5HFM

Gp41-targeting HIV-1 fusion inhibitors with hook-like Ile-Asp-Leu tail

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Envelope glycoprotein gp160,gp41 CHR region	polymer	82	9446.8	6	UniProt (Q70626) Pfam (PF00517) UniProt (by SIFTS) (P04578)	Human immunodeficiency virus 1 (HIV-1)	Env polyprotein
2	G, H (B, F)	TRIS(HYDROXYETHYL)AMINOMETHANE	non-polymer		163.2	2	Chemie (TAM)
3	I, J, K, L, M... (A, B, C, D, E...)	water	water		18.0	142	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F: 539 - 581 (UniProt: Q70626)

PDB	External Database	Details
Gly 535	-	expression tag
Pro 536	-	expression tag
Met 537	-	expression tag
Ala 538	-	expression tag

A, B, C, D, E, F: 622 - 656 (PDB: 5HFM)

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	56681.1
Non-Polymers*	Number of molecules	2
	Total formula weight	326.4
All*	Total formula weight	57007.5

*Water molecules are not included.