1BAF
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![BU of 1baf by Molmil](/molmil-images/mine/1baf) | 2.9 ANGSTROMS RESOLUTION STRUCTURE OF AN ANTI-DINITROPHENYL-SPIN-LABEL MONOCLONAL ANTIBODY FAB FRAGMENT WITH BOUND HAPTEN | Descriptor: | IGG1-KAPPA AN02 FAB (HEAVY CHAIN), IGG1-KAPPA AN02 FAB (LIGHT CHAIN), N-(2-AMINO-ETHYL)-4,6-DINITRO-N'-(2,2,6,6-TETRAMETHYL-1-OXY-PIPERIDIN-4-YL)-BENZENE-1,3-DIAMINE | Authors: | Leahy, D.J, Brunger, A.T, Fox, R.O, Hynes, T.R. | Deposit date: | 1992-01-16 | Release date: | 1994-01-31 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | 2.9 A resolution structure of an anti-dinitrophenyl-spin-label monoclonal antibody Fab fragment with bound hapten. J.Mol.Biol., 221, 1991
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1FNF
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![BU of 1fnf by Molmil](/molmil-images/mine/1fnf) | |
1CD8
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![BU of 1cd8 by Molmil](/molmil-images/mine/1cd8) | |
1M6B
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![BU of 1m6b by Molmil](/molmil-images/mine/1m6b) | Structure of the HER3 (ERBB3) Extracellular Domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Receptor protein-tyrosine kinase erbB-3, ... | Authors: | Leahy, D.J, Cho, H.-S. | Deposit date: | 2002-07-15 | Release date: | 2002-08-02 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure of the extracellular region of HER3 reveals an interdomain tether. Science, 297, 2002
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1LFA
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![BU of 1lfa by Molmil](/molmil-images/mine/1lfa) | CD11A I-DOMAIN WITH BOUND MN++ | Descriptor: | CD11A, CHLORIDE ION, MANGANESE (II) ION | Authors: | Leahy, D.J, Qu, A. | Deposit date: | 1995-09-08 | Release date: | 1996-01-29 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin. Proc.Natl.Acad.Sci.USA, 92, 1995
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1ZOP
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![BU of 1zop by Molmil](/molmil-images/mine/1zop) | CD11A I-DOMAIN WITH BOUND MAGNESIUM ION | Descriptor: | CHLORIDE ION, I-DOMAIN FRAGMENT OF LFA-1, MANGANESE (II) ION | Authors: | Leahy, D.J, Qu, A. | Deposit date: | 1996-06-21 | Release date: | 1996-12-07 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin. Structure, 4, 1996
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1ZOO
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![BU of 1zoo by Molmil](/molmil-images/mine/1zoo) | CD11A I-DOMAIN WITH BOUND MAGNESIUM ION | Descriptor: | CHLORIDE ION, LEUKOCYTE ADHESION GLYCOPROTEIN, MAGNESIUM ION | Authors: | Leahy, D.J, Qu, A. | Deposit date: | 1996-06-21 | Release date: | 1996-12-07 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin. Structure, 4, 1996
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1ZON
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![BU of 1zon by Molmil](/molmil-images/mine/1zon) | CD11A I-DOMAIN WITHOUT BOUND CATION | Descriptor: | LEUKOCYTE ADHESION GLYCOPROTEIN | Authors: | Leahy, D.J, Qu, A. | Deposit date: | 1996-06-20 | Release date: | 1996-12-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin. Structure, 4, 1996
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1TEN
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![BU of 1ten by Molmil](/molmil-images/mine/1ten) | |
1VHH
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![BU of 1vhh by Molmil](/molmil-images/mine/1vhh) | A POTENTIAL CATALYTIC SITE WITHIN THE AMINO-TERMINAL SIGNALLING DOMAIN OF SONIC HEDGEHOG | Descriptor: | SONIC HEDGEHOG, SULFATE ION, ZINC ION | Authors: | Hall, T.M.T, Porter, J.A, Beachy, P.A, Leahy, D.J. | Deposit date: | 1995-10-03 | Release date: | 1996-01-29 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A potential catalytic site revealed by the 1.7-A crystal structure of the amino-terminal signalling domain of Sonic hedgehog. Nature, 378, 1995
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3U9U
