6V9Y
 
 | | Structure of TRPA1 bound with A-967079, PMAL-C8 | | Descriptor: | Transient receptor potential cation channel subfamily A member 1 | | Authors: | Zhao, J, Lin King, J.V, Paulsen, C.E, Cheng, Y, Julius, D. | | Deposit date: | 2019-12-16 | | Release date: | 2020-05-06 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Irritant-evoked activation and calcium modulation of the TRPA1 receptor.
Nature, 585, 2020
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6V9X
 | | Structure of TRPA1 modified by iodoacetamide, PMAL-C8 | | Descriptor: | Transient receptor potential cation channel subfamily A member 1 | | Authors: | Zhao, J, Lin King, J.V, Paulsen, C.E, Cheng, Y, Julius, D. | | Deposit date: | 2019-12-16 | | Release date: | 2020-05-06 | | Last modified: | 2020-09-16 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Irritant-evoked activation and calcium modulation of the TRPA1 receptor.
Nature, 585, 2020
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8SBE
 | | Structure of the rat vesicular glutamate transporter 2 determined by single-particle Cryo-EM | | Descriptor: | Vesicular glutamate transporter 2 | | Authors: | Li, F, Finer-Moore, J, Eriksen, J, Cheng, Y, Edwards, R, Stroud, R. | | Deposit date: | 2023-04-03 | | Release date: | 2023-05-03 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Ion transport and regulation in a synaptic vesicle glutamate transporter.
Science, 368, 2020
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6V9V
 | | Structure of TRPA1 modified by Bodipy-iodoacetamide with bound calcium, LMNG | | Descriptor: | CALCIUM ION, Transient receptor potential cation channel subfamily A member 1, ~{N}-[[2,2-bis(fluoranyl)-10,12-dimethyl-1,3-diaza-2$l^{4}-boratricyclo[7.3.0.0^{3,7}]dodeca-4,6,9,11-tetraen-4-yl]methyl]ethanamide | | Authors: | Zhao, J, Lin King, J.V, Paulsen, C.E, Cheng, Y, Julius, D. | | Deposit date: | 2019-12-16 | | Release date: | 2020-05-06 | | Last modified: | 2020-09-16 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Irritant-evoked activation and calcium modulation of the TRPA1 receptor.
Nature, 585, 2020
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6BQV
 | | Human TRPM4 ion channel in lipid nanodiscs in a calcium-bound state | | Descriptor: | CALCIUM ION, CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 4 | | Authors: | Autzen, H.E, Myasnikov, A.G, Campbell, M.G, Asarnow, D, Julius, D, Cheng, Y. | | Deposit date: | 2017-11-28 | | Release date: | 2017-12-20 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structure of the human TRPM4 ion channel in a lipid nanodisc.
Science, 359, 2018
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6V9W
 | | Structure of TRPA1 (ligand-free) with bound calcium, LMNG | | Descriptor: | CALCIUM ION, Transient receptor potential cation channel subfamily A member 1 | | Authors: | Zhao, J, Lin King, J.V, Paulsen, C.E, Cheng, Y, Julius, D. | | Deposit date: | 2019-12-16 | | Release date: | 2020-05-06 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Irritant-evoked activation and calcium modulation of the TRPA1 receptor.
Nature, 585, 2020
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6BQR
 | | Human TRPM4 ion channel in lipid nanodiscs in a calcium-free state | | Descriptor: | CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 4 | | Authors: | Autzen, H.E, Myasnikov, A.G, Campbell, M.G, Asarnow, D, Julius, D, Cheng, Y. | | Deposit date: | 2017-11-28 | | Release date: | 2017-12-20 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structure of the human TRPM4 ion channel in a lipid nanodisc.
Science, 359, 2018
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6DJP
 | | Integrin alpha-v beta-8 in complex with the Fabs 8B8 and 68 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 68 heavy chain Fab, ... | | Authors: | Cormier, A, Campbell, M.G, Nishimura, S.L, Cheng, Y. | | Deposit date: | 2018-05-25 | | Release date: | 2018-07-25 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (4.8 Å) | | Cite: | Cryo-EM structure of the alpha v beta 8 integrin reveals a mechanism for stabilizing integrin extension.
