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PDB: 103 件
1EEL
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STRUCTURE OF A COMPLEX BETWEEN THE DNA SEQUENCE DCGCGAATTCGCG AND BIS[PIPERIDINO-ETHYL]-FURAMIDINE
分子名称: 2,5-BIS-[4-[CYCLOPENTA-1,3-DIEN-5-YLAMINO-1-AMINOMETHYL]-PHEN-1-YL]FURAN, 5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'
著者Neidle, S, Simpson, I.J.
登録日2000-02-01
公開日2000-02-09
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献A thermodynamic and structural analysis of DNA minor-groove complex formation.
J.Mol.Biol., 300, 2000
453D
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5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'-BENZIMIDAZOLE COMPLEX
分子名称: 4-{[4-HYDROXY-PHENYL]-1H-BENZIMIDAZOLE-5-YL}-BENZIMIDAZOLE-2-YL-[4-HYDROXY-BENZENE], DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3')
著者Neidle, S.
登録日1999-02-18
公開日2000-05-15
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Symmetric bis-benzimidazoles, a new class of sequence-selective DNA-binding molecules
J.Chem.Soc.,Chem.Commun., 1999
1EM0
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BU of 1em0 by Molmil
COMPLEX OF D(CCTAGG) WITH TETRA-[N-METHYL-PYRIDYL] PORPHYRIN
分子名称: DNA (5'-D(*(CBR)P*CP*TP*AP*GP*G)-3'), MAGNESIUM ION, TETRA[N-METHYL-PYRIDYL] PORPHYRIN-NICKEL
著者Neidle, S, Sanderson, M, Bennett, M, Krah, A, Wien, F, Garman, E, McKenna, R.
登録日2000-03-14
公開日2000-08-21
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (0.9 Å)
主引用文献A DNA-porphyrin minor-groove complex at atomic resolution: the structural consequences of porphyrin ruffling.
Proc.Natl.Acad.Sci.USA, 97, 2000
2I5A
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BU of 2i5a by Molmil
Crystal structure of a DB1055-D(CGCGAATTCGCG)2 complex
分子名称: 2-{3'-[AMINO(IMINO)METHYL]BIPHENYL-4-YL}-1H-BENZIMIDAZOLE-5-CARBOXIMIDAMIDE, 5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3', MAGNESIUM ION
著者Neidle, S, Lee, M.P.H.
登録日2006-08-24
公開日2008-04-08
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Crystal structure of a DB1055-D(CGCGAATTCGCG)2 complex
To be Published
4KWX
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Linear structure of the Holliday junction sequence (TCGGCGCCGA)
分子名称: 5'-D(*TP*CP*GP*GP*CP*GP*CP*CP*GP*A)-3', MAGNESIUM ION
著者Skamrova, G, Laponogov, I, Campbell, N, Neidle, S.
登録日2013-05-24
公開日2014-11-26
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Linear structure of the Holliday junction sequence (TCGGCGCCGA)
To be Published
2O3M
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BU of 2o3m by Molmil
Monomeric G-DNA tetraplex from human C-kit promoter
分子名称: 5'-D(*AP*GP*GP*GP*AP*GP*GP*GP*CP*GP*CP*TP*GP*GP*GP*AP*GP*GP*AP*GP*GP*G)-3'
著者Phan, A.T, Kuryavyi, V.V, Burge, S, Neidle, S, Patel, D.J.
登録日2006-12-01
公開日2007-05-22
最終更新日2023-12-27
実験手法SOLUTION NMR
主引用文献Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter.
J.Am.Chem.Soc., 129, 2007
4WO2
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CRYSTAL STRUCTURE OF HUMAN NATIVE CKIT PROTO-ONCOGENE PROMOTER QUADRUPLEX DNA
分子名称: DNA (5'-D(*AP*GP*GP*GP*AP*GP*GP*GP*CP*GP*CP*TP*GP*GP*GP*AP*GP*GP*AP*GP*GP*G)-3'), POTASSIUM ION
著者wei, D, parkinson, g.n, neidle, s.
