102D

SEQUENCE-DEPENDENT DRUG BINDING TO THE MINOR GROOVE OF DNA: THE CRYSTAL STRUCTURE OF THE DNA DODECAMER D(CGCAAATTTGCG)2 COMPLEXED WITH PROPAMIDINE

Summary for 102D

DescriptorDNA (5'-D(*CP*GP*CP*AP*AP*AP*TP*TP*TP*GP*CP*G)-3'), 1,3-BIS(AMIDINOPHENOXY)PROPANE (3 entities in total)
Functional Keywordsb-dna, double helix, complexed with drug, dna
Total number of polymer chains2
Total molecular weight7637.17
Authors
Nunn, C.M.,Neidle, S. (deposition date: 1994-12-15, release date: 1995-02-07, Last modification date: 2011-07-13)
Primary citation
Nunn, C.M.,Neidle, S.
Sequence-dependent drug binding to the minor groove of DNA: crystal structure of the DNA dodecamer d(CGCAAATTTGCG)2 complexed with propamidine.
J.Med.Chem., 38:2317-2325, 1995
PubMed: 7608897 (PDB entries with the same primary citation)
DOI: 10.1021/jm00013a008
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.2 Å)
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Structure validation

ClashscoreRSRZ outliers20MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 102d
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Molmil generated image of 102d
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Molmil generated image of 102d
rotated about y axis by 90°
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