Nat. Struct. Mol. Biol., 25, 2018
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5IRX
 | | Structure of TRPV1 in complex with DkTx and RTX, determined in lipid nanodisc | | Descriptor: | (2S)-2-(acetyloxy)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}propyl pentanoate, (2S)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate, (4R,7S)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(pentanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphatetradecan-1-aminium, ... | | Authors: | Gao, Y, Cao, E, Julius, D, Cheng, Y. | | Deposit date: | 2016-03-14 | | Release date: | 2016-05-25 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (2.95 Å) | | Cite: | TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action.
Nature, 534, 2016
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6UJB
 | | Integrin alpha-v beta-8 in complex with the Fabs C6D4 and 11D12v2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C6D4 heavy chain Fab, ... | | Authors: | Campbell, M.G, Cormier, A, Cheng, Y, Nishimura, S.L. | | Deposit date: | 2019-10-02 | | Release date: | 2020-02-05 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (3.51 Å) | | Cite: | Cryo-EM Reveals Integrin-Mediated TGF-beta Activation without Release from Latent TGF-beta.
Cell, 180, 2020
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8JMW
 | | Fibril form of serine peptidase Vpr | | Descriptor: | S8 family serine peptidase | | Authors: | Cao, Q, Cheng, Y. | | Deposit date: | 2023-06-05 | | Release date: | 2023-12-06 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Serine peptidase Vpr forms enzymatically active fibrils outside Bacillus bacteria revealed by cryo-EM.
Nat Commun, 14, 2023
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6WBV
 | | Structure of human ferroportin bound to hepcidin and cobalt in lipid nanodisc | | Descriptor: | (1S)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PENTANOYLOXY)METHYL]ETHYL OCTANOATE, COBALT (II) ION, Fab45D8 Heavy Chain, ... | | Authors: | Billesboelle, C.B, Azumaya, C.M, Gonen, S, Powers, A, Kretsch, R.C, Schneider, S, Arvedson, T, Dror, R.O, Cheng, Y, Manglik, A. | | Deposit date: | 2020-03-27 | | Release date: | 2020-09-09 | | Last modified: | 2020-11-11 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms.
Nature, 586, 2020
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6W4S
 | | Structure of apo human ferroportin in lipid nanodisc | | Descriptor: | Fab45D8 Heavy Chain, Fab45D8 Light Chain, Solute carrier family 40 member 1 | | Authors: | Billesboelle, C.B, Azumaya, C.M, Gonen, S, Powers, A, Kretsch, R.C, Schneider, S, Arvedson, T, Dror, R.O, Cheng, Y, Manglik, A. | | Deposit date: | 2020-03-11 | | Release date: | 2020-09-09 | | Last modified: | 2020-11-11 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms.
Nature, 586, 2020
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5IS0
 | | Structure of TRPV1 in complex with capsazepine, determined in lipid nanodisc | | Descriptor: | Transient receptor potential cation channel subfamily V member 1, capsazepine | | Authors: | Gao, Y, Cao, E, Julius, D, Cheng, Y. | | Deposit date: | 2016-03-15 | | Release date: | 2016-05-25 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.43 Å) | | Cite: | TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action.
Nature, 534, 2016
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3AMS
 | | Crystal Structures of Bacillus subtilis Alkaline Phytase in Complex with Ca2+, Cd2+, Co2+, Ni2+, Mg2+ and myo-Inositol Hexasulfate | | Descriptor: | 3-phytase, CADMIUM ION, CALCIUM ION, ... | | Authors: | Zeng, Y.F, Ko, T.P, Lai, H.L, Cheng, Y.S, Wu, T.H, Ma, Y, Yang, C.S, Cheng, K.J, Huang, C.H, Guo, R.T, Liu, J.R. | | Deposit date: | 2010-08-22 | | Release date: | 2011-04-13 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.08 Å) | | Cite: | Crystal structures of Bacillus alkaline phytase in complex with divalent metal ions and inositol hexasulfate
J.Mol.Biol., 409, 2011
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2B6P
 | | X-ray structure of lens Aquaporin-0 (AQP0) (lens MIP) in an open pore state | | Descriptor: | Lens fiber major intrinsic protein | | Authors: | Gonen, T, Cheng, Y, Sliz, P, Hiroaki, Y, Fujiyoshi, Y, Harrison, S.C, Walz, T. | | Deposit date: | 2005-10-03 | | Release date: | 2005-12-06 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Lipid-protein interactions in double-layered two-dimensional AQP0 crystals.
