62, 2019
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7DQZ
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![BU of 7dqz by Molmil](/molmil-images/mine/7dqz) | Crystal structure of SARS 3C-like protease in apo form | Descriptor: | 3C-like proteinase | Authors: | Zhang, Y.T, Gao, H.X, Zhou, H, Zhong, F.L, Hu, X.H, Zhou, X.L, Lin, C, Wang, Q.S, Li, J, Zhang, J. | Deposit date: | 2020-12-24 | Release date: | 2021-09-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Structure-Based Discovery and Structural Basis of a Novel Broad-Spectrum Natural Product against the Main Protease of Coronavirus. J.Virol., 96, 2022
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3TL0
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![BU of 3tl0 by Molmil](/molmil-images/mine/3tl0) | Structure of SHP2 N-SH2 domain in complex with RLNpYAQLWHR peptide | Descriptor: | RLNpYAQLWHR peptide, SULFATE ION, Tyrosine-protein phosphatase non-receptor type 11 | Authors: | Zhang, Y, Zhang, J, Yuan, C, Hard, R.L, Park, I.H, Li, C, Bell, C.E, Pei, D. | Deposit date: | 2011-08-29 | Release date: | 2011-09-28 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Simultaneous binding of two peptidyl ligands by a SRC homology 2 domain. Biochemistry, 50, 2011
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3TKZ
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![BU of 3tkz by Molmil](/molmil-images/mine/3tkz) | Structure of the SHP-2 N-SH2 domain in a 1:2 complex with RVIpYFVPLNR peptide | Descriptor: | PROTEIN (RVIpYFVPLNR peptide), Tyrosine-protein phosphatase non-receptor type 11 | Authors: | Zhang, Y, Zhang, J, Yuan, C, Hard, R.L, Park, I.H, Li, C, Bell, C.E, Pei, D. | Deposit date: | 2011-08-29 | Release date: | 2011-10-26 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Simultaneous binding of two peptidyl ligands by a SRC homology 2 domain. Biochemistry, 50, 2011
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6LPI
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![BU of 6lpi by Molmil](/molmil-images/mine/6lpi) | Crystal Structure of AHAS holo-enzyme | Descriptor: | Acetolactate synthase isozyme 1 large subunit, Acetolactate synthase isozyme 1 small subunit, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Zhang, Y, Yang, X, Xi, Z, Shen, Y. | Deposit date: | 2020-01-10 | Release date: | 2020-11-18 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.849 Å) | Cite: | Molecular architecture of the acetohydroxyacid synthase holoenzyme. Biochem.J., 477, 2020
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6MG8
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![BU of 6mg8 by Molmil](/molmil-images/mine/6mg8) | Structural basis for cholesterol transport-like activity of the Hedgehog receptor Patched | Descriptor: | CHOLESTEROL, Protein patched homolog 1 | Authors: | Zhang, Y, Bulkley, D, Xin, Y, Roberts, K.J, Asarnow, D.E, Sharma, A, Myers, B.R, Cho, W, Cheng, Y, Beachy, P.A. | Deposit date: | 2018-09-13 | Release date: | 2018-11-28 | Last modified: | 2022-03-16 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched. Cell, 175, 2018
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8JNC
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![BU of 8jnc by Molmil](/molmil-images/mine/8jnc) | Crystal structure of cytochrome P450 IkaD from Streptomyces sp. ZJ306, in complex with the substrate 10-epi-maltophilin | Descriptor: | (1Z,3E,5S,8R,9S,10S,11R,13R,15R,16S,18Z,24S,25S)-11-ethyl-2,24-dihydroxy-10-methyl-21,26-diazapentacyclo[23.2.1.09,13.08,15.05,16]octacosa-1(2),3,18-triene-7,20,27,28-tetraone, Cytochrome P450, FORMIC ACID, ... | Authors: | Zhang, Y.L, Zhang, L.P, Zhang, C.S. | Deposit date: | 2023-06-06 | Release date: | 2023-11-15 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A Mechanistic Understanding of the Distinct Regio- and Chemoselectivity of Multifunctional P450s by Structural Comparison of IkaD and CftA Complexed with Common Substrates. Angew.Chem.Int.Ed.Engl., 62, 2023
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7DDY
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![BU of 7ddy by Molmil](/molmil-images/mine/7ddy) | |
3F3R
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![BU of 3f3r by Molmil](/molmil-images/mine/3f3r) | Crystal structure of yeast Thioredoxin1-glutathione mixed disulfide complex | Descriptor: | GLUTATHIONE, SULFATE ION, Thioredoxin-1 | Authors: | Zhang, Y.R, Bao, R, Zhou, C.Z, Chen, Y.X. | Deposit date: | 2008-10-31 | Release date: | 2009-10-20 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural and kinetic analysis of Saccharomyces cerevisiae thioredoxin Trx1: implications for the catalytic mechanism of GSSG reduced by the thioredoxin system Biochim.Biophys.Acta, 1794, 2009
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6VYM
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![BU of 6vym by Molmil](/molmil-images/mine/6vym) | Cryo-EM structure of mechanosensitive channel MscS in PC-18:1 nanodiscs treated with beta-cyclodextran | Descriptor: | Mechanosensitive channel MscS | Authors: | Zhang, Y, Daday, C, Gu, R, Cox, C.D, Martinac, B, Groot, B, Walz, T. | Deposit date: | 2020-02-27 | Release date: | 2021-02-10 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Visualization of the mechanosensitive ion channel MscS under membrane tension. Nature, 590, 2021
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6VYL