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![BU of 3u9u by Molmil](/molmil-images/mine/3u9u) | Crystal Structure of Extracellular Domain of Human ErbB4/Her4 in complex with the Fab fragment of mAb1479 | Descriptor: | Fab Heavy Chain, Fab Light Chain, Receptor tyrosine-protein kinase erbB-4 | Authors: | Hollmen, M, Liu, P, Wildiers, H, Reinvall, I, Vandorpe, T, Smeets, A, Deraedt, K, Vahlberg, T, Joensuu, H, Leahy, D.J, Schoffski, P, Elenius, K. | Deposit date: | 2011-10-19 | Release date: | 2012-10-31 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.42 Å) | Cite: | Proteolytic processing of ErbB4 in breast cancer. Plos One, 7, 2012
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6JFV
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![BU of 6jfv by Molmil](/molmil-images/mine/6jfv) | The crystal structure of 2B-2B complex from keratins 5 and 14 (C367A mutant of K14) | Descriptor: | Keratin, type I cytoskeletal 14, type II cytoskeletal 5 | Authors: | Kim, M.S, Lee, C.H, Coulombe, P.A, Leahy, D.J. | Deposit date: | 2019-02-12 | Release date: | 2020-01-22 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure-Function Analyses of a Keratin Heterotypic Complex Identify Specific Keratin Regions Involved in Intermediate Filament Assembly. Structure, 28, 2020
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3D1M
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4X3H
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![BU of 4x3h by Molmil](/molmil-images/mine/4x3h) | CRYSTAL STRUCTURE OF ARC N-LOBE COMPLEXED WITH STARGAZIN PEPTIDE | Descriptor: | Activity-regulated cytoskeleton-associated protein, VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-2 SUBUNIT | Authors: | zhang, W, ward, m, leahy, d, worley, p. | Deposit date: | 2014-11-30 | Release date: | 2015-06-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.401 Å) | Cite: | Structural basis of arc binding to synaptic proteins: implications for cognitive disease. Neuron, 86, 2015
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4X3I
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![BU of 4x3i by Molmil](/molmil-images/mine/4x3i) | The crystal structure of Arc N-lobe complexed with CAMK2A fragment | Descriptor: | Activity-regulated cytoskeleton-associated protein, CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA | Authors: | Zhang, W, Ward, M, Leahy, D, Worley, P. | Deposit date: | 2014-11-30 | Release date: | 2015-06-03 | Last modified: | 2017-09-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis of arc binding to synaptic proteins: implications for cognitive disease. Neuron, 86, 2015
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4X3X
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![BU of 4x3x by Molmil](/molmil-images/mine/4x3x) | The crystal structure of Arc C-lobe | Descriptor: | Activity-regulated cytoskeleton-associated protein | Authors: | Zhang, W, Ward, M, Leahy, D, Worley, P. | Deposit date: | 2014-12-01 | Release date: | 2015-06-03 | Last modified: | 2017-09-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis of arc binding to synaptic proteins: implications for cognitive disease. Neuron, 86, 2015
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4PFJ
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![BU of 4pfj by Molmil](/molmil-images/mine/4pfj) | The structure of bi-acetylated SAHH | Descriptor: | ADENOSINE, Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Kavran, J.M, Wang, Y, Cole, P.A, Leahy, D.J. | Deposit date: | 2014-04-29 | Release date: | 2014-10-01 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Regulation of s-adenosylhomocysteine hydrolase by lysine acetylation. J.Biol.Chem., 289, 2014
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4PGF
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![BU of 4pgf by Molmil](/molmil-images/mine/4pgf) | The structure of mono-acetylated SAHH | Descriptor: | ADENOSINE, Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Kavran, J.M, Wang, Y, Cole, P.A, Leahy, D.J. | Deposit date: | 2014-05-01 | Release date: | 2014-10-01 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Regulation of s-adenosylhomocysteine hydrolase by lysine acetylation. J.Biol.Chem., 289, 2014
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1AT0