登録日2014-10-15
公開日2014-10-22
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献CRYSTAL STRUCTURE OF HUMAN NATIVE CKIT-1 PROTO-ONCOGENE PROMOTER QUADRUPLEX DNA
TO BE PUBLISHED
4WO3
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THE SECOND C-KIT DNA QUADRUPLEX CRYSTAL STRUCTURE
分子名称: DNA (5'-D(*AP*GP*GP*GP*AP*GP*GP*GP*CP*GP*CP*TP*GP*GP*GP*AP*GP*GP*AP*GP*GP*G)-3'), POTASSIUM ION
著者Wei, D, Neidle, S.
登録日2014-10-15
公開日2014-10-29
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.73 Å)
主引用文献THE SECOND C-KIT1 DNA QUADRUPLEX CRYSTAL STRUCTURE
TO BE PUBLISHED
3MIJ
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BU of 3mij by Molmil
Crystal structure of a telomeric RNA G-quadruplex complexed with an acridine-based ligand.
分子名称: N,N'-[acridine-3,6-diylbis(1H-1,2,3-triazole-1,4-diylbenzene-3,1-diyl)]bis[3-(diethylamino)propanamide], POTASSIUM ION, RNA (5'-R(*UP*AP*GP*GP*GP*UP*UP*AP*GP*GP*GP*U)-3')
著者Collie, G.W, Neidle, S, Parkinson, G.N.
登録日2010-04-10
公開日2011-02-16
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural basis of telomeric RNA quadruplex-acridine ligand recognition.
J.Am.Chem.Soc., 133, 2011
2NLM
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BU of 2nlm by Molmil
Crystal structure of the DB 911- D(CGCGAATTCGCG)2 complex at 2.05 A resolution.
分子名称: 2-{4'-[AMINO(IMINO)METHYL]BIPHENYL-3-YL}-1H-BENZIMIDAZOLE-6-CARBOXIMIDAMIDE, 5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3', MAGNESIUM ION
著者Lee, M.P.H, Neidle, S.
登録日2006-10-20
公開日2007-10-30
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Crystal structure of the DB 911 - D(CGCGAATTCGCG)2 complex at 2.05 A resolution.
To be Published
109D
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BU of 109d by Molmil
VARIABILITY IN DNA MINOR GROOVE WIDTH RECOGNISED BY LIGAND BINDING: THE CRYSTAL STRUCTURE OF A BIS-BENZIMIDAZOLE COMPOUND BOUND TO THE DNA DUPLEX D(CGCGAATTCGCG)2
分子名称: 5-(2-IMIDAZOLINYL)-2-[2-(4-HYDROXYPHENYL)-5-BENZIMIDAZOLYL]BENZIMIDAZOLE, DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'), MAGNESIUM ION
著者Czarny, A, Boykin, D.W, Wood, A.A, Nunn, C.M, Neidle, S, Zhao, M, Wilson, W.D.
登録日1995-02-15
公開日1995-05-08
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Variability in DNA minor groove width recognised by ligand binding: the crystal structure of a bis-benzimidazole compound bound to the DNA duplex d(CGCGAATTCGCG)2.
Nucleic Acids Res., 23, 1995
166D
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DRUG-DNA MINOR GROOVE RECOGNITION: CRYSTAL STRUCTURE OF GAMMA-OXAPENTAMIDINE COMPLEXED WITH D(CGCGAATTCGCG)2
分子名称: 1,5-DI(4-AMIDINOPHENOXY)-3-OXA-PENTANE, DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3')
著者Nunn, C.M, Jenkins, T.C, Neidle, S.
登録日1994-03-17
公開日1994-10-15
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of gamma-oxapentamidine complexed with d(CGCGAATTCGCG)2. The effects of drug structural change on DNA minor-groove recognition.
Eur.J.Biochem., 226, 1994
8XPA
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BU of 8xpa by Molmil
Crystal structure of d(ACGmCCGT/ACGGCGT)
分子名称: DNA (5'-D(P*AP*CP*GP*(5CM)P*CP*GP*T)-3'), DNA (5'-D(P*AP*CP*GP*GP*CP*GP*T)-3'), MAGNESIUM ION, ...
著者Hou, M.H, Lin, S.M, Neidle, S.
登録日2024-01-03
公開日2024-05-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of d(ACGmCCGT/ACGGCGT)
To Be Published
4DA3
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BU of 4da3 by Molmil
Crystal structure of an intramolecular human telomeric DNA G-quadruplex 21-mer bound by the naphthalene diimide compound MM41.
分子名称: 4,9-bis{[3-(4-methylpiperazin-1-yl)propyl]amino}-2,7-bis[3-(morpholin-4-yl)propyl]benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetrone, DNA (5'-D(*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*G)-3'), POTASSIUM ION
著者Collie, G.W, Neidle, S.
登録日2012-01-12
公開日2013-01-30
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure-based design and evaluation of naphthalene diimide g-quadruplex ligands as telomere targeting agents in pancreatic cancer cells.
J.Med.Chem., 56, 2013
4DAQ
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Crystal structure of an intramolecular human telomeric DNA G-quadruplex 21-mer bound by the naphthalene diimide compound BMSG-SH-3
分子名称: 2,7-bis[3-(4-methylpiperazin-1-yl)propyl]-4,9-bis{[3-(4-methylpiperazin-1-yl)propyl]amino}benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetrone, DNA (5'-D(*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*G)-3'), POTASSIUM ION
著者Collie, G.W, Neidle, S.
登録日2012-01-13
公開日2013-01-16
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.754 Å)
主引用文献Structure-based design and evaluation of naphthalene diimide g-quadruplex ligands as telomere targeting agents in pancreatic cancer cells.
J.Med.Chem., 56, 2013
3OIE
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BU of 3oie by Molmil
Crystal structure of the DB1880-D(CGCGAATTCGCG)2 complex
分子名称: 5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3', MAGNESIUM ION, N',N''-{furan-2,5-diylbis[3-(piperidin-4-yloxy)benzene-4,1-diyl]}dipyridine-2-carboximidamide
著者Lin, S, Neidle, S, Campbell, N.
登録日2010-08-19
公開日2011-01-19
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of the DB1880-D(CGCGAATTCGCG)2 complex
To be Published
3IBK
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Crystal structure of a telomeric RNA quadruplex
分子名称: POTASSIUM ION, RNA (5'-R(*(5BU)P*AP*GP*GP*GP*UP*UP*AP*GP*GP*GP*U)-3')
著者Collie, G.W, Neidle, S, Parkinson, G.N.
登録日2009-07-16
公開日2010-05-12
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex
Nucleic Acids Res., 38, 2010
1PRP
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CRYSTAL STRUCTURE OF D(CGCGAATTCGCG) COMPLEXED WITH PROPAMIDINE, A SHORT-CHAIN HOMOLOGUE OF THE DRUG PENTAMIDIN
分子名称: 1,3-BIS(AMIDINOPHENOXY)PROPANE, DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3')
著者Nunn, C.M, Jenkins, T.C, Neidle, S.
登録日1993-07-23
公開日1994-01-15
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of d(CGCGAATTCGCG) complexed with propamidine, a short-chain homologue of the drug pentamidine.
Biochemistry, 32, 1993
4H29
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B-raf dimer DNA quadruplex
分子名称: DNA (5'-D(*GP*GP*GP*CP*GP*GP*GP*GP*AP*GP*GP*GP*GP*GP*AP*AP*GP*GP*GP*A)-3'), POTASSIUM ION
著者Wei, D, Parkinson, G, Neidle, S.
登録日2012-09-12
公開日2013-07-31
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.991 Å)
主引用文献Crystal Structure of a Promoter Sequence in the B-raf Gene Reveals an Intertwined Dimer Quadruplex.
