Crystal structure of the Mycobacterium tuberculosis PknB mutant kinase domain in complex with KT5720

Summary for 3F69

DescriptorSerine/threonine-protein kinase pknB, hexyl (5S,6R,8R)-6-hydroxy-5-methyl-13-oxo-5,6,7,8-tetrahydro-13H-5,8-epoxy-4b,8a,14-triazadibenzo[b,h]cycloocta[1,2,3,4-jkl]cyclopenta[e]-as-indacene-6-carboxylate, SULFATE ION, ... (4 entities in total)
Functional Keywordsprotein kinase, pknb, mycobacterium tuberculosis, kt5720, structural genomics, structual genomics, cocrystallization of pknb kinase domain and inhibitors, tb structural genomics consortium, tbsgc, atp-binding, kinase, magnesium, metal-binding, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase
Biological sourceMycobacterium tuberculosis
Total number of polymer chains2
Total molecular weight68556.4
Alber, T.,Mieczkowski, C.A.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2008-11-05, release date: 2008-12-02, Last modification date: 2017-10-25)
Primary citation
Mieczkowski, C.,Iavarone, A.T.,Alber, T.
Auto-activation mechanism of the Mycobacterium tuberculosis PknB receptor Ser/Thr kinase.
Embo J., 27:3186-3197, 2008
PubMed: 19008858 (PDB entries with the same primary citation)
DOI: 10.1038/emboj.2008.236
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.267100.2%2.9%2.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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