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![BU of 1at0 by Molmil](/molmil-images/mine/1at0) | 17-kDA fragment of hedgehog C-terminal autoprocessing domain | Descriptor: | 17-HEDGEHOG | Authors: | Hall, T.M.T, Porter, J.A, Young, K.E, Koonin, E.V, Beachy, P.A, Leahy, D.J. | Deposit date: | 1997-08-15 | Release date: | 1997-11-12 | Last modified: | 2017-09-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of a Hedgehog autoprocessing domain: homology between Hedgehog and self-splicing proteins. Cell(Cambridge,Mass.), 91, 1997
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3U7U
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![BU of 3u7u by Molmil](/molmil-images/mine/3u7u) | Crystal structure of extracellular region of human epidermal growth factor receptor 4 in complex with neuregulin-1 beta | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Neuregulin 1, Receptor tyrosine-protein kinase erbB-4 | Authors: | Liu, P, Cleveland IV, T.E, Bouyain, S, Longo, P.A, Leahy, D.J. | Deposit date: | 2011-10-14 | Release date: | 2012-08-29 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.03 Å) | Cite: | A single ligand is sufficient to activate EGFR dimers. Proc.Natl.Acad.Sci.USA, 109, 2012
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3U2P
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![BU of 3u2p by Molmil](/molmil-images/mine/3u2p) | Crystal structure of N-terminal three extracellular domains of ErbB4/Her4 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Receptor tyrosine-protein kinase erbB-4 | Authors: | Liu, P, Bouyain, S, Elgenbrot, C, Leahy, D.J. | Deposit date: | 2011-10-04 | Release date: | 2011-11-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.57 Å) | Cite: | The ErbB4 extracellular region retains a tethered-like conformation in the absence of the tether. Protein Sci., 21, 2012
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1DDV
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![BU of 1ddv by Molmil](/molmil-images/mine/1ddv) | CRYSTAL STRUCTURE OF THE HOMER EVH1 DOMAIN WITH BOUND MGLUR PEPTIDE | Descriptor: | GLGF-DOMAIN PROTEIN HOMER, METABOTROPIC GLUTAMATE RECEPTOR MGLUR5 | Authors: | Beneken, J, Tu, J.C, Xiao, B, Worley, P.F, Leahy, D.J. | Deposit date: | 1999-11-11 | Release date: | 2000-05-10 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition. Neuron, 26, 2000
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1N8Z
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![BU of 1n8z by Molmil](/molmil-images/mine/1n8z) | Crystal structure of extracellular domain of human HER2 complexed with Herceptin Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Herceptin Fab (antibody) - heavy chain, Herceptin Fab (antibody) - light chain, ... | Authors: | Cho, H.-S, Mason, K, Ramyar, K.X, Stanley, A.M, Gabelli, S.B, Denney Jr, D.W, Leahy, D.J. | Deposit date: | 2002-11-21 | Release date: | 2003-02-18 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | Structure of the Extracellular Region of HER2 Alone and in Complex with the Herceptin Fab Nature, 421, 2003
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1N8Y
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![BU of 1n8y by Molmil](/molmil-images/mine/1n8y) | Crystal structure of the extracellular region of rat HER2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, protooncoprotein | Authors: | Cho, H.-S, Mason, K, Ramyar, K.X, Stanley, A.M, Gabelli, S.B, Denney Jr, D.W, Leahy, D.J. | Deposit date: | 2002-11-21 | Release date: | 2003-02-18 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of the Extracellular Region of HER2 Alone and in complex with the Herceptin Fab Nature, 421, 2003
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1OT8
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![BU of 1ot8 by Molmil](/molmil-images/mine/1ot8) | Structure of the Ankyrin Domain of the Drosophila Notch Receptor | Descriptor: | MAGNESIUM ION, Neurogenic locus Notch protein | Authors: | Zweifel, M.E, Leahy, D.J, Hughson, F.M, Barrick, D. | Deposit date: | 2003-03-21 | Release date: | 2003-10-28 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure and stability of the ankyrin domain of the Drosophila Notch receptor Protein Sci., 12, 2003
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