Nature, 438, 2005
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8T3L
 | | TRPV1 in nanodisc bound with 2 LPA molecules in neighboring monomers | | Descriptor: | (2R)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate, (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, SODIUM ION, ... | | Authors: | Arnold, W.R, Julius, D, Cheng, Y. | | Deposit date: | 2023-06-07 | | Release date: | 2024-05-08 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structural basis of TRPV1 modulation by endogenous bioactive lipids.
Nat.Struct.Mol.Biol., 2024
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8T0E
 | | TRPV1 in Nanodisc not bound with lysophosphatidic acid (apo) | | Descriptor: | (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, SODIUM ION, Transient receptor potential cation channel subfamily V member 1 | | Authors: | Arnold, W.R, Cheng, Y. | | Deposit date: | 2023-05-31 | | Release date: | 2024-05-08 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural basis of TRPV1 modulation by endogenous bioactive lipids.
Nat.Struct.Mol.Biol., 2024
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8T0C
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8T10
 | | TRPV1 in nanodisc bound with two LPA molecules in opposite monomers | | Descriptor: | (2R)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate, (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, SODIUM ION, ... | | Authors: | Arnold, W.R, Julius, D, Cheng, Y. | | Deposit date: | 2023-06-01 | | Release date: | 2024-05-08 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structural basis of TRPV1 modulation by endogenous bioactive lipids.
Nat.Struct.Mol.Biol., 2024
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8T3M
 | | TRPV1 in nanodisc bound with 3 LPA molecules | | Descriptor: | (2R)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate, SODIUM ION, Transient receptor potential cation channel subfamily V member 1, ... | | Authors: | Arnold, W.R, Julius, D, Cheng, Y. | | Deposit date: | 2023-06-07 | | Release date: | 2024-05-08 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structural basis of TRPV1 modulation by endogenous bioactive lipids.
Nat.Struct.Mol.Biol., 2024
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8T0Y
 | | TRPV1 in nanodisc bound with one LPA in one monomer | | Descriptor: | (2R)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate, (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, SODIUM ION, ... | | Authors: | Arnold, W.R, Cheng, Y. | | Deposit date: | 2023-06-01 | | Release date: | 2024-05-08 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structural basis of TRPV1 modulation by endogenous bioactive lipids.
Nat.Struct.Mol.Biol., 2024
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5GSK
 | | Crystal structure of duplex DNA3 in complex with Hg(II) and Sr(II) | | Descriptor: | DNA (5'-D(*GP*GP*TP*CP*GP*TP*CP*C)-3'), MERCURY (II) ION, STRONTIUM ION | | Authors: | Liu, H.H, Wang, R, Yao, Q.Q, Cheng, Y.Q, Yang, C, Luo, Q, Wu, B.X, Li, J.X, Ma, J.B, Sheng, J, Gan, J.H. | | Deposit date: | 2016-08-16 | | Release date: | 2017-02-08 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.05 Å) | | Cite: | Flexibility and stabilization of HgII-mediated C:T and T:T base pairs in DNA duplex
Nucleic Acids Res., 45, 2017
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2B6O
 | | Electron crystallographic structure of lens Aquaporin-0 (AQP0) (lens MIP) at 1.9A resolution, in a closed pore state | | Descriptor: | 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, Lens fiber major intrinsic protein | | Authors: | Gonen, T, Cheng, Y, Sliz, P, Hiroaki, Y, Fujiyoshi, Y, Harrison, S.C, Walz, T. | | Deposit date: | 2005-10-03 | | Release date: | 2005-12-06 | | Last modified: | 2023-08-23 | | Method: | ELECTRON CRYSTALLOGRAPHY (1.9 Å) | | Cite: | Lipid-protein interactions in double-layered two-dimensional AQP0 crystals.
Nature, 438, 2005
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3AMD
 | | Crystal structures of Thermotoga maritima Cel5A, apo form and tetramer/au | | Descriptor: | Endoglucanase | | Authors: | Wu, T.H, Huang, C.H, Ko, T.P, Lai, H.L, Ma, Y, Cheng, Y.S, Liu, J.R, Guo, R.T. | | Deposit date: | 2010-08-19 | | Release date: | 2011-08-10 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Diverse substrate recognition mechanism revealed by Thermotoga maritima Cel5A structures in complex with cellotetraose, cellobiose and mannotriose
Biochim.Biophys.Acta, 1814, 2011
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