3F69

Crystal structure of the Mycobacterium tuberculosis PknB mutant kinase domain in complex with KT5720

Summary for 3F69

Entry DOI	10.2210/pdb3f69/pdb
Descriptor	Serine/threonine-protein kinase pknB, hexyl (5S,6R,8R)-6-hydroxy-5-methyl-13-oxo-5,6,7,8-tetrahydro-13H-5,8-epoxy-4b,8a,14-triazadibenzo[b,h]cycloocta[1,2,3,4-jkl]c yclopenta[e]-as-indacene-6-carboxylate, SULFATE ION, ... (4 entities in total)
Functional Keywords	protein kinase, pknb, mycobacterium tuberculosis, kt5720, structural genomics, structual genomics, cocrystallization of pknb kinase domain and inhibitors, tb structural genomics consortium, tbsgc, atp-binding, kinase, magnesium, metal-binding, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	2
Total formula weight	68556.40
Authors	Alber, T.,Mieczkowski, C.A.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2008-11-05, release date: 2008-12-02, Last modification date: 2024-04-03)
Primary citation	Mieczkowski, C.,Iavarone, A.T.,Alber, T. Auto-activation mechanism of the Mycobacterium tuberculosis PknB receptor Ser/Thr kinase. Embo J., 27:3186-3197, 2008 Cited by PubMed: 19008858 DOI: 10.1038/emboj.2008.236 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation