3C7T
 
 | | Crystal structure of the ecdysone phosphate phosphatase, EPPase, from Bombix mori in complex with tungstate | | 分子名称: | CHLORIDE ION, Ecdysteroid-phosphate phosphatase, IODIDE ION, ... | | 著者 | Chen, Y, Carpino, N, Nassar, N. | | 登録日 | 2008-02-08 | | 公開日 | 2009-03-24 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | Structural and functional characterization of the c-terminal domain of the ecdysteroid phosphate phosphatase from Bombyx mori reveals a new enzymatic activity.
Biochemistry, 47, 2008
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4PE8
 | | Crystal structure of TatD in complex with trinucleotide DNA | | 分子名称: | DNA (5'-D(*GP*CP*T)-3'), Tat-linked quality control protein TatD | | 著者 | Chen, Y, Li, C.-L, Hsiao, Y.-Y, Duh, Y, Yuan, H.S. | | 登録日 | 2014-04-23 | | 公開日 | 2014-08-27 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.894 Å) | | 主引用文献 | Structure and function of TatD exonuclease in DNA repair.
Nucleic Acids Res., 42, 2014
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6B5I
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6LQX
 | | Crystal structure of the CBP bromodomain in complex with small molecule LC-CPin7 | | 分子名称: | (1~{S},6~{R})-6-[(1-methoxycarbonyl-3,4-dihydro-2~{H}-quinolin-6-yl)carbamoyl]cyclohex-3-ene-1-carboxylic acid, CREB-binding protein, SODIUM ION | | 著者 | Chen, Y, Zhang, F, Sun, Z, Bi, X, Luo, C. | | 登録日 | 2020-01-14 | | 公開日 | 2021-01-20 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | | 主引用文献 | Design, synthesis and biological evaluation of novel small molecule inhibitor of the CBP bromodomain with possible anti-leukemia effects
To Be Published
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3BU8
 | | Crystal Structure of TRF2 TRFH domain and TIN2 peptide complex | | 分子名称: | TERF1-interacting nuclear factor 2, Telomeric repeat-binding factor 2 | | 著者 | Chen, Y, Yang, Y, van Overbeek, M, Donigian, J.R, Baciu, P, de Lange, T, Lei, M. | | 登録日 | 2008-01-02 | | 公開日 | 2008-02-19 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.
Science, 319, 2008
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3BQO
 | | Crystal Structure of TRF1 TRFH domain and TIN2 peptide complex | | 分子名称: | TERF1-interacting nuclear factor 2, Telomeric repeat-binding factor 1 | | 著者 | Chen, Y, Yang, Y, van Overbeek, M, Donigian, J.R, Baciu, P, de Lange, T, Lei, M. | | 登録日 | 2007-12-20 | | 公開日 | 2008-02-19 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.
Science, 319, 2008
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3BUA
 | | Crystal Structure of TRF2 TRFH domain and APOLLO peptide complex | | 分子名称: | DNA cross-link repair 1B protein, Telomeric repeat-binding factor 2 | | 著者 | Chen, Y, Yang, Y, van Overbeek, M, Donigian, J.R, Baciu, P, de Lange, T, Lei, M. | | 登録日 | 2008-01-02 | | 公開日 | 2008-02-19 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.
Science, 319, 2008
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6DJ3
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6JTK
 | | Crystal structure of NagZ from Neisseria gonorrhoeae in complex with N-trifluoroacetyl-D-glucosamine | | 分子名称: | 2,2,2-tris(fluoranyl)-N-[(2R,3R,4R,5S,6R)-6-(hydroxymethyl)-2,4,5-tris(oxidanyl)oxan-3-yl]ethanamide, Beta-hexosaminidase | | 著者 | Chen, Y. | | 登録日 | 2019-04-11 | | 公開日 | 2020-05-13 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structure of NagZ from Neisseria gonorrhoeae in complex with N-trifluoroacetyl-D-glucosamine
To Be Published
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8UAP
 | | Crystal Structure of Human G Protein-Coupled Receptor Kinase 5 D311N in Complex with CCG273441 | | 分子名称: | (3Z)-3-{[4-(2-chloroacetamido)-3,5-dimethyl-1H-pyrrol-2-yl]methylidene}-N-[(1R)-1-(4-fluorophenyl)ethyl]-2-oxo-2,3-dihydro-1H-indole-5-carboxamide, G protein-coupled receptor kinase 5 | | 著者 | Chen, Y, Tesmer, J.J.G. | | 登録日 | 2023-09-21 | | 公開日 | 2023-12-13 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Development of a new class of potent and highly selective G protein-coupled receptor kinase 5 inhibitors and structural insight from crystal structures of inhibitor complexes.