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![BU of 6vyl by Molmil](/molmil-images/mine/6vyl) | Cryo-EM structure of mechanosensitive channel MscS in PC-10 nanodiscs | Descriptor: | Mechanosensitive channel MscS | Authors: | Zhang, Y, Daday, C, Gu, R, Cox, C.D, Martinac, B, Groot, B, Walz, T. | Deposit date: | 2020-02-27 | Release date: | 2021-02-10 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Visualization of the mechanosensitive ion channel MscS under membrane tension. Nature, 590, 2021
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6VRJ
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![BU of 6vrj by Molmil](/molmil-images/mine/6vrj) | |
6VYK
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![BU of 6vyk by Molmil](/molmil-images/mine/6vyk) | Cryo-EM structure of mechanosensitive channel MscS in PC-18:1 nanodiscs | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Mechanosensitive channel MscS | Authors: | Zhang, Y, Daday, C, Gu, R, Cox, C.D, Martinac, B, Groot, B, Walz, T. | Deposit date: | 2020-02-27 | Release date: | 2021-02-10 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Visualization of the mechanosensitive ion channel MscS under membrane tension. Nature, 590, 2021
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3F3Q
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![BU of 3f3q by Molmil](/molmil-images/mine/3f3q) | Crystal structure of the oxidised form of thioredoxin 1 from saccharomyces cerevisiae | Descriptor: | Thioredoxin-1, ZINC ION | Authors: | Zhang, Y.R, Bao, R, Zhou, C.Z, Chen, Y.X. | Deposit date: | 2008-10-31 | Release date: | 2009-10-20 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Structural and kinetic analysis of Saccharomyces cerevisiae thioredoxin Trx1: implications for the catalytic mechanism of GSSG reduced by the thioredoxin system Biochim.Biophys.Acta, 1794, 2009
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2O3J
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![BU of 2o3j by Molmil](/molmil-images/mine/2o3j) | Structure of Caenorhabditis Elegans UDP-Glucose Dehydrogenase | Descriptor: | GLYCEROL, UDP-glucose 6-dehydrogenase | Authors: | Zhang, Y, Zhan, C, Patskovsky, Y, Ramagopal, U, Shi, W, Toro, R, Wengerter, B.C, Milst, S, Vidal, M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2006-12-01 | Release date: | 2006-12-12 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Crystal Structure of Caenorhabditis Elegans Udp-Glucose Dehydrogenase To be Published
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6O7G
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![BU of 6o7g by Molmil](/molmil-images/mine/6o7g) | |
6LTS
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![BU of 6lts by Molmil](/molmil-images/mine/6lts) | |
8H91
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![BU of 8h91 by Molmil](/molmil-images/mine/8h91) | |
2MN6
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![BU of 2mn6 by Molmil](/molmil-images/mine/2mn6) | |
2MN7
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![BU of 2mn7 by Molmil](/molmil-images/mine/2mn7) | |
2MI2
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![BU of 2mi2 by Molmil](/molmil-images/mine/2mi2) | |
6O3Y
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![BU of 6o3y by Molmil](/molmil-images/mine/6o3y) | Crystal structure of yeast Nrd1 CID in complex with Sen1 NIM3 | Descriptor: | CHLORIDE ION, Helicase SEN1, Protein NRD1 | Authors: | Zhang, Y, Tong, L. | Deposit date: | 2019-02-27 | Release date: | 2019-06-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.799 Å) | Cite: | Identification of Three Sequence Motifs in the Transcription Termination Factor Sen1 that Mediate Direct Interactions with Nrd1. Structure, 27, 2019
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2P72
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![BU of 2p72 by Molmil](/molmil-images/mine/2p72) | crystal structure of a glycosyltransferase involved in the glycosylation of the major capsid of PBCV-1 | Descriptor: | MANGANESE (II) ION, Putative glycosyltransferase (Mannosyltransferase) involved in glycosylating the PBCV-1 major capsid protein, URIDINE-5'-DIPHOSPHATE-GLUCOSE | Authors: | Zhang, Y, Xiang, Y, Van Etten, J.L, Rossmann, M.G. | Deposit date: | 2007-03-19 | Release date: | 2007-08-21 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure and function of a chlorella virus-encoded glycosyltransferase. Structure, 15, 2007
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2P73
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![BU of 2p73 by Molmil](/molmil-images/mine/2p73) | crystal structure of a glycosyltransferase involved in the glycosylation of the major capsid of PBCV-1 | Descriptor: | MANGANESE (II) ION, Putative glycosyltransferase (Mannosyltransferase) involved in glycosylating the PBCV-1 major capsid protein, URIDINE-5'-DIPHOSPHATE | Authors: | Zhang, Y, Xiang, Y, Van Etten, J.L, Rossmann, M.G. | Deposit date: | 2007-03-19 | Release date: | 2007-08-21 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure and function of a chlorella virus-encoded glycosyltransferase. Structure, 15, 2007
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2P6W
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![BU of 2p6w by Molmil](/molmil-images/mine/2p6w) | Crystal structure of a glycosyltransferase involved in the glycosylation of the major capsid of PBCV-1 | Descriptor: | CITRATE ANION, MANGANESE (II) ION, Putative glycosyltransferase (Mannosyltransferase) involved in glycosylating the PBCV-1 major capsid protein | Authors: | Zhang, Y, Ye, X, Van Etten, J.L, Rossmann, M.G. | Deposit date: | 2007-03-19 | Release date: | 2007-08-21 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure and function of a chlorella virus-encoded glycosyltransferase. Structure, 15, 2007
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