1YPI
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3F69
| Crystal structure of the Mycobacterium tuberculosis PknB mutant kinase domain in complex with KT5720 | Descriptor: | SULFATE ION, Serine/threonine-protein kinase pknB, hexyl (5S,6R,8R)-6-hydroxy-5-methyl-13-oxo-5,6,7,8-tetrahydro-13H-5,8-epoxy-4b,8a,14-triazadibenzo[b,h]cycloocta[1,2,3,4-jkl]c yclopenta[e]-as-indacene-6-carboxylate | Authors: | Alber, T, Mieczkowski, C.A, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2008-11-05 | Release date: | 2008-12-02 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Auto-activation mechanism of the Mycobacterium tuberculosis PknB receptor Ser/Thr kinase. Embo J., 27, 2008
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3UQC
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4IMY
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3NBU
| Crystal structure of pGI glucosephosphate isomerase | Descriptor: | CHLORIDE ION, Glucose-6-phosphate isomerase | Authors: | Alber, T, Zubieta, C, Totir, M, May, A, Echols, N. | Deposit date: | 2010-06-04 | Release date: | 2011-06-29 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Macro-to-Micro Structural Proteomics: Native Source Proteins for High-Throughput Crystallization. Plos One, 7, 2012
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1DCO
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1DCP
| DCOH, A BIFUNCTIONAL PROTEIN-BINDING TRANSCRIPTIONAL COACTIVATOR, COMPLEXED WITH BIOPTERIN | Descriptor: | 7,8-DIHYDROBIOPTERIN, DCOH | Authors: | Cronk, J.D, Endrizzi, J.A, Alber, T. | Deposit date: | 1996-05-16 | Release date: | 1996-12-07 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | High-resolution structures of the bifunctional enzyme and transcriptional coactivator DCoH and its complex with a product analogue. Protein Sci., 5, 1996
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1DCH
| CRYSTAL STRUCTURE OF DCOH, A BIFUNCTIONAL, PROTEIN-BINDING TRANSCRIPTION COACTIVATOR | Descriptor: | DCOH (DIMERIZATION COFACTOR OF HNF-1), SULFATE ION | Authors: | Endrizzi, J.A, Cronk, J.D, Wang, W, Crabtree, G.R, Alber, T. | Deposit date: | 1995-01-24 | Release date: | 1996-03-08 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of DCoH, a bifunctional, protein-binding transcriptional coactivator. Science, 268, 1995
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1EKX
| THE ISOLATED, UNREGULATED CATALYTIC TRIMER OF ASPARTATE TRANSCARBAMOYLASE COMPLEXED WITH BISUBSTRATE ANALOG PALA (N-(PHOSPHONACETYL)-L-ASPARTATE) | Descriptor: | ASPARTATE TRANSCARBAMOYLASE, CALCIUM ION, N-(PHOSPHONACETYL)-L-ASPARTIC ACID | Authors: | Endrizzi, J.A, Beernink, P.T, Alber, T, Schachman, H.K. | Deposit date: | 2000-03-09 | Release date: | 2000-05-12 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Binding of bisubstrate analog promotes large structural changes in the unregulated catalytic trimer of aspartate transcarbamoylase: implications for allosteric regulation induced cell migration. Proc.Natl.Acad.Sci.USA, 97, 2000
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2OZ5
| Crystal structure of Mycobacterium tuberculosis protein tyrosine phosphatase PtpB in complex with the specific inhibitor OMTS | Descriptor: | Phosphotyrosine protein phosphatase ptpb, {(3-CHLOROBENZYL)[(5-{[(3,3-DIPHENYLPROPYL)AMINO]SULFONYL}-2-THIENYL)METHYL]AMINO}(OXO)ACETIC ACID | Authors: | Grundner, C, Gee, C.L, Alber, T, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2007-02-23 | Release date: | 2007-05-01 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Basis for Selective Inhibition of Mycobacterium tuberculosis Protein Tyrosine Phosphatase PtpB. Structure, 15, 2007
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1BB1
| CRYSTAL STRUCTURE OF A DESIGNED, THERMOSTABLE HETEROTRIMERIC COILED COIL | Descriptor: | CHLORIDE ION, DESIGNED, THERMOSTABLE HETEROTRIMERIC COILED COIL | Authors: | Nautiyal, S, Alber, T. | Deposit date: | 1998-04-28 | Release date: | 1999-02-02 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of a designed, thermostable, heterotrimeric coiled coil. Protein Sci., 8, 1999
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1ZIJ
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1ZII
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1ZIK
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1ZIL
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1ZIM
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1GCM
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3K7Z
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2GKG
| Receiver domain from Myxococcus xanthus social motility protein FrzS | Descriptor: | response regulator homolog | Authors: | Echols, N, Fraser, J, Merlie, J, Zusman, D, Alber, T. | Deposit date: | 2006-04-01 | Release date: | 2007-03-13 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | An atypical receiver domain controls the dynamic polar localization of the Myxococcus xanthus social motility protein FrzS. Mol.Microbiol., 65, 2007
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1F93
| CRYSTAL STRUCTURE OF A COMPLEX BETWEEN THE DIMERIZATION DOMAIN OF HNF-1 ALPHA AND THE COACTIVATOR DCOH | Descriptor: | DIMERIZATION COFACTOR OF HEPATOCYTE NUCLEAR FACTOR 1-ALPHA, HEPATOCYTE NUCLEAR FACTOR 1-ALPHA | Authors: | Rose, R.B, Bayle, J.H, Endrizzi, J.A, Cronk, J.D, Crabtree, G.R, Alber, T. | Deposit date: | 2000-07-06 | Release date: | 2000-09-20 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis of dimerization, coactivator recognition and MODY3 mutations in HNF-1alpha. Nat.Struct.Biol., 7, 2000
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1GCL
| GCN4 LEUCINE ZIPPER CORE MUTANT P-LI | Descriptor: | GCN4 | Authors: | Harbury, P.B, Zhang, T, Kim, P.S, Alber, T. | Deposit date: | 1993-10-20 | Release date: | 1995-06-03 | Last modified: | 2013-04-24 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A switch between two-, three-, and four-stranded coiled coils in GCN4 leucine zipper mutants. Science, 262, 1993
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1DEB
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2H34
| Apoenzyme crystal structure of the tuberculosis serine/threonine kinase, PknE | Descriptor: | BROMIDE ION, SODIUM ION, Serine/threonine-protein kinase pknE | Authors: | Gay, L.M, Ng, H.L, Alber, T. | Deposit date: | 2006-05-22 | Release date: | 2006-07-18 | Last modified: | 2017-10-18 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | A Conserved Dimer and Global Conformational Changes in the Structure of apo-PknE Ser/Thr Protein Kinase from Mycobacterium tuberculosis. J.Mol.Biol., 360, 2006
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1RB6
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1RB5
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