5EQJ
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![BU of 5eqj by Molmil](/molmil-images/mine/5eqj) | Crystal structure of the two-subunit tRNA m1A58 methyltransferase from Saccharomyces cerevisiae | Descriptor: | tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61, tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 | Authors: | Zhu, Y, Wang, M, Wang, C, Fan, X, Jiang, X, Teng, M, Li, X. | Deposit date: | 2015-11-13 | Release date: | 2016-09-14 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of the two-subunit tRNA m(1)A58 methyltransferase TRM6-TRM61 from Saccharomyces cerevisiae. Sci Rep, 6, 2016
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5HFM
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![BU of 5hfm by Molmil](/molmil-images/mine/5hfm) | Gp41-targeting HIV-1 fusion inhibitors with hook-like Ile-Asp-Leu tail | Descriptor: | Envelope glycoprotein gp160,gp41 CHR region, TRIS(HYDROXYETHYL)AMINOMETHANE | Authors: | Zhu, Y, Ye, S, Zhang, R. | Deposit date: | 2016-01-07 | Release date: | 2017-01-11 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.298 Å) | Cite: | Rational improvement of gp41-targeting HIV-1 fusion inhibitors: an innovatively designed Ile-Asp-Leu tail with alternative conformations Sci Rep, 6, 2016
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5HFL
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![BU of 5hfl by Molmil](/molmil-images/mine/5hfl) | |
5H0N
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![BU of 5h0n by Molmil](/molmil-images/mine/5h0n) | |
7E9T
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![BU of 7e9t by Molmil](/molmil-images/mine/7e9t) | Nanometer resolution in situ structure of SARS-CoV-2 post-fusion spike | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S2, ... | Authors: | Zhu, Y, Tai, L, Zhu, G, Yin, G, Sun, F. | Deposit date: | 2021-03-05 | Release date: | 2021-11-17 | Last modified: | 2022-03-23 | Method: | ELECTRON MICROSCOPY (10.9 Å) | Cite: | Nanometer-resolution in situ structure of the SARS-CoV-2 postfusion spike protein. Proc.Natl.Acad.Sci.USA, 118, 2021
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6LXT
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![BU of 6lxt by Molmil](/molmil-images/mine/6lxt) | Structure of post fusion core of 2019-nCoV S2 subunit | Descriptor: | Spike protein S2, TETRAETHYLENE GLYCOL, ZINC ION | Authors: | Zhu, Y, Sun, F. | Deposit date: | 2020-02-11 | Release date: | 2020-02-26 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion. Cell Res., 30, 2020
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7CWK
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3TG7
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![BU of 3tg7 by Molmil](/molmil-images/mine/3tg7) | Crystal structure of Adenovirus serotype 5 hexon at 1.6A resolution | Descriptor: | Hexon protein | Authors: | Zhu, Y, Roszak, A.W, Isaacs, N.W, McVey, J.H, Nicklin, S.A, Baker, A.H. | Deposit date: | 2011-08-17 | Release date: | 2011-11-02 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | crystal structure of Adenovirus serotype 5 hexon at 1.6A resolution To be Published
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8I7O
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![BU of 8i7o by Molmil](/molmil-images/mine/8i7o) | In situ structure of axonemal doublet microtubules in mouse sperm with 16-nm repeat | Descriptor: | Cilia and flagella-associated protein 77, Cilia- and flagella-associated protein 20, Cilia- and flagella-associated protein 276, ... | Authors: | Zhu, Y, Yin, G.L, Tai, L.H, Sun, F. | Deposit date: | 2023-02-01 | Release date: | 2023-10-11 | Last modified: | 2023-12-06 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | In-cell structural insight into the stability of sperm microtubule doublet. Cell Discov, 9, 2023
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8I7R
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![BU of 8i7r by Molmil](/molmil-images/mine/8i7r) | In situ structure of axonemal doublet microtubules in mouse sperm with 48-nm repeat | Descriptor: | Cilia and flagella-associated protein 77, Cilia- and flagella-associated protein 107, Cilia- and flagella-associated protein 141, ... | Authors: | Zhu, Y, Yin, G.L, Tai, L.H, Sun, F. | Deposit date: | 2023-02-02 | Release date: | 2023-10-11 | Last modified: | 2023-12-06 | Method: | ELECTRON MICROSCOPY (6.5 Å) | Cite: | In-cell structural insight into the stability of sperm microtubule doublet. Cell Discov, 9, 2023
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6JGY
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![BU of 6jgy by Molmil](/molmil-images/mine/6jgy) | Crystal structure of LASV-GP2 in a post fusion conformation | Descriptor: | Pre-glycoprotein polyprotein GP complex | Authors: | Zhu, Y, Zhang, X, Chen, B, Ye, S, Zhang, R. | Deposit date: | 2019-02-15 | Release date: | 2019-09-11 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.389 Å) | Cite: | Crystal Structure of Refolding Fusion Core of Lassa Virus GP2 and Design of Lassa Virus Fusion Inhibitors. Front Microbiol, 10, 2019
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7F01
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![BU of 7f01 by Molmil](/molmil-images/mine/7f01) | |
7FB3
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![BU of 7fb3 by Molmil](/molmil-images/mine/7fb3) | |
7FB0
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![BU of 7fb0 by Molmil](/molmil-images/mine/7fb0) | |
7FB1