J.Am.Chem.Soc., 135, 2013
102D
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SEQUENCE-DEPENDENT DRUG BINDING TO THE MINOR GROOVE OF DNA: THE CRYSTAL STRUCTURE OF THE DNA DODECAMER D(CGCAAATTTGCG)2 COMPLEXED WITH PROPAMIDINE
分子名称: 1,3-BIS(AMIDINOPHENOXY)PROPANE, DNA (5'-D(*CP*GP*CP*AP*AP*AP*TP*TP*TP*GP*CP*G)-3')
著者Nunn, C.M, Neidle, S.
登録日1994-12-15
公開日1995-02-07
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Sequence-dependent drug binding to the minor groove of DNA: crystal structure of the DNA dodecamer d(CGCAAATTTGCG)2 complexed with propamidine.
J.Med.Chem., 38, 1995
3QCR
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BU of 3qcr by Molmil
Incomplete structural model of a human telomeric DNA quadruplex-acridine complex.
分子名称: Human telomeric repeat deoxyribonucleic acid, N,N'-[acridine-3,6-diylbis(1H-1,2,3-triazole-1,4-diylbenzene-3,1-diyl)]bis[3-(diethylamino)propanamide], POTASSIUM ION
著者Collie, G.W, Neidle, S, Parkinson, G.N.
登録日2011-01-17
公開日2011-02-16
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural basis of telomeric RNA quadruplex-acridine ligand recognition.
J.Am.Chem.Soc., 133, 2011
1D80
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CRYSTAL STRUCTURE OF AN OLIGONUCLEOTIDE DUPLEX CONTAINING G.G BASE-PAIRS: THE INFLUENCE OF MISPAIRING ON DNA BACKBONE CONFORMATION
分子名称: DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*GP*GP*CP*G)-3')
著者Skelly, J.V, Edwards, K.J, Jenkins, T.C, Neidle, S.
登録日1992-06-17
公開日1993-07-15
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of an oligonucleotide duplex containing G.G base pairs: influence of mispairing on DNA backbone conformation.
Proc.Natl.Acad.Sci.USA, 90, 1993
1D64
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CRYSTAL STRUCTURE OF A PENTAMIDINE-OLIGONUCLEOTIDE COMPLEX: IMPLICATIONS FOR DNA-BINDING PROPERTIES
分子名称: 1,5-BIS(4-AMIDINOPHENOXY)PENTANE, DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3')
著者Edwards, K.J, Jenkins, T.C, Neidle, S.
登録日1992-03-02
公開日1993-01-15
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of a pentamidine-oligonucleotide complex: implications for DNA-binding properties.
Biochemistry, 31, 1992
1D65
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MOLECULAR STRUCTURE OF THE B-DNA DODECAMER D(CGCAAATTTGCG)2; AN EXAMINATION OF PROPELLER TWIST AND MINOR-GROOVE WATER STRUCTURE AT 2.2 ANGSTROMS RESOLUTION
分子名称: DNA (5'-D(*CP*GP*CP*AP*AP*AP*TP*TP*TP*GP*CP*G)-3')
著者Edwards, K.J, Brown, D.G, Spink, N, Neidle, S.
登録日1992-03-02
公開日1993-01-15
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Molecular structure of the B-DNA dodecamer d(CGCAAATTTGCG)2. An examination of propeller twist and minor-groove water structure at 2.2 A resolution.
J.Mol.Biol., 226, 1992
2KQH
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A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics
分子名称: 5'-D(*CP*GP*GP*GP*CP*GP*GP*GP*CP*GP*CP*GP*AP*GP*GP*GP*AP*GP*GP*GP*T)-3', POTASSIUM ION
著者Hsu, S.-T.D, Varnai, P, Bugaut, A, Reszka, A.P, Neidle, S, Balasubramanian, S.
登録日2009-11-05
公開日2009-11-24
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics
J.Am.Chem.Soc., 131, 2009

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