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PDB: 41 件
5ZBF
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BU of 5zbf by Molmil
Crystal structure of 4-hydroxyphenylpyruvic acid bound AerE from Microcystis aeruginosa
分子名称: 3-(4-HYDROXY-PHENYL)PYRUVIC ACID, Cupin domain protein, FE (II) ION
著者Qiu, X, Zhu, W.
登録日2018-02-11
公開日2019-02-13
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural and functional insights into the role of a cupin superfamily isomerase in the biosynthesis of Choi moiety of aeruginosin.
J. Struct. Biol., 205, 2019
8SUE
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BU of 8sue by Molmil
Human asparagine synthetase (apo-ASNS)
分子名称: Asparagine synthetase [glutamine-hydrolyzing]
著者Coricello, A, Zhu, W, Lupia, A, Gratteri, C, Vos, M, Chaptal, V, Alcaro, S, Takagi, Y, Richards, N.
登録日2023-05-12
公開日2024-05-22
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Human asparagine synthetase (apo-ASNS)
To Be Published
7TFP
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BU of 7tfp by Molmil
Human Ornithine Aminotransferase cocrystallized with its inhibitor, (1S,3S)-3-amino-4-(difluoromethylene)cyclopentane-1-carboxylic acid.
分子名称: (1S,3S,4S)-3-amino-4-(fluoromethyl)cyclopentane-1-carboxylic acid, Ornithine aminotransferase, mitochondrial, ...
著者Butrin, A, Zhu, W, Silverman, R, Liu, D.
登録日2022-01-06
公開日2022-04-06
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.71 Å)
主引用文献Rational Design, Synthesis, and Mechanism of (3 S ,4 R )-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase.
J.Am.Chem.Soc., 144, 2022
7TEV
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BU of 7tev by Molmil
Human Ornithine Aminotransferase cocrystallized with its inhibitor, (3S,4R)-3-amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylate
分子名称: (1S,3R,4S)-3-formyl-4-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]cyclopentane-1-carboxylic acid, Ornithine aminotransferase, mitochondrial
著者Butrin, A, Zhu, W, Silverman, R, Liu, D.
登録日2022-01-05
公開日2022-04-06
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Rational Design, Synthesis, and Mechanism of (3 S ,4 R )-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase.
J.Am.Chem.Soc., 144, 2022
7TED
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BU of 7ted by Molmil
Human Ornithine Aminotransferase cocrystallized with its inhibitor, (S,E)-3-amino-4-(fluoromethylene)cyclopent-1-ene-1-carboxylate
分子名称: (1S,3R,4S)-3-formyl-4-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]cyclopentane-1-carboxylic acid, Ornithine aminotransferase, mitochondrial, ...
著者Butrin, A, Zhu, W, Silverman, R, Liu, D.
登録日2022-01-04
公開日2022-04-06
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.63 Å)
主引用文献Rational Design, Synthesis, and Mechanism of (3 S ,4 R )-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase.
J.Am.Chem.Soc., 144, 2022
4FYG
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BU of 4fyg by Molmil
Structural basis for substrate recognition by a novel Legionella phosphoinositide phosphatase
分子名称: (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dibutanoate, SidF, inhibitor of growth family, ...
著者Hsu, F.S, Zhu, W, Brennan, L, Tao, L, Luo, Z.Q, Mao, Y.
登録日2012-07-04
公開日2012-08-22
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.822 Å)
主引用文献Structural basis for substrate recognition by a unique Legionella phosphoinositide phosphatase.
Proc.Natl.Acad.Sci.USA, 109, 2012
4FYE
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BU of 4fye by Molmil
Crystal structure of a Legionella phosphoinositide phosphatase, SidF
分子名称: PHOSPHATE ION, SidF, inhibitor of growth family, ...
著者Hsu, F.S, Zhu, W, Brennan, L, Tao, L, Luo, Z.Q, Mao, Y.
登録日2012-07-04
公開日2012-08-22
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.413 Å)
主引用文献Structural basis for substrate recognition by a unique Legionella phosphoinositide phosphatase.
Proc.Natl.Acad.Sci.USA, 109, 2012
4FYF
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BU of 4fyf by Molmil
Structural basis for substrate recognition by a novel Legionella phosphoinositide phosphatase
分子名称: MERCURY (II) ION, PHOSPHATE ION, SidF, ...
著者Hsu, F.S, Zhu, W, Brennan, L, Tao, L, Luo, Z.Q, Mao, Y.
登録日2012-07-04
公開日2012-08-22
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.424 Å)
主引用文献Structural basis for substrate recognition by a unique Legionella phosphoinositide phosphatase.