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![BU of 7fb1 by Molmil](/molmil-images/mine/7fb1) | |
7FB4
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![BU of 7fb4 by Molmil](/molmil-images/mine/7fb4) | |
6OMM
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![BU of 6omm by Molmil](/molmil-images/mine/6omm) | Cryo-EM structure of formyl peptide receptor 2/lipoxin A4 receptor in complex with Gi | Descriptor: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhuang, Y, Liu, H, de Waal, P.W, Zhou, X.E, Wang, L, Meng, X, Zhao, G, Kang, Y, Melcher, K, Xu, H.E, Zhang, C. | Deposit date: | 2019-04-19 | Release date: | 2020-02-26 | Method: | ELECTRON MICROSCOPY (3.17 Å) | Cite: | Structure of formylpeptide receptor 2-Gicomplex reveals insights into ligand recognition and signaling. Nat Commun, 11, 2020
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6AKY
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![BU of 6aky by Molmil](/molmil-images/mine/6aky) | The Crystal structure of Human Chemokine Receptor CCR5 in complex with compound 34 | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4,4-difluoro-N-[(1S)-3-{(3-exo)-3-[3-methyl-5-(propan-2-yl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]octan-8-yl}-1-(thiophen-3-yl)propyl]cyclohexane-1-carboxamide, C-C chemokine receptor type 5,Rubredoxin,C-C chemokine receptor type 5, ... | Authors: | Zhu, Y, Zhao, Q, Wu, B. | Deposit date: | 2018-09-04 | Release date: | 2018-10-24 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure-Based Design of 1-Heteroaryl-1,3-propanediamine Derivatives as a Novel Series of CC-Chemokine Receptor 5 Antagonists. J. Med. Chem., 61, 2018
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6AKX
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![BU of 6akx by Molmil](/molmil-images/mine/6akx) | The Crystal structure of Human Chemokine Receptor CCR5 in complex with compound 21 | Descriptor: | C-C chemokine receptor type 5,Rubredoxin,C-C chemokine receptor type 5, N-[(1S)-3-{(3-exo)-3-[3-methyl-5-(propan-2-yl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]octan-8-yl}-1-(thiophen-2-yl)propyl]cyclopentanecarboxamide, NITRATE ION, ... | Authors: | Zhu, Y, Zhao, Q, Wu, B. | Deposit date: | 2018-09-04 | Release date: | 2018-10-24 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure-Based Design of 1-Heteroaryl-1,3-propanediamine Derivatives as a Novel Series of CC-Chemokine Receptor 5 Antagonists. J. Med. Chem., 61, 2018
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7WVY
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![BU of 7wvy by Molmil](/molmil-images/mine/7wvy) | Cryo-EM structure of the human formyl peptide receptor 2 in complex with Abeta42 and Gi2 | Descriptor: | Amyloid-beta A4 protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B. | Deposit date: | 2022-02-11 | Release date: | 2022-04-13 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin. Nat Commun, 13, 2022
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7WVW
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![BU of 7wvw by Molmil](/molmil-images/mine/7wvw) | Cryo-EM structure of the human formyl peptide receptor 2 in complex with fMYFINILTL and Gi2 | Descriptor: | FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B. | Deposit date: | 2022-02-11 | Release date: | 2022-04-13 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin. Nat Commun, 13, 2022
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7WVV
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![BU of 7wvv by Molmil](/molmil-images/mine/7wvv) | Cryo-EM structure of the human formyl peptide receptor 2 in complex with fMLFII and Gi2 | Descriptor: | FME-LEU-PHE-ILE-ILE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B. | Deposit date: | 2022-02-11 | Release date: | 2022-04-13 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin. Nat Commun, 13, 2022
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7WVU
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![BU of 7wvu by Molmil](/molmil-images/mine/7wvu) | Cryo-EM structure of the human formyl peptide receptor 1 in complex with fMLF and Gi1 | Descriptor: | FME-LEU-PHE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B. | Deposit date: | 2022-02-11 | Release date: | 2022-04-13 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin. Nat Commun, 13, 2022
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7WVX
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![BU of 7wvx by Molmil](/molmil-images/mine/7wvx) | Cryo-EM structure of the human formyl peptide receptor 2 in complex with fhumanin and Gi2 | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-2, ... | Authors: | Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B. | Deposit date: | 2022-02-11 | Release date: | 2022-04-13 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin. Nat Commun, 13, 2022
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7WGX
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![BU of 7wgx by Molmil](/molmil-images/mine/7wgx) | SARS-CoV-2 spike glycoprotein trimer in closed state after treatment with Cathepsin L | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-2-[[5-[(Z)-(3-ethenyl-4-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-1H-pyrrol-2-yl]methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid, ... | Authors: | Zhu, Y, Tai, L, Yin, G, Sun, F. | Deposit date: | 2021-12-29 | Release date: | 2023-01-04 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies Cell Discov, 8, 2022
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