Eur.J.Med.Chem., 264, 2023
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8UAQ
 | | Crystal Structure of Human G Protein-Coupled Receptor Kinase 5 in Complex with GRL018-21 | | 分子名称: | (3Z)-N-[(1R)-1-(4-fluorophenyl)ethyl]-3-[(4-{[(2S)-2-(furan-2-yl)-2-hydroxyacetyl]amino}-3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-2-oxo-2,3-dihydro-1H-indole-5-carboxamide, G protein-coupled receptor kinase 5 | | 著者 | Chen, Y, Tesmer, J.J.G. | | 登録日 | 2023-09-21 | | 公開日 | 2023-12-13 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Development of a new class of potent and highly selective G protein-coupled receptor kinase 5 inhibitors and structural insight from crystal structures of inhibitor complexes.
Eur.J.Med.Chem., 264, 2023
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6JTI
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6JTL
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6JTJ
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2IKQ
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8YO7
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4GIT
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3M9E
 | | Thyroid hormone beta DNA binding domain homodimer with inverted palindrome TRE | | 分子名称: | DNA (5'-D(*AP*TP*TP*GP*AP*CP*CP*TP*CP*AP*GP*CP*TP*GP*AP*GP*GP*TP*CP*AP*AP*T)-3'), Thyroid hormone receptor beta, ZINC ION | | 著者 | Chen, Y. | | 登録日 | 2010-03-22 | | 公開日 | 2010-08-18 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.406 Å) | | 主引用文献 | Structure of a thyroid hormone receptor DNA-binding domain homodimer bound to an inverted palindrome DNA response element.
Mol.Endocrinol., 24, 2010
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3M70
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4L3N
 | | Crystal structure of the receptor-binding domain from newly emerged Middle East respiratory syndrome coronavirus | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, S protein | | 著者 | Chen, Y, Rajashankar, K.R, Yang, Y, Agnihothram, S.S, Liu, C, Lin, Y.-L, Baric, R.S, Li, F. | | 登録日 | 2013-06-06 | | 公開日 | 2013-07-31 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | | 主引用文献 | Crystal structure of the receptor-binding domain from newly emerged middle East respiratory syndrome coronavirus.
J.Virol., 87, 2013
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1CQ4
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2NYM
 | | Crystal Structure of Protein Phosphatase 2A (PP2A) with C-terminus truncated catalytic subunit | | 分子名称: | MANGANESE (II) ION, Protein phosphatase 2, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, ... | | 著者 | Chen, Y, Xing, Y, Xu, Y, Chao, Y, Lin, Z, Jeffrey, P.D, Shi, Y. | | 登録日 | 2006-11-21 | | 公開日 | 2006-12-12 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | Structure of the Protein Phosphatase 2A Holoenzyme.
Cell(Cambridge,Mass.), 127, 2006
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8GK7
 | | MsbA bound to cerastecin C | | 分子名称: | 2-[(4-butylbenzene-1-sulfonyl)amino]-5-[(3-{4-[(4-butylbenzene-1-sulfonyl)amino]-3-carboxyanilino}-3-oxopropyl)carbamoyl]benzoic acid, Lipid A export ATP-binding/permease protein MsbA, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | 著者 | Chen, Y, Klein, D. | | 登録日 | 2023-03-17 | | 公開日 | 2024-04-24 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | | 主引用文献 | Cerastecins inhibit membrane lipooligosaccharide transport in drug-resistant Acinetobacter baumannii.
Nat Microbiol, 9, 2024
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5GTM
 | | Modified human MxA, nucleotide-free form | | 分子名称: | Interferon-induced GTP-binding protein Mx1 | | 著者 | Chen, Y, Gao, S. | | 登録日 | 2016-08-22 | | 公開日 | 2017-05-31 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.896 Å) | | 主引用文献 | Conformational dynamics of dynamin-like MxA revealed by single-molecule FRET
Nat Commun, 8, 2017
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8IHE
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