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7LON

Ornithine Aminotransferase (OAT) cocrystallized with its inactivator - (1S,3S)-3-amino-4-(difluoromethylene)cyclohexene-1-carboxylic acid

Summary for 7LON
Entry DOI10.2210/pdb7lon/pdb
DescriptorOrnithine aminotransferase, mitochondrial, THREONINE, (1R,3S,4R)-3-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]-4-methylcyclohexane-1-carboxylic acid, ... (4 entities in total)
Functional Keywordsornithine aminotransferase, oat, aminotransferase, inactivator, inhibitor, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains3
Total formula weight136103.38
Authors
Butrin, A.,Zhu, W.,Liu, D.,Silverman, R. (deposition date: 2021-02-10, release date: 2021-08-25, Last modification date: 2023-10-18)
Primary citationZhu, W.,Doubleday, P.F.,Butrin, A.,Weerawarna, P.M.,Melani, R.D.,Catlin, D.S.,Dwight, T.A.,Liu, D.,Kelleher, N.L.,Silverman, R.B.
Remarkable and Unexpected Mechanism for ( S )-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase.
J.Am.Chem.Soc., 143:8193-8207, 2021
Cited by
PubMed: 34014654
DOI: 10.1021/jacs.1c03572
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.95 Å)
Structure validation

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