5HFM

Gp41-targeting HIV-1 fusion inhibitors with hook-like Ile-Asp-Leu tail

Summary for 5HFM

• Entry DOI: 10.2210/pdb5hfm/pdb
• Related: 5HFL
• Descriptor: Envelope glycoprotein gp160,gp41 CHR region, TRIS(HYDROXYETHYL)AMINOMETHANE (3 entities in total)
• Functional Keywords: hiv-1 fusion inhibitor, ile-asp-leu tail, hook-like tail, viral protein
• Biological source: Human immunodeficiency virus 1 (HIV-1); More
• Total number of polymer chains: 6
• Total formula weight: 57007.50

Authors

Zhu, Y.,Ye, S.,Zhang, R. (deposition date: 2016-01-07, release date: 2017-01-11, Last modification date: 2024-03-20)

• Primary citation: Zhu, Y.,Su, S.,Qin, L.,Wang, Q.,Shi, L.,Ma, Z.,Tang, J.,Jiang, S.,Lu, L.,Ye, S.,Zhang, R.; Rational improvement of gp41-targeting HIV-1 fusion inhibitors: an innovatively designed Ile-Asp-Leu tail with alternative conformations; Sci Rep, 6:31983-31983, 2016; PubMed: 27666394; DOI: 10.1038/srep31983

Experimental method

X-RAY DIFFRACTION (2.298 Å)