Proc.Natl.Acad.Sci.USA, 109, 2012
7LNM
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BU of 7lnm by Molmil
Ornithine Aminotransferase (OAT) cocrystallized with its inactivator - (1S,3S)-3-amino-4-(difluoromethylene)cyclopentene-1-carboxylic acid
分子名称: (1~{R},3~{S},4~{R})-3-methyl-4-[[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylamino]cyclopentane-1-carboxylic acid, Ornithine aminotransferase, mitochondrial
著者Butrin, A, Catlin, D, Zhu, W, Liu, D, Silverman, R.
登録日2021-02-07
公開日2021-08-25
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Remarkable and Unexpected Mechanism for ( S )-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase.
J.Am.Chem.Soc., 143, 2021
7LON
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BU of 7lon by Molmil
Ornithine Aminotransferase (OAT) cocrystallized with its inactivator - (1S,3S)-3-amino-4-(difluoromethylene)cyclohexene-1-carboxylic acid
分子名称: (1R,3S,4R)-3-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]-4-methylcyclohexane-1-carboxylic acid, Ornithine aminotransferase, mitochondrial, ...
著者Butrin, A, Zhu, W, Liu, D, Silverman, R.
登録日2021-02-10
公開日2021-08-25
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Remarkable and Unexpected Mechanism for ( S )-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase.
J.Am.Chem.Soc., 143, 2021
7LOM
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BU of 7lom by Molmil
Ornithine Aminotransferase (OAT) soaked with its inactivator - (1S,3S)-3-amino-4-(difluoromethylene)cyclohexene-1-carboxylic acid
分子名称: (3~{S},4~{S})-4-methyl-3-[[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylamino]cyclohexene-1-carboxylic acid, (4~{R})-4-(fluoranylmethyl)-3-[[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylamino]cyclohexene-1-carboxylic acid, Ornithine aminotransferase, ...
著者Butrin, A, Zhu, W, Liu, D, Silverman, R.
登録日2021-02-10
公開日2021-08-25
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Remarkable and Unexpected Mechanism for ( S )-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase.
J.Am.Chem.Soc., 143, 2021
3TH8
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BU of 3th8 by Molmil
Structure of E. coli undecaprenyl diphosphate synthase complexed with BPH-1063
分子名称: (2Z)-4-({3-[3-(hexyloxy)phenyl]propyl}amino)-2-hydroxy-4-oxobut-2-enoic acid, Undecaprenyl pyrophosphate synthase
著者Cao, R, Zhu, W, Zhang, Y, Oldfield, E.
登録日2011-08-18
公開日2012-07-04
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.114 Å)
主引用文献HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis.
ACS Med Chem Lett, 3, 2012
6JHB
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BU of 6jhb by Molmil
Crystal structure of NADPH and 4-hydroxyphenylpyruvic acid bound AerF from Microcystis aeruginosa
分子名称: 3-(4-HYDROXY-PHENYL)PYRUVIC ACID, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Short chain dehydrogenase family protein
著者Qiu, X, Wei, Y, Zhu, W.
登録日2019-02-17
公開日2019-11-27
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Structural and functional investigation of AerF, a NADPH-dependent alkenal double bond reductase participating in the biosynthesis of Choi moiety of aeruginosin
J.Struct.Biol., 2019
6LK0
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BU of 6lk0 by Molmil
Crystal structure of human wild type TRIP13
分子名称: Pachytene checkpoint protein 2 homolog
著者Wang, Y, Huang, J, Li, B, Xue, H, Tricot, G, Hu, L, Xu, Z, Sun, X, Chang, S, Gao, L, Tao, Y, Xu, H, Xie, Y, Xiao, W, Yu, D, Kong, Y, Chen, G, Sun, X, Lian, F, Zhang, N, Wu, X, Mao, Z, Zhan, F, Zhu, W, Shi, J.
登録日2019-12-17
公開日2020-01-22
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献A Small-Molecule Inhibitor Targeting TRIP13 Suppresses Multiple Myeloma Progression.
Cancer Res., 80, 2020
7BDV
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BU of 7bdv by Molmil
Structure of Can2 from Sulfobacillus thermosulfidooxidans in complex with cyclic tetra-adenylate (cA4)
分子名称: Can2, Cyclic tetraadenosine monophosphate (cA4)
著者McQuarrie, S, McMahon, S.A, Gloster, T.M, White, M.F, Graham, S, Zhu, W, Gruschow, S.
登録日2020-12-22
公開日2021-03-03
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献The CRISPR ancillary effector Can2 is a dual-specificity nuclease potentiating type III CRISPR defence.
Nucleic Acids Res., 49, 2021
8GXR
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BU of 8gxr by Molmil
crystal structure of UBC domain of UBE2O
分子名称: (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O, CITRIC ACID
著者Fu, Z, Zhu, W, Huang, H.
登録日2022-09-21
公開日2023-09-27
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献crystal structure of UBE2O
To Be Published
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件を2024-08-07に